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GSE55662: Plasticity of transcriptional regulation under antibiotic stress
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Results for PurR
Z-value: 0.81
Transcription factors associated with PurR
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| purR | 0.52 | 1.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| pyrC Show fit | 1.49 |
dihydroorotase |
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| purR Show fit | 0.96 |
PurR transcriptional repressor |
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| hflD-purB Show fit | 0.89 |
adenylosuccinate lyase lysogenization regulator |
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| purEK Show fit | 0.76 |
N5-carboxyaminoimidazole ribonucleotide synthetase N5-carboxyaminoimidazole ribonucleotide mutase |
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| purC Show fit | 0.67 |
phosphoribosylaminoimidazole-succinocarboxamide synthase |
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| cvpA-purF-ubiX Show fit | 0.54 |
membrane protein required for colicin V production amidophosphoribosyl transferase 3-octaprenyl-4-hydroxybenzoate carboxy-lyase partner protein |
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| guaBA Show fit | 0.49 |
IMP dehydrogenase GMP synthetase |
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| prs Show fit | 0.47 |
ribose-phosphate diphosphokinase |
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| speAB Show fit | 0.44 |
agmatinase arginine decarboxylase, biosynthetic |
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| purMN Show fit | 0.41 |
phosphoribosylglycinamide formyltransferase 1 phosphoribosylformylglycinamide cyclo-ligase |
Network of associatons between targets according to the STRING database.
First level regulatory network of PurR
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.5 | GO:0006221 | pyrimidine nucleotide biosynthetic process(GO:0006221) |
| 0.2 | 1.0 | GO:0045936 | negative regulation of phosphorus metabolic process(GO:0010563) negative regulation of phosphate metabolic process(GO:0045936) |
| 0.0 | 0.9 | GO:0009408 | response to heat(GO:0009408) |
| 0.0 | 0.7 | GO:0033014 | tetrapyrrole metabolic process(GO:0033013) tetrapyrrole biosynthetic process(GO:0033014) |
| 0.2 | 0.5 | GO:0046037 | GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037) GTP metabolic process(GO:0046039) guanosine-containing compound biosynthetic process(GO:1901070) |
| 0.2 | 0.5 | GO:0006015 | 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391) |
| 0.1 | 0.5 | GO:0044550 | secondary metabolite biosynthetic process(GO:0044550) |
| 0.1 | 0.4 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.0 | 0.1 | GO:0019464 | glycine decarboxylation via glycine cleavage system(GO:0019464) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.5 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.2 | 1.0 | GO:0001141 | transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding(GO:0001141) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217) |
| 0.3 | 0.9 | GO:0016842 | amidine-lyase activity(GO:0016842) |
| 0.1 | 0.8 | GO:0016879 | ligase activity, forming carbon-nitrogen bonds(GO:0016879) |
| 0.1 | 0.7 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.1 | 0.5 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.0 | 0.5 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
| 0.1 | 0.4 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.1 | 0.4 | GO:0016882 | cyclo-ligase activity(GO:0016882) |
| 0.1 | 0.2 | GO:0016635 | oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635) |