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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for NtrC

Z-value: 0.95

Transcription factors associated with NtrC

Gene Symbol Gene ID Gene Info
glnG NtrC transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
glnG0.811.5e-02Click!

Activity profile of NtrC motif

Sorted Z-values of NtrC motif

Promoter Log-likelihood Transcript Gene Gene Info
nac 3.30 Nac DNA-binding transcriptional dual regulator
glnK-amtB 3.22 nitrogen regulatory protein GlnK
ammonia / ammonium transporter
glnALG 2.72 NtrB
glutamine synthetase
NtrC transcriptional dual regulator
yhdWXYZ 2.64 putative transport protein, ABC superfamily - periplasmic binding protein
putative transport protein, ABC superfamily - membrane component
putative transport protein, ABC superfamily - ATP-binding component
putative transport protein, ABC superfamily - membrane component
cbl 2.52 Cbl DNA-binding transcriptional activator
glnLG 2.41 NtrC transcriptional dual regulator
NtrB
patA 1.92 putrescine aminotransferase
potFGHI 1.61 putrescine ABC transporter - membrane subunit
putrescine ABC transporter - membrane subunit
putrescine ABC transporter - ATP binding subunit
putrescine ABC transporter - periplasmic binding protein
argT-hisJQMP 1.15 lysine/arginine/ornithine ABC transporter / histidine ABC transporter - membrane subunit
lysine / arginine / ornithine ABC transporter / histidine ABC transporter - ATP binding subunit
lysine / arginine / ornithine ABC transporter - periplasmic binding protein
lysine / arginine / ornithine ABC transporter / histidine ABC transporter - membrane subunit
histidine ABC transporter - periplasmic binding protein
ddpXABCDF 0.41 D-Ala-D-Ala dipeptidase
YddP
YddO
YddS
YddR
YddQ
rutABCDEFG 0.08 predicted aminoacrylate peracid reductase
peroxyureidoacrylate / ureidoacrylate amido hydrolase
pyrimidine oxygenase
uracil:H+ symporter RutG
flavin reductase
predicted malonic semialdehyde reductase
predicted aminoacrylate hydrolase
astCADBE 0.03 arginine succinyltransferase
succinylarginine dihydrolase
succinylornithine transaminase
aldehyde dehydrogenase
succinylglutamate desuccinylase

Network of associatons between targets according to the STRING database.

First level regulatory network of NtrC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0006808 regulation of nitrogen utilization(GO:0006808)
0.6 2.5 GO:0006791 sulfur utilization(GO:0006791)
0.5 1.6 GO:0015847 polyamine transport(GO:0015846) putrescine transport(GO:0015847)
0.5 1.9 GO:0009447 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.3 1.2 GO:0090467 L-arginine import(GO:0043091) L-amino acid import(GO:0043092) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine import into cell(GO:1902765) L-arginine transmembrane transport(GO:1903400) L-lysine transmembrane transport(GO:1903401) arginine transmembrane transport(GO:1903826)
0.2 0.6 GO:0019740 nitrogen utilization(GO:0019740)
0.1 2.4 GO:0000160 phosphorelay signal transduction system(GO:0000160) protein autophosphorylation(GO:0046777)
0.1 3.3 GO:1903508 positive regulation of transcription, DNA-templated(GO:0045893) positive regulation of RNA metabolic process(GO:0051254) positive regulation of RNA biosynthetic process(GO:1902680) positive regulation of nucleic acid-templated transcription(GO:1903508)
0.0 0.4 GO:0006024 aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024) peptidoglycan biosynthetic process(GO:0009252)
0.0 0.0 GO:0006527 succinate metabolic process(GO:0006105) arginine catabolic process(GO:0006527)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 6.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 4.8 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.2 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.4 1.2 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.4 5.1 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 2.0 GO:0008483 transaminase activity(GO:0008483)
0.1 0.4 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.0 3.3 GO:0003700 transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.1 GO:0005350 monooxygenase activity(GO:0004497) pyrimidine nucleobase transmembrane transporter activity(GO:0005350)