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GSE55662: Plasticity of transcriptional regulation under antibiotic stress
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Results for Nac
Z-value: 2.11
Transcription factors associated with Nac
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nac | 0.97 | 8.5e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| nac Show fit | 15.01 |
Nac DNA-binding transcriptional dual regulator |
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| serA Show fit | 9.81 |
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| feaR Show fit | 6.93 |
FeaR DNA-binding transcriptional activator |
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| ydcSTUV-patD Show fit | 4.29 |
γ-aminobutyraldehyde dehydrogenase putative transport protein, ABC family - membrane component putative transport protein, ABC superfamily - ATP binding component putative transport protein, ABC superfamily - membrane component putative transport protein, ABC superfamily - periplasmic binding protein / polyhydroxybutyrate synthase |
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| asnC Show fit | 4.22 |
AsnC DNA-binding transcriptional dual regulator |
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| codBA Show fit | 3.78 |
cytosine transporter cytosine deaminase |
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| gabDTP Show fit | 3.28 |
succinate-semialdehyde dehydrogenase (NADP+) 4-aminobutyrate aminotransferase 4-aminobutyrate:H+ symporter |
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| asnC-mioC-mnmG Show fit | 2.83 |
flavoprotein involved in biotin synthesis protein involved in modification of U34 in tRNA AsnC DNA-binding transcriptional dual regulator |
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| asnC-mioC Show fit | 2.33 |
flavoprotein involved in biotin synthesis AsnC DNA-binding transcriptional dual regulator |
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| gltBDF Show fit | 2.10 |
glutamate synthase, large subunit glutamate synthase, small subunit periplasmic protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nac
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 21.9 | GO:1902680 | positive regulation of transcription, DNA-templated(GO:0045893) positive regulation of RNA metabolic process(GO:0051254) positive regulation of RNA biosynthetic process(GO:1902680) positive regulation of nucleic acid-templated transcription(GO:1903508) |
| 1.9 | 9.4 | GO:0043200 | response to amino acid(GO:0043200) |
| 0.7 | 4.3 | GO:0009447 | polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447) |
| 1.3 | 3.8 | GO:0006208 | pyrimidine nucleobase catabolic process(GO:0006208) pyrimidine nucleobase transport(GO:0015855) |
| 0.7 | 3.3 | GO:0006591 | ornithine metabolic process(GO:0006591) arginine biosynthetic process via ornithine(GO:0042450) |
| 0.7 | 2.1 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.9 | GO:0005829 | cytosol(GO:0005829) |
| 0.1 | 4.3 | GO:0098533 | ATP-binding cassette (ABC) transporter complex(GO:0043190) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949) |
| 0.0 | 2.1 | GO:0030288 | outer membrane-bounded periplasmic space(GO:0030288) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.0 | GO:0003700 | transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.6 | 9.4 | GO:0016597 | amino acid binding(GO:0016597) |
| 0.4 | 6.9 | GO:0000987 | bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding(GO:0000986) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159) |
| 0.9 | 4.3 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 1.3 | 3.8 | GO:0005350 | pyrimidine nucleobase transmembrane transporter activity(GO:0005350) |
| 1.1 | 3.3 | GO:0004777 | succinate-semialdehyde dehydrogenase (NAD+) activity(GO:0004777) |
| 0.3 | 1.8 | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) |