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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for Nac

Z-value: 2.11

Transcription factors associated with Nac

Gene Symbol Gene ID Gene Info
nac
nac Nac DNA-binding transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nac0.978.5e-05Click!

Activity profile of Nac motif

Sorted Z-values of Nac motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
nac 15.01
nac
Nac DNA-binding transcriptional dual regulator
serA 9.81

feaR 6.93
feaR
FeaR DNA-binding transcriptional activator
ydcSTUV-patD 4.29
patD
ydcV
ydcT
ydcU
ydcS
γ-aminobutyraldehyde dehydrogenase
putative transport protein, ABC family - membrane component
putative transport protein, ABC superfamily - ATP binding component
putative transport protein, ABC superfamily - membrane component
putative transport protein, ABC superfamily - periplasmic binding protein / polyhydroxybutyrate synthase
asnC 4.22
asnC
AsnC DNA-binding transcriptional dual regulator
codBA 3.78
codB
codA
cytosine transporter
cytosine deaminase
gabDTP 3.28
gabD
gabT
gabP
succinate-semialdehyde dehydrogenase (NADP+)
4-aminobutyrate aminotransferase
4-aminobutyrate:H+ symporter
asnC-mioC-mnmG 2.83
mioC
mnmG
asnC
flavoprotein involved in biotin synthesis
protein involved in modification of U34 in tRNA
AsnC DNA-binding transcriptional dual regulator
asnC-mioC 2.33
mioC
asnC
flavoprotein involved in biotin synthesis
AsnC DNA-binding transcriptional dual regulator
gltBDF 2.10
gltB
gltD
gltF
glutamate synthase, large subunit
glutamate synthase, small subunit
periplasmic protein

Network of associatons between targets according to the STRING database.

First level regulatory network of Nac

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 9.4 GO:0043200 response to amino acid(GO:0043200)
1.3 3.8 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) pyrimidine nucleobase transport(GO:0015855)
0.7 4.3 GO:0009447 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.7 2.1 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.7 3.3 GO:0006591 ornithine metabolic process(GO:0006591) arginine biosynthetic process via ornithine(GO:0042450)
0.4 21.9 GO:1902680 positive regulation of transcription, DNA-templated(GO:0045893) positive regulation of RNA metabolic process(GO:0051254) positive regulation of RNA biosynthetic process(GO:1902680) positive regulation of nucleic acid-templated transcription(GO:1903508)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 GO:0098533 ATP-binding cassette (ABC) transporter complex(GO:0043190) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)
0.0 2.1 GO:0030288 outer membrane-bounded periplasmic space(GO:0030288)
0.0 11.9 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0005350 pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
1.1 3.3 GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity(GO:0004777)
0.9 4.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.6 9.4 GO:0016597 amino acid binding(GO:0016597)
0.4 6.9 GO:0000987 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding(GO:0000986) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.3 1.8 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.3 15.0 GO:0003700 transcription factor activity, sequence-specific DNA binding(GO:0003700)