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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for Mlc

Z-value: 0.75

Transcription factors associated with Mlc

Gene Symbol Gene ID Gene Info
mlc
mlc Mlc DNA-binding transcriptional repressor
mtfA
mtfA Mlc titration factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mlc0.791.9e-02Click!

Activity profile of Mlc motif

Sorted Z-values of Mlc motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
mlc-ynfK 2.16
mlc
ynfK
Mlc DNA-binding transcriptional repressor
predicted dethiobiotin synthetase
ptsG 1.34
ptsG
glucose PTS permease - PtsG subunit
ptsHI-crr 1.02
ptsI
ptsH
crr
PTS enzyme I
HPr
Enzyme IIAGlc; Crr
mlc 1.02
mlc
Mlc DNA-binding transcriptional repressor

Network of associatons between targets according to the STRING database.

First level regulatory network of Mlc

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0046323 glucose transport(GO:0015758) glucose import(GO:0046323)
0.3 1.0 GO:0045912 carbohydrate utilization(GO:0009758) regulation of glucose metabolic process(GO:0010906) regulation of cellular catabolic process(GO:0031329) regulation of cellular carbohydrate catabolic process(GO:0043471) negative regulation of carbohydrate metabolic process(GO:0045912)
0.2 2.2 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 1.0 GO:0008047 enzyme activator activity(GO:0008047)
0.1 1.3 GO:0090563 protein-phosphocysteine-sugar phosphotransferase activity(GO:0090563)