ISMARA results: MarA

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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for MarA

Z-value: 0.73

Transcription factors associated with MarA

Gene Symbol	Gene ID	Gene Info
marA RegulonDB EcoCyc	marA	MarA DNA-binding transcriptional dual regulator

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
marA		-0.09	8.4e-01	Click!
marR		-0.09	8.4e-01	Click!

Activity profile of MarA motif

Sorted Z-values of MarA motif

Top targets:

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Promoter	Log-likelihood	Gene	Gene Info
yncE Show fit	4.89	yncE RegulonDB EcoCyc Show fit	conserved protein
poxB Show fit	1.62	poxB RegulonDB EcoCyc Show fit	pyruvate oxidase
acnA Show fit	1.30	acnA RegulonDB EcoCyc Show fit	aconitate hydratase 1
marRAB Show fit	1.02	marB RegulonDB EcoCyc Show fit marA RegulonDB EcoCyc Show fit marR RegulonDB EcoCyc Show fit	multiple antibiotic resistance protein MarA DNA-binding transcriptional dual regulator MarR DNA-binding transcriptional repressor
pqiAB Show fit	0.87	pqiB RegulonDB EcoCyc Show fit pqiA RegulonDB EcoCyc Show fit	paraquat-inducible protein B paraquat-inducible protein A
micF Show fit	0.79	micF RegulonDB EcoCyc Show fit	MicF
fpr Show fit	0.71	fpr RegulonDB EcoCyc Show fit	flavodoxin-NADP⁺ reductase/ferredoxin-NADP⁺ reductase
nfo Show fit	0.53	nfo RegulonDB EcoCyc Show fit	endonuclease IV
waaYZ Show fit	0.51	waaZ RegulonDB EcoCyc Show fit waaY RegulonDB EcoCyc Show fit	protein involved in KdoIII attachment during lipopolysaccharide core biosynthesis lipopolysaccharide core heptose (II) kinase
acrZ Show fit	0.49	acrZ RegulonDB EcoCyc Show fit	small membrane protein that interacts with the AcrAB-TolC multidrug efflux pump

Showing 1 to 10 of 16 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MarA

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	GO:0051289	pyruvate metabolic process(GO:0006090) protein tetramerization(GO:0051262) protein homotetramerization(GO:0051289)
0.4	1.3	GO:0006097	glyoxylate cycle(GO:0006097)
0.3	1.0	GO:0000303	response to superoxide(GO:0000303)
0.1	1.0	GO:0097237	cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.2	0.5	GO:0036460	cellular response to cell envelope stress(GO:0036460)
0.1	0.5	GO:0006284	base-excision repair(GO:0006284)
0.1	0.5	GO:0046401	lipopolysaccharide core region biosynthetic process(GO:0009244) lipopolysaccharide core region metabolic process(GO:0046401)
0.1	0.2	GO:0046256	trinitrotoluene metabolic process(GO:0018973) 2,4,6-trinitrotoluene metabolic process(GO:0018974) nitrotoluene metabolic process(GO:0019326) 2,4,6-trinitrotoluene catabolic process(GO:0046256) trinitrotoluene catabolic process(GO:0046260) nitrotoluene catabolic process(GO:0046263) toluene-containing compound metabolic process(GO:0072490) toluene-containing compound catabolic process(GO:0072491)
0.0	0.2	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.1	GO:0031329	regulation of cellular catabolic process(GO:0031329) regulation of cellular carbohydrate catabolic process(GO:0043471)

Showing 1 to 10 of 12 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.1	GO:0030288	outer membrane-bounded periplasmic space(GO:0030288)
0.0	0.7	GO:0019867	outer membrane(GO:0019867)

Showing 1 to 2 of 2 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.1	GO:0003677	DNA binding(GO:0003677)
0.2	1.6	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.1	1.3	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1	0.7	GO:0071949	FAD binding(GO:0071949)
0.1	0.5	GO:0015238	drug transmembrane transporter activity(GO:0015238)
0.1	0.5	GO:0008081	endodeoxyribonuclease activity(GO:0004520) phosphoric diester hydrolase activity(GO:0008081)
0.1	0.3	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1	0.2	GO:0015307	drug:proton antiporter activity(GO:0015307)
0.0	0.2	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0	0.1	GO:0034567	chromate reductase activity(GO:0034567)

Showing 1 to 10 of 11 entries

Results for MarA

Z-value: 0.73

Transcription factors associated with MarA

Activity-expression correlation:

Activity profile of MarA motif

Sorted Z-values of MarA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MarA

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category: