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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for Lrp

Z-value: 2.06

Transcription factors associated with Lrp

Gene Symbol Gene ID Gene Info
lrp
lrp Lrp transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lrp0.561.5e-01Click!

Activity profile of Lrp motif

Sorted Z-values of Lrp motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
ompC 12.12
ompC
outer membrane protein C
ssrS 10.68
ssrS
6S RNA
rrsD-ileU-alaU-rrlD-rrfD-thrV-rrfF 8.99
rrlD
ileU
alaU
thrV
rrfF
rrsD
rrfD
rrlD 23S ribosomal RNA
tRNAileU
tRNAalaU
tRNAthrV
rrfF 5S ribosomal RNA
rrsD 16S ribosomal RNA
rrfD 5S ribosomal RNA
rrsC-gltU-rrlC-rrfC 8.73
rrlC
gltU
rrfC
rrsC
rrlC 23S ribosomal RNA
tRNAgltU
rrfC 5S ribosomal RNA
rrsC 16S ribosomal RNA
rrsG-gltW-rrlG-rrfG 8.31
rrlG
gltW
rrfG
rrsG
rrlG 23S ribosomal RNA
tRNAgltW
rrfG 5S ribosomal RNA
rrsG 16S ribosomal RNA
rrsE-gltV-rrlE-rrfE 8.27
rrlE
gltV
rrsE
rrfE
rrlE 23S ribosomal RNA
tRNAgltV
rrsE 16S ribosomal RNA
rrfE 5S ribosomal RNA
rrsA-ileT-alaT-rrlA-rrfA 7.98
rrlA
ileT
alaT
rrsA
rrfA
23S ribosomal RNA (rrlA)
tRNAileT
tRNAalaT
16S ribosomal RNA (rrsA)
5S ribosomal RNA (rrfA)
rrsH-ileV-alaV-rrlH-rrfH 7.77
rrlH
rrfH
rrsH
ileV
alaV
rrlH 23S ribosomal RNA
rrfH 5S ribosomal RNA
rrsH 16S ribosomal RNA
tRNAileV
tRNAalaV
rrsB-gltT-rrlB-rrfB 7.74
rrlB
gltT
rrfB
rrsB
rrlB 23S ribosomal RNA
tRNAgltT
rrfB 5S ribosomal RNA
rrsB 16S ribosomal RNA
lysU 6.44
lysU
lysine-tRNA ligase / Ap4A synthetase / Ap3A synthetase
micF 4.15
micF
MicF
oppABCDF 3.52
oppA
oppC
oppB
oppD
oppF
peptide ABC transporter - periplasmic binding protein
murein tripeptide ABC transporter / peptide ABC transporter - putative membrane subunit
murein tripeptide ABC transporter / peptide ABC transporter - putative membrane subunit
murein tripeptide ABC transporter / peptide ABC transporter - putative ATP binding subunit
murein tripeptide ABC transporter / peptide ABC transporter - putative ATP binding subunit
kbl-tdh 3.47
tdh
kbl
threonine dehydrogenase
2-amino-3-ketobutyrate CoA ligase
adhE 2.61
adhE
aldehyde-alcohol dehydrogenase
hdeAB-yhiD 2.31
yhiD
hdeB
hdeA
inner membrane protein YhiD
HdeB monomer
HdeA monomer, chaperone active form
osmC 1.61
osmC
osmotically inducible peroxiredoxin
cadBA 1.49
cadA
cadB
lysine decarboxylase 1
lysine:cadaverine antiporter
gltBDF 0.83
gltB
gltD
gltF
glutamate synthase, large subunit
glutamate synthase, small subunit
periplasmic protein
gcvTHP 0.77
gcvH
gcvP
gcvT
glycine cleavage system H protein
glycine decarboxylase
aminomethyltransferase
ilvL 0.66
ilvL
ilvGEDA operon leader peptide
sdaA 0.57
sdaA
L-serine deaminase I
lrp 0.52
lrp
Lrp transcriptional dual regulator

Network of associatons between targets according to the STRING database.

First level regulatory network of Lrp

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 12.1 GO:0015748 organophosphate ester transport(GO:0015748)
0.9 3.5 GO:0006857 oligopeptide transport(GO:0006857) oligopeptide transmembrane transport(GO:0035672)
0.9 2.6 GO:0006067 ethanol metabolic process(GO:0006067)
0.8 3.8 GO:0071468 cellular response to acidic pH(GO:0071468)
0.7 3.5 GO:0006567 threonine catabolic process(GO:0006567)
0.3 6.4 GO:0043039 tRNA aminoacylation for protein translation(GO:0006418) tRNA aminoacylation(GO:0043039)
0.3 0.6 GO:0006565 L-serine catabolic process(GO:0006565)
0.3 0.8 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.3 0.8 GO:0006544 glycine metabolic process(GO:0006544) glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 1.1 GO:0006972 hyperosmotic response(GO:0006972)
0.1 0.5 GO:0043200 response to amino acid(GO:0043200)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 12.1 GO:0045203 integral component of cell outer membrane(GO:0045203)
0.0 0.8 GO:1990204 oxidoreductase complex(GO:1990204)
0.0 0.5 GO:1904949 ATP-binding cassette (ABC) transporter complex(GO:0043190) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0035673 oligopeptide transporter activity(GO:0015198) peptidoglycan transporter activity(GO:0015647) oligopeptide transmembrane transporter activity(GO:0035673)
0.8 2.3 GO:0051087 chaperone binding(GO:0051087)
0.5 1.6 GO:0051920 peroxiredoxin activity(GO:0051920)
0.4 1.5 GO:0015491 L-lysine transmembrane transporter activity(GO:0015189) cation:cation antiporter activity(GO:0015491)
0.3 6.4 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.2 3.5 GO:0008198 ferrous iron binding(GO:0008198)
0.1 0.8 GO:0031405 lipoic acid binding(GO:0031405)
0.1 2.6 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)