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GSE55662: Plasticity of transcriptional regulation under antibiotic stress
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Results for H-NS
Z-value: 1.56
Transcription factors associated with H-NS
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hns | -0.09 | 8.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| cydAB Show fit | 4.63 |
cytochrome bd-I terminal oxidase subunit I cytochrome bd-I terminal oxidase subunit II |
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| gspAB Show fit | 3.97 |
calcium-binding protein required for initiation of chromosome replication general secretory pathway component, cryptic |
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| gspCDEFGHIJKLMO Show fit | 3.27 |
putative protein secretion protein for export putative protein secretion protein for export putative protein secretion protein for export putative protein secretion protein for export putative protein secretion protein for export putative protein secretion protein for export putative protein secretion protein for export putative protein secretion protein for export putative protein secretion protein for export leader peptidase, integral membrane protein putative protein secretion protein for export putative protein secretion protein |
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| caiF Show fit | 2.70 |
CaiF transcriptional activator |
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| acrEF Show fit | 2.65 |
AcrEF-TolC multidrug efflux pump - permease subunit AcrEF-TolC multidrug efflux pump - membrane fusion protein |
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| chiA Show fit | 2.52 |
endochitinase |
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| ydeO Show fit | 2.30 |
YdeO DNA-binding transcriptional dual regulator |
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| yjjQ-bglJ Show fit | 1.88 |
BglJ DNA-binding transcriptional regulator YjjQ DNA-binding transcriptional repressor |
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| proVWX Show fit | 1.74 |
glycine betaine / proline ABC transporter - periplasmic binding protein glycine betaine / proline ABC transporter - membrane subunit glycine betaine / proline ABC transporter - ATP binding subunit |
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| stpA Show fit | 1.65 |
H-NS-like DNA-binding transcriptional repressor with RNA chaperone activity |
Network of associatons between targets according to the STRING database.
First level regulatory network of H-NS
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.6 | GO:0019646 | aerobic electron transport chain(GO:0019646) |
| 1.2 | 3.7 | GO:0009437 | carnitine metabolic process(GO:0009437) |
| 0.4 | 3.3 | GO:0071806 | protein transmembrane transport(GO:0071806) |
| 0.0 | 2.2 | GO:0051254 | positive regulation of transcription, DNA-templated(GO:0045893) positive regulation of RNA metabolic process(GO:0051254) positive regulation of RNA biosynthetic process(GO:1902680) positive regulation of nucleic acid-templated transcription(GO:1903508) |
| 0.9 | 1.7 | GO:0015697 | quaternary ammonium group transport(GO:0015697) amino-acid betaine transport(GO:0015838) |
| 0.2 | 1.6 | GO:0006855 | drug transmembrane transport(GO:0006855) |
| 0.4 | 1.3 | GO:0051715 | cell killing(GO:0001906) cytolysis(GO:0019835) killing of cells of other organism(GO:0031640) modification of morphology or physiology of other organism(GO:0035821) disruption of cells of other organism(GO:0044364) cytolysis in other organism(GO:0051715) |
| 0.2 | 1.2 | GO:0015766 | disaccharide transport(GO:0015766) disaccharide catabolic process(GO:0046352) |
| 0.3 | 1.1 | GO:0009097 | isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097) |
| 0.1 | 1.1 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.4 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.0 | 4.8 | GO:0005886 | plasma membrane(GO:0005886) |
| 1.5 | 4.6 | GO:0070069 | cytochrome complex(GO:0070069) |
| 0.3 | 1.3 | GO:0005576 | extracellular region(GO:0005576) |
| 0.3 | 1.2 | GO:0043227 | membrane-bounded organelle(GO:0043227) intracellular membrane-bounded organelle(GO:0043231) |
| 0.1 | 1.1 | GO:1990234 | transferase complex(GO:1990234) |
| 0.0 | 1.0 | GO:0030288 | outer membrane-bounded periplasmic space(GO:0030288) |
| 0.0 | 0.1 | GO:0042995 | cell projection(GO:0042995) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.0 | GO:0003700 | transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 1.5 | 4.6 | GO:0016679 | oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor(GO:0016682) |
| 0.2 | 2.5 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 0.1 | 2.3 | GO:0008233 | peptidase activity(GO:0008233) |
| 0.2 | 1.8 | GO:0001140 | transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding(GO:0001140) |
| 0.6 | 1.7 | GO:0099600 | amine transmembrane transporter activity(GO:0005275) transmembrane receptor activity(GO:0099600) |
| 0.1 | 1.3 | GO:0015238 | drug transmembrane transporter activity(GO:0015238) |
| 0.4 | 1.2 | GO:0070492 | O-acetyltransferase activity(GO:0016413) oligosaccharide binding(GO:0070492) |
| 0.4 | 1.1 | GO:0008706 | 6-phospho-beta-glucosidase activity(GO:0008706) |
| 0.4 | 1.1 | GO:0003984 | acetolactate synthase activity(GO:0003984) |