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GSE55662: Plasticity of transcriptional regulation under antibiotic stress
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Results for GadE
Z-value: 1.38
Transcription factors associated with GadE
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| gadE | 0.84 | 8.8e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| purA Show fit | 8.67 |
adenylosuccinate synthetase |
||
| gadE-mdtEF Show fit | 6.94 |
MdtEF-TolC multidrug efflux pump - permease subunit MdtEF-TolC multidrug efflux pump - membrane fusion protein GadE DNA-binding transcriptional activator |
||
| gnd Show fit | 6.40 |
6-phosphogluconate dehydrogenase, decarboxylating |
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| skp-lpxD-fabZ-lpxA Show fit | 4.52 |
UDP-N-acetylglucosamine acyltransferase UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase periplasmic chaperone 3-hydroxy-acyl-[acyl-carrier-protein] dehydratase |
||
| hdeAB-yhiD Show fit | 4.10 |
inner membrane protein YhiD HdeB monomer HdeA monomer, chaperone active form |
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| lrp Show fit | 3.88 |
Lrp transcriptional dual regulator |
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| hdeD Show fit | 2.96 |
acid-resistance membrane protein |
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| gadE Show fit | 1.65 |
GadE DNA-binding transcriptional activator |
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| gltBDF Show fit | 1.41 |
glutamate synthase, large subunit glutamate synthase, small subunit periplasmic protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of GadE
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 8.7 | GO:0046040 | IMP metabolic process(GO:0046040) |
| 0.8 | 6.9 | GO:0006855 | drug transmembrane transport(GO:0006855) |
| 1.3 | 6.4 | GO:0046177 | D-gluconate metabolic process(GO:0019521) D-gluconate catabolic process(GO:0046177) |
| 1.5 | 4.5 | GO:0032978 | protein insertion into membrane from inner side(GO:0032978) |
| 0.8 | 4.1 | GO:0071468 | cellular response to acidic pH(GO:0071468) |
| 0.8 | 3.9 | GO:0006551 | alanine metabolic process(GO:0006522) leucine metabolic process(GO:0006551) pyruvate family amino acid metabolic process(GO:0009078) leucine biosynthetic process(GO:0009098) response to amino acid(GO:0043200) |
| 0.3 | 3.0 | GO:0009268 | response to pH(GO:0009268) |
| 0.5 | 1.4 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.2 | GO:0005829 | cytosol(GO:0005829) |
| 0.1 | 10.0 | GO:0030288 | outer membrane-bounded periplasmic space(GO:0030288) |
| 0.0 | 6.4 | GO:0005886 | plasma membrane(GO:0005886) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.7 | GO:0016879 | ligase activity, forming carbon-nitrogen bonds(GO:0016879) |
| 0.5 | 6.9 | GO:0015238 | drug transmembrane transporter activity(GO:0015238) |
| 0.2 | 6.4 | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616) |
| 1.5 | 4.5 | GO:0019171 | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity(GO:0008693) 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity(GO:0019171) 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity(GO:0047451) |
| 1.4 | 4.1 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 3.9 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.2 | 1.4 | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) |