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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for GadE

Z-value: 1.38

Transcription factors associated with GadE

Gene Symbol Gene ID Gene Info
gadE
gadE DNA-binding transcriptional activator GadE

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gadE0.848.8e-03Click!

Activity profile of GadE motif

Sorted Z-values of GadE motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
purA 8.67
purA
adenylosuccinate synthetase
gadE-mdtEF 6.94
mdtF
mdtE
gadE
MdtEF-TolC multidrug efflux pump - permease subunit
MdtEF-TolC multidrug efflux pump - membrane fusion protein
GadE DNA-binding transcriptional activator
gnd 6.40
gnd
6-phosphogluconate dehydrogenase, decarboxylating
skp-lpxD-fabZ-lpxA 4.52
lpxA
lpxD
skp
fabZ
UDP-N-acetylglucosamine acyltransferase
UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase
periplasmic chaperone
3-hydroxy-acyl-[acyl-carrier-protein] dehydratase
hdeAB-yhiD 4.10
yhiD
hdeB
hdeA
inner membrane protein YhiD
HdeB monomer
HdeA monomer, chaperone active form
lrp 3.88
lrp
Lrp transcriptional dual regulator
hdeD 2.96
hdeD
acid-resistance membrane protein
gadE 1.65
gadE
GadE DNA-binding transcriptional activator
gltBDF 1.41
gltB
gltD
gltF
glutamate synthase, large subunit
glutamate synthase, small subunit
periplasmic protein

Network of associatons between targets according to the STRING database.

First level regulatory network of GadE

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.7 GO:0046040 IMP metabolic process(GO:0046040)
1.5 4.5 GO:0032978 protein insertion into membrane from inner side(GO:0032978)
1.3 6.4 GO:0046177 D-gluconate metabolic process(GO:0019521) D-gluconate catabolic process(GO:0046177)
0.8 4.1 GO:0071468 cellular response to acidic pH(GO:0071468)
0.8 3.9 GO:0006551 alanine metabolic process(GO:0006522) leucine metabolic process(GO:0006551) pyruvate family amino acid metabolic process(GO:0009078) leucine biosynthetic process(GO:0009098) response to amino acid(GO:0043200)
0.8 6.9 GO:0006855 drug transmembrane transport(GO:0006855)
0.5 1.4 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.3 3.0 GO:0009268 response to pH(GO:0009268)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 10.0 GO:0030288 outer membrane-bounded periplasmic space(GO:0030288)
0.0 18.2 GO:0005829 cytosol(GO:0005829)
0.0 6.4 GO:0005886 plasma membrane(GO:0005886)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0019171 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity(GO:0008693) 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity(GO:0019171) 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity(GO:0047451)
1.4 4.1 GO:0051087 chaperone binding(GO:0051087)
0.5 6.9 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.3 8.7 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.2 1.4 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.2 6.4 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 3.9 GO:0042802 identical protein binding(GO:0042802)