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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for FlhDC

Z-value: 1.75

Transcription factors associated with FlhDC

Gene Symbol Gene ID Gene Info
flhC
flhC DNA-binding transcriptional dual regulator FlhC
flhD
flhD DNA-binding transcriptional dual regulator FlhD

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
flhD-0.676.9e-02Click!
flhC-0.676.9e-02Click!

Activity profile of FlhDC motif

Sorted Z-values of FlhDC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
glpABC 7.12
glpA
glpC
glpB
anaerobic glycerol-3-phosphate dehydrogenase subunit A
anaerobic glycerol-3-phosphate dehydrogenase subunit C
anaerobic glycerol-3-phosphate dehydrogenase subunit B
yecR 7.08
yecR
predicted protein
flhBAE 6.51
flhB
flhA
flhE
flagellar biosynthesis protein FlhB
flagellar biosynthesis protein FlhA
flagellar protein
fliDST 4.81
fliT
fliD
fliS
flagellar biosynthesis protein FliT
flagellar cap protein FliD; filament capping protein; enables filament assembly
flagellar biosynthesis protein FliS
pdeH 4.65
pdeH
c-di-GMP phosphodiesterase
flgAMN 4.27
flgA
flgN
flgM
flagellar biosynthesis; assembly of basal-body periplasmic P ring
flagellar biosynthesis protein FlgN
anti-sigma factor for FliA (σ28)
flgBCDEFGHIJ 3.93
flgC
flgB
flgG
flgF
flgE
flgD
flgJ
flgI
flgH
flagellar basal-body rod protein FlgC
flagellar basal-body rod protein FlgB
flagellar basal-body rod protein FlgG
flagellar basal-body rod protein FlgF
flagellar hook protein FlgE
flagellar biosynthesis, initiation of hook assembly
FlgJ
flagellar P-ring protein FlgI
flagellar L-ring protein FlgH; basal-body outer-membrane L (lipopolysaccharide layer) ring protein
flgKL 3.11
flgK
flgL
flagellar biosynthesis, hook-filament junction protein 1
flagellar biosynthesis; hook-filament junction protein
fliLMNOPQR 2.98
fliQ
fliP
fliR
fliM
fliL
fliO
fliN
flagellar biosynthesis protein FliQ
flagellar biosynthesis protein FliP
flagellar biosynthesis protein FliR
flagellar motor switch protein FliM
flagellar protein FliL
flagellar biosynthesis protein FliO
flagellar motor switch protein FliN
ycgR 2.18
ycgR
molecular brake that regulates flagellar motility in response to c-di-GMP
nrfABCDEFG 1.59
nrfF
nrfG
nrfD
nrfE
nrfB
nrfC
nrfA
activator of formate-dependent nitrite reductase complex
NrfG
formate dependent nitrite reductase - NrfD subunit
formate-dependent nitrite reductase; possible assembly function
formate-dependent nitrite reductase - penta-heme cytochrome c
formate-dependent nitrite reductase, 4Fe-4S subunit
formate dependent nitrite reductase - NrfA subunit
fliFGHIJK 0.86
fliI
fliH
fliK
fliJ
fliG
fliF
flagellum-specific ATP synthase FliI
flagellar biosynthesis protein FliH
flagellar hook-length control protein FliK
flagellar biosynthesis protein FliJ
flagellar motor switch protein FliG
flagellar M-ring protein FliF; basal-body MS(membrane and supramembrane)-ring and collar protein
hydN-hypF 0.81
hypF
hydN
hydrogenase maturation protein, carbamoyltransferase
putative electron transport protein HydN
ygbK 0.71
ygbK
conserved protein
fliE 0.65
fliE
flagellar basal-body protein FliE
gltI-sroC-gltJKL 0.38
sroC
gltI
gltK
gltJ
gltL
SroC
glutamate / aspartate ABC transporter - periplasmic binding protein
glutamate / aspartate ABC transporter - membrane subunit
glutamate / aspartate ABC transporter - membrane subunit
glutamate / aspartate ABC transporter - ATP binding subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of FlhDC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 10.5 GO:0044781 bacterial-type flagellum assembly(GO:0044780) bacterial-type flagellum organization(GO:0044781)
1.2 20.9 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) bacterial-type flagellum-dependent cell motility(GO:0071973) archaeal or bacterial-type flagellum-dependent cell motility(GO:0097588)
0.7 8.7 GO:0022900 electron transport chain(GO:0022900)
0.1 0.4 GO:1901998 toxin transport(GO:1901998)
0.0 0.8 GO:0051604 protein maturation(GO:0051604)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 19.1 GO:0009288 bacterial-type flagellum(GO:0009288)
0.3 7.1 GO:1990204 oxidoreductase complex(GO:1990204)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.9 4.7 GO:0071111 cyclic-guanylate-specific phosphodiesterase activity(GO:0071111)
0.4 2.2 GO:0030551 cyclic nucleotide binding(GO:0030551) cyclic-di-GMP binding(GO:0035438)
0.4 1.6 GO:0016662 oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662)
0.3 2.4 GO:0016989 sigma factor antagonist activity(GO:0016989)
0.2 0.8 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0 0.4 GO:0016597 amino acid binding(GO:0016597)
0.0 5.8 GO:0005515 protein binding(GO:0005515)