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GSE55662: Plasticity of transcriptional regulation under antibiotic stress
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Results for CysB
Z-value: 2.42
Transcription factors associated with CysB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| cysB | -0.85 | 7.6e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| ybdN Show fit | 10.85 |
conserved protein |
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| ssuEADCB Show fit | 10.78 |
NADPH-dependent FMN reductase alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate ABC transporter - periplasmic binding protein aliphatic sulfonate ABC transporter - membrane subunit aliphatic sulfonate ABC transporter - ATP binding subunit |
||
| cbl Show fit | 10.13 |
Cbl DNA-binding transcriptional activator |
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| ygeH Show fit | 9.22 |
predicted transcriptional regulator |
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| dgcZ Show fit | 8.21 |
diguanylate cyclase |
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| yciW Show fit | 5.97 |
predicted oxidoreductase |
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| yfbR Show fit | 5.89 |
dCMP phosphohydrolase |
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| cysDNC Show fit | 5.28 |
sulfate adenylyltransferase, CysD subunit sulfate adenylyltransferase, CysN subunit adenylylsulfate kinase |
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| cysPUWAM Show fit | 5.09 |
sulfate / thiosulfate ABC transporter - membrane subunit cysteine synthase B sulfate / thiosulfate ABC transporter - membrane subunit sulfate / thiosulfate ABC transporter - ATP binding subunit sulfate / thiosulfate ABC transporter - periplasmic binding protein CysP |
||
| hslJ Show fit | 4.97 |
lipoprotein implicated in Novobiocin resistance |
Network of associatons between targets according to the STRING database.
First level regulatory network of CysB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 15.0 | GO:0042908 | cellular response to sulfate starvation(GO:0009970) xenobiotic transport(GO:0042908) |
| 2.7 | 8.2 | GO:1902116 | negative regulation of organelle organization(GO:0010639) negative regulation of cell projection organization(GO:0031345) cell adhesion involved in biofilm formation(GO:0043708) negative regulation of organelle assembly(GO:1902116) negative regulation of bacterial-type flagellum assembly(GO:1902209) |
| 2.0 | 5.9 | GO:0009162 | pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130) deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) |
| 0.1 | 5.3 | GO:0016310 | phosphorylation(GO:0016310) |
| 0.7 | 5.1 | GO:0072348 | sulfur compound transport(GO:0072348) |
| 0.1 | 5.0 | GO:0009408 | response to heat(GO:0009408) |
| 1.1 | 4.4 | GO:0006791 | sulfur utilization(GO:0006791) |
| 0.0 | 1.0 | GO:0055114 | oxidation-reduction process(GO:0055114) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 10.8 | GO:0055052 | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing(GO:0055052) |
| 0.3 | 9.3 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 10.8 | GO:0004497 | monooxygenase activity(GO:0004497) |
| 2.1 | 8.2 | GO:0052621 | diguanylate cyclase activity(GO:0052621) |
| 2.0 | 5.9 | GO:0050897 | cobalt ion binding(GO:0050897) |
| 0.6 | 5.3 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.8 | 5.1 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 1.4 | 4.2 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
| 0.2 | 1.0 | GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 10.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 10.1 | REACTOME SIGNALING BY THE B CELL RECEPTOR BCR | Genes involved in Signaling by the B Cell Receptor (BCR) |