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GSE55662: Plasticity of transcriptional regulation under antibiotic stress

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Results for CysB

Z-value: 2.42

Transcription factors associated with CysB

Gene Symbol Gene ID Gene Info
cysB
cysB CysB transcriptional dual regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
cysB-0.857.6e-03Click!

Activity profile of CysB motif

Sorted Z-values of CysB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
ybdN 10.85
ybdN
conserved protein
ssuEADCB 10.78
ssuE
ssuD
ssuA
ssuC
ssuB
NADPH-dependent FMN reductase
alkanesulfonate monooxygenase, FMNH2-dependent
aliphatic sulfonate ABC transporter - periplasmic binding protein
aliphatic sulfonate ABC transporter - membrane subunit
aliphatic sulfonate ABC transporter - ATP binding subunit
cbl 10.13
cbl
Cbl DNA-binding transcriptional activator
ygeH 9.22
ygeH
predicted transcriptional regulator
dgcZ 8.21
dgcZ
diguanylate cyclase
yciW 5.97
yciW
predicted oxidoreductase
yfbR 5.89
yfbR
dCMP phosphohydrolase
cysDNC 5.28
cysD
cysN
cysC
sulfate adenylyltransferase, CysD subunit
sulfate adenylyltransferase, CysN subunit
adenylylsulfate kinase
cysPUWAM 5.09
cysU
cysM
cysW
cysA
cysP
sulfate / thiosulfate ABC transporter - membrane subunit
cysteine synthase B
sulfate / thiosulfate ABC transporter - membrane subunit
sulfate / thiosulfate ABC transporter - ATP binding subunit
sulfate / thiosulfate ABC transporter - periplasmic binding protein CysP
hslJ 4.97
hslJ
lipoprotein implicated in Novobiocin resistance
tauABCD 4.24
tauB
tauC
tauA
tauD
taurine ABC transporter - ATP binding subunit
taurine ABC transporter - membrane subunit
taurine ABC transporter - periplasmic binding protein
taurine dioxygenase
yoaC 2.32
yoaC
predicted protein
cysJIH 0.96
cysI
cysH
cysJ
sulfite reductase, hemoprotein subunit
3'-phospho-adenylylsulfate reductase
sulfite reductase, flavoprotein subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of CysB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 15.0 GO:0042908 cellular response to sulfate starvation(GO:0009970) xenobiotic transport(GO:0042908)
2.7 8.2 GO:1902116 negative regulation of organelle organization(GO:0010639) negative regulation of cell projection organization(GO:0031345) cell adhesion involved in biofilm formation(GO:0043708) negative regulation of organelle assembly(GO:1902116) negative regulation of bacterial-type flagellum assembly(GO:1902209)
2.0 5.9 GO:0009162 pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130) deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)
1.1 4.4 GO:0006791 sulfur utilization(GO:0006791)
0.7 5.1 GO:0072348 sulfur compound transport(GO:0072348)
0.1 5.0 GO:0009408 response to heat(GO:0009408)
0.1 5.3 GO:0016310 phosphorylation(GO:0016310)
0.0 1.0 GO:0055114 oxidation-reduction process(GO:0055114)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 10.8 GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing(GO:0055052)
0.3 9.3 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190) ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.8 GO:0004497 monooxygenase activity(GO:0004497)
2.1 8.2 GO:0052621 diguanylate cyclase activity(GO:0052621)
2.0 5.9 GO:0050897 cobalt ion binding(GO:0050897)
1.4 4.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.8 5.1 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.6 5.3 GO:0070566 adenylyltransferase activity(GO:0070566)
0.2 1.0 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.1 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.1 REACTOME SIGNALING BY THE B CELL RECEPTOR BCR Genes involved in Signaling by the B Cell Receptor (BCR)