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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for wt1a+wt1b

Z-value: 1.90

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Transcription factors associated with wt1a+wt1b

Gene Symbol Gene ID Gene Info
ENSDARG00000007990 WT1 transcription factor b
ENSDARG00000031420 WT1 transcription factor a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
wt1adr11_v1_chr25_-_15214161_152141610.881.5e-06Click!
wt1bdr11_v1_chr18_-_45617146_456171460.391.1e-01Click!

Activity profile of wt1a+wt1b motif

Sorted Z-values of wt1a+wt1b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_147574 7.05 ENSDART00000104762
ENSDART00000131635
solute carrier family 16 (aromatic amino acid transporter), member 10
chr16_-_54405976 6.64 ENSDART00000055395
odd-skipped related transciption factor 2
chr15_+_31526225 6.48 ENSDART00000154456
WD40 repeat domain 95
chr2_-_44183613 5.98 ENSDART00000079596
cell adhesion molecule 3
chr6_-_60104628 5.78 ENSDART00000057463
ENSDART00000169188
prostate transmembrane protein, androgen induced 1
chr3_-_22829710 5.40 ENSDART00000055659
cytochrome b561
chr7_-_10560964 5.30 ENSDART00000172761
ENSDART00000170476
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
chr2_-_44183451 5.00 ENSDART00000111246
cell adhesion molecule 3
chr1_-_59422880 4.98 ENSDART00000167244
si:ch211-188p14.2
chr7_+_16166558 4.90 ENSDART00000173785
si:ch73-367j5.3
chr16_+_10918252 4.83 ENSDART00000172949
POU class 2 homeobox 2a
chr12_-_11649690 4.78 ENSDART00000149713
BTB (POZ) domain containing 16
chr10_-_5857548 4.57 ENSDART00000166933
si:ch211-281k19.2
chr24_+_42131564 4.40 ENSDART00000153854
WW domain containing E3 ubiquitin protein ligase 1
chr20_-_9580446 4.10 ENSDART00000014168
zinc finger protein 36, C3H type-like 1b
chr24_+_33622769 4.05 ENSDART00000079342
dynein, axonemal, heavy chain 5 like
chr13_-_36703164 4.05 ENSDART00000044357
cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr20_+_27242595 4.04 ENSDART00000149300
si:dkey-85n7.6
chr25_+_1732838 3.96 ENSDART00000159555
ENSDART00000168161
fibulin 1
chr14_+_80685 3.87 ENSDART00000188443
stromal antigen 3
chr24_+_42127983 3.87 ENSDART00000190157
ENSDART00000176032
ENSDART00000175790
WW domain containing E3 ubiquitin protein ligase 1
chr5_-_68022631 3.82 ENSDART00000143199
WAS protein family, member 3a
chr3_+_7617353 3.72 ENSDART00000165551
zgc:109949
chr21_-_308852 3.67 ENSDART00000151613
LHFPL tetraspan subfamily member 2a
chr19_+_636886 3.65 ENSDART00000149192
telomerase reverse transcriptase
chr19_-_31802296 3.64 ENSDART00000103640
hes-related family bHLH transcription factor with YRPW motif 1
chr16_+_10963602 3.63 ENSDART00000141032
POU class 2 homeobox 2a
chr22_+_18187857 3.63 ENSDART00000166300
myocyte enhancer factor 2b
chr3_+_14388010 3.60 ENSDART00000171726
ENSDART00000165452
transmembrane protein 56b
chr1_-_59571758 3.55 ENSDART00000193546
ENSDART00000167087
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr3_-_1190132 3.55 ENSDART00000149709
single-pass membrane protein with aspartate-rich tail 1a
chr19_+_63567 3.37 ENSDART00000165657
ENSDART00000165183
zinc fingers and homeoboxes 2b
chr16_+_4838808 3.31 ENSDART00000179363
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr19_+_233143 3.27 ENSDART00000175273
synaptic Ras GTPase activating protein 1a
chr1_-_411331 3.26 ENSDART00000092524
RAS p21 protein activator 3
chr5_-_46273938 3.25 ENSDART00000080033
si:ch211-130m23.3
chr1_-_58562129 3.23 ENSDART00000159070
solute carrier family 27 (fatty acid transporter), member 1b
chr24_+_42132962 3.15 ENSDART00000187739
WW domain containing E3 ubiquitin protein ligase 1
chr19_+_48111285 3.13 ENSDART00000169420
NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 2
chr20_+_54356272 3.07 ENSDART00000145735
zinc finger protein 410
chr1_-_51734524 3.07 ENSDART00000109640
ENSDART00000122628
JunB proto-oncogene, AP-1 transcription factor subunit a
chr3_-_16289826 3.05 ENSDART00000131972
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr5_-_22619879 3.05 ENSDART00000051623
zgc:113208
chr4_-_22472653 3.04 ENSDART00000066903
ENSDART00000130072
ENSDART00000123369
lysine (K)-specific methyltransferase 2E
chr17_-_31695217 3.03 ENSDART00000104332
ENSDART00000143090
lin-52 DREAM MuvB core complex component
chr23_-_19140781 3.03 ENSDART00000143580
si:ch73-381f5.2
chr22_-_34872533 2.97 ENSDART00000167176
slit homolog 1b (Drosophila)
chr22_+_18188045 2.97 ENSDART00000140106
myocyte enhancer factor 2b
chr23_+_19182819 2.90 ENSDART00000131804
si:dkey-93l1.4
chr7_-_10606 2.87 ENSDART00000192650
ENSDART00000186761

chr9_+_2507526 2.85 ENSDART00000166579
WAS/WASL interacting protein family, member 1a
chr8_+_2456854 2.85 ENSDART00000133938
ENSDART00000002764
polymerase (DNA directed), beta
chr8_+_54284961 2.85 ENSDART00000122692
plexin D1
chr25_+_35774544 2.85 ENSDART00000034737
ENSDART00000188162
copine VIII
chr3_+_1211242 2.80 ENSDART00000171287
ENSDART00000165769
polymerase (DNA-directed), delta interacting protein 3
chr8_-_34762163 2.78 ENSDART00000114080
SET domain containing 1B, b
chr24_-_4450238 2.71 ENSDART00000066835
frizzled class receptor 8a
chr5_-_2689753 2.71 ENSDART00000172699
guanine nucleotide binding protein (G protein), gamma 10
chr5_+_32924669 2.71 ENSDART00000085219
LIM domain only 4a
chr10_+_439692 2.70 ENSDART00000147740
zinc finger, DHHC-type containing 8a
chr2_+_33747509 2.67 ENSDART00000134187
si:dkey-31m5.5
chr18_+_5549672 2.67 ENSDART00000184970
nicotinamide nucleotide transhydrogenase 2
chr7_-_18168493 2.64 ENSDART00000127428
pellino E3 ubiquitin protein ligase family member 3
chr23_+_19691146 2.60 ENSDART00000143001
si:dkey-93l1.6
chr1_-_58561963 2.56 ENSDART00000165040
solute carrier family 27 (fatty acid transporter), member 1b
chr16_+_4839078 2.53 ENSDART00000150111
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr6_-_9922266 2.51 ENSDART00000151549
Pim proto-oncogene, serine/threonine kinase, related 73
chr25_+_150570 2.51 ENSDART00000170892
ADAM metallopeptidase domain 10b
chr3_+_22079219 2.50 ENSDART00000122782
KAT8 regulatory NSL complex subunit 1b
chr25_+_192116 2.48 ENSDART00000153983
zgc:114188
chr2_+_33722547 2.46 ENSDART00000139193
si:dkey-31m5.5
chr4_-_16001118 2.43 ENSDART00000041070
ENSDART00000125389
mesoderm specific transcript
chr19_+_935565 2.41 ENSDART00000113368
ring finger protein 5
chr4_+_41602 2.41 ENSDART00000159640
putative homeodomain transcription factor 2
chr21_-_43117327 2.38 ENSDART00000122352
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2
chr7_+_73630751 2.38 ENSDART00000159745
si:dkey-46i9.1
chr10_+_45345574 2.36 ENSDART00000166085
peptidylprolyl isomerase Ab (cyclophilin A)
chr6_-_39160422 2.33 ENSDART00000148661
signal transducer and activator of transcription 2
chr23_+_9560991 2.30 ENSDART00000081433
ENSDART00000131594
ENSDART00000130069
ENSDART00000138601
adhesion regulating molecule 1
chr18_+_33788340 2.30 ENSDART00000136950
si:dkey-145c18.2
chr1_+_54908895 2.27 ENSDART00000145652
golgin A7 family, member Ba
chr14_-_9522364 2.27 ENSDART00000054689
atonal bHLH transcription factor 8
chr10_+_10351685 2.26 ENSDART00000109432
cerebral endothelial cell adhesion molecule
chr22_-_16180849 2.26 ENSDART00000090390
vascular cell adhesion molecule 1b
chr24_+_24831727 2.24 ENSDART00000080969
tripartite motif containing 55b
chr4_-_68563862 2.24 ENSDART00000182970

chr23_+_9560797 2.23 ENSDART00000180014
adhesion regulating molecule 1
chr8_-_29719393 2.22 ENSDART00000077635
si:ch211-103n10.5
chr19_-_10043142 2.20 ENSDART00000193016
glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a
chr11_+_25459697 2.17 ENSDART00000161481
opsin 1 (cone pigments), short-wave-sensitive 2
chr23_-_46201008 2.15 ENSDART00000160110
transglutaminase 1 like 4
chr21_-_22114625 2.14 ENSDART00000177426
ENSDART00000135410
ELMO/CED-12 domain containing 1
chr10_-_28835771 2.12 ENSDART00000192220
ENSDART00000188436
activated leukocyte cell adhesion molecule a
chr22_+_38310957 2.10 ENSDART00000040550
Tnf receptor-associated factor 5
chr22_+_15898221 2.09 ENSDART00000062587
Kruppel-like factor 2a
chr6_-_442163 2.06 ENSDART00000163564
ENSDART00000189134
ENSDART00000169789
GRB2-related adaptor protein 2b
chr12_+_2522642 2.06 ENSDART00000152567
FERM and PDZ domain containing 2
chr21_-_45878872 2.04 ENSDART00000029763
sap30-like
chr19_-_19442983 2.03 ENSDART00000052649
sb:cb649
chr20_+_18209895 2.00 ENSDART00000111063
potassium channel tetramerization domain containing 1
chr1_+_57371447 2.00 ENSDART00000152229
ENSDART00000181077
si:dkey-27j5.3
chr11_+_41560792 2.00 ENSDART00000127292
potassium voltage-gated channel, shaker-related subfamily, beta member 2 a
chr3_+_32492467 1.97 ENSDART00000151329
transient receptor potential cation channel, subfamily M, member 4a
chr25_+_24250247 1.96 ENSDART00000064646
transmembrane protein 86A
chr15_+_1397811 1.95 ENSDART00000102125
schwannomin interacting protein 1
chr20_-_26420939 1.95 ENSDART00000110883
A kinase (PRKA) anchor protein 12b
chr12_+_695619 1.93 ENSDART00000161691
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
chr12_+_9880493 1.92 ENSDART00000055019
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4
chr21_-_5056812 1.91 ENSDART00000139713
ENSDART00000140859
zgc:77838
chr14_+_42172257 1.90 ENSDART00000074362
protocadherin 18b
chr14_-_2933185 1.88 ENSDART00000161677
ENSDART00000162446
ENSDART00000109378
si:dkey-201i24.6
chr2_+_26288301 1.88 ENSDART00000017668
polypyrimidine tract binding protein 1a
chr13_-_31435137 1.88 ENSDART00000057441
reticulon 1a
chr11_-_4302251 1.85 ENSDART00000182554

chr6_-_59942335 1.85 ENSDART00000168416
F-box and leucine-rich repeat protein 3b
chr16_-_1757521 1.80 ENSDART00000124660
activating signal cointegrator 1 complex subunit 3
chr22_-_11714104 1.80 ENSDART00000145265
ENSDART00000063127
ENSDART00000183743
crystallin, gamma S1
chr21_-_39058490 1.79 ENSDART00000114885
aldehyde dehydrogenase 3 family, member A2b
chr14_+_24283915 1.78 ENSDART00000172868
kelch-like family member 3
chr17_+_53311618 1.77 ENSDART00000166517
ankyrin repeat and SOCS box containing 2b
chr1_-_51157454 1.76 ENSDART00000047851
jagged 1a
chr20_-_26421112 1.76 ENSDART00000183767
ENSDART00000182330
A kinase (PRKA) anchor protein 12b
chr1_-_59232267 1.75 ENSDART00000169658
ENSDART00000163257
A kinase (PRKA) anchor protein 8-like
chr14_+_42172677 1.72 ENSDART00000148544
protocadherin 18b
chr9_+_19489514 1.72 ENSDART00000152032
ENSDART00000114256
ENSDART00000190572
ENSDART00000147571
ENSDART00000151918
ENSDART00000152034
si:ch211-140m22.7
chr1_-_54107321 1.71 ENSDART00000148382
ENSDART00000150357
regulatory factor X, 1b (influences HLA class II expression)
chr20_+_13894123 1.69 ENSDART00000007744
solute carrier family 30 (zinc transporter), member 1a
chr4_+_1600034 1.69 ENSDART00000146779
solute carrier family 38, member 2
chr9_+_1654284 1.69 ENSDART00000062854
nuclear factor, erythroid 2-like 2a
chr2_+_24304854 1.66 ENSDART00000078972
fat storage-inducing transmembrane protein 1
chr14_-_12822 1.65 ENSDART00000180650
ENSDART00000188819
muscle segment homeobox 1a
chr4_-_68569527 1.65 ENSDART00000192091

chr25_+_22683640 1.64 ENSDART00000131993
Usher syndrome 1C
chr1_-_51474974 1.63 ENSDART00000152719
sprouty-related, EVH1 domain containing 2a
chr12_+_41510492 1.62 ENSDART00000170976
ENSDART00000176164
kinesin family member 5B, b
chr15_-_47822597 1.62 ENSDART00000193236
ENSDART00000161391

chr19_-_617246 1.61 ENSDART00000062551
cytochrome P450, family 51
chr8_-_52715911 1.60 ENSDART00000168241
tubulin, beta 2b
chr7_-_51102479 1.59 ENSDART00000174023
collagen, type IV, alpha 6
chr22_-_367569 1.57 ENSDART00000041895
SSU72 homolog, RNA polymerase II CTD phosphatase
chr5_+_51443009 1.57 ENSDART00000083350
Ras protein-specific guanine nucleotide-releasing factor 2b
chr14_-_45346558 1.56 ENSDART00000090844
zgc:153018
chr6_+_31684 1.56 ENSDART00000188853
ENSDART00000184553

chr22_+_2860260 1.55 ENSDART00000106221
si:dkey-20i20.2
chr20_-_54381034 1.55 ENSDART00000136779
ectonucleoside triphosphate diphosphohydrolase 5b
chr1_+_22174251 1.54 ENSDART00000137429
dynein, axonemal, heavy chain 6
chr20_+_16173618 1.53 ENSDART00000192109
ENSDART00000104112
ENSDART00000129633
zyg-11 homolog (C. elegans)
chr19_+_33701734 1.51 ENSDART00000123270
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_-_39005317 1.51 ENSDART00000014207
myosin, light chain 1, alkali; skeletal, fast
chr16_-_13613475 1.50 ENSDART00000139102
D site albumin promoter binding protein b
chr20_+_18740518 1.49 ENSDART00000142196
family with sequence similarity 167, member Ab
chr25_-_37501371 1.48 ENSDART00000160498

chr22_+_10752511 1.46 ENSDART00000081188
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
chr16_-_54810464 1.46 ENSDART00000030658
zinc finger and BTB domain containing 7B
chr14_+_30910114 1.43 ENSDART00000187166
ENSDART00000078187
forkhead box O4
chr21_+_5801105 1.42 ENSDART00000151225
ENSDART00000184487
cyclin G2
chr10_+_10210455 1.42 ENSDART00000144214
SH2 domain containing 3Ca
chr5_-_16351306 1.41 ENSDART00000168643

chr8_-_1884955 1.41 ENSDART00000081563
si:dkey-178e17.3
chr22_+_10752787 1.41 ENSDART00000186542
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
chr8_+_8298439 1.40 ENSDART00000170566
SRSF protein kinase 3
chr17_-_43466317 1.40 ENSDART00000155313
heat shock protein 4 like
chr20_-_5369105 1.40 ENSDART00000114316
serine palmitoyltransferase, long chain base subunit 2b
chr22_-_17729778 1.39 ENSDART00000192132
si:ch73-63e15.2
chr22_+_1006573 1.37 ENSDART00000123458
peroxisome proliferator-activated receptor delta a
chr8_-_9118958 1.36 ENSDART00000037922
solute carrier family 6 (neurotransmitter transporter), member 8
chr18_-_15467446 1.36 ENSDART00000187847
endonuclease, polyU-specific C
chr4_+_39742119 1.33 ENSDART00000176004

chr1_-_625875 1.33 ENSDART00000167331
amyloid beta (A4) precursor protein a
chr11_-_236766 1.32 ENSDART00000163978
dual specificity phosphatase 7
chr5_+_11840905 1.31 ENSDART00000030444
tescalcin a
chr16_-_44399335 1.31 ENSDART00000165058
regulating synaptic membrane exocytosis 2a
chr1_-_49225890 1.30 ENSDART00000111598
chemokine (C-X-C motif) ligand 18b
chr9_-_8454060 1.29 ENSDART00000110158
insulin receptor substrate 2b
chr11_+_40649412 1.28 ENSDART00000043016
ENSDART00000134560
solute carrier family 45, member 1
chr6_+_59808677 1.28 ENSDART00000164469
calcium/calmodulin-dependent serine protein kinase b
chr1_-_51157660 1.27 ENSDART00000137172
jagged 1a
chr1_+_55293424 1.27 ENSDART00000152464
zgc:172106
chr9_-_105135 1.24 ENSDART00000180126

chr21_+_103194 1.24 ENSDART00000162755
zyg-11 related, cell cycle regulator
chr5_+_22969651 1.22 ENSDART00000089992
ENSDART00000145477
high mobility group nucleosomal binding domain 7
chr1_-_53907092 1.22 ENSDART00000007732
calpain 9
chr11_+_6456146 1.21 ENSDART00000036939
growth arrest and DNA-damage-inducible, beta a
chr11_+_6819050 1.21 ENSDART00000104289
RAB3A, member RAS oncogene family, b
chr5_-_38777852 1.19 ENSDART00000131603
si:dkey-58f10.4
chr19_+_1964005 1.18 ENSDART00000172049
SH3-domain binding protein 5a (BTK-associated)
chr5_-_12093618 1.17 ENSDART00000161542
leucine rich repeat containing 74B
chr10_+_32561317 1.17 ENSDART00000109029
microtubule-associated protein 6a
chr5_+_43870389 1.17 ENSDART00000141002
zgc:112966
chr11_-_236984 1.17 ENSDART00000170778
dual specificity phosphatase 7
chr21_-_22325124 1.16 ENSDART00000142100
glycerophosphodiester phosphodiesterase domain containing 4b
chr12_+_5189776 1.15 ENSDART00000081298
leucine-rich, glioma inactivated 1b
chr16_-_44349845 1.15 ENSDART00000170932
regulating synaptic membrane exocytosis 2a
chr2_+_24781026 1.14 ENSDART00000145692
phosphodiesterase 4C, cAMP-specific a
chr22_-_188102 1.14 ENSDART00000125391
ENSDART00000170463

chr2_+_20793982 1.13 ENSDART00000014785
proteoglycan 4a
chr23_-_40779334 1.13 ENSDART00000141432
si:dkeyp-27c8.1
chr4_+_16710001 1.11 ENSDART00000035899
plakophilin 2
chr19_+_33701366 1.10 ENSDART00000162517
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr17_+_24615091 1.10 ENSDART00000064739
ribosomal protein L13a

Network of associatons between targets according to the STRING database.

First level regulatory network of wt1a+wt1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0032060 bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969)
1.2 3.6 GO:0007571 age-dependent general metabolic decline(GO:0007571)
1.2 5.8 GO:0071071 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.9 2.7 GO:0021531 spinal cord radial glial cell differentiation(GO:0021531) eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.8 5.8 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.8 2.3 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.8 5.3 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.7 2.1 GO:0003223 ventricular compact myocardium morphogenesis(GO:0003223)
0.7 2.7 GO:0006740 NADPH regeneration(GO:0006740)
0.7 2.0 GO:0002369 T cell cytokine production(GO:0002369)
0.6 1.8 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.6 1.7 GO:0010312 detoxification of zinc ion(GO:0010312) stress response to zinc ion(GO:1990359)
0.5 2.6 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.5 1.6 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.5 1.9 GO:0060468 negative regulation of fertilization(GO:0060467) prevention of polyspermy(GO:0060468) cortical granule exocytosis(GO:0060471)
0.4 0.9 GO:1904861 excitatory synapse assembly(GO:1904861)
0.4 3.7 GO:0046546 development of primary male sexual characteristics(GO:0046546)
0.4 1.2 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.4 3.3 GO:0043363 nucleate erythrocyte differentiation(GO:0043363)
0.3 1.0 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.3 1.0 GO:0019695 choline metabolic process(GO:0019695)
0.3 1.9 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.3 4.5 GO:0043248 proteasome assembly(GO:0043248)
0.3 2.7 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.3 0.9 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
0.3 4.0 GO:0036158 outer dynein arm assembly(GO:0036158)
0.3 1.6 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.3 1.6 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.3 3.8 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 0.9 GO:0006843 mitochondrial citrate transport(GO:0006843)
0.2 1.8 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.2 3.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2 0.6 GO:0009085 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.2 3.1 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.2 0.8 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2 0.6 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.2 0.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 0.6 GO:0001692 histamine metabolic process(GO:0001692)
0.2 0.9 GO:0023041 neuronal signal transduction(GO:0023041)
0.2 0.9 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.2 2.0 GO:0098900 regulation of action potential(GO:0098900)
0.2 2.3 GO:0060337 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.2 2.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 0.9 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.2 1.2 GO:1904019 epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035)
0.2 1.7 GO:0006868 glutamine transport(GO:0006868)
0.2 1.7 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.2 3.0 GO:0030878 thyroid gland development(GO:0030878)
0.2 1.1 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.2 1.4 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.1 1.0 GO:0060855 venous endothelial cell migration involved in lymph vessel development(GO:0060855)
0.1 0.4 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.1 0.4 GO:0050968 chemosensory behavior(GO:0007635) detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.1 0.6 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 1.0 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 2.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.1 1.4 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 0.4 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.1 0.8 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.1 2.2 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.9 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 1.2 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 0.7 GO:0008206 bile acid biosynthetic process(GO:0006699) bile acid metabolic process(GO:0008206)
0.1 0.9 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.1 2.2 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.1 0.5 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 2.9 GO:0001569 patterning of blood vessels(GO:0001569)
0.1 0.2 GO:0032369 negative regulation of lipid transport(GO:0032369)
0.1 1.0 GO:0030325 adrenal gland development(GO:0030325)
0.1 0.6 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.1 1.6 GO:0001964 startle response(GO:0001964)
0.1 0.5 GO:0003210 cardiac atrium formation(GO:0003210)
0.1 0.8 GO:0051673 membrane disruption in other organism(GO:0051673)
0.1 2.1 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 2.1 GO:0018149 peptide cross-linking(GO:0018149)
0.1 2.5 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 2.9 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.1 2.8 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 1.5 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.1 8.8 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.1 1.9 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 1.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 1.9 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.1 2.8 GO:0021602 cranial nerve morphogenesis(GO:0021602)
0.1 0.8 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 2.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.3 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.1 0.4 GO:0036268 swimming(GO:0036268)
0.1 5.4 GO:0022900 electron transport chain(GO:0022900)
0.1 1.5 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.1 0.3 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.1 1.7 GO:0043049 otic placode formation(GO:0043049)
0.1 5.5 GO:0001945 lymph vessel development(GO:0001945)
0.1 2.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 1.4 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1 0.7 GO:1902042 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.1 0.2 GO:0045023 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
0.1 2.8 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 20.9 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 5.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 0.6 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.1 0.3 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.1 1.2 GO:0048854 brain morphogenesis(GO:0048854)
0.0 2.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.6 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.5 GO:0021754 facial nucleus development(GO:0021754)
0.0 1.2 GO:0019835 cytolysis(GO:0019835)
0.0 0.8 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 1.6 GO:0001878 response to yeast(GO:0001878)
0.0 0.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 1.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.6 GO:0060536 cartilage morphogenesis(GO:0060536)
0.0 0.4 GO:0007608 sensory perception of smell(GO:0007608)
0.0 1.3 GO:0071219 cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)
0.0 0.6 GO:1900006 positive regulation of dendrite development(GO:1900006)
0.0 1.4 GO:0050727 regulation of inflammatory response(GO:0050727)
0.0 0.1 GO:0071387 cellular response to cortisol stimulus(GO:0071387)
0.0 1.1 GO:0007586 digestion(GO:0007586)
0.0 0.2 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 1.1 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 1.0 GO:0021514 ventral spinal cord interneuron differentiation(GO:0021514)
0.0 1.0 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.8 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 1.0 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 1.8 GO:0031076 embryonic camera-type eye development(GO:0031076)
0.0 0.4 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 0.3 GO:0009712 catecholamine metabolic process(GO:0006584) catechol-containing compound metabolic process(GO:0009712)
0.0 0.9 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.3 GO:1904825 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.6 GO:1904894 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.0 1.4 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.3 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.2 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 1.3 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 1.2 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.3 GO:0010883 regulation of lipid storage(GO:0010883)
0.0 0.4 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.0 0.7 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.8 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.0 GO:0072025 distal convoluted tubule development(GO:0072025) late distal convoluted tubule development(GO:0072068)
0.0 0.2 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 2.4 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 0.7 GO:0045197 establishment or maintenance of apical/basal cell polarity(GO:0035088) establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197) establishment or maintenance of bipolar cell polarity(GO:0061245)
0.0 0.1 GO:0015893 folic acid transport(GO:0015884) drug transport(GO:0015893) methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.0 0.5 GO:0042129 regulation of T cell proliferation(GO:0042129)
0.0 0.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 2.2 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 0.4 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.0 1.8 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.7 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.2 GO:0060034 notochord cell differentiation(GO:0060034)
0.0 0.9 GO:0070121 Kupffer's vesicle development(GO:0070121)
0.0 0.6 GO:0060215 primitive hemopoiesis(GO:0060215)
0.0 0.3 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 2.0 GO:0051260 protein homooligomerization(GO:0051260)
0.0 1.1 GO:0017148 negative regulation of translation(GO:0017148)
0.0 0.1 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 3.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.5 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 1.0 GO:0030048 actin filament-based movement(GO:0030048)
0.0 1.5 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.0 1.9 GO:0048793 pronephros development(GO:0048793)
0.0 0.3 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.3 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.6 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 1.8 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 0.6 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.8 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.4 4.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.4 2.9 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.3 4.0 GO:0036157 outer dynein arm(GO:0036157)
0.3 2.0 GO:0070062 extracellular exosome(GO:0070062)
0.3 3.5 GO:1990246 uniplex complex(GO:1990246)
0.3 1.6 GO:0098651 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.3 3.7 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.3 1.0 GO:0005588 collagen type V trimer(GO:0005588)
0.2 3.8 GO:0031209 SCAR complex(GO:0031209)
0.2 3.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 0.9 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 2.8 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.2 1.6 GO:0002141 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142) stereocilium tip(GO:0032426)
0.2 0.9 GO:0018444 translation release factor complex(GO:0018444)
0.2 2.5 GO:0044545 NSL complex(GO:0044545)
0.2 3.9 GO:0008278 cohesin complex(GO:0008278)
0.2 2.7 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.2 2.8 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.2 2.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 2.6 GO:0090568 nuclear transcriptional repressor complex(GO:0090568)
0.1 2.1 GO:0005801 cis-Golgi network(GO:0005801)
0.1 2.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 1.6 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 1.1 GO:0014704 intercalated disc(GO:0014704)
0.1 0.5 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 1.3 GO:0005869 dynactin complex(GO:0005869)
0.1 1.2 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.6 GO:0019908 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.1 1.9 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788)
0.1 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 1.0 GO:0043209 myelin sheath(GO:0043209)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 5.0 GO:0000786 nucleosome(GO:0000786)
0.0 0.7 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 2.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.0 GO:0031901 early endosome membrane(GO:0031901)
0.0 2.9 GO:0030027 lamellipodium(GO:0030027)
0.0 0.2 GO:0034359 mature chylomicron(GO:0034359)
0.0 0.4 GO:0044295 axonal growth cone(GO:0044295)
0.0 4.1 GO:0016607 nuclear speck(GO:0016607)
0.0 1.5 GO:0030286 dynein complex(GO:0030286)
0.0 4.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 2.5 GO:0005884 actin filament(GO:0005884)
0.0 0.7 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.8 GO:0008305 integrin complex(GO:0008305)
0.0 1.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.2 GO:0098802 plasma membrane receptor complex(GO:0098802)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.3 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 2.0 GO:0005840 ribosome(GO:0005840)
0.0 1.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0000293 ferric-chelate reductase activity(GO:0000293)
1.8 7.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.2 3.6 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
1.2 5.8 GO:0070412 R-SMAD binding(GO:0070412)
0.8 2.5 GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945)
0.8 4.5 GO:0061133 endopeptidase activator activity(GO:0061133)
0.7 5.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.7 2.7 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.6 2.9 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.6 2.3 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.4 3.8 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.4 2.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.3 1.0 GO:0043185 vascular endothelial growth factor receptor 3 binding(GO:0043185)
0.3 1.3 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.3 1.0 GO:0046923 ER retention sequence binding(GO:0046923)
0.3 0.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.3 3.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 2.0 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2 2.0 GO:0016803 ether hydrolase activity(GO:0016803)
0.2 2.5 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.2 0.8 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 1.4 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.2 0.8 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.2 0.8 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.2 4.7 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.2 0.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 1.1 GO:0019215 intermediate filament binding(GO:0019215)
0.2 3.1 GO:0033691 sialic acid binding(GO:0033691)
0.2 1.8 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.2 2.5 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.2 1.6 GO:0008420 CTD phosphatase activity(GO:0008420)
0.2 5.6 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 2.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 1.3 GO:0008506 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2 3.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 0.9 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 3.0 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 2.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 1.7 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 0.9 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 6.6 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 2.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 2.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 3.0 GO:0005112 Notch binding(GO:0005112)
0.1 0.6 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.1 1.7 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.1 3.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 2.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.7 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.8 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 1.5 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.1 1.8 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 0.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 1.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.7 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 1.8 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 0.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 2.7 GO:0099604 ligand-gated calcium channel activity(GO:0099604)
0.1 0.8 GO:0005158 insulin receptor binding(GO:0005158)
0.1 2.0 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 1.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 3.6 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 0.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 1.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 1.2 GO:0004860 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.0 2.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.8 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 1.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 2.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.7 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 3.6 GO:0008201 heparin binding(GO:0008201)
0.0 1.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 2.0 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.3 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750) lipoprotein particle receptor binding(GO:0070325)
0.0 1.1 GO:0005518 collagen binding(GO:0005518)
0.0 3.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.3 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 1.5 GO:0044325 ion channel binding(GO:0044325)
0.0 0.7 GO:0051018 protein kinase A binding(GO:0051018)
0.0 12.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 5.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 2.0 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 1.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.9 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 1.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.4 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.1 GO:0015350 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.0 0.3 GO:0005504 fatty acid binding(GO:0005504)
0.0 3.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 5.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.3 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.8 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.3 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.3 17.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 1.0 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.2 5.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 3.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 5.7 PID BCR 5PATHWAY BCR signaling pathway
0.1 2.1 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 1.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.5 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 0.4 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 1.9 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.3 5.8 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.3 2.9 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.3 2.3 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.2 2.6 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.2 1.9 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.2 2.5 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.2 12.8 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.2 2.7 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.1 1.0 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 0.7 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 0.8 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 3.9 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 2.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 3.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 3.6 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.1 3.0 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.9 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 0.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.6 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.1 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.6 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.9 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.6 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.1 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization