ISMARA results: pou3f2a+pou3f2b+pou3f3a+pou3f3b

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for pou3f2a+pou3f2b+pou3f3a+pou3f3b

Z-value: 1.48

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Transcription factors associated with pou3f2a+pou3f2b+pou3f3a+pou3f3b

Gene Symbol	Gene ID	Gene Info
pou3f3a NCBI UniProt	ENSDARG00000042032	POU class 3 homeobox 3a
pou3f2a NCBI UniProt	ENSDARG00000070220	POU class 3 homeobox 2a
pou3f2b NCBI UniProt	ENSDARG00000076262	POU class 3 homeobox 2b
pou3f3b NCBI UniProt	ENSDARG00000095896	POU class 3 homeobox 3b
pou3f2b NCBI UniProt	ENSDARG00000112713	POU class 3 homeobox 2b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
pou3f3b	dr11_v1_chr6_+_14949950_14949950	-0.92	9.2e-08	Click!
pou3f3a	dr11_v1_chr9_-_6661657_6661666	0.89	6.6e-07	Click!
pou3f2a	dr11_v1_chr4_+_5741733_5741733	-0.55	1.7e-02	Click!
pou3f2b	dr11_v1_chr16_+_32559821_32559821	0.07	7.9e-01	Click!

Activity profile of pou3f2a+pou3f2b+pou3f3a+pou3f3b motif

Sorted Z-values of pou3f2a+pou3f2b+pou3f3a+pou3f3b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_4245902 Show fit	6.47	ENSDART00000151851	gdf3 NCBI UniProt Show fit	growth differentiation factor 3
chr6_+_28208973 Show fit	4.11	ENSDART00000171216 ENSDART00000171377 ENSDART00000167389 ENSDART00000166988	LSM2 (1 of many) NCBI UniProt Show fit	si:ch73-14h10.2
chr19_+_20201593 Show fit	3.79	ENSDART00000163026	igf2bp3 NCBI UniProt Show fit	insulin-like growth factor 2 mRNA binding protein 3
chr13_-_36761379 Show fit	3.67	ENSDART00000131534 ENSDART00000029824	map4k5 NCBI UniProt Show fit	mitogen-activated protein kinase kinase kinase kinase 5
chr18_-_7032227 Show fit	3.51	ENSDART00000127138	calub NCBI UniProt Show fit	calumenin b
chr2_-_47620806 Show fit	3.49	ENSDART00000038228	ap1s3b NCBI UniProt Show fit	adaptor-related protein complex 1, sigma 3 subunit, b
chr24_-_5713799 Show fit	3.45	ENSDART00000137293	dia1b NCBI UniProt Show fit	deleted in autism 1b
chr4_-_1785120 Show fit	2.95	ENSDART00000103463	dnajc2 NCBI UniProt Show fit	DnaJ (Hsp40) homolog, subfamily C, member 2
chr5_+_29794058 Show fit	2.73	ENSDART00000045410	thy1 NCBI UniProt Show fit	Thy-1 cell surface antigen
chr10_-_21362071 Show fit	2.59	ENSDART00000125167	avd NCBI UniProt Show fit	avidin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of pou3f2a+pou3f2b+pou3f3a+pou3f3b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.9	GO:0000398	RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
1.3	6.5	GO:0038107	nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.7	4.5	GO:0032447	tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.1	4.4	GO:0051028	mRNA transport(GO:0051028)
0.0	4.2	GO:0090630	activation of GTPase activity(GO:0090630)
0.5	3.8	GO:0070933	histone H4 deacetylation(GO:0070933)
0.0	3.6	GO:0032259	methylation(GO:0032259)
0.8	3.1	GO:1903292	protein localization to Golgi membrane(GO:1903292)
0.3	3.1	GO:0006999	nuclear pore organization(GO:0006999)
0.2	3.0	GO:0007076	mitotic chromosome condensation(GO:0007076)

Showing 1 to 10 of 259 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.2	GO:0000139	Golgi membrane(GO:0000139)
0.0	4.4	GO:0005794	Golgi apparatus(GO:0005794)
0.0	4.1	GO:0005802	trans-Golgi network(GO:0005802)
0.5	3.5	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.1	3.5	GO:0031901	early endosome membrane(GO:0031901)
0.1	3.4	GO:0005637	nuclear inner membrane(GO:0005637)
0.3	3.3	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	3.1	GO:0030117	membrane coat(GO:0030117) coated membrane(GO:0048475)
0.1	3.0	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.3	2.9	GO:0032021	NELF complex(GO:0032021)

Showing 1 to 10 of 106 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.9	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.0	6.7	GO:0042393	histone binding(GO:0042393)
0.0	6.2	GO:0005125	cytokine activity(GO:0005125)
0.1	5.3	GO:0019208	phosphatase regulator activity(GO:0019208)
1.0	5.1	GO:0009374	biotin binding(GO:0009374)
0.1	5.1	GO:0000049	tRNA binding(GO:0000049)
0.3	3.8	GO:0031078	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1	3.8	GO:0000030	mannosyltransferase activity(GO:0000030)
0.6	3.7	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.1	3.3	GO:0003688	DNA replication origin binding(GO:0003688)

Showing 1 to 10 of 188 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.2	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	5.1	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	3.8	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	3.4	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.1	3.0	PID AURORA B PATHWAY	Aurora B signaling
0.1	1.9	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	1.9	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.1	1.8	PID REELIN PATHWAY	Reelin signaling pathway
0.1	1.7	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.1	1.5	PID BMP PATHWAY	BMP receptor signaling

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.6	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	3.5	REACTOME DIABETES PATHWAYS	Genes involved in Diabetes pathways
0.2	3.3	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1	3.1	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1	2.7	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.1	2.7	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	2.6	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	2.4	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.2	2.2	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.2	2.2	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide

Showing 1 to 10 of 56 entries

Results for pou3f2a+pou3f2b+pou3f3a+pou3f3b

Z-value: 1.48

Motif logo

Transcription factors associated with pou3f2a+pou3f2b+pou3f3a+pou3f3b

Activity-expression correlation:

Activity profile of pou3f2a+pou3f2b+pou3f3a+pou3f3b motif

Sorted Z-values of pou3f2a+pou3f2b+pou3f3a+pou3f3b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of pou3f2a+pou3f2b+pou3f3a+pou3f3b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: