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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for nr2e3
Z-value: 1.36
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Transcription factors associated with nr2e3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nr2e3 | dr11_v1_chr25_+_22274642_22274642 | -0.90 | 4.1e-07 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_27550768 Show fit | 3.94 |
ENSDART00000142313
|
si:dkeyp-46h3.8 |
|
| chr21_-_30293224 Show fit | 3.60 |
ENSDART00000101051
|
stem-loop binding protein 2 |
|
| chr11_-_3494964 Show fit | 3.29 |
ENSDART00000162369
|
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3b |
|
| chr12_+_30789611 Show fit | 3.24 |
ENSDART00000181501
|
aldehyde dehydrogenase 18 family, member A1 |
|
| chr19_-_27564980 Show fit | 3.23 |
ENSDART00000171967
|
si:dkeyp-46h3.8 |
|
| chr23_+_2740741 Show fit | 3.20 |
ENSDART00000134938
|
zgc:114123 |
|
| chr17_-_2596125 Show fit | 3.13 |
ENSDART00000175740
|
zona pellucida glycoprotein 3, tandem duplicate 2 |
|
| chr24_-_10014512 Show fit | 3.01 |
ENSDART00000124341
ENSDART00000191630 |
zgc:171474 |
|
| chr13_-_6252498 Show fit | 2.82 |
ENSDART00000115157
|
tubulin, alpha 4 like |
|
| chr25_+_22319940 Show fit | 2.77 |
ENSDART00000154065
ENSDART00000153492 ENSDART00000024866 ENSDART00000154376 |
cytochrome P450, family 11, subfamily A, polypeptide 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of nr2e3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 10.7 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.1 | 6.7 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.0 | 5.2 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.4 | 4.7 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.0 | 4.7 | GO:0006413 | translational initiation(GO:0006413) |
| 0.5 | 4.3 | GO:0003428 | growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428) |
| 0.1 | 3.8 | GO:1902652 | cholesterol metabolic process(GO:0008203) secondary alcohol metabolic process(GO:1902652) |
| 0.5 | 3.7 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.4 | 3.2 | GO:0040038 | meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038) |
| 0.4 | 3.2 | GO:0006561 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.2 | 4.0 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 4.0 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.3 | 3.7 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) |
| 0.0 | 3.5 | GO:0016604 | nuclear body(GO:0016604) |
| 0.0 | 3.3 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 3.0 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
| 0.1 | 2.6 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.1 | 2.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.3 | 2.5 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.9 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 1.0 | 10.7 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
| 0.0 | 8.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 5.6 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.7 | 4.7 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.1 | 4.5 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 4.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 4.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 4.1 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.9 | 3.7 | GO:0030228 | lipoprotein particle receptor activity(GO:0030228) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.1 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 2.2 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.1 | 1.9 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 1.8 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.7 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 1.5 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 1.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 1.3 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 1.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 4.7 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.4 | 3.3 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.3 | 3.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 3.0 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.0 | 2.1 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 1.8 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.2 | 1.7 | REACTOME EARLY PHASE OF HIV LIFE CYCLE | Genes involved in Early Phase of HIV Life Cycle |
| 0.0 | 1.6 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 1.5 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |