ISMARA results: ikzf1

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for ikzf1

Z-value: 1.03

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Transcription factors associated with ikzf1

Gene Symbol	Gene ID	Gene Info
ikzf1 NCBI UniProt	ENSDARG00000013539	IKAROS family zinc finger 1 (Ikaros)

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ikzf1	dr11_v1_chr13_-_15982707_15982707	-0.79	1.1e-04	Click!

Activity profile of ikzf1 motif

Sorted Z-values of ikzf1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_1009831 Show fit	4.09	ENSDART00000172414	fabp1b.2 NCBI UniProt Show fit	fatty acid binding protein 1b, liver, tandem duplicate 2
chr25_+_30196039 Show fit	3.43	ENSDART00000005299	hsd17b12a NCBI UniProt Show fit	hydroxysteroid (17-beta) dehydrogenase 12a
chr7_+_67699009 Show fit	3.29	ENSDART00000192810	zgc:162592 NCBI UniProt Show fit	zgc:162592
chr11_-_1550709 Show fit	2.53	ENSDART00000110097	si:ch73-303b9.1 NCBI UniProt Show fit	si:ch73-303b9.1
chr1_-_33645967 Show fit	2.26	ENSDART00000192758	cldng NCBI UniProt Show fit	claudin g
chr21_+_13383413 Show fit	2.20	ENSDART00000151345	zgc:113162 NCBI UniProt Show fit	zgc:113162
chr10_-_25217347 Show fit	2.20	ENSDART00000036906	kpna7 NCBI UniProt Show fit	karyopherin alpha 7 (importin alpha 8)
chr23_-_45955177 Show fit	2.15	ENSDART00000165963 ENSDART00000186649 ENSDART00000185773	LO017850.1 NCBI UniProt Show fit
chr5_+_39099172 Show fit	2.14	ENSDART00000006079	bmp2k NCBI UniProt Show fit	BMP2 inducible kinase
chr24_-_34680956 Show fit	2.09	ENSDART00000171009	ctnna1 NCBI UniProt Show fit	catenin (cadherin-associated protein), alpha 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ikzf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.8	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.4	3.4	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.2	3.0	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
0.0	3.0	GO:0051028	mRNA transport(GO:0051028)
0.1	2.4	GO:0016082	synaptic vesicle priming(GO:0016082)
0.5	2.3	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2	2.2	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	2.2	GO:0032924	activin receptor signaling pathway(GO:0032924)
0.1	2.1	GO:1901222	regulation of NIK/NF-kappaB signaling(GO:1901222)
0.3	2.0	GO:0044819	mitotic G1/S transition checkpoint(GO:0044819)

Showing 1 to 10 of 128 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.7	GO:0070160	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1	2.7	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.2	2.2	GO:0048179	activin receptor complex(GO:0048179)
0.0	2.2	GO:0031201	SNARE complex(GO:0031201)
0.0	2.2	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.5	2.1	GO:1990498	mitotic spindle microtubule(GO:1990498)
0.1	2.1	GO:0030057	desmosome(GO:0030057)
0.0	1.9	GO:0005814	centriole(GO:0005814)
0.2	1.6	GO:0042788	polysomal ribosome(GO:0042788)
0.1	1.6	GO:0000164	protein phosphatase type 1 complex(GO:0000164)

Showing 1 to 10 of 61 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.8	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
0.4	6.1	GO:0005504	fatty acid binding(GO:0005504)
0.6	4.8	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	4.4	GO:0019905	syntaxin binding(GO:0019905)
0.4	3.4	GO:0004303	estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.3	3.0	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
0.1	2.9	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	2.6	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	2.2	GO:0030276	clathrin binding(GO:0030276)
0.5	2.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)

Showing 1 to 10 of 93 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	PID P73PATHWAY	p73 transcription factor network
0.1	2.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	1.3	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	1.1	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	1.0	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	0.9	PID MYC PATHWAY	C-MYC pathway
0.1	0.8	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	0.8	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.8	PID E2F PATHWAY	E2F transcription factor network
0.0	0.7	PID CDC42 REG PATHWAY	Regulation of CDC42 activity

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation
0.1	1.9	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.1	1.9	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	1.5	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1	1.4	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
0.0	1.4	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.1	1.3	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	1.2	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	1.2	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.1	1.1	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation

Showing 1 to 10 of 33 entries

Results for ikzf1

Z-value: 1.03

Motif logo

Transcription factors associated with ikzf1

Activity-expression correlation:

Activity profile of ikzf1 motif

Sorted Z-values of ikzf1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ikzf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: