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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for foxo4
Z-value: 2.03
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Transcription factors associated with foxo4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxo4 | dr11_v1_chr14_+_30910114_30910114 | -0.55 | 1.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_31511739 Show fit | 7.11 |
ENSDART00000049420
|
N-myc downstream regulated 1b |
|
| chr15_+_19990068 Show fit | 6.17 |
ENSDART00000154033
ENSDART00000054428 |
zgc:112083 |
|
| chr4_-_1720648 Show fit | 5.56 |
ENSDART00000103484
|
growth arrest-specific 2 like 3 |
|
| chr16_-_26820634 Show fit | 5.24 |
ENSDART00000111156
|
pyruvate dehyrogenase phosphatase catalytic subunit 1 |
|
| chr13_+_22675802 Show fit | 5.08 |
ENSDART00000145538
ENSDART00000143312 |
zgc:193505 |
|
| chr7_+_46019780 Show fit | 4.82 |
ENSDART00000163991
|
cyclin E1 |
|
| chr7_+_33372680 Show fit | 4.71 |
ENSDART00000193436
ENSDART00000099988 |
glucuronic acid epimerase b |
|
| chr1_+_45969240 Show fit | 4.64 |
ENSDART00000042086
|
Rho guanine nucleotide exchange factor (GEF) 7b |
|
| chr5_-_33236637 Show fit | 4.58 |
ENSDART00000085512
ENSDART00000144694 |
KN motif and ankyrin repeat domains 1b |
|
| chr4_-_4256300 Show fit | 4.40 |
ENSDART00000103319
ENSDART00000150279 |
CD9 molecule b |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxo4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.2 | GO:0032272 | negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272) |
| 0.1 | 8.3 | GO:0006606 | protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593) |
| 1.1 | 7.9 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
| 0.3 | 6.6 | GO:0008078 | mesodermal cell migration(GO:0008078) |
| 0.1 | 6.3 | GO:1904029 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
| 0.7 | 5.9 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.8 | 5.6 | GO:0021534 | cell proliferation in hindbrain(GO:0021534) |
| 1.3 | 5.2 | GO:1904184 | regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184) |
| 0.4 | 4.8 | GO:1904263 | positive regulation of TORC1 signaling(GO:1904263) |
| 0.1 | 4.8 | GO:0071599 | otic vesicle development(GO:0071599) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.2 | 7.3 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.2 | 7.2 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 6.9 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 6.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 6.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 5.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 5.3 | GO:0000785 | chromatin(GO:0000785) |
| 0.0 | 5.3 | GO:0005813 | centrosome(GO:0005813) |
| 0.0 | 5.0 | GO:0036464 | cytoplasmic ribonucleoprotein granule(GO:0036464) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.8 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 7.1 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 1.7 | 6.6 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.1 | 6.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.4 | 5.9 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.4 | 5.6 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 5.6 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.1 | 5.4 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 1.3 | 5.2 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.0 | 5.1 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.3 | 4.8 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 3.9 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.2 | 3.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 3.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 3.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 2.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 2.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 1.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 1.9 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.4 | 5.2 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.2 | 4.8 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 3.7 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.4 | 3.5 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.2 | 3.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 3.2 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 3.2 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 2.7 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 2.7 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |