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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for foxo4

Z-value: 2.03

Motif logo

Transcription factors associated with foxo4

Gene Symbol Gene ID Gene Info
ENSDARG00000055792 forkhead box O4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
foxo4dr11_v1_chr14_+_30910114_30910114-0.551.7e-02Click!

Activity profile of foxo4 motif

Sorted Z-values of foxo4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_31511739 7.11 ENSDART00000049420
N-myc downstream regulated 1b
chr15_+_19990068 6.17 ENSDART00000154033
ENSDART00000054428
zgc:112083
chr4_-_1720648 5.56 ENSDART00000103484
growth arrest-specific 2 like 3
chr16_-_26820634 5.24 ENSDART00000111156
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr13_+_22675802 5.08 ENSDART00000145538
ENSDART00000143312
zgc:193505
chr7_+_46019780 4.82 ENSDART00000163991
cyclin E1
chr7_+_33372680 4.71 ENSDART00000193436
ENSDART00000099988
glucuronic acid epimerase b
chr1_+_45969240 4.64 ENSDART00000042086
Rho guanine nucleotide exchange factor (GEF) 7b
chr5_-_33236637 4.58 ENSDART00000085512
ENSDART00000144694
KN motif and ankyrin repeat domains 1b
chr4_-_4256300 4.40 ENSDART00000103319
ENSDART00000150279
CD9 molecule b
chr14_+_15155684 4.07 ENSDART00000167966
zgc:158852
chr23_+_13533885 4.06 ENSDART00000144386
uridine-cytidine kinase 1-like 1b
chr11_+_2710530 4.06 ENSDART00000132768
ENSDART00000030921
ENSDART00000040147
mitogen-activated protein kinase 14b
chr16_-_41714988 3.99 ENSDART00000138798
centrosomal protein 85
chr22_-_28777557 3.93 ENSDART00000135214
ENSDART00000131761
ENSDART00000005112
si:dkeyp-34c12.1
chr5_+_44846434 3.83 ENSDART00000145299
ENSDART00000136521
KN motif and ankyrin repeat domains 1a
chr12_+_22404108 3.78 ENSDART00000153055
high density lipoprotein binding protein b
chr6_-_39700965 3.75 ENSDART00000156645
extra spindle pole bodies like 1, separase
chr9_+_2041535 3.72 ENSDART00000093187
limb and neural patterns a
chr22_-_28777374 3.72 ENSDART00000188206
si:dkeyp-34c12.1
chr3_-_15475067 3.67 ENSDART00000025324
ENSDART00000139575
spinster homolog 1 (Drosophila)
chr23_-_3758637 3.67 ENSDART00000131536
ENSDART00000139408
ENSDART00000137826
high mobility group AT-hook 1a
chr9_+_24088062 3.62 ENSDART00000126198
leucine rich repeat (in FLII) interacting protein 1a
chr15_+_46313082 3.61 ENSDART00000153830
si:ch1073-190k2.1
chr5_+_3891485 3.55 ENSDART00000129329
ENSDART00000091711
RPA interacting protein
chr3_+_32411343 3.50 ENSDART00000186287
ENSDART00000141793
RAS related
chr17_+_33158350 3.47 ENSDART00000104476
sorting nexin 9a
chr5_-_65121747 3.46 ENSDART00000165556
torsin family 2, member A
chr15_-_44052927 3.46 ENSDART00000166209
wu:fb44b02
chr14_+_35424539 3.42 ENSDART00000171809
ENSDART00000162185
synaptotagmin-like 4
chr11_-_25257045 3.41 ENSDART00000130477
snail family zinc finger 1a
chr7_-_51749683 3.31 ENSDART00000083190
histone deacetylase 8
chr8_+_12951155 3.27 ENSDART00000081601
choline/ethanolamine phosphotransferase 1a
chr17_+_14965570 3.23 ENSDART00000066604
G protein-coupled receptor 137c
chr19_-_12965020 3.22 ENSDART00000128975
solute carrier family 25 (mitochondrial folate carrier), member 32a
chr11_-_25257595 3.21 ENSDART00000123567
snail family zinc finger 1a
chr5_+_28271412 3.19 ENSDART00000031727
vesicle-associated membrane protein 8 (endobrevin)
chr3_-_26191960 3.19 ENSDART00000113843
yippee-like 3
chr5_+_44805269 3.14 ENSDART00000136965
cathepsin La
chr3_+_10152092 3.12 ENSDART00000066053
chromobox homolog 2 (Drosophila Pc class)
chr9_-_12659140 3.10 ENSDART00000058565
PTTG1 interacting protein b
chr11_-_34577034 3.09 ENSDART00000133302
ENSDART00000184367
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a
chr5_-_69212184 3.05 ENSDART00000053963
methionine adenosyltransferase II, alpha b
chr11_+_11120532 3.03 ENSDART00000026135
ENSDART00000189872
lymphocyte antigen 75
chr17_+_25856671 3.03 ENSDART00000064817
WAPL cohesin release factor a
chr16_+_42667560 3.01 ENSDART00000023452
dpy-19-like 1, like (H. sapiens)
chr15_-_28587490 3.00 ENSDART00000186196
slingshot protein phosphatase 2a
chr6_-_13022166 2.95 ENSDART00000157139
transmembrane BAX inhibitor motif containing 1a
chr15_-_28587147 2.93 ENSDART00000156049
slingshot protein phosphatase 2a
chr15_-_30984557 2.93 ENSDART00000080328
neurofibromin 1a
chr5_+_44846280 2.92 ENSDART00000084370
KN motif and ankyrin repeat domains 1a
chr10_-_38243579 2.91 ENSDART00000150159
ubiquitin specific peptidase 25
chr17_-_7218481 2.84 ENSDART00000181967
sterile alpha motif domain containing 5
chr6_+_38626926 2.82 ENSDART00000190339
ATPase phospholipid transporting 10A
chr5_+_22579975 2.73 ENSDART00000080877
tumor necrosis factor (ligand) superfamily, member 10 like 4
chr10_-_6588793 2.72 ENSDART00000163788
chromodomain helicase DNA binding protein 1
chr20_+_53368611 2.71 ENSDART00000060432
cell division cycle 40 homolog (S. cerevisiae)
chr3_-_29962345 2.67 ENSDART00000136819
branched chain amino-acid transaminase 2, mitochondrial
chr14_-_32876280 2.66 ENSDART00000173168
si:rp71-46j2.7
chr22_-_18240968 2.65 ENSDART00000027605
transmembrane protein 161A
chr19_-_3821678 2.63 ENSDART00000169639
si:dkey-206d17.12
chr19_-_868187 2.62 ENSDART00000186626
eomesodermin homolog a
chr17_+_32622933 2.61 ENSDART00000077418
cathepsin Ba
chr25_+_7494181 2.59 ENSDART00000165005
catalase
chr15_-_37589600 2.58 ENSDART00000154641
proline and serine rich 3
chr7_-_51749895 2.55 ENSDART00000175523
ENSDART00000189639
histone deacetylase 8
chr20_-_52928541 2.53 ENSDART00000162812
farnesyl-diphosphate farnesyltransferase 1
chr6_-_32045951 2.51 ENSDART00000016629
ENSDART00000139055
EF-hand calcium binding domain 7
chr10_+_32050906 2.49 ENSDART00000137373
si:ch211-266i6.3
chr16_-_39267185 2.49 ENSDART00000058550
ENSDART00000133642
glycerol-3-phosphate dehydrogenase 1 like
chr5_-_22602979 2.47 ENSDART00000146287
non-POU domain containing, octamer-binding
chr13_+_9368621 2.44 ENSDART00000109126
Alstrom syndrome protein 1
chr2_-_42492201 2.42 ENSDART00000180762
ENSDART00000009093
extended synaptotagmin-like protein 2a
chr9_+_41459759 2.41 ENSDART00000132501
ENSDART00000100265
nuclear envelope integral membrane protein 2
chr2_-_4787566 2.40 ENSDART00000160663
ENSDART00000157808
tyrosine kinase, non-receptor, 2b
chr2_+_16696052 2.40 ENSDART00000022356
ENSDART00000164329
protein phosphatase 1, regulatory (inhibitor) subunit 7
chr11_+_18612421 2.37 ENSDART00000110621
nuclear receptor coactivator 3
chr21_-_13662237 2.36 ENSDART00000091647
ENSDART00000151547
patatin-like phospholipase domain containing 7a
chr13_+_11828516 2.36 ENSDART00000110141
suppressor of fused homolog (Drosophila)
chr22_-_5171362 2.36 ENSDART00000124889
tumor necrosis factor, alpha-induced protein 8-like 1
chr6_-_8244474 2.36 ENSDART00000151358
ral guanine nucleotide dissociation stimulator-like 3a
chr13_-_33207367 2.35 ENSDART00000146138
ENSDART00000109667
ENSDART00000182741
thyroid hormone receptor interactor 11
chr20_+_25904199 2.34 ENSDART00000016864
solute carrier family 35, member F6
chr5_-_22602780 2.33 ENSDART00000011699
non-POU domain containing, octamer-binding
chr10_+_28160265 2.32 ENSDART00000022484
ring finger protein, transmembrane 1
chr12_+_8822717 2.30 ENSDART00000021628
receptor accessory protein 3b
chr24_-_21343982 2.29 ENSDART00000012653
spindle and centriole associated protein 1
chr4_-_16876281 2.24 ENSDART00000016690
ENSDART00000044005
ENSDART00000042874
ENSDART00000125762
ENSDART00000185974
thymopoietin a
chr23_+_31596441 2.23 ENSDART00000053534
TBP-like 1
chr14_-_15155384 2.21 ENSDART00000172666
UV-stimulated scaffold protein A
chr23_-_36449111 2.20 ENSDART00000110478
zgc:174906
chr17_-_9962578 2.20 ENSDART00000021942
e2f-associated phosphoprotein
chr17_-_15546862 2.20 ENSDART00000091021
collagen, type X, alpha 1a
chr11_+_18873619 2.19 ENSDART00000176141
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr9_+_37366973 2.17 ENSDART00000016370
disrupted in renal carcinoma 2
chr13_-_21650404 2.17 ENSDART00000078352
tetraspanin 14
chr20_+_1385674 2.16 ENSDART00000145981
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr3_-_33113879 2.15 ENSDART00000044677
retinoic acid receptor, alpha b
chr10_-_15879569 2.14 ENSDART00000136789
tight junction protein 2a (zona occludens 2)
chr15_+_34069746 2.11 ENSDART00000163513
ADP-ribosylation factor-like 4aa
chr3_-_25369557 2.06 ENSDART00000055491
SMAD specific E3 ubiquitin protein ligase 2
chr3_-_13546610 2.05 ENSDART00000159647
amidohydrolase domain containing 2
chr17_+_44030692 2.04 ENSDART00000049503
pellino E3 ubiquitin protein ligase family member 2
chr17_+_38295847 2.04 ENSDART00000008532
MAP3K12 binding inhibitory protein 1
chr15_+_39977461 2.04 ENSDART00000063786
calcium binding protein 39
chr24_-_25004553 2.03 ENSDART00000080997
ENSDART00000136860
zinc finger, DHHC-type containing 20b
chr22_+_38276024 2.03 ENSDART00000143792
REST corepressor 3
chr21_-_43398122 2.03 ENSDART00000050533
cyclin I family, member 2
chr3_+_46762703 2.03 ENSDART00000133283
protein kinase C substrate 80K-H
chr19_+_46222918 2.02 ENSDART00000158703
vacuolar protein sorting 28 (yeast)
chr19_-_25119443 2.01 ENSDART00000148953
protein tyrosine phosphatase type IVA, member 3
chr19_+_31585341 2.01 ENSDART00000052185
geminin, DNA replication inhibitor
chr4_-_14954029 1.99 ENSDART00000038642
solute carrier family 26 (anion exchanger), member 5
chr22_-_5171829 1.97 ENSDART00000140313
tumor necrosis factor, alpha-induced protein 8-like 1
chr23_+_31942040 1.96 ENSDART00000088607
nuclear envelope integral membrane protein 1
chr23_-_17450746 1.95 ENSDART00000145399
ENSDART00000136457
ENSDART00000133125
ENSDART00000145719
ENSDART00000147524
ENSDART00000005366
ENSDART00000104680
tumor protein D52-like 2b
chr6_-_40922971 1.94 ENSDART00000155363
SFI1 centrin binding protein
chr3_+_32403758 1.93 ENSDART00000156982
si:ch211-195b15.8
chr5_-_51998708 1.93 ENSDART00000097194
serine incorporator 5
chr23_-_10722664 1.93 ENSDART00000146526
ENSDART00000129022
ENSDART00000104985
forkhead box P1a
chr19_+_46222428 1.93 ENSDART00000183984
vacuolar protein sorting 28 (yeast)
chr8_+_16990120 1.92 ENSDART00000018934
phosphodiesterase 4D, cAMP-specific
chr22_+_14117078 1.91 ENSDART00000013575
basic leucine zipper and W2 domains 1a
chr21_+_19547806 1.90 ENSDART00000159707
ENSDART00000184869
ENSDART00000181321
ENSDART00000058487
ENSDART00000058485
retinoic acid induced 14
chr25_-_25142387 1.90 ENSDART00000031814
tumor susceptibility 101a
chr21_-_13661631 1.89 ENSDART00000184408
patatin-like phospholipase domain containing 7a
chr16_+_5612547 1.89 ENSDART00000140226
ENSDART00000189352
si:dkey-283b15.4
chr7_+_38808027 1.89 ENSDART00000052323
harbinger transposase derived 1
chr5_-_56924747 1.88 ENSDART00000014028
protein phosphatase, Mg2+/Mn2+ dependent, 1Db
chr24_+_39211288 1.87 ENSDART00000061540
im:7160594
chr17_-_23709347 1.87 ENSDART00000124661
3'-phosphoadenosine 5'-phosphosulfate synthase 2a
chr18_+_16749091 1.87 ENSDART00000061265
ring finger protein 141
chr3_+_35498119 1.86 ENSDART00000178963
trinucleotide repeat containing 6a
chr13_-_13030851 1.85 ENSDART00000009499
nuclear receptor binding SET domain protein 2
chr10_-_36633882 1.85 ENSDART00000077161
ENSDART00000137688
remodeling and spacing factor 1b, tandem duplicate 1
remodeling and spacing factor 1b, tandem duplicate 1
chr5_+_41477526 1.84 ENSDART00000153567
protein inhibitor of activated STAT, 2
chr7_-_13906409 1.81 ENSDART00000062257
solute carrier family 39 (zinc transporter), member 1
chr23_-_10723009 1.80 ENSDART00000189721
forkhead box P1a
chr5_+_55934129 1.79 ENSDART00000050969
transmembrane protein 150Ab
chr2_+_1988036 1.79 ENSDART00000155956
synovial sarcoma, X breakpoint 2 interacting protein a
chr24_-_19718077 1.77 ENSDART00000109107
ENSDART00000056082
cysteine-serine-rich nuclear protein 1b
chr12_-_25380028 1.76 ENSDART00000142674
zinc finger protein 36, C3H type-like 2
chr17_-_14966384 1.75 ENSDART00000105064
thioredoxin domain containing 16
chr7_+_56472585 1.73 ENSDART00000135259
ENSDART00000073596
increased sodium tolerance 1 homolog (yeast)
chr8_-_25716074 1.71 ENSDART00000007482
testis specific protein, Y-linked
chr10_-_35186310 1.70 ENSDART00000127805
POM121 transmembrane nucleoporin
chr17_+_24111392 1.65 ENSDART00000180123
ENSDART00000182787
ENSDART00000189752
ENSDART00000184940
ENSDART00000185363
ENSDART00000064067
EH domain binding protein 1
chr6_-_42336987 1.63 ENSDART00000128777
ENSDART00000075601
Fanconi anemia, complementation group D2
chr8_+_20488322 1.63 ENSDART00000036630
zgc:101100
chr1_+_53321878 1.62 ENSDART00000143909
TBC1 domain family, member 9 (with GRAM domain)
chr25_+_22017182 1.62 ENSDART00000156517
si:dkey-217l24.1
chr1_-_23596391 1.59 ENSDART00000155184
ligand dependent nuclear receptor corepressor-like
chr21_+_20386865 1.58 ENSDART00000144366
si:dkey-30k6.5
chr17_-_22573311 1.58 ENSDART00000141523
ENSDART00000140022
ENSDART00000079390
ENSDART00000188644
exonuclease 1
chr24_+_37709191 1.57 ENSDART00000066558
2,4-dienoyl CoA reductase 2, peroxisomal
chr17_+_32360673 1.56 ENSDART00000155519
si:ch211-139d20.3
chr17_-_37474689 1.56 ENSDART00000103980
cysteine-rich protein 2
chr20_-_35470891 1.56 ENSDART00000152993
ENSDART00000016090
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr13_+_42602406 1.56 ENSDART00000133388
ENSDART00000147996
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
chr14_-_30490465 1.56 ENSDART00000173107
mitochondrial calcium uptake family, member 3b
chr14_+_26439227 1.55 ENSDART00000054183
G protein-coupled receptor 137
chr19_-_34063567 1.54 ENSDART00000157815
ENSDART00000183907
engulfment and cell motility 1 (ced-12 homolog, C. elegans)
chr18_+_6857071 1.53 ENSDART00000018735
ENSDART00000181969
DnaJ (Hsp40) homolog, subfamily A, member 2, like
chr20_+_23742574 1.52 ENSDART00000050559
SH3 domain containing ring finger 1
chr5_+_53009083 1.52 ENSDART00000157836
histidine triad nucleotide binding protein 2
chr3_+_19685873 1.52 ENSDART00000006490
tousled-like kinase 2
chr5_-_40190949 1.51 ENSDART00000175588
WD repeat and FYVE domain containing 3
chr3_-_15679107 1.50 ENSDART00000080441
zgc:66443
chr13_+_1100197 1.50 ENSDART00000139560
protein phosphatase 3, regulatory subunit B, alpha a
chr11_+_21586335 1.50 ENSDART00000091182
zgc:101564
chr22_-_11520405 1.49 ENSDART00000063157
solute carrier family 26 (anion exchanger), member 11
chr5_+_1965296 1.49 ENSDART00000156224
DEAH (Asp-Glu-Ala-His) box polypeptide 33
chr21_+_34088377 1.48 ENSDART00000170070
myotubularin related protein 1b
chr11_-_26701611 1.48 ENSDART00000083010
acyl-CoA dehydrogenase family, member 9
chr1_-_23595779 1.48 ENSDART00000134860
ENSDART00000138852
ligand dependent nuclear receptor corepressor-like
chr8_+_8643901 1.48 ENSDART00000142076
ENSDART00000075624
ubiquitin specific peptidase 11
chr11_+_24313931 1.47 ENSDART00000017599
ENSDART00000166045
RAS (RAD and GEM)-like GTP-binding 1
chr24_+_14240196 1.46 ENSDART00000124740
nuclear receptor coactivator 2
chr17_-_11417904 1.45 ENSDART00000103228
AT rich interactive domain 4A (RBP1-like)
chr21_+_34088110 1.44 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
myotubularin related protein 1b
chr16_+_6944311 1.43 ENSDART00000144763
ELL associated factor 1
chr21_-_9782502 1.41 ENSDART00000158836
Rho GTPase activating protein 24
chr16_+_6944564 1.40 ENSDART00000104252
ELL associated factor 1
chr10_+_11260170 1.38 ENSDART00000155742
hydroxysteroid dehydrogenase like 2
chr6_-_35309661 1.35 ENSDART00000114960
nitric oxide synthase 1 (neuronal) adaptor protein a
chr21_-_27272657 1.35 ENSDART00000040754
ENSDART00000175009
MAP/microtubule affinity-regulating kinase 2a
chr21_+_17051478 1.35 ENSDART00000047201
ENSDART00000161650
ENSDART00000167298
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a
chr8_-_18879905 1.34 ENSDART00000100491
SH3-domain GRB2-like 1b
chr7_-_38570299 1.33 ENSDART00000143815
cugbp, Elav-like family member 1
chr6_-_40657653 1.30 ENSDART00000154359
peptidylprolyl isomerase (cyclophilin)-like 1
chr9_+_2343096 1.30 ENSDART00000062292
ENSDART00000191722
ENSDART00000135180
activating transcription factor 2
chr18_+_41561285 1.30 ENSDART00000169621
bromodomain adjacent to zinc finger domain, 1B
chr14_-_7885707 1.28 ENSDART00000029981
protein phosphatase 3, catalytic subunit, beta isozyme
chr7_+_24528866 1.27 ENSDART00000180552
si:dkeyp-75h12.2
chr5_-_32074534 1.27 ENSDART00000112342
ENSDART00000135855
actin related protein 2/3 complex, subunit 5-like, b
chr24_-_5932982 1.26 ENSDART00000138412
ENSDART00000135124
ENSDART00000007373
acyl-CoA binding domain containing 5a
chr20_+_22799857 1.26 ENSDART00000058527
sec1 family domain containing 2
chr15_-_5720583 1.25 ENSDART00000158034
ENSDART00000190332
ENSDART00000109599
URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
chr18_-_20466061 1.23 ENSDART00000060311
progestin and adipoQ receptor family member Va
chr5_-_66749535 1.23 ENSDART00000132183
K(lysine) acetyltransferase 5b

Network of associatons between targets according to the STRING database.

First level regulatory network of foxo4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0071896 protein localization to adherens junction(GO:0071896)
1.3 5.2 GO:1904184 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
1.2 3.7 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371) positive regulation of endoplasmic reticulum tubular network organization(GO:1903373)
1.1 7.9 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
1.0 3.0 GO:0060623 regulation of chromosome condensation(GO:0060623)
1.0 2.9 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.9 2.6 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.8 5.6 GO:0021534 cell proliferation in hindbrain(GO:0021534)
0.8 1.5 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037)
0.7 5.9 GO:0070933 histone H4 deacetylation(GO:0070933)
0.7 2.7 GO:0009098 leucine biosynthetic process(GO:0009098)
0.7 2.6 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.6 3.2 GO:0070254 mucus secretion(GO:0070254)
0.6 2.5 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.6 1.9 GO:0034036 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.6 1.9 GO:0097676 histone H3-K36 dimethylation(GO:0097676)
0.6 2.4 GO:1904590 regulation of protein import into nucleus(GO:0042306) negative regulation of protein import into nucleus(GO:0042308) negative regulation of nucleocytoplasmic transport(GO:0046823) negative regulation of protein localization to nucleus(GO:1900181) regulation of protein import(GO:1904589) negative regulation of protein import(GO:1904590)
0.6 4.1 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.5 1.6 GO:1990918 double-strand break repair involved in meiotic recombination(GO:1990918)
0.5 1.6 GO:0051026 chiasma assembly(GO:0051026)
0.5 2.0 GO:0006046 N-acetylglucosamine catabolic process(GO:0006046)
0.5 4.1 GO:0044211 CTP salvage(GO:0044211)
0.5 4.5 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.5 2.0 GO:0019532 oxalate transport(GO:0019532)
0.5 2.4 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.5 2.9 GO:0060251 regulation of glial cell proliferation(GO:0060251)
0.4 1.3 GO:0071514 genetic imprinting(GO:0071514)
0.4 3.9 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.4 2.0 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.4 4.8 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.4 4.7 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.4 1.1 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.4 1.1 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.3 3.5 GO:0045199 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.3 2.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.3 1.3 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031) pancreas morphogenesis(GO:0061113)
0.3 2.5 GO:0045338 farnesyl diphosphate metabolic process(GO:0045338)
0.3 2.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.3 2.2 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.3 6.6 GO:0008078 mesodermal cell migration(GO:0008078)
0.3 1.2 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.3 3.7 GO:0090398 cellular senescence(GO:0090398)
0.3 1.5 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.3 3.3 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.3 0.8 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.2 1.4 GO:1900028 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.2 0.9 GO:0060300 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.2 2.8 GO:0046599 regulation of centriole replication(GO:0046599)
0.2 0.9 GO:0098920 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.2 2.1 GO:0003139 secondary heart field specification(GO:0003139)
0.2 1.3 GO:0030242 pexophagy(GO:0030242)
0.2 1.2 GO:0006004 fucose metabolic process(GO:0006004)
0.2 1.4 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.2 1.5 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.2 17.2 GO:0032272 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.2 2.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 0.5 GO:0036316 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.2 0.7 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.2 2.5 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.2 1.0 GO:0051883 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.2 1.0 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.2 3.5 GO:0014812 muscle cell migration(GO:0014812)
0.2 2.2 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.1 0.7 GO:0051972 regulation of telomerase activity(GO:0051972)
0.1 1.9 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 1.1 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.1 2.2 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.1 8.3 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.1 1.9 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 6.3 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 1.9 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 1.2 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 1.0 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.1 1.2 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 3.5 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1 2.7 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.1 2.0 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.1 2.1 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 1.6 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.8 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.1 1.8 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 2.0 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.7 GO:0007032 endosome organization(GO:0007032)
0.1 1.3 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 1.0 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.1 2.0 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 0.2 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.1 3.4 GO:0030901 midbrain development(GO:0030901)
0.1 3.8 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 1.6 GO:0006298 mismatch repair(GO:0006298)
0.1 0.7 GO:0061056 sclerotome development(GO:0061056)
0.1 4.8 GO:0071599 otic vesicle development(GO:0071599)
0.1 3.4 GO:0016575 histone deacetylation(GO:0016575)
0.1 1.8 GO:0016925 protein sumoylation(GO:0016925)
0.1 2.0 GO:0045332 phospholipid translocation(GO:0045332)
0.1 2.0 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.4 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 3.0 GO:0000281 mitotic cytokinesis(GO:0000281)
0.1 4.7 GO:0031101 fin regeneration(GO:0031101)
0.0 1.2 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.4 GO:0007140 male meiosis(GO:0007140)
0.0 1.1 GO:0051307 meiotic chromosome separation(GO:0051307)
0.0 0.8 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 3.3 GO:0048916 posterior lateral line development(GO:0048916)
0.0 1.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.2 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.0 0.4 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 1.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0051295 establishment of meiotic spindle localization(GO:0051295)
0.0 0.6 GO:0046686 response to cadmium ion(GO:0046686)
0.0 1.5 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 0.3 GO:0060561 apoptotic process involved in morphogenesis(GO:0060561)
0.0 1.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.4 GO:1903844 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) regulation of cellular response to transforming growth factor beta stimulus(GO:1903844)
0.0 0.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.7 GO:0044273 glycosaminoglycan catabolic process(GO:0006027) sulfur compound catabolic process(GO:0044273)
0.0 0.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.5 GO:0045766 positive regulation of angiogenesis(GO:0045766)
0.0 1.3 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.4 GO:0051984 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of chromosome segregation(GO:0051984) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 0.9 GO:0032526 response to retinoic acid(GO:0032526)
0.0 0.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 2.3 GO:0007030 Golgi organization(GO:0007030)
0.0 0.7 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.2 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 3.4 GO:0009953 dorsal/ventral pattern formation(GO:0009953)
0.0 0.4 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 0.8 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.7 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 1.2 GO:0048477 oogenesis(GO:0048477)
0.0 0.5 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.7 GO:0048821 erythrocyte development(GO:0048821)
0.0 2.0 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 0.4 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 0.6 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.3 GO:0008272 sulfate transport(GO:0008272)
0.0 0.6 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 1.6 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.1 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 2.9 GO:0006887 exocytosis(GO:0006887)
0.0 0.7 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 1.1 GO:0006413 translational initiation(GO:0006413)
0.0 0.2 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0098826 endoplasmic reticulum tubular network membrane(GO:0098826)
1.2 4.8 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.6 1.8 GO:0031213 RSF complex(GO:0031213)
0.5 2.0 GO:0017177 glucosidase II complex(GO:0017177)
0.5 1.9 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.4 2.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.4 2.8 GO:0032783 ELL-EAF complex(GO:0032783)
0.3 1.4 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.3 1.0 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.3 1.2 GO:0097268 cytoophidium(GO:0097268)
0.2 3.9 GO:0000813 ESCRT I complex(GO:0000813)
0.2 2.3 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.2 1.1 GO:0005899 insulin receptor complex(GO:0005899)
0.2 1.3 GO:0005955 calcineurin complex(GO:0005955)
0.2 3.1 GO:0000792 heterochromatin(GO:0000792)
0.2 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.2 1.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 7.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 1.6 GO:0032300 mismatch repair complex(GO:0032300)
0.2 7.2 GO:0031941 filamentous actin(GO:0031941)
0.1 1.2 GO:0071797 LUBAC complex(GO:0071797)
0.1 1.6 GO:1990246 uniplex complex(GO:1990246)
0.1 3.8 GO:0005844 polysome(GO:0005844)
0.1 9.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 2.0 GO:0032039 integrator complex(GO:0032039)
0.1 1.2 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 1.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 1.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 1.2 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 6.9 GO:0030027 lamellipodium(GO:0030027)
0.1 0.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 1.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 3.6 GO:0072686 mitotic spindle(GO:0072686)
0.1 6.2 GO:0016607 nuclear speck(GO:0016607)
0.0 5.0 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 4.0 GO:0030141 secretory granule(GO:0030141)
0.0 4.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 5.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.3 GO:0045495 pole plasm(GO:0045495)
0.0 0.7 GO:0000784 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.0 4.3 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.7 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.3 GO:0000796 condensin complex(GO:0000796)
0.0 1.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.6 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.2 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.6 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 2.2 GO:0005581 collagen trimer(GO:0005581)
0.0 2.1 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 5.3 GO:0000785 chromatin(GO:0000785)
0.0 5.3 GO:0005813 centrosome(GO:0005813)
0.0 0.3 GO:0000922 spindle pole(GO:0000922)
0.0 0.9 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.8 GO:0000793 condensed chromosome(GO:0000793)
0.0 3.2 GO:0070382 exocytic vesicle(GO:0070382)
0.0 0.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.1 GO:0034704 voltage-gated calcium channel complex(GO:0005891) calcium channel complex(GO:0034704)
0.0 0.4 GO:0043195 terminal bouton(GO:0043195)
0.0 3.8 GO:0005764 lysosome(GO:0005764)
0.0 0.5 GO:0016605 PML body(GO:0016605)
0.0 6.2 GO:0000139 Golgi membrane(GO:0000139)
0.0 4.0 GO:0005730 nucleolus(GO:0005730)
0.0 1.4 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 1.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.3 GO:0005925 focal adhesion(GO:0005925)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.6 GO:0051059 NF-kappaB binding(GO:0051059)
1.3 5.2 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
1.2 4.7 GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity(GO:0047464)
1.1 3.2 GO:0008517 folic acid transporter activity(GO:0008517)
0.8 2.5 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.8 3.0 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.7 2.7 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.7 3.3 GO:0004307 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.6 2.5 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.6 1.9 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.5 1.6 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.5 4.1 GO:0004849 uridine kinase activity(GO:0004849)
0.5 1.5 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.5 2.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.4 3.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.4 5.9 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.4 1.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.4 5.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 0.9 GO:0031701 angiotensin receptor binding(GO:0031701)
0.3 1.2 GO:0003883 CTP synthase activity(GO:0003883)
0.3 2.9 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.3 2.5 GO:0004096 catalase activity(GO:0004096)
0.3 1.1 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.3 2.2 GO:0031419 cobalamin binding(GO:0031419)
0.3 1.9 GO:0035173 histone kinase activity(GO:0035173)
0.2 4.7 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.2 1.4 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.2 2.4 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.2 1.1 GO:0005009 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.2 1.3 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 3.0 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 0.6 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.2 0.7 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.2 0.7 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.2 1.0 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.2 0.8 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.2 1.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.2 1.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 5.4 GO:0004707 MAP kinase activity(GO:0004707)
0.1 1.8 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 1.9 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 0.7 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 3.0 GO:0019213 deacetylase activity(GO:0019213)
0.1 3.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 2.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 2.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 2.3 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1 3.5 GO:0019003 GDP binding(GO:0019003)
0.1 7.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.9 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 3.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 6.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.2 GO:0031267 small GTPase binding(GO:0031267)
0.1 13.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 3.1 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.5 GO:0008142 oxysterol binding(GO:0008142)
0.1 1.6 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 1.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.6 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 1.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 1.0 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 2.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.1 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.1 1.3 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.2 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 1.2 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 0.8 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 1.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 1.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 1.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 5.6 GO:0019905 syntaxin binding(GO:0019905)
0.1 4.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 1.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 1.4 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 2.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 2.4 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.6 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.7 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.8 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.3 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.6 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 5.1 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 2.8 GO:0060090 binding, bridging(GO:0060090)
0.0 0.2 GO:0030332 cyclin binding(GO:0030332)
0.0 0.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.6 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 1.5 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.4 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.1 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.0 1.7 GO:0004518 nuclease activity(GO:0004518)
0.0 1.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.4 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.8 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 3.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.2 3.8 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.2 3.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 3.5 PID RAS PATHWAY Regulation of Ras family activation
0.1 1.9 PID ARF 3PATHWAY Arf1 pathway
0.1 0.8 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 2.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 5.7 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 1.3 PID RHOA PATHWAY RhoA signaling pathway
0.1 1.9 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 1.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.5 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 2.1 PID BMP PATHWAY BMP receptor signaling
0.1 1.6 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.4 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.4 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.1 PID FOXO PATHWAY FoxO family signaling
0.0 0.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.4 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.3 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.5 PID RB 1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.4 5.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.4 3.5 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.4 1.5 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3 1.6 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 2.0 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 2.5 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.2 2.0 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.2 2.6 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.2 3.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 3.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.2 4.8 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 2.0 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.2 1.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 2.1 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 2.7 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 5.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 3.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.9 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 2.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 0.6 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 3.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 2.7 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 0.5 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 0.9 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 1.2 REACTOME PRE NOTCH EXPRESSION AND PROCESSING Genes involved in Pre-NOTCH Expression and Processing
0.1 1.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 0.8 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 1.9 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 2.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 0.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 0.9 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.7 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 1.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 1.0 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases