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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for e2f2_e2f5
Z-value: 1.21
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Transcription factors associated with e2f2_e2f5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| e2f5 | dr11_v1_chr2_-_31686353_31686403 | 0.87 | 2.6e-06 | Click! |
| E2F2 | dr11_v1_chr17_-_27266053_27266053 | 0.69 | 1.4e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_-_4439311 Show fit | 2.90 |
ENSDART00000169317
|
ubiquitin-like with PHD and ring finger domains 1 |
|
| chr3_-_54607166 Show fit | 2.78 |
ENSDART00000021977
|
DNA (cytosine-5-)-methyltransferase 1 |
|
| chr8_-_1219815 Show fit | 2.73 |
ENSDART00000016800
ENSDART00000149969 |
zinc finger protein 367 |
|
| chr11_-_11792766 Show fit | 2.39 |
ENSDART00000011657
|
cell division cycle 6 homolog (S. cerevisiae) |
|
| chr21_-_27413294 Show fit | 2.25 |
ENSDART00000131646
|
solute carrier family 29 (equilibrative nucleoside transporter), member 2 |
|
| chr2_-_29923630 Show fit | 2.10 |
ENSDART00000158844
ENSDART00000031130 |
PAX interacting (with transcription-activation domain) protein 1 |
|
| chr9_+_22780901 Show fit | 2.05 |
ENSDART00000110992
ENSDART00000143972 |
replication timing regulatory factor 1 |
|
| chr2_-_29923403 Show fit | 2.01 |
ENSDART00000144672
|
PAX interacting (with transcription-activation domain) protein 1 |
|
| chr16_+_41015163 Show fit | 2.01 |
ENSDART00000058586
|
DEK proto-oncogene |
|
| chr7_+_41812817 Show fit | 1.95 |
ENSDART00000174165
|
origin recognition complex, subunit 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of e2f2_e2f5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 7.4 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
| 0.1 | 5.9 | GO:0032200 | telomere maintenance(GO:0000723) telomere organization(GO:0032200) |
| 0.0 | 5.3 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 0.5 | 4.0 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.4 | 4.0 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.1 | 3.6 | GO:2000779 | regulation of double-strand break repair(GO:2000779) |
| 0.4 | 2.5 | GO:0000076 | DNA replication checkpoint(GO:0000076) |
| 0.6 | 2.3 | GO:0006272 | leading strand elongation(GO:0006272) |
| 0.4 | 2.3 | GO:0015862 | uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864) |
| 0.2 | 2.3 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.1 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 3.2 | GO:0005730 | nucleolus(GO:0005730) |
| 0.2 | 2.9 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.1 | 2.6 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.0 | 2.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.3 | 1.9 | GO:0031261 | DNA replication preinitiation complex(GO:0031261) |
| 0.0 | 1.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 1.4 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.3 | 1.3 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.0 | 1.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | GO:0042393 | histone binding(GO:0042393) |
| 0.5 | 3.5 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.2 | 2.9 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.1 | 2.4 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.2 | 2.3 | GO:1990404 | protein ADP-ribosylase activity(GO:1990404) |
| 0.1 | 2.3 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 1.8 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.0 | 1.8 | GO:0031072 | heat shock protein binding(GO:0031072) |
| 0.1 | 1.6 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.1 | 1.4 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 5.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 4.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 2.9 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.4 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 1.4 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 0.9 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 10.8 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.4 | 8.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 2.4 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.1 | 2.3 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 2.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 1.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 1.1 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.0 | 1.0 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 1.0 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 0.9 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |