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Results for ZMS1

Z-value: 0.76

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Transcription factors associated with ZMS1

Gene Symbol Gene ID Gene Info
RSF2
S000003888 Zinc-finger protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RSF2YJR127C0.876.9e-09Click!

Activity profile of ZMS1 motif

Sorted Z-values of ZMS1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YKL163W 13.40
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YGR067C 11.87 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YDR342C 11.10
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YOR100C 10.87
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YDR277C 10.53
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YKL217W 9.85
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YLR327C 9.53
TMA10
Protein of unknown function that associates with ribosomes
YGR243W 9.16
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFR053C 8.84
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YDR536W 8.55
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YFL052W 7.31 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YOR382W 7.03
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YOR348C 6.87
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YMR107W 6.84
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YJR115W 6.57 Putative protein of unknown function
YKR097W 6.45
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YKL026C 6.27
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YOR178C 6.16
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YDR343C 6.04
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YML042W 5.96
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YJR095W 5.83
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YDR119W-A 5.68 Putative protein of unknown function
YPL054W 5.65
LEE1
Zinc-finger protein of unknown function
YOL052C-A 5.61
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YNR073C 5.52 Putative mannitol dehydrogenase
YEL039C 5.29
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YEL011W 5.11
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YMR175W 5.01
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YIL057C 5.00 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YPL230W 4.99
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YOR383C 4.96
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YMR081C 4.92
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YLR312C 4.69
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YGR032W 4.64
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YFR017C 4.64 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YMR194C-B 4.51 Putative protein of unknown function
YHR096C 4.49
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YOR374W 4.35
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YOR120W 4.17
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YGR183C 4.12
QCR9
Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YKL109W 3.99
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YHR217C 3.94 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YKL044W 3.92 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL222C 3.92
FMP45
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YNR002C 3.88
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YLR023C 3.87
IZH3
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YPR184W 3.72
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YNR034W-A 3.66 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YGL062W 3.61
PYC1
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YIL162W 3.59
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YBR105C 3.56
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YLR377C 3.41
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YJL045W 3.34 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YGR043C 3.31
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YDR096W 3.23
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YOR343C 3.23 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YIL155C 3.12
GUT2
Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YDL194W 3.12
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YML089C 3.12 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YHR092C 3.10
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YKL043W 3.06
PHD1
Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YPR030W 3.04
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YFL011W 3.03
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YPL119C 2.99
DBP1
Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs
YMR272C 2.86
SCS7
Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YOL084W 2.79
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YMR195W 2.73
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YPL061W 2.72
ALD6
Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YBR033W 2.71
EDS1
Putative zinc cluster protein; YBR033W is not an essential gene
YHL032C 2.71
GUT1
Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
YDR010C 2.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER084W 2.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR021C 2.67
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YAR053W 2.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL117W 2.55
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YOL051W 2.51
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YNL144C 2.49 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YHR218W 2.49 Helicase-like protein encoded within the telomeric Y' element
YMR017W 2.45
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YDR216W 2.45
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YIL055C 2.44 Putative protein of unknown function
YPR005C 2.38
HAL1
Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
YOL154W 2.36
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YPL262W 2.35
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YLL053C 2.33 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YDR178W 2.33
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YJL103C 2.28
GSM1
Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YPR026W 2.25
ATH1
Acid trehalase required for utilization of extracellular trehalose
YIL136W 2.25
OM45
Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YJL199C 2.24
MBB1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YHL021C 2.23
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YDL079C 2.22
MRK1
Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YBR051W 2.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YER150W 2.21
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YNL036W 2.21
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YBR117C 2.20
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YPL186C 2.20
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YAR035W 2.20
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YOL060C 2.19
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YLR174W 2.18
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YKL093W 2.17
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YMR280C 2.17
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YCR007C 2.17 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YAL039C 2.15
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YBR050C 2.15
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YGL146C 2.15 Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YPL024W 2.14
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YEL012W 2.14
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YPL201C 2.12
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YFL064C 2.09 Putative protein of unknown function
YLL052C 2.09
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YER121W 2.08 Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YKL031W 2.08 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YPR015C 2.08 Putative protein of unknown function
YLR438W 2.07
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YFL063W 2.07 Dubious open reading frame, based on available experimental and comparative sequence data
YEL070W 2.05
DSF1
Deletion suppressor of mpt5 mutation
YGL045W 2.05
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YPR151C 2.05
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YBR298C 2.01
MAL31
Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C
YHR211W 2.01
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YLR122C 2.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YMR174C 1.98
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YBR203W 1.97
COS111
Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL085W 1.97
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YOR031W 1.97
CRS5
Copper-binding metallothionein, required for wild-type copper resistance
YER187W 1.97 Putative protein of unknown function; induced in respiratory-deficient cells
YOR376W 1.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YML090W 1.96 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YDR186C 1.96 Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YJL133C-A 1.96 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR132C 1.95
AGP2
High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YLR332W 1.93
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YMR105C 1.92
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YAR060C 1.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL142W 1.91
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YJR096W 1.91 Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YGR144W 1.90
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YBR201C-A 1.89 Putative protein of unknown function
YPL185W 1.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YPR006C 1.84
ICL2
2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YOL081W 1.84
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YLR331C 1.82
JIP3
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YGR023W 1.80
MTL1
Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YDL244W 1.79
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YOR065W 1.78
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YCR010C 1.76
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YLR437C-A 1.76 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YDR259C 1.75
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YJR151C 1.74
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YHR033W 1.72 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YPR150W 1.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YDR406W 1.71
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YCL025C 1.70
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YGR022C 1.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YFL062W 1.69
COS4
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YGR258C 1.69
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YLR258W 1.68
GSY2
Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YIL099W 1.68
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YAL061W 1.66
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YDR247W 1.64
VHS1
Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YLR123C 1.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YPL026C 1.63
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YKL085W 1.62
MDH1
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YBR047W 1.60
FMP23
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR328W 1.59
PDR10
ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p
YJL102W 1.59
MEF2
Mitochondrial elongation factor involved in translational elongation
YPL057C 1.58
SUR1
Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p
YOR235W 1.58
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YDL223C 1.56
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YAL062W 1.55
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YLR149C 1.55 Putative protein of unknown function; YLR149C is not an essential gene
YPR160W 1.54
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YGR256W 1.52
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YJL220W 1.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2
YML128C 1.50
MSC1
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YGL163C 1.49
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YLR279W 1.49 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML091C 1.49
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YML131W 1.48 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YDL214C 1.48
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YBL033C 1.48
RIB1
GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
YGL117W 1.48 Putative protein of unknown function
YPR154W 1.47
PIN3
Protein that induces appearance of [PIN+] prion when overproduced
YHR198C 1.46
AIM18
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YOR211C 1.44
MGM1
Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YPR036W-A 1.44 Protein of unknown function; transcription is regulated by Pdr1p
YKL141W 1.44
SDH3
Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YIL045W 1.43
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YPL017C 1.42
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YHR212C 1.42 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL096W 1.42
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YJR120W 1.41 Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YOR152C 1.41 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YAL034C 1.40
FUN19
Non-essential protein of unknown function
YCR079W 1.40
PTC6
Mitochondrial protein phosphatase of type 2C with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase
YDR306C 1.39 F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
YPL250C 1.39
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YPR013C 1.39 Putative zinc finger protein; YPR013C is not an essential gene
YER067W 1.38 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene

Network of associatons between targets according to the STRING database.

First level regulatory network of ZMS1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 18.0 GO:0006848 pyruvate transport(GO:0006848)
3.7 11.0 GO:0015755 fructose transport(GO:0015755)
2.7 8.2 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
2.4 2.4 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
2.2 6.6 GO:0019413 acetate biosynthetic process(GO:0019413)
2.0 7.9 GO:0015804 neutral amino acid transport(GO:0015804)
1.7 5.1 GO:0015740 C4-dicarboxylate transport(GO:0015740)
1.7 6.6 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
1.5 7.4 GO:0015793 glycerol transport(GO:0015793)
1.5 14.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.4 4.2 GO:0042843 D-xylose catabolic process(GO:0042843)
1.4 6.9 GO:0005980 glycogen catabolic process(GO:0005980)
1.4 4.1 GO:0032780 negative regulation of ATPase activity(GO:0032780)
1.3 10.7 GO:0015891 siderophore transport(GO:0015891)
1.3 5.3 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
1.3 27.5 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
1.2 3.7 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
1.2 3.6 GO:0051469 vesicle fusion with vacuole(GO:0051469)
1.1 3.3 GO:0019541 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
1.1 3.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
1.1 18.0 GO:0005978 glycogen biosynthetic process(GO:0005978)
1.0 3.1 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
1.0 3.1 GO:0005993 trehalose catabolic process(GO:0005993)
1.0 8.7 GO:0006097 glyoxylate cycle(GO:0006097)
0.9 6.6 GO:0000023 maltose metabolic process(GO:0000023)
0.9 1.8 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.9 3.5 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.9 3.4 GO:0006527 arginine catabolic process(GO:0006527)
0.8 4.9 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.8 3.2 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.8 1.6 GO:0006108 malate metabolic process(GO:0006108)
0.8 3.1 GO:0071467 cellular response to pH(GO:0071467)
0.8 0.8 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.8 3.8 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.7 2.2 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.6 3.2 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.6 2.5 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.6 0.6 GO:0071456 cellular response to hypoxia(GO:0071456)
0.6 1.2 GO:0006102 isocitrate metabolic process(GO:0006102)
0.6 8.7 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.6 2.4 GO:0015976 carbon utilization(GO:0015976)
0.6 17.6 GO:0006094 gluconeogenesis(GO:0006094)
0.6 3.5 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.6 2.3 GO:0006083 acetate metabolic process(GO:0006083)
0.5 1.6 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.5 1.0 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.5 5.4 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.5 1.9 GO:0070054 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.5 1.8 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.4 3.6 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.4 0.4 GO:0043902 positive regulation of multi-organism process(GO:0043902)
0.4 1.7 GO:0032079 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.4 1.7 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.4 1.2 GO:0001324 age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324)
0.4 1.6 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.4 1.9 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.4 3.8 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.4 0.4 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.4 1.1 GO:0042743 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.4 1.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.4 1.1 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.3 1.4 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.3 1.4 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.3 1.4 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.3 5.4 GO:0019740 nitrogen utilization(GO:0019740)
0.3 1.7 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.3 0.6 GO:0009190 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.3 0.9 GO:0006545 glycine biosynthetic process(GO:0006545)
0.3 0.8 GO:0006598 polyamine catabolic process(GO:0006598)
0.3 1.4 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 0.8 GO:0019748 secondary metabolic process(GO:0019748)
0.3 1.8 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.3 1.0 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.2 4.2 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.2 0.7 GO:0008216 spermidine metabolic process(GO:0008216)
0.2 0.7 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.2 0.9 GO:0006112 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.2 3.7 GO:0006754 ATP biosynthetic process(GO:0006754)
0.2 3.2 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.2 1.4 GO:0006855 drug transmembrane transport(GO:0006855)
0.2 1.8 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.2 0.9 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.2 0.7 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.2 0.6 GO:0044209 AMP salvage(GO:0044209)
0.2 0.2 GO:0046185 aldehyde catabolic process(GO:0046185)
0.2 1.0 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 1.2 GO:0006099 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.2 0.6 GO:1903137 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.2 3.3 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.2 4.7 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.2 0.6 GO:0034090 maintenance of meiotic sister chromatid cohesion(GO:0034090)
0.2 0.8 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.2 7.1 GO:0009060 aerobic respiration(GO:0009060)
0.2 1.1 GO:0071322 cellular response to carbohydrate stimulus(GO:0071322)
0.2 1.8 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.2 0.2 GO:0051098 regulation of binding(GO:0051098)
0.2 0.4 GO:0008272 sulfate transport(GO:0008272)
0.2 0.2 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.2 0.9 GO:0044070 regulation of anion transport(GO:0044070)
0.2 0.5 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.2 0.5 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.2 0.6 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.2 0.8 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.2 1.5 GO:0046686 response to cadmium ion(GO:0046686)
0.2 0.6 GO:0072367 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.2 0.2 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.2 0.3 GO:0000304 response to singlet oxygen(GO:0000304)
0.2 0.6 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.2 0.9 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.2 0.9 GO:0045117 azole transport(GO:0045117)
0.1 0.3 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.1 2.0 GO:0001101 response to acid chemical(GO:0001101)
0.1 0.4 GO:0036257 multivesicular body organization(GO:0036257)
0.1 0.3 GO:0043335 protein unfolding(GO:0043335)
0.1 0.7 GO:0072348 sulfur compound transport(GO:0072348)
0.1 0.4 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 0.4 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.1 1.0 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.1 GO:2000142 regulation of transcription initiation from RNA polymerase II promoter(GO:0060260) regulation of DNA-templated transcription, initiation(GO:2000142)
0.1 0.6 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 0.6 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 2.5 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.8 GO:0034440 fatty acid beta-oxidation(GO:0006635) fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
0.1 0.1 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.1 0.2 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.3 GO:0010039 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.1 0.1 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.1 0.3 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.5 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.8 GO:0006119 oxidative phosphorylation(GO:0006119)
0.1 5.7 GO:0007031 peroxisome organization(GO:0007031)
0.1 0.5 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.1 GO:0070726 cell wall assembly(GO:0070726)
0.1 0.4 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.1 0.9 GO:0016575 histone deacetylation(GO:0016575)
0.1 0.2 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 0.3 GO:0072414 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.1 0.3 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.1 1.1 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.1 0.5 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.2 GO:0090527 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.1 1.2 GO:0000767 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753) cell morphogenesis involved in conjugation(GO:0000767)
0.1 0.7 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.6 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.1 0.5 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 1.1 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.1 0.4 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.4 GO:0016241 regulation of macroautophagy(GO:0016241)
0.1 1.0 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 2.7 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 0.1 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 0.6 GO:0051181 cofactor transport(GO:0051181)
0.1 0.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 0.9 GO:0007129 synapsis(GO:0007129)
0.1 0.3 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.1 1.1 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.3 GO:0032979 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979)
0.1 0.1 GO:0031297 replication fork processing(GO:0031297)
0.1 0.3 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.1 0.2 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.1 0.4 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 0.2 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 0.2 GO:0043954 cellular component maintenance(GO:0043954)
0.1 0.2 GO:0046464 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.1 0.3 GO:0006573 valine metabolic process(GO:0006573) valine biosynthetic process(GO:0009099)
0.1 3.7 GO:0048468 ascospore formation(GO:0030437) cell development(GO:0048468)
0.1 0.5 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 0.1 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.1 0.4 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 0.2 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.1 0.8 GO:0022900 electron transport chain(GO:0022900)
0.1 0.3 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 2.0 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 1.6 GO:0006631 fatty acid metabolic process(GO:0006631)
0.0 0.8 GO:0042493 response to drug(GO:0042493)
0.0 0.1 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.0 0.2 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.0 0.2 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.0 0.2 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.2 GO:0070058 tRNA gene clustering(GO:0070058)
0.0 0.5 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.3 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.5 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.1 GO:0055088 lipid homeostasis(GO:0055088)
0.0 0.4 GO:0015802 basic amino acid transport(GO:0015802)
0.0 0.3 GO:0006826 iron ion transport(GO:0006826)
0.0 0.5 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.1 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.0 0.1 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of sulfur metabolic process(GO:0042762)
0.0 0.2 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.3 GO:0009092 homoserine metabolic process(GO:0009092)
0.0 0.5 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.2 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.5 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.0 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.0 0.0 GO:0097271 protein localization to bud neck(GO:0097271)
0.0 0.1 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.0 0.1 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.1 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.0 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.6 GO:0042176 regulation of protein catabolic process(GO:0042176)
0.0 0.1 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.0 0.1 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.0 0.0 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.0 GO:0032365 intracellular lipid transport(GO:0032365)
0.0 0.1 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.1 GO:0043461 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.0 0.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0000018 regulation of DNA recombination(GO:0000018)
0.0 0.3 GO:0016573 histone acetylation(GO:0016573)
0.0 0.0 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.0 GO:0017004 cytochrome complex assembly(GO:0017004)
0.0 0.1 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.0 GO:0050667 homocysteine metabolic process(GO:0050667)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
1.3 5.3 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
1.1 9.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.1 4.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.0 9.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.8 2.4 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.8 4.8 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.8 5.4 GO:0034657 GID complex(GO:0034657)
0.8 3.8 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.7 1.4 GO:0030061 mitochondrial crista(GO:0030061)
0.6 4.8 GO:0042597 periplasmic space(GO:0042597)
0.5 1.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.4 7.3 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.4 0.4 GO:0005775 vacuolar lumen(GO:0005775)
0.4 1.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 4.2 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.4 4.7 GO:0070469 respiratory chain(GO:0070469)
0.4 1.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 1.4 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 2.5 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.3 20.3 GO:0005576 extracellular region(GO:0005576)
0.3 1.1 GO:0032116 SMC loading complex(GO:0032116)
0.3 5.6 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 1.7 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.2 39.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 7.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 1.3 GO:0034967 Set3 complex(GO:0034967)
0.2 0.6 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 1.6 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 1.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 3.0 GO:0070847 core mediator complex(GO:0070847)
0.1 3.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 0.3 GO:0032126 eisosome(GO:0032126)
0.1 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.5 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.4 GO:0030870 Mre11 complex(GO:0030870)
0.1 1.4 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.2 GO:0001400 mating projection base(GO:0001400)
0.1 0.2 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.1 0.2 GO:0070985 TFIIK complex(GO:0070985)
0.1 0.9 GO:0000974 Prp19 complex(GO:0000974)
0.1 0.3 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 1.7 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 0.3 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.1 1.1 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.3 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 0.8 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 39.2 GO:0005739 mitochondrion(GO:0005739)
0.0 0.9 GO:0005811 lipid particle(GO:0005811)
0.0 0.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.8 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0033551 monopolin complex(GO:0033551)
0.0 0.3 GO:0000942 condensed chromosome outer kinetochore(GO:0000940) condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.1 GO:0000817 COMA complex(GO:0000817)
0.0 0.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.6 GO:0009277 fungal-type cell wall(GO:0009277)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.1 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0031499 TRAMP complex(GO:0031499)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.0 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0097346 Ino80 complex(GO:0031011) INO80-type complex(GO:0097346)
0.0 0.0 GO:0033309 SBF transcription complex(GO:0033309)
0.0 0.2 GO:0005682 U5 snRNP(GO:0005682)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 19.9 GO:0015295 solute:proton symporter activity(GO:0015295)
2.7 8.2 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
2.7 8.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
2.2 8.8 GO:0004396 hexokinase activity(GO:0004396)
2.1 6.3 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
1.8 5.3 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
1.6 6.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.4 4.3 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
1.4 2.8 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.3 5.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
1.3 3.8 GO:0048038 quinone binding(GO:0048038)
1.2 7.5 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.2 3.7 GO:0090599 alpha-glucosidase activity(GO:0090599)
1.2 1.2 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
1.1 3.4 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.1 3.4 GO:0005536 glucose binding(GO:0005536)
1.1 14.9 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
1.1 3.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
1.0 3.1 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
1.0 4.1 GO:0005537 mannose binding(GO:0005537)
1.0 3.1 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
1.0 4.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.9 3.8 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.9 8.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.9 2.8 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.9 7.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.8 4.8 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.7 2.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.7 8.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.7 11.1 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.6 3.2 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.6 2.5 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.6 1.2 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.6 1.8 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.6 2.3 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.5 2.2 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.5 2.7 GO:0008198 ferrous iron binding(GO:0008198)
0.5 1.0 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.5 0.5 GO:0051185 coenzyme transporter activity(GO:0051185)
0.5 0.5 GO:0004075 biotin carboxylase activity(GO:0004075)
0.4 3.0 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.4 2.4 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.4 1.6 GO:0015294 solute:cation symporter activity(GO:0015294)
0.4 2.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.4 1.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 4.5 GO:0005199 structural constituent of cell wall(GO:0005199)
0.4 1.5 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.4 7.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.3 1.0 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.3 2.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.3 5.5 GO:0015297 antiporter activity(GO:0015297)
0.3 0.9 GO:0016289 CoA hydrolase activity(GO:0016289)
0.3 0.3 GO:0032451 demethylase activity(GO:0032451) histone demethylase activity(GO:0032452)
0.3 1.8 GO:0015293 symporter activity(GO:0015293)
0.3 0.9 GO:0005253 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.3 3.6 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.3 2.7 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.3 1.3 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.3 1.0 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 1.0 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.2 4.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 1.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 0.9 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.2 0.7 GO:0070569 uridylyltransferase activity(GO:0070569)
0.2 0.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 2.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 0.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 2.1 GO:0004872 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.2 0.6 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.2 0.6 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.2 0.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 1.6 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.2 0.9 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.2 1.5 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 0.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 0.8 GO:0051213 dioxygenase activity(GO:0051213)
0.2 0.8 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.2 0.6 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 1.2 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.1 1.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.6 GO:0030246 carbohydrate binding(GO:0030246)
0.1 1.7 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.3 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 0.6 GO:0017022 myosin binding(GO:0017022)
0.1 0.4 GO:0043812 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 0.6 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.1 0.4 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 0.4 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 2.2 GO:0036459 obsolete ubiquitin thiolesterase activity(GO:0004221) thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 0.3 GO:0016898 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.1 1.9 GO:0050661 NADP binding(GO:0050661)
0.1 0.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.7 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.3 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 6.6 GO:0016758 transferase activity, transferring hexosyl groups(GO:0016758)
0.1 1.9 GO:0005507 copper ion binding(GO:0005507)
0.1 1.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 0.3 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.1 0.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.2 GO:0001026 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.1 1.5 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 0.3 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.9 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 2.9 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.2 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 0.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.4 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 1.1 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.2 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 0.2 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.1 0.6 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.1 0.2 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.1 0.3 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.1 0.2 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.2 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 0.6 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.4 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.2 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.1 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.6 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.4 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 0.2 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.6 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 1.1 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.1 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.4 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.0 0.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.2 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.2 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.2 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.0 0.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.5 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.0 0.2 GO:0051184 cofactor transporter activity(GO:0051184)
0.0 0.4 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.0 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.1 GO:0005102 receptor binding(GO:0005102)
0.0 0.4 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 1.0 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.1 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.0 0.3 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.9 2.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.6 0.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.4 1.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.3 1.0 PID TELOMERASE PATHWAY Regulation of Telomerase
0.3 2.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.3 1.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 1.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 0.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 1.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 0.3 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 0.1 PID FOXO PATHWAY FoxO family signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 10.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.7 1.5 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.6 1.9 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.6 1.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.3 1.3 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.3 0.5 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 0.1 REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
0.0 0.2 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.2 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.0 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.0 0.2 REACTOME TRANSCRIPTION Genes involved in Transcription