Results for ZMS1
Z-value: 0.76
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Transcription factors associated with ZMS1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
RSF2
|
S000003888 | Zinc-finger protein |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YKL163W Show fit | 13.40 |
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway |
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| YGR067C Show fit | 11.87 |
Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p |
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| YDR342C Show fit | 11.10 |
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels |
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| YOR100C Show fit | 10.87 |
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation |
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| YDR277C Show fit | 10.53 |
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation |
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| YKL217W Show fit | 9.85 |
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose |
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| YLR327C Show fit | 9.53 |
Protein of unknown function that associates with ribosomes |
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| YGR243W Show fit | 9.16 |
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
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| YFR053C Show fit | 8.84 |
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p |
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| YDR536W Show fit | 8.55 |
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZMS1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 27.5 | GO:0015749 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 4.5 | 18.0 | GO:0006848 | pyruvate transport(GO:0006848) |
| 1.1 | 18.0 | GO:0005978 | glycogen biosynthetic process(GO:0005978) |
| 0.6 | 17.6 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 1.5 | 14.5 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 3.7 | 11.0 | GO:0015755 | fructose transport(GO:0015755) |
| 1.3 | 10.7 | GO:0015891 | siderophore transport(GO:0015891) |
| 1.0 | 8.7 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.6 | 8.7 | GO:0051156 | glucose 6-phosphate metabolic process(GO:0051156) |
| 2.7 | 8.2 | GO:0006577 | amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 39.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 39.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.3 | 20.3 | GO:0005576 | extracellular region(GO:0005576) |
| 1.1 | 9.1 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 1.0 | 9.1 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.4 | 7.3 | GO:0031307 | intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307) |
| 0.2 | 7.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 1.6 | 6.3 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.3 | 5.6 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.8 | 5.4 | GO:0034657 | GID complex(GO:0034657) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 19.9 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 1.1 | 14.9 | GO:0005353 | fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578) |
| 0.7 | 11.1 | GO:0020037 | heme binding(GO:0020037) tetrapyrrole binding(GO:0046906) |
| 2.2 | 8.8 | GO:0004396 | hexokinase activity(GO:0004396) |
| 0.9 | 8.5 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.7 | 8.5 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
| 2.7 | 8.2 | GO:0016406 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 2.7 | 8.1 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 1.2 | 7.5 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.9 | 7.3 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.9 | 2.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 2.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.2 | 1.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.4 | 1.1 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.3 | 1.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 1.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 1.0 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.6 | 0.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 0.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 10.7 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.6 | 1.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.6 | 1.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.7 | 1.5 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.3 | 1.3 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |
| 0.3 | 0.5 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 0.2 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.0 | 0.2 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 0.2 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.2 | REACTOME TRANSCRIPTION | Genes involved in Transcription |