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Results for YPL230W

Z-value: 2.04

Activity profile of YPL230W motif

Sorted Z-values of YPL230W motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YMR175W 55.15
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YMR107W 36.48
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YHR139C 32.33
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YKL217W 32.32
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YGR087C 32.17
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YOL052C-A 30.88
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YNR034W-A 28.73 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YNL117W 26.46
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YEL039C 26.01
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YPL223C 25.65
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YOR348C 25.61
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YBR072W 25.32
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YDL085W 24.80
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YOR393W 24.74
ERR1
Protein of unknown function, has similarity to enolases
YHR096C 24.53
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YKL163W 23.52
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YOL084W 23.21
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YIL136W 23.07
OM45
Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YMR174C 22.81
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YGR067C 22.54 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YNL194C 22.54 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YAL062W 22.22
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YMR081C 22.07
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YDR096W 21.91
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YGR236C 21.69
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER065C 21.48
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YAL054C 21.42
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YIL099W 20.18
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YPL230W 19.44
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YIL057C 18.56 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YGR088W 18.18
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YDR343C 18.16
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YFR017C 17.63 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YGR243W 17.46
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR117C 17.04
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YFR053C 16.97
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YMR206W 16.86 Putative protein of unknown function; YMR206W is not an essential gene
YPL054W 16.83
LEE1
Zinc-finger protein of unknown function
YMR105C 16.76
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YDL222C 16.62
FMP45
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YCR021C 16.44
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YLR377C 16.40
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YPL036W 15.92
PMA2
Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YPR026W 15.84
ATH1
Acid trehalase required for utilization of extracellular trehalose
YFL030W 15.82
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YOR391C 15.79
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YIL101C 15.50
XBP1
Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YKL026C 15.39
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YPR010C-A 15.25 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YOR100C 15.14
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YBL049W 14.73
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YAL034C 14.49
FUN19
Non-essential protein of unknown function
YAL061W 14.45
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YDR070C 14.28
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER103W 14.05
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YDL218W 13.98 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YBL015W 13.89
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YDR171W 13.73
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YDR258C 13.54
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YJR095W 13.42
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YMR251W 13.28
GTO3
Omega class glutathione transferase; putative cytosolic localization
YGR043C 13.01
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YLR312C 12.97
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YMR194C-B 12.74 Putative protein of unknown function
YPL271W 12.29
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YOL085W-A 12.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YJR115W 12.22 Putative protein of unknown function
YDR043C 11.94
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YDR536W 11.76
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YDL214C 11.74
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YDL169C 11.63
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YPR151C 11.61
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YPL250C 11.34
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YER084W 11.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR327C 11.32
TMA10
Protein of unknown function that associates with ribosomes
YEL011W 11.16
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YLR149C 11.00 Putative protein of unknown function; YLR149C is not an essential gene
YHL040C 10.99
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YKL031W 10.95 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YDR119W-A 10.85 Putative protein of unknown function
YAR035W 10.83
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YBR241C 10.82 Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
YDR406W 10.80
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YDR277C 10.76
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YBL078C 10.51
ATG8
Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YGR248W 10.45
SOL4
6-phosphogluconolactonase with similarity to Sol3p
YLL026W 10.42
HSP104
Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation
YDR342C 10.42
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YPL186C 10.41
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YPL222W 10.37
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCL048W-A 10.31 Putative protein of unknown function
YGR256W 10.22
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YGL096W 10.21
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YKL148C 10.16
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YER150W 9.82
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YJL089W 9.69
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YGR144W 9.68
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YAR053W 9.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML128C 9.52
MSC1
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YLR178C 9.49
TFS1
Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway
YKL093W 9.48
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YFL051C 9.44 Putative protein of unknown function; YFL051C is not an essential gene
YKL103C 9.39
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YIL045W 9.38
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YIL100W 9.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YER067W 9.26 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YPL185W 9.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YHR139C-A 9.04 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR438W 9.01
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YDL204W 8.97
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YOR031W 8.88
CRS5
Copper-binding metallothionein, required for wild-type copper resistance
YKL065W-A 8.88 Putative protein of unknown function
YNL115C 8.85 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
YPR192W 8.81
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YBL075C 8.77
SSA3
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YDR542W 8.59
PAU10
Hypothetical protein
YML100W 8.55
TSL1
Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YBR201C-A 8.54 Putative protein of unknown function
YEL008W 8.49 Hypothetical protein predicted to be involved in metabolism
YOL060C 8.46
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YPR007C 8.38
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YPL240C 8.35
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YKL109W 8.32
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YIL100C-A 8.32 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL163C 8.32 Putative protein of unknown function
YFL058W 8.31
THI5
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YKL107W 8.25 Putative protein of unknown function
YMR013C 8.24
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YPR036W-A 8.23 Protein of unknown function; transcription is regulated by Pdr1p
YOR186W 8.14 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YOR178C 8.12
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YGR070W 8.08
ROM1
GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YGR201C 8.07 Putative protein of unknown function
YHR033W 7.98 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YFL011W 7.96
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YMR118C 7.95 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YOR392W 7.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat
YLR437C-A 7.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YBR054W 7.87
YRO2
Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YCR025C 7.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YML089C 7.80 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YMR195W 7.75
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YBR147W 7.74
RTC2
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YNL093W 7.72
YPT53
GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YEL009C 7.71
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YPL017C 7.66
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YJL103C 7.61
GSM1
Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YGR066C 7.49 Putative protein of unknown function
YIL122W 7.48
POG1
Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YIL125W 7.46
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YMR169C 7.46
ALD3
Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
YIR039C 7.43
YPS6
Putative GPI-anchored aspartic protease
YPR027C 7.43 Putative protein of unknown function
YER121W 7.38 Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YPL247C 7.32 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; YPL247C is not an essential gene
YNL180C 7.31
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YDL210W 7.27
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YAR050W 7.17
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YPL061W 7.16
ALD6
Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YLL056C 7.02 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YAR060C 6.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL114W 6.97 Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene
YBR214W 6.94
SDS24
One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis
YLR080W 6.89
EMP46
Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YHR087W 6.83
RTC3
Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity
YPL092W 6.83
SSU1
Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YLL053C 6.80 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YOL047C 6.76 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YKL102C 6.75 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YDR077W 6.69
SED1
Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
YJL045W 6.63 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YAL063C 6.62
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YNL179C 6.61 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YNL036W 6.59
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YKR097W 6.57
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YNL144C 6.55 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YDL196W 6.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YCR005C 6.35
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YOL082W 6.33
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YBR230C 6.32
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YBR280C 6.22
SAF1
F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
YEL030C-A 6.21 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YEL059W 6.17 Dubious open reading frame unlikely to encode a functional protein
YIL107C 6.16
PFK26
6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A
YOR374W 6.15
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YHR082C 6.09
KSP1
Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation
YHR211W 6.04
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YJR048W 6.03
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YKL085W 6.03
MDH1
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YLL052C 6.02
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YOR394W 6.02
PAU21
Hypothetical protein
YOR346W 6.00
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YDR403W 5.99
DIT1
Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure
YJL141C 5.97
YAK1
Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal
YOR066W 5.97
MSA1
Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YOR343C 5.96 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YLL055W 5.91
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YMR103C 5.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL197C 5.81
ASF2
Anti-silencing protein that causes derepression of silent loci when overexpressed
YAL005C 5.80
SSA1
ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall

Network of associatons between targets according to the STRING database.

First level regulatory network of YPL230W

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
13.4 53.7 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
13.2 53.0 GO:0006848 pyruvate transport(GO:0006848)
11.4 34.1 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
9.1 27.2 GO:0032780 negative regulation of ATPase activity(GO:0032780)
8.9 26.7 GO:0043335 protein unfolding(GO:0043335)
8.0 31.9 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
7.2 21.7 GO:0005993 trehalose catabolic process(GO:0005993)
7.1 28.6 GO:0015804 neutral amino acid transport(GO:0015804)
7.0 21.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
6.7 60.4 GO:0006097 glyoxylate cycle(GO:0006097)
6.2 43.7 GO:0006083 acetate metabolic process(GO:0006083)
5.8 23.2 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
5.7 56.6 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
5.7 17.0 GO:0015755 fructose transport(GO:0015755)
5.6 28.2 GO:0005980 glycogen catabolic process(GO:0005980)
5.6 16.9 GO:0006545 glycine biosynthetic process(GO:0006545)
5.6 11.2 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
5.4 16.3 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
4.9 4.9 GO:0097306 positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) cellular response to ethanol(GO:0071361) cellular response to alcohol(GO:0097306)
4.6 13.7 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
4.4 21.9 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
4.4 4.4 GO:0046487 glyoxylate metabolic process(GO:0046487)
4.3 12.8 GO:0019676 ammonia assimilation cycle(GO:0019676)
4.3 12.8 GO:0015740 C4-dicarboxylate transport(GO:0015740)
4.1 24.4 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
4.1 16.3 GO:0071467 cellular response to pH(GO:0071467)
4.0 20.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
3.8 30.0 GO:0015758 glucose transport(GO:0015758)
3.4 13.6 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
3.4 58.0 GO:0005978 glycogen biosynthetic process(GO:0005978)
3.3 13.1 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
3.2 28.6 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
3.2 9.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
3.1 3.1 GO:0051193 regulation of cofactor metabolic process(GO:0051193) regulation of coenzyme metabolic process(GO:0051196)
3.0 11.9 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
3.0 8.9 GO:0006108 malate metabolic process(GO:0006108)
2.9 5.8 GO:0006538 glutamate catabolic process(GO:0006538)
2.8 8.4 GO:0042843 D-xylose catabolic process(GO:0042843)
2.8 11.2 GO:0006598 polyamine catabolic process(GO:0006598)
2.8 27.8 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
2.8 11.0 GO:0015793 glycerol transport(GO:0015793)
2.7 5.5 GO:0006013 mannose metabolic process(GO:0006013)
2.7 8.1 GO:0090630 activation of GTPase activity(GO:0090630)
2.7 42.6 GO:0006754 ATP biosynthetic process(GO:0006754)
2.6 7.9 GO:0006003 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
2.6 13.2 GO:0034487 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
2.6 10.4 GO:0006527 arginine catabolic process(GO:0006527)
2.6 33.5 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
2.5 12.7 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
2.4 18.9 GO:0015891 siderophore transport(GO:0015891)
2.2 2.2 GO:0044109 cellular alcohol catabolic process(GO:0044109)
2.2 2.2 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
2.2 2.2 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
2.2 6.5 GO:1903138 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
2.1 10.5 GO:0046058 cAMP metabolic process(GO:0046058)
2.1 18.8 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
2.0 2.0 GO:0019568 arabinose metabolic process(GO:0019566) arabinose catabolic process(GO:0019568)
1.8 7.4 GO:0015976 carbon utilization(GO:0015976)
1.8 3.7 GO:0006102 isocitrate metabolic process(GO:0006102)
1.8 9.1 GO:0043954 cellular component maintenance(GO:0043954)
1.8 43.4 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
1.7 28.4 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
1.7 6.7 GO:0032108 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
1.6 1.6 GO:0042732 D-xylose metabolic process(GO:0042732)
1.6 6.5 GO:0006537 glutamate biosynthetic process(GO:0006537)
1.6 4.7 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
1.5 4.6 GO:0042126 nitrate metabolic process(GO:0042126) nitrate assimilation(GO:0042128)
1.5 15.3 GO:0006119 oxidative phosphorylation(GO:0006119)
1.5 1.5 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
1.4 5.8 GO:0032048 cardiolipin metabolic process(GO:0032048)
1.4 2.8 GO:0072353 age-dependent response to reactive oxygen species(GO:0001315) cellular age-dependent response to reactive oxygen species(GO:0072353)
1.4 5.5 GO:0046461 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
1.4 4.1 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
1.3 21.3 GO:0046364 gluconeogenesis(GO:0006094) hexose biosynthetic process(GO:0019319) monosaccharide biosynthetic process(GO:0046364)
1.3 3.9 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
1.3 5.2 GO:0015847 putrescine transport(GO:0015847)
1.3 17.9 GO:0006749 glutathione metabolic process(GO:0006749)
1.2 2.5 GO:0019541 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
1.2 6.2 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
1.2 3.7 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
1.2 11.0 GO:0007130 synaptonemal complex assembly(GO:0007130)
1.2 7.3 GO:0000492 box C/D snoRNP assembly(GO:0000492)
1.2 3.6 GO:0019748 secondary metabolic process(GO:0019748)
1.2 4.8 GO:0046185 aldehyde catabolic process(GO:0046185)
1.2 15.3 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
1.1 3.4 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
1.1 2.3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.1 6.7 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
1.1 5.5 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
1.1 15.3 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
1.1 45.2 GO:0070590 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
1.0 2.1 GO:0000409 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
1.0 2.1 GO:0000821 regulation of arginine metabolic process(GO:0000821)
1.0 4.0 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
1.0 2.0 GO:0001323 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324) age-dependent general metabolic decline(GO:0007571)
1.0 1.9 GO:0045117 azole transport(GO:0045117)
1.0 2.9 GO:0009106 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
1.0 6.7 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.9 2.8 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.9 4.7 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.9 3.8 GO:0032370 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.9 5.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.9 0.9 GO:0043270 positive regulation of ion transport(GO:0043270)
0.9 40.4 GO:0009060 aerobic respiration(GO:0009060)
0.9 3.6 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.9 0.9 GO:0036257 multivesicular body organization(GO:0036257)
0.9 3.5 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.9 1.7 GO:0007129 synapsis(GO:0007129)
0.8 3.4 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.8 2.4 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.8 0.8 GO:0015691 cadmium ion transport(GO:0015691)
0.8 12.7 GO:0001101 response to acid chemical(GO:0001101)
0.8 6.3 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.8 0.8 GO:0070726 cell wall assembly(GO:0070726)
0.8 8.5 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.8 7.0 GO:0070987 error-free translesion synthesis(GO:0070987)
0.8 7.5 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.7 23.9 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.7 2.2 GO:0000304 response to singlet oxygen(GO:0000304)
0.7 0.7 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.7 1.4 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.7 2.2 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.7 5.0 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.7 2.8 GO:0046503 glycerolipid catabolic process(GO:0046503)
0.7 7.8 GO:0072348 sulfur compound transport(GO:0072348)
0.7 7.5 GO:0045144 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.6 1.9 GO:0006638 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.6 3.9 GO:0046686 response to cadmium ion(GO:0046686)
0.6 2.5 GO:0051503 adenine nucleotide transport(GO:0051503)
0.6 0.6 GO:0051606 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.6 3.1 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.6 0.6 GO:0015688 iron chelate transport(GO:0015688)
0.6 6.9 GO:0016925 protein sumoylation(GO:0016925)
0.6 2.5 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.6 1.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.6 2.5 GO:0010255 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to carbohydrate stimulus(GO:0071322) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.6 4.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.6 5.8 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.6 4.0 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.6 2.8 GO:0006112 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.6 1.7 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.5 2.2 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.5 2.2 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.5 0.5 GO:0034440 fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
0.5 2.7 GO:0000023 maltose metabolic process(GO:0000023)
0.5 1.1 GO:0042148 strand invasion(GO:0042148)
0.5 3.1 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.5 2.0 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.5 3.0 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.5 1.5 GO:0071168 protein localization to chromatin(GO:0071168)
0.5 1.9 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.5 2.4 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.5 3.4 GO:0018345 protein palmitoylation(GO:0018345)
0.5 1.4 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.4 2.2 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.4 1.3 GO:0010039 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.4 8.9 GO:0022900 electron transport chain(GO:0022900)
0.4 0.8 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.4 2.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.4 2.0 GO:0008053 mitochondrial fusion(GO:0008053)
0.4 1.2 GO:0000302 response to reactive oxygen species(GO:0000302)
0.4 2.0 GO:0006265 DNA topological change(GO:0006265)
0.4 2.0 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.4 0.8 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.4 6.8 GO:0006895 Golgi to endosome transport(GO:0006895)
0.4 2.8 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.4 5.5 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.4 7.4 GO:0031503 protein complex localization(GO:0031503)
0.4 1.9 GO:0045033 peroxisome inheritance(GO:0045033)
0.4 0.8 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.4 2.6 GO:0030100 regulation of endocytosis(GO:0030100)
0.4 14.8 GO:0007031 peroxisome organization(GO:0007031)
0.4 1.4 GO:0051260 protein homooligomerization(GO:0051260)
0.4 0.7 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.3 1.0 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.3 4.1 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.3 0.7 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.3 1.3 GO:0043462 regulation of ATPase activity(GO:0043462)
0.3 0.7 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.3 0.7 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.3 0.7 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.3 0.7 GO:1903321 negative regulation of protein ubiquitination(GO:0031397) negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of protein modification by small protein conjugation or removal(GO:1903321)
0.3 1.3 GO:0000755 cytogamy(GO:0000755)
0.3 6.5 GO:0016579 protein deubiquitination(GO:0016579)
0.3 0.3 GO:0055075 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.3 1.0 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.3 2.2 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.3 4.1 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.3 13.8 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.3 0.6 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.3 0.9 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.3 1.8 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.3 0.9 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.3 2.1 GO:0006874 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)
0.3 2.9 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.3 2.2 GO:0031167 rRNA methylation(GO:0031167)
0.3 9.0 GO:0030437 ascospore formation(GO:0030437) cell development(GO:0048468)
0.3 0.5 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.3 0.8 GO:0042407 cristae formation(GO:0042407)
0.3 3.0 GO:0006312 mitotic recombination(GO:0006312)
0.3 1.3 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.3 1.8 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.3 0.5 GO:0032006 regulation of TOR signaling(GO:0032006)
0.3 1.0 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 1.7 GO:0010821 regulation of mitochondrion organization(GO:0010821)
0.2 2.9 GO:0000902 cell morphogenesis(GO:0000902)
0.2 1.0 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.2 1.2 GO:0019722 calcium-mediated signaling(GO:0019722)
0.2 0.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.2 0.2 GO:0071218 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.2 0.7 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 2.3 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.2 0.2 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.2 0.7 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.2 1.1 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.2 1.8 GO:0000132 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.2 1.0 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.2 1.2 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.2 0.2 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.2 0.8 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.2 0.6 GO:0060194 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.2 0.7 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.2 0.7 GO:0032979 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979)
0.2 0.7 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.2 2.6 GO:0000209 protein polyubiquitination(GO:0000209)
0.2 0.7 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.2 0.2 GO:0051098 regulation of binding(GO:0051098)
0.2 0.5 GO:0090399 replicative senescence(GO:0090399)
0.2 1.5 GO:0090114 COPII-coated vesicle budding(GO:0090114)
0.1 1.6 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.1 0.3 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.6 GO:0015809 arginine transport(GO:0015809)
0.1 1.6 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.1 GO:0019321 pentose metabolic process(GO:0019321) pentose catabolic process(GO:0019323)
0.1 0.1 GO:0034086 regulation of sister chromatid cohesion(GO:0007063) maintenance of sister chromatid cohesion(GO:0034086) regulation of maintenance of sister chromatid cohesion(GO:0034091)
0.1 0.7 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.3 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 0.5 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.1 0.1 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.1 0.8 GO:0006452 translational frameshifting(GO:0006452)
0.1 0.6 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.1 0.6 GO:0042537 benzene-containing compound metabolic process(GO:0042537)
0.1 0.5 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 0.4 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 0.2 GO:0000348 mRNA branch site recognition(GO:0000348)
0.1 0.2 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.5 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.1 0.1 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.1 0.6 GO:0031578 mitotic spindle orientation checkpoint(GO:0031578)
0.1 0.5 GO:0044088 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.1 1.5 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.1 0.6 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.1 0.2 GO:0097271 protein localization to bud neck(GO:0097271)
0.1 1.6 GO:0098656 anion transmembrane transport(GO:0098656)
0.1 0.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.1 GO:0009250 glucan biosynthetic process(GO:0009250)
0.1 0.2 GO:0022603 regulation of anatomical structure morphogenesis(GO:0022603)
0.1 0.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 0.6 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 0.1 GO:0051180 vitamin transport(GO:0051180)
0.1 0.1 GO:0035822 gene conversion(GO:0035822)
0.1 0.2 GO:0072479 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.1 0.5 GO:0001300 chronological cell aging(GO:0001300)
0.1 0.4 GO:0070272 proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.1 0.1 GO:0031111 negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.1 0.6 GO:0048278 vesicle docking(GO:0048278)
0.1 0.8 GO:1902534 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.1 0.4 GO:0015893 drug transport(GO:0015893)
0.1 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.3 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.4 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 0.3 GO:0016575 histone deacetylation(GO:0016575)
0.1 0.2 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.0 0.1 GO:0015802 basic amino acid transport(GO:0015802)
0.0 1.1 GO:0034976 response to endoplasmic reticulum stress(GO:0034976)
0.0 0.1 GO:0042762 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of sulfur metabolic process(GO:0042762)
0.0 0.0 GO:0032989 cellular component morphogenesis(GO:0032989)
0.0 0.2 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.0 0.1 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.0 0.2 GO:0009306 protein secretion(GO:0009306)
0.0 0.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.0 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.0 0.0 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.0 GO:2001040 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.0 0.1 GO:0070058 tRNA gene clustering(GO:0070058)
0.0 0.1 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.0 0.1 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.1 GO:0009410 response to xenobiotic stimulus(GO:0009410)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
8.5 25.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
5.6 16.8 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
4.4 13.3 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
4.4 21.9 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
3.4 40.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
3.3 29.3 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
3.2 41.1 GO:0070469 respiratory chain(GO:0070469)
3.1 9.4 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
2.9 23.1 GO:0042597 periplasmic space(GO:0042597)
2.9 22.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
2.8 11.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
2.8 8.3 GO:0001400 mating projection base(GO:0001400)
2.8 13.8 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
2.6 7.7 GO:0031166 integral component of vacuolar membrane(GO:0031166)
2.5 17.8 GO:0034657 GID complex(GO:0034657)
2.5 32.0 GO:0005619 ascospore wall(GO:0005619)
2.2 4.4 GO:0032126 eisosome(GO:0032126)
2.2 39.3 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
2.0 15.8 GO:0000328 fungal-type vacuole lumen(GO:0000328)
1.8 3.5 GO:0005775 vacuolar lumen(GO:0005775)
1.6 9.9 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
1.5 16.9 GO:0005832 chaperonin-containing T-complex(GO:0005832)
1.3 2.6 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
1.3 13.0 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
1.0 4.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
1.0 46.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
1.0 2.9 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.8 15.2 GO:0005811 lipid particle(GO:0005811)
0.8 2.5 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.8 3.3 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.7 2.2 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.7 16.0 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.7 11.4 GO:0098562 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.7 3.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.7 2.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.6 2.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.6 0.6 GO:0032585 multivesicular body membrane(GO:0032585)
0.5 2.7 GO:0070772 PAS complex(GO:0070772)
0.5 3.1 GO:0008180 COP9 signalosome(GO:0008180)
0.5 78.0 GO:0000322 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.5 9.2 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.5 3.5 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.5 69.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.5 8.4 GO:0070822 Sin3-type complex(GO:0070822)
0.5 1.8 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.4 1.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 257.2 GO:0005739 mitochondrion(GO:0005739)
0.4 4.7 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.4 0.4 GO:0030870 Mre11 complex(GO:0030870)
0.4 2.1 GO:0034967 Set3 complex(GO:0034967)
0.4 0.7 GO:0032389 MutLalpha complex(GO:0032389)
0.3 3.5 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.3 1.4 GO:0019867 nuclear outer membrane(GO:0005640) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.2 3.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 5.3 GO:0005770 late endosome(GO:0005770)
0.2 4.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 1.2 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2 1.0 GO:0005869 dynactin complex(GO:0005869)
0.2 3.8 GO:0016592 mediator complex(GO:0016592)
0.2 0.5 GO:0032807 DNA ligase IV complex(GO:0032807)
0.2 0.8 GO:0031262 Ndc80 complex(GO:0031262)
0.2 0.3 GO:0070211 Snt2C complex(GO:0070211)
0.2 2.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.1 1.8 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.5 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 0.8 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.4 GO:0000417 HIR complex(GO:0000417)
0.1 0.6 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.5 GO:0097196 Shu complex(GO:0097196)
0.1 0.7 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.4 GO:0033551 monopolin complex(GO:0033551)
0.1 1.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.2 GO:0070847 core mediator complex(GO:0070847)
0.1 0.8 GO:0000124 SAGA complex(GO:0000124)
0.1 0.3 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.1 GO:0034099 luminal surveillance complex(GO:0034099)
0.1 0.4 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.1 0.2 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.8 GO:0005682 U5 snRNP(GO:0005682)
0.1 0.3 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.3 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.1 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.0 0.1 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0000818 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.0 0.1 GO:0008623 CHRAC(GO:0008623)
0.0 0.0 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.1 GO:0000798 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.0 0.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.1 GO:0005669 transcription factor TFIID complex(GO:0005669)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
11.4 34.1 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
10.2 30.6 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
10.1 50.6 GO:0015295 solute:proton symporter activity(GO:0015295)
8.5 25.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
8.0 31.9 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
7.3 22.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
7.2 21.7 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
7.1 21.4 GO:0016208 AMP binding(GO:0016208)
6.9 20.6 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
6.6 26.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
5.6 22.6 GO:0005537 mannose binding(GO:0005537)
5.0 15.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
5.0 15.0 GO:0016289 CoA hydrolase activity(GO:0016289)
4.8 19.1 GO:0004396 hexokinase activity(GO:0004396)
4.6 23.2 GO:0050308 sugar-phosphatase activity(GO:0050308)
4.6 13.7 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
4.5 26.9 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
4.4 21.9 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
3.8 11.3 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
3.7 7.5 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
3.5 14.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
3.5 28.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
3.4 20.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
3.3 26.4 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
3.3 13.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
3.3 46.0 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
3.3 13.1 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
3.2 22.4 GO:0004364 glutathione transferase activity(GO:0004364)
3.1 52.7 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
3.1 12.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
2.8 11.3 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
2.7 13.7 GO:0008198 ferrous iron binding(GO:0008198)
2.7 18.9 GO:0016833 oxo-acid-lyase activity(GO:0016833)
2.3 25.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
2.3 4.5 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
2.0 2.0 GO:0051185 coenzyme transporter activity(GO:0051185)
1.9 23.3 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
1.9 9.3 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
1.8 7.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.8 8.9 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
1.7 1.7 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
1.7 5.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
1.7 1.7 GO:1901474 azole transmembrane transporter activity(GO:1901474)
1.6 6.5 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
1.6 9.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.4 2.7 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.4 4.1 GO:0070569 uridylyltransferase activity(GO:0070569)
1.4 16.2 GO:0022838 substrate-specific channel activity(GO:0022838)
1.3 5.3 GO:0004180 carboxypeptidase activity(GO:0004180)
1.3 6.5 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
1.3 1.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.3 7.6 GO:0090599 alpha-glucosidase activity(GO:0090599)
1.3 15.1 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
1.2 10.0 GO:0004713 protein tyrosine kinase activity(GO:0004713)
1.2 3.6 GO:0015385 sodium:proton antiporter activity(GO:0015385)
1.2 1.2 GO:0032452 histone demethylase activity(GO:0032452)
1.2 4.8 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
1.1 85.4 GO:0051082 unfolded protein binding(GO:0051082)
1.1 12.1 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
1.1 2.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.1 9.8 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
1.0 1.0 GO:0016615 malate dehydrogenase activity(GO:0016615)
1.0 8.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
1.0 7.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
1.0 3.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
1.0 17.6 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
1.0 6.8 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.9 12.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.9 2.7 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.9 2.7 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.9 8.8 GO:0031386 protein tag(GO:0031386)
0.9 16.7 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.9 8.7 GO:0015293 symporter activity(GO:0015293)
0.9 9.6 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.9 4.3 GO:0017022 myosin binding(GO:0017022)
0.8 2.5 GO:0004629 phospholipase C activity(GO:0004629)
0.8 2.5 GO:0019776 Atg8 ligase activity(GO:0019776)
0.8 2.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.8 2.5 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.8 4.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.8 5.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.7 10.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.7 1.5 GO:0045118 azole transporter activity(GO:0045118)
0.7 1.5 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.7 2.9 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.7 0.7 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.7 4.4 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.7 2.2 GO:0005536 glucose binding(GO:0005536)
0.7 2.1 GO:0016872 intramolecular lyase activity(GO:0016872)
0.7 3.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.7 3.4 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.7 2.0 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091)
0.7 1.4 GO:0015491 monovalent cation:proton antiporter activity(GO:0005451) solute:cation antiporter activity(GO:0015298) solute:proton antiporter activity(GO:0015299) cation:cation antiporter activity(GO:0015491)
0.7 3.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.7 1.3 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.6 6.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.6 3.7 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.6 3.1 GO:0004075 biotin carboxylase activity(GO:0004075)
0.6 1.8 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.6 15.5 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.6 27.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.6 5.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.6 3.5 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.6 1.7 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.5 5.5 GO:0004872 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.5 3.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.5 12.5 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.5 2.6 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.5 5.1 GO:0035064 methylated histone binding(GO:0035064)
0.5 4.4 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.5 2.5 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.5 1.9 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.5 1.9 GO:0005102 receptor binding(GO:0005102)
0.5 7.5 GO:0003713 transcription coactivator activity(GO:0003713)
0.5 2.8 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.5 5.9 GO:0045182 translation regulator activity(GO:0045182)
0.4 3.6 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.4 2.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 1.8 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.4 3.9 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.4 1.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.4 7.0 GO:0050661 NADP binding(GO:0050661)
0.4 6.5 GO:0005507 copper ion binding(GO:0005507)
0.4 1.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.3 12.7 GO:0043492 ATPase activity, coupled to movement of substances(GO:0043492)
0.3 0.7 GO:0017048 Rho GTPase binding(GO:0017048)
0.3 4.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.3 3.6 GO:0015297 antiporter activity(GO:0015297)
0.3 7.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.3 1.0 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.3 1.3 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.3 1.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 2.6 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.3 3.7 GO:0017171 serine hydrolase activity(GO:0017171)
0.3 0.9 GO:0000150 recombinase activity(GO:0000150)
0.3 0.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.3 0.5 GO:0015145 monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149) sugar transmembrane transporter activity(GO:0051119)
0.3 1.3 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.2 1.0 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.2 15.6 GO:0005543 phospholipid binding(GO:0005543)
0.2 0.9 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 4.2 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 0.6 GO:0070336 flap-structured DNA binding(GO:0070336)
0.2 0.8 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 1.0 GO:0051213 dioxygenase activity(GO:0051213)
0.2 0.6 GO:0016898 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.2 1.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.2 GO:0031072 heat shock protein binding(GO:0031072)
0.2 0.4 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.2 1.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 0.7 GO:0008169 C-methyltransferase activity(GO:0008169)
0.2 1.2 GO:0032947 protein complex scaffold(GO:0032947)
0.2 0.8 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.1 9.7 GO:0019787 ubiquitin-like protein transferase activity(GO:0019787)
0.1 1.0 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.1 0.7 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.4 GO:0003691 double-stranded telomeric DNA binding(GO:0003691) G-quadruplex DNA binding(GO:0051880)
0.1 1.8 GO:0005509 calcium ion binding(GO:0005509)
0.1 1.3 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 1.2 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 3.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.3 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 7.8 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 1.7 GO:0031491 nucleosome binding(GO:0031491)
0.1 0.2 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.1 1.1 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 0.3 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.1 0.1 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.1 0.3 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 0.6 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 0.2 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.1 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 1.0 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.5 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.7 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.2 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.2 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.1 GO:0032183 SUMO binding(GO:0032183)
0.0 0.1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) thiol oxidase activity(GO:0016972)
0.0 0.3 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 0.0 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.0 0.1 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.5 PID IL4 2PATHWAY IL4-mediated signaling events
3.2 9.5 PID ERBB4 PATHWAY ErbB4 signaling events
3.0 14.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
2.5 7.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.9 3.8 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
1.7 1.7 PID AR PATHWAY Coregulation of Androgen receptor activity
1.1 3.2 PID FOXO PATHWAY FoxO family signaling
0.8 4.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.7 1.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.7 2.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 1.1 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.3 1.0 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 289.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 0.1 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.0 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.0 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 20.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
4.7 9.5 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
3.8 42.0 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
3.0 9.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
1.8 3.7 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.4 1.6 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.4 3.6 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.4 1.1 REACTOME TRIF MEDIATED TLR3 SIGNALING Genes involved in TRIF mediated TLR3 signaling
0.3 1.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.3 0.9 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.3 0.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 1.3 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 273.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.2 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C