Navigation
Downloads

Results for YOX1

Z-value: 1.05

Motif logo

logo of

Transcription factors associated with YOX1

Gene Symbol Gene ID Gene Info
YOX1
S000004489 Homeobox transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
YOX1YML027W-0.311.2e-01Click!

Activity profile of YOX1 motif

Sorted Z-values of YOX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YJR094W-A 6.71
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YOL086C 6.52
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YFR056C 6.17 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YFR055W 5.86
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YHR180W-A 4.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YPR119W 3.79
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YNR001W-A 3.62 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YHR181W 3.27
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YDR471W 3.03
RPL27B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein
YLR333C 3.00
RPS25B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YOR369C 2.89
RPS12
Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YGR108W 2.85
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YDR278C 2.72 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL085C 2.72 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YPR157W 2.67 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YHR141C 2.64
RPL42B
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YOR096W 2.46
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YDR279W 2.30
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YLR154C 2.19
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YPL143W 2.19
RPL33A
N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
YJR094C 2.08
IME1
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YGR034W 1.92
RPL26B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YER137C 1.91 Putative protein of unknown function
YOR342C 1.89 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YOR137C 1.86
SIA1
Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose
YDR497C 1.82
ITR1
Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
YGL031C 1.82
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YMR032W 1.79
HOF1
Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YCR018C 1.78
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YBR158W 1.74
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YGL039W 1.73 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YHR216W 1.73
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YFR054C 1.72 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL180W 1.70
RPL17A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
YBR084C-A 1.68
RPL19A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YIR021W 1.67
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YOR047C 1.67
STD1
Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YPL090C 1.66
RPS6A
Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YMR321C 1.66 Putative protein of unknown function
YOR385W 1.59 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene
YNL043C 1.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YKL218C 1.55
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YHR094C 1.51
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YMR246W 1.47
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YLR167W 1.43
RPS31
Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B
YDR345C 1.41
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YDL241W 1.39 Putative protein of unknown function; YDL241W is not an essential gene
YJL145W 1.39
SFH5
Putative phosphatidylinositol transfer protein (PITP), exhibits phosphatidylinositol- but not phosphatidylcholine-transfer activity, localized to cytosol and microsomes, similar to Sec14p; may be PITP regulator rather than actual PITP
YDL082W 1.38
RPL13A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein
YNL337W 1.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL030W 1.35
RPL30
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YEL040W 1.35
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YPL007C 1.34
TFC8
One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90
YGR229C 1.27
SMI1
Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
YGR151C 1.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C
YMR123W 1.25
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YDL083C 1.25
RPS16B
Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins
YBR085W 1.22
AAC3
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration
YHL033C 1.21
RPL8A
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YAL003W 1.20
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YJL148W 1.20
RPA34
RNA polymerase I subunit A34.5
YGL179C 1.19
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YAL067W-A 1.18 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YAR018C 1.15
KIN3
Nonessential protein kinase with unknown cellular role
YEL054C 1.14
RPL12A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YGL158W 1.13
RCK1
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YNL058C 1.12 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene
YHR201C 1.12
PPX1
Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
YDR098C 1.11
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YDR033W 1.09
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YIL169C 1.08 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YLR301W 1.07 Protein of unknown function that interacts with Sec72p
YJR123W 1.07
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YGR185C 1.06
TYS1
Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyr
YPL183C 1.05
RTT10
Cytoplasmic protein with a role in regulation of Ty1 transposition
YDL211C 1.05 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YDR209C 1.04 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
YIL009W 1.04
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YGL242C 1.02 Putative protein of unknown function; deletion mutant is viable
YLR154W-C 1.01
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YDR190C 1.01
RVB1
Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
YDR071C 1.01
PAA1
Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
YLR409C 0.99
UTP21
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YER056C-A 0.98
RPL34A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein
YOR103C 0.98
OST2
Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YBL023C 0.97
MCM2
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YOR104W 0.96
PIN2
Protein that induces appearance of [PIN+] prion when overproduced
YKL154W 0.96
SRP102
Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane
YFR051C 0.96
RET2
Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YDR108W 0.93
GSG1
Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication
YBR012C 0.92 Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
YOR073W-A 0.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR
YNL079C 0.91
TPM1
Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
YDR326C 0.90
YSP2
Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification
YJL105W 0.90
SET4
Protein of unknown function, contains a SET domain
YER131W 0.87
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YER135C 0.86 Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene
YDR144C 0.85
MKC7
GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p
YBL108W 0.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL078W 0.81
NIS1
Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
YNL042W-B 0.80 Putative protein of unknown function
YER001W 0.80
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YKL073W 0.79
LHS1
Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway
YLR335W 0.78
NUP2
Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
YLR154W-B 0.78 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YKL223W 0.76 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR089C 0.76
GAR1
Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YGL123C-A 0.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YDR021W 0.75
FAL1
Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
YMR049C 0.75
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YLR274W 0.74
MCM5
Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YEL034C-A 0.74 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A
YNL069C 0.73
RPL16B
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YIL009C-A 0.73
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YGL085W 0.73 Putative protein of unknown function, has homology to Staphylococcus aureus nuclease; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS
YGL123W 0.72
RPS2
Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YEL029C 0.72
BUD16
Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YKL153W 0.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YDR415C 0.71 Putative protein of unknown function
YNL057W 0.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR011C 0.69
IPP1
Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YGL157W 0.69 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YBR248C 0.69
HIS7
Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor
YOR074C 0.69
CDC21
Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
YCR099C 0.68 Putative protein of unknown function
YGR255C 0.68
COQ6
Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
YMR108W 0.68
ILV2
Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
YER177W 0.67
BMH1
14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YGR092W 0.66
DBF2
Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis
YLL024C 0.65
SSA2
ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall
YPR010C 0.65
RPA135
RNA polymerase I subunit A135
YKL074C 0.65
MUD2
Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
YER134C 0.65 Putative protein of unknown function; non-essential gene
YOR319W 0.65
HSH49
U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
YDR399W 0.64
HPT1
Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YGL040C 0.64
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YJL107C 0.64 Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YJL126W 0.64
NIT2
Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YKL128C 0.64
PMU1
Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YDR445C 0.63 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR097W 0.63
JJJ3
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YJL169W 0.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
YHR144C 0.62
DCD1
Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YGL241W 0.61
KAP114
Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear
YNL016W 0.61
PUB1
Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes
YKL224C 0.60
PAU16
Putative protein of unknown function
YLR196W 0.60
PWP1
Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YGR139W 0.59 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR082C 0.59 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL141C 0.59 Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YMR106C 0.59
YKU80
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YOR004W 0.59
UTP23
Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function
YGR040W 0.58
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YHR018C 0.58
ARG4
Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
YNL189W 0.57
SRP1
Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
YBL097W 0.57
BRN1
Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics
YLR154W-A 0.57 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGR208W 0.56
SER2
Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
YGR138C 0.56
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YDR450W 0.56
RPS18A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YOR180C 0.56
DCI1
Peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, involved in fatty acid metabolism, contains peroxisome targeting signals at amino and carboxy termini
YDR037W 0.55
KRS1
Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YJR071W 0.55 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR142W 0.55
CHS7
Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER
YER136W 0.55
GDI1
GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YCR090C 0.55 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene
YLR013W 0.54
GAT3
Protein containing GATA family zinc finger motifs
YHR136C 0.54
SPL2
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YOR181W 0.53
LAS17
Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
YCR098C 0.53
GIT1
Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
YER049W 0.53
TPA1
Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability
YPR060C 0.53
ARO7
Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
YPL256C 0.53
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YML121W 0.53
GTR1
Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
YJR070C 0.52
LIA1
Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YLL045C 0.52
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YPL239W 0.52
YAR1
Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
YOR058C 0.51
ASE1
Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate
YMR119W 0.50
ASI1
Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YDR416W 0.50
SYF1
Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression; similar to Drosophila crooked neck protein
YGR156W 0.50
PTI1
Pta1p Interacting protein
YOR356W 0.50 Mitochondrial protein with similarity to flavoprotein-type oxidoreductases; found in a large supramolecular complex with other mitochondrial dehydrogenases
YEL027W 0.50
CUP5
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YDR060W 0.49
MAK21
Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
YGR107W 0.49 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR133C 0.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YBR104W 0.48
YMC2
Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YGR140W 0.48
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YDR153C 0.48
ENT5
Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
YKL205W 0.48
LOS1
Nuclear pore protein involved in nuclear export of pre-tRNA
YLR257W 0.48 Putative protein of unknown function
YBR089W 0.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30
YGL054C 0.47
ERV14
Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon
YBR181C 0.47
RPS6B
Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
YJL208C 0.47
NUC1
Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
YLR256W 0.47
HAP1
Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
YOR087W 0.47
YVC1
Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
YPR156C 0.46
TPO3
Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YIL117C 0.46
PRM5
Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
YPL112C 0.46
PEX25
Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p

Network of associatons between targets according to the STRING database.

First level regulatory network of YOX1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.9 6.3 GO:0019655 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.9 6.2 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.7 3.0 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.7 4.7 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.6 1.7 GO:0006183 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.6 1.7 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.5 2.7 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.5 1.5 GO:0009157 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.4 1.3 GO:0048024 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
0.3 0.9 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.3 1.3 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.3 1.2 GO:0015886 heme transport(GO:0015886)
0.3 3.3 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.3 44.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.3 1.2 GO:0000296 spermine transport(GO:0000296)
0.3 1.4 GO:0017157 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.3 0.8 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.3 2.0 GO:0015791 polyol transport(GO:0015791)
0.2 0.7 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.2 0.7 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.2 1.0 GO:0048313 Golgi inheritance(GO:0048313)
0.2 0.6 GO:0006177 GMP biosynthetic process(GO:0006177) guanosine-containing compound biosynthetic process(GO:1901070)
0.2 1.5 GO:0043457 regulation of cellular respiration(GO:0043457)
0.2 1.9 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.2 1.7 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.2 0.6 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.2 0.6 GO:0000348 mRNA branch site recognition(GO:0000348)
0.2 1.2 GO:0001009 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.2 0.9 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.2 2.6 GO:0010383 cell wall polysaccharide metabolic process(GO:0010383)
0.2 0.5 GO:1902223 tyrosine biosynthetic process(GO:0006571) L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.2 2.7 GO:0032508 DNA duplex unwinding(GO:0032508)
0.2 0.5 GO:0051225 spindle assembly(GO:0051225)
0.2 0.9 GO:0007535 donor selection(GO:0007535)
0.2 0.7 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.2 0.8 GO:0006344 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392)
0.2 0.3 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.2 0.2 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015)
0.2 1.5 GO:0006613 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 0.6 GO:0032231 regulation of actin filament bundle assembly(GO:0032231) positive regulation of actin filament bundle assembly(GO:0032233)
0.1 0.3 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.1 2.2 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.1 1.4 GO:0052803 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.1 0.6 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.1 0.3 GO:0071825 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.1 0.4 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.1 0.8 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.5 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.1 0.8 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 1.3 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.1 1.3 GO:1903338 regulation of cell wall organization or biogenesis(GO:1903338)
0.1 0.6 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.5 GO:0043097 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.1 0.4 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.1 0.4 GO:0002252 immune effector process(GO:0002252) immune system process(GO:0002376) response to virus(GO:0009615) response to external biotic stimulus(GO:0043207) defense response to virus(GO:0051607) response to other organism(GO:0051707) defense response to other organism(GO:0098542)
0.1 0.4 GO:0043171 peptide catabolic process(GO:0043171)
0.1 1.3 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.1 0.6 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.1 0.5 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 0.2 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.1 0.5 GO:0030497 fatty acid elongation(GO:0030497)
0.1 1.0 GO:0042991 transcription factor import into nucleus(GO:0042991)
0.1 0.7 GO:0009099 valine biosynthetic process(GO:0009099)
0.1 0.6 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.1 GO:0097271 protein localization to bud neck(GO:0097271)
0.1 0.4 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.1 0.8 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.1 0.8 GO:0034063 stress granule assembly(GO:0034063)
0.1 1.1 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 0.9 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 3.3 GO:0051445 regulation of meiotic nuclear division(GO:0040020) regulation of meiotic cell cycle(GO:0051445)
0.1 0.7 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.1 0.9 GO:0007120 axial cellular bud site selection(GO:0007120)
0.1 0.2 GO:0010452 regulation of histone H3-K36 methylation(GO:0000414) histone H3-K36 methylation(GO:0010452)
0.1 0.4 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.3 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.1 0.7 GO:0006591 ornithine metabolic process(GO:0006591)
0.1 0.3 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.2 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.1 0.2 GO:0008655 pyrimidine-containing compound salvage(GO:0008655)
0.1 0.4 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 0.2 GO:0043419 urea metabolic process(GO:0019627) urea catabolic process(GO:0043419)
0.1 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1 0.2 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.1 0.3 GO:0009097 isoleucine biosynthetic process(GO:0009097)
0.1 0.7 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.1 0.3 GO:0034755 intracellular copper ion transport(GO:0015680) iron ion transmembrane transport(GO:0034755)
0.1 0.2 GO:2000877 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.1 0.8 GO:0042181 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.1 0.5 GO:0016559 peroxisome fission(GO:0016559)
0.1 1.9 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 0.1 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.1 0.1 GO:0009847 spore germination(GO:0009847)
0.1 1.4 GO:0012501 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.1 0.3 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.8 GO:0006415 translational termination(GO:0006415)
0.1 1.6 GO:0006379 mRNA cleavage(GO:0006379)
0.1 0.1 GO:0033182 regulation of histone ubiquitination(GO:0033182)
0.1 0.6 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.5 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.1 0.2 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.1 0.5 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.3 GO:0006116 NADH oxidation(GO:0006116)
0.1 0.2 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.1 0.3 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.1 0.5 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 0.9 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.1 0.9 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.1 1.2 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.1 0.6 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.2 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0 0.1 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.0 1.4 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.5 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.9 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 1.2 GO:0006414 translational elongation(GO:0006414)
0.0 2.4 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 0.2 GO:0051320 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.0 1.4 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.1 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.0 0.1 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.2 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.0 0.1 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.0 0.2 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503) rDNA condensation(GO:0070550)
0.0 0.4 GO:0033673 negative regulation of protein kinase activity(GO:0006469) negative regulation of kinase activity(GO:0033673)
0.0 0.1 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.0 0.3 GO:0009263 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.7 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 0.2 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.3 GO:0090522 vesicle tethering involved in exocytosis(GO:0090522)
0.0 0.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.2 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.0 0.2 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.0 0.1 GO:0030811 regulation of glycolytic process(GO:0006110) regulation of nucleoside metabolic process(GO:0009118) regulation of nucleotide catabolic process(GO:0030811) regulation of ATP metabolic process(GO:1903578)
0.0 0.2 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.2 GO:0045116 protein neddylation(GO:0045116)
0.0 0.1 GO:0010922 positive regulation of phosphatase activity(GO:0010922)
0.0 0.3 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.3 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.3 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.1 GO:0042173 regulation of sporulation resulting in formation of a cellular spore(GO:0042173) regulation of sporulation(GO:0043937)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.1 GO:0042304 regulation of fatty acid biosynthetic process(GO:0042304) regulation of phosphatidylglycerol biosynthetic process(GO:1901351) negative regulation of phosphatidylglycerol biosynthetic process(GO:1901352)
0.0 0.2 GO:0010526 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.0 0.2 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.5 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.0 0.2 GO:0030473 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.0 0.1 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.0 0.6 GO:0051170 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) nuclear import(GO:0051170) single-organism nuclear import(GO:1902593)
0.0 0.1 GO:0032147 activation of protein kinase activity(GO:0032147)
0.0 0.9 GO:0007088 regulation of mitotic nuclear division(GO:0007088)
0.0 0.0 GO:0051093 negative regulation of developmental process(GO:0051093)
0.0 0.2 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.1 GO:0001308 progressive alteration of chromatin involved in cell aging(GO:0001301) progressive alteration of chromatin involved in replicative cell aging(GO:0001304) negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308) heterochromatin assembly(GO:0031507)
0.0 0.1 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.2 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.7 GO:0051726 regulation of cell cycle(GO:0051726)
0.0 0.1 GO:0042938 dipeptide transport(GO:0042938)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.1 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.0 0.0 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.0 0.3 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 1.0 GO:0008033 tRNA processing(GO:0008033)
0.0 0.0 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.3 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.0 0.3 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.4 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 0.3 GO:0006094 gluconeogenesis(GO:0006094)
0.0 0.1 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.1 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.0 0.1 GO:0032845 negative regulation of telomere maintenance(GO:0032205) negative regulation of homeostatic process(GO:0032845)
0.0 0.1 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 0.1 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.0 GO:0046021 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021)
0.0 0.2 GO:0048311 mitochondrion inheritance(GO:0000001) mitochondrion distribution(GO:0048311)
0.0 0.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.6 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.4 1.8 GO:0044697 HICS complex(GO:0044697)
0.4 31.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 17.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 1.0 GO:0070209 ASTRA complex(GO:0070209) R2TP complex(GO:0097255)
0.3 1.5 GO:0042555 MCM complex(GO:0042555)
0.2 0.7 GO:0070545 PeBoW complex(GO:0070545)
0.2 1.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 3.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 1.3 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.2 1.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.2 0.8 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.2 2.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 1.7 GO:0000142 cellular bud neck contractile ring(GO:0000142)
0.2 1.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.2 1.4 GO:0000144 cellular bud neck septin ring(GO:0000144)
0.2 0.5 GO:0016363 nuclear matrix(GO:0016363)
0.2 1.7 GO:0000243 commitment complex(GO:0000243)
0.1 0.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 1.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.4 GO:0031415 NatA complex(GO:0031415)
0.1 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 3.3 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 1.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.6 GO:0032116 SMC loading complex(GO:0032116)
0.1 2.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.0 GO:0051233 spindle midzone(GO:0051233)
0.1 0.3 GO:0000145 exocyst(GO:0000145)
0.1 0.4 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 0.6 GO:0030689 Noc complex(GO:0030689)
0.1 0.8 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.9 GO:0042597 periplasmic space(GO:0042597)
0.1 0.4 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.1 0.5 GO:0034448 EGO complex(GO:0034448)
0.1 0.5 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.7 GO:0031933 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.1 0.4 GO:0055087 Ski complex(GO:0055087)
0.1 0.5 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.5 GO:0008278 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.1 0.4 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.6 GO:0030867 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.1 0.2 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.1 0.3 GO:0071819 DUBm complex(GO:0071819)
0.1 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.1 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 4.6 GO:0005816 microtubule organizing center(GO:0005815) spindle pole body(GO:0005816)
0.1 0.1 GO:0031391 Elg1 RFC-like complex(GO:0031391)
0.1 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.3 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 0.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.3 GO:0030478 actin cap(GO:0030478)
0.1 0.2 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 0.5 GO:0005655 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.1 2.0 GO:0005811 lipid particle(GO:0005811)
0.1 1.0 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.1 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.2 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.7 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.6 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.3 GO:0005940 septin ring(GO:0005940)
0.0 0.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.3 GO:0034456 UTP-C complex(GO:0034456)
0.0 0.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.4 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 2.0 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.0 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 3.6 GO:0005933 cellular bud(GO:0005933)
0.0 1.4 GO:0030686 90S preribosome(GO:0030686)
0.0 0.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.2 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.7 GO:0005844 polysome(GO:0005844)
0.0 0.2 GO:0070772 PAS complex(GO:0070772)
0.0 0.1 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0000938 GARP complex(GO:0000938)
0.0 0.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)
0.0 0.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.7 GO:0043332 mating projection tip(GO:0043332)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401) ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.1 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0030897 HOPS complex(GO:0030897)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.1 GO:0034044 exomer complex(GO:0034044)
0.0 0.2 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 0.1 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.1 6.5 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
1.0 5.9 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.8 2.3 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.6 2.5 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.6 1.7 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.5 2.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.4 1.6 GO:0016841 ammonia-lyase activity(GO:0016841)
0.3 1.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.3 1.5 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.3 0.6 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.3 1.2 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.3 6.6 GO:0019901 protein kinase binding(GO:0019901)
0.3 0.8 GO:0051219 phosphoprotein binding(GO:0051219)
0.3 1.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 48.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 1.4 GO:0030145 manganese ion binding(GO:0030145)
0.2 1.2 GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.2 0.5 GO:0000339 RNA cap binding(GO:0000339)
0.2 2.5 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 0.5 GO:0019003 GDP binding(GO:0019003)
0.2 0.9 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.2 0.9 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.2 1.3 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 0.5 GO:0005262 calcium channel activity(GO:0005262)
0.1 1.0 GO:0005216 ion channel activity(GO:0005216)
0.1 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 1.4 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 1.1 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.7 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 0.1 GO:0015645 fatty acid ligase activity(GO:0015645) very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.9 GO:0051015 actin filament binding(GO:0051015)
0.1 0.6 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.1 1.2 GO:0004497 monooxygenase activity(GO:0004497)
0.1 0.5 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.1 0.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.7 GO:0043177 carboxylic acid binding(GO:0031406) organic acid binding(GO:0043177)
0.1 0.3 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.1 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.4 GO:0008242 omega peptidase activity(GO:0008242)
0.1 0.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 1.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.3 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 0.5 GO:0008312 7S RNA binding(GO:0008312)
0.1 3.6 GO:0030674 protein binding, bridging(GO:0030674)
0.1 1.4 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.4 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.3 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.1 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.7 GO:0004529 exodeoxyribonuclease activity(GO:0004529)
0.1 0.4 GO:0004075 biotin carboxylase activity(GO:0004075)
0.1 0.9 GO:0030276 clathrin binding(GO:0030276)
0.1 0.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 0.3 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.5 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 1.4 GO:0030515 snoRNA binding(GO:0030515)
0.1 1.2 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.2 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.1 0.2 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.2 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 0.3 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.1 0.2 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.1 0.2 GO:0009922 fatty acid elongase activity(GO:0009922)
0.1 0.4 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.1 3.5 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.1 0.6 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 1.7 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.5 GO:0004526 ribonuclease MRP activity(GO:0000171) ribonuclease P activity(GO:0004526)
0.1 0.2 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.1 1.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.7 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 1.1 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.0 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.7 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.2 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.0 0.2 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.1 GO:0001082 transcription factor activity, RNA polymerase I transcription factor binding(GO:0001082)
0.0 0.2 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.2 GO:0019206 nucleoside kinase activity(GO:0019206)
0.0 1.5 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.2 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 1.4 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.6 GO:0015605 organophosphate ester transmembrane transporter activity(GO:0015605)
0.0 0.2 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.0 0.2 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.0 0.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.0 0.7 GO:0004536 endodeoxyribonuclease activity(GO:0004520) deoxyribonuclease activity(GO:0004536)
0.0 0.3 GO:0019239 deaminase activity(GO:0019239)
0.0 0.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.7 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.7 GO:0016866 intramolecular transferase activity(GO:0016866)
0.0 0.2 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0001168 RNA polymerase I transcription factor activity, sequence-specific DNA binding(GO:0001167) transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.0 0.8 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 0.5 GO:0051536 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.3 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.1 GO:0016410 N-acyltransferase activity(GO:0016410)
0.0 1.3 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.2 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.3 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 0.2 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.1 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.0 0.1 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 0.1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0 0.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.2 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 0.1 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.4 GO:0016853 isomerase activity(GO:0016853)
0.0 0.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.8 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.2 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.1 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.2 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 0.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.8 PID ATR PATHWAY ATR signaling pathway
0.1 0.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 0.3 PID E2F PATHWAY E2F transcription factor network
0.0 0.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.0 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.1 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 1.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 0.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 0.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 2.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 0.3 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 0.2 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 0.6 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 0.2 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.1 0.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 0.4 REACTOME PROTEIN FOLDING Genes involved in Protein folding
0.0 0.2 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.4 REACTOME M G1 TRANSITION Genes involved in M/G1 Transition
0.0 0.1 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.0 0.1 REACTOME APOPTOSIS Genes involved in Apoptosis
0.0 0.1 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.1 REACTOME DEADENYLATION DEPENDENT MRNA DECAY Genes involved in Deadenylation-dependent mRNA decay
0.0 0.1 REACTOME TRANSCRIPTION Genes involved in Transcription