Results for YNR063W

Z-value: 0.56

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Transcription factors associated with YNR063W

Gene Symbol Gene ID Gene Info
S000005346 Putative zinc-cluster protein of unknown function

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of YNR063W motif

Sorted Z-values of YNR063W motif

Promoter Log-likelihood Transcript Gene Gene Info
YHR094C 8.59 Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YFR055W 4.62 Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 4.02 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YOL086C 3.99 Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YKR075C 3.35 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YOR101W 3.22 GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YJL115W 3.15 Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YNL178W 3.13 Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YOR315W 3.05 Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YGL209W 2.97 Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YKL063C 2.80 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YLR301W 2.74 Protein of unknown function that interacts with Sec72p
YHR141C 2.64 Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YKL096W-A 2.44 Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YOR050C 2.35 Hypothetical protein
YDR044W 2.34 Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YJR094W-A 2.33 Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YBL063W 2.25 Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YDR002W 2.24 Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YKL110C 2.17 Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YNR001W-A 2.13 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YKR041W 2.08 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YJL162C 2.02 Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YDL211C 1.98 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YGR052W 1.97 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDR037W 1.96 Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YFL015C 1.96 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YFL015W-A 1.95 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL241W 1.92 Putative protein of unknown function; YDL241W is not an essential gene
YGR051C 1.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YLR432W 1.89 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YDR345C 1.86 Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YOR063W 1.86 Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YOR342C 1.78 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YGR050C 1.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR033W 1.75 Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YDL023C 1.74 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YGR251W 1.70 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YKR038C 1.66 Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YOL101C 1.63 Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YLR154W-A 1.60 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YOR163W 1.58 Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases
YMR001C-A 1.55 Putative protein of unknown function
YDL022C-A 1.53 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YLR154C 1.52 Ribonuclease H2 subunit, required for RNase H2 activity
YDL055C 1.49 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YHR007C 1.45 Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YDR074W 1.45 Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YNL231C 1.45 Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YDR279W 1.44 Ribonuclease H2 subunit, required for RNase H2 activity
YDL022W 1.44 NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YHR216W 1.42 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YLR154W-B 1.42 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YMR290W-A 1.41 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YCL022C 1.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W
YOL085C 1.37 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YDL047W 1.33 Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YLR411W 1.32 High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YOR028C 1.31 Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YNL153C 1.30 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YMR290C 1.30 ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YGR040W 1.28 Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YMR037C 1.26 Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YJL177W 1.25 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins
YMR011W 1.24 High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YPL183C 1.23 Cytoplasmic protein with a role in regulation of Ty1 transposition
YFR054C 1.23 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER028C 1.22 Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes
YJR105W 1.22 Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YOR313C 1.20 Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YBL085W 1.18 Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YIL009W 1.17 Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YOR029W 1.16 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YLR154W-C 1.16 Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YPL265W 1.15 Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly
YER137C 1.14 Putative protein of unknown function
YBR158W 1.13 Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YNL065W 1.12 Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YIL056W 1.10 Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YML077W 1.08 Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi
YPL250W-A 1.07 Identified by fungal homology and RT-PCR
YOR314W 1.05 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER045C 1.05 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources
YNL069C 0.98 N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YOL015W 0.98 Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
YOR047C 0.98 Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YER046W 0.96 Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
YER131W 0.93 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YLR180W 0.93 S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YOR030W 0.93 Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p
YHR089C 0.92 Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YFL016C 0.92 Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YIL096C 0.91 Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit
YCL018W 0.91 Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YOR181W 0.91 Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
YKL062W 0.90 Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YPL137C 0.90 Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments
YDR098C 0.89 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YKR099W 0.88 Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
YBR167C 0.88 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YIR021W 0.88 Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YGL157W 0.87 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YAL038W 0.87 Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YLR100W 0.87 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs
YDR344C 0.86 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR367W 0.85 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YDR531W 0.85 Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC; catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YER012W 0.83 Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YHR013C 0.82 Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YKL165C 0.82 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YKL120W 0.82 Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YPL238C 0.79 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
YBR206W 0.79 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3
YOR051C 0.79 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YOR130C 0.78 Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
YMR009W 0.78 Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YIL118W 0.76 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YNL043C 0.76 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YKL081W 0.76 Translation elongation factor EF-1 gamma
YMR102C 0.76 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YPL178W 0.75 Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YIL009C-A 0.75 Component of the telomerase holoenzyme, involved in telomere replication
YPL177C 0.75 Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YJL107C 0.74 Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YMR083W 0.74 Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YLR129W 0.74 Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
YDL111C 0.73 Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp4p, Rrp41p, Rrp43p and Dis3p
YGL158W 0.73 Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YKL154W 0.73 Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane
YNL118C 0.73 Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family
YGL148W 0.71 Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YDL048C 0.71 Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YOR226C 0.71 Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YGR148C 0.71 Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YBR210W 0.70 Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YHR148W 0.70 Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
YLR353W 0.70 Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
YHR142W 0.70 Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER
YLR191W 0.70 Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
YOR087W 0.68 Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
YJR145C 0.68 Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YOR180C 0.67 Peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, involved in fatty acid metabolism, contains peroxisome targeting signals at amino and carboxy termini
YHR128W 0.66 Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YPL237W 0.66 Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
YNL141W 0.65 Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
YJL106W 0.65 Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YJR094C 0.65 Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YMR106C 0.65 Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YER120W 0.64 Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog
YOR162C 0.63 Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes
YBR106W 0.63 Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YHR095W 0.63 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR133C 0.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YOR222W 0.62 Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
YMR320W 0.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR049C 0.62 Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YML043C 0.61 Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YMR300C 0.61 Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
YOL031C 0.60 Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
YEL068C 0.59 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR014C 0.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YEL033W 0.59 Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
YFR001W 0.59 Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles
YDR278C 0.59 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML018C 0.59 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene
YHR193C 0.58 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
YMR199W 0.58 G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YEL029C 0.58 Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YLR357W 0.58 Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance
YOR026W 0.57 Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
YNL035C 0.57 Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene
YLR257W 0.57 Putative protein of unknown function
YER036C 0.57 ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YOL040C 0.57 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YPL144W 0.57 Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
YML115C 0.56 Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
YPL131W 0.56 Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly
YJL200C 0.56 Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YGR157W 0.56 Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
YGL039W 0.55 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YLR420W 0.55 Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YHR046C 0.54 Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
YCL063W 0.54 Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YOL039W 0.54 Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YEL053C 0.54 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
YPR148C 0.54 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YMR267W 0.54 Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
YBR081C 0.54 Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex
YGR293C 0.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W
YAR002W 0.53 Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance
YDL082W 0.53 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein
YBR011C 0.52 Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YER119C-A 0.52 Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2
YCR035C 0.52 Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp4p and Dis3p; required for efficient maturation of 5.8S, 18S and 25S rRNA
YDL173W 0.52 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDL173W is not an essential gene
YDL134C 0.52 Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
YHR136C 0.52 Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YMR220W 0.52 Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YOL016C 0.51 Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II
YBR023C 0.51 Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan

Network of associatons between targets according to the STRING database.

First level regulatory network of YNR063W

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
1.1 3.2 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
1.0 3.0 GO:0046039 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.8 2.5 GO:0090342 regulation of cell aging(GO:0090342) regulation of replicative cell aging(GO:1900062)
0.8 3.3 GO:1900436 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.8 3.2 GO:0000092 mitotic anaphase B(GO:0000092)
0.8 3.1 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.6 3.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-dependent nucleosome organization(GO:0034723) positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.6 5.7 GO:0006116 NADH oxidation(GO:0006116)
0.5 1.6 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.5 1.5 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.4 3.0 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.4 1.2 GO:0071478 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.4 1.2 GO:0035953 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.4 1.4 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.3 1.0 GO:0044209 AMP salvage(GO:0044209)
0.3 2.4 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.3 3.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.3 1.7 GO:0032233 regulation of actin filament bundle assembly(GO:0032231) positive regulation of actin filament bundle assembly(GO:0032233)
0.3 3.7 GO:0015758 glucose transport(GO:0015758)
0.3 0.7 GO:0043096 purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083)
0.3 1.0 GO:0046495 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.3 1.4 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.2 0.9 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.2 0.7 GO:0008272 sulfate transport(GO:0008272)
0.2 1.5 GO:0005992 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.2 1.1 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.2 0.6 GO:0032365 intracellular lipid transport(GO:0032365) negative regulation of transcription factor import into nucleus(GO:0042992)
0.2 0.8 GO:0015867 ATP transport(GO:0015867)
0.2 0.8 GO:0010138 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.2 0.8 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 2.0 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.2 1.1 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.2 1.7 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.2 0.7 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.2 1.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.2 0.9 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.2 0.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.2 0.7 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.2 0.8 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.2 0.5 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.2 0.2 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.2 0.8 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.2 1.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.2 1.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.2 0.8 GO:0070814 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.2 0.8 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.2 0.3 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.2 0.6 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.2 1.8 GO:0033967 box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963)
0.2 1.4 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.2 0.3 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.1 3.3 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.1 0.6 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.1 0.4 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
0.1 0.6 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 0.1 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.1 1.7 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1 0.7 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.1 2.3 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.1 1.5 GO:0006458 'de novo' protein folding(GO:0006458)
0.1 0.3 GO:0019348 polyprenol metabolic process(GO:0016093) polyprenol biosynthetic process(GO:0016094) dolichol metabolic process(GO:0019348) dolichol biosynthetic process(GO:0019408)
0.1 1.5 GO:0006817 phosphate ion transport(GO:0006817)
0.1 0.5 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.1 0.7 GO:0009098 leucine biosynthetic process(GO:0009098)
0.1 0.6 GO:0007535 donor selection(GO:0007535)
0.1 0.9 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 0.4 GO:0006567 threonine catabolic process(GO:0006567)
0.1 0.9 GO:0071267 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.1 1.2 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.1 0.9 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 3.7 GO:0006694 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.1 0.7 GO:0006855 drug transmembrane transport(GO:0006855)
0.1 15.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 1.4 GO:0007120 axial cellular bud site selection(GO:0007120)
0.1 2.5 GO:0006885 regulation of pH(GO:0006885)
0.1 0.3 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.1 0.3 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.1 0.6 GO:0009113 purine nucleobase biosynthetic process(GO:0009113)
0.1 1.2 GO:0051278 cell wall chitin biosynthetic process(GO:0006038) fungal-type cell wall chitin biosynthetic process(GO:0034221) fungal-type cell wall polysaccharide biosynthetic process(GO:0051278) fungal-type cell wall polysaccharide metabolic process(GO:0071966)
0.1 1.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.3 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 0.2 GO:1901070 GMP biosynthetic process(GO:0006177) guanosine-containing compound biosynthetic process(GO:1901070)
0.1 0.1 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.1 0.3 GO:0060548 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.1 0.6 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082)
0.1 1.2 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.1 0.4 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.1 0.4 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.1 2.9 GO:0043038 amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039)
0.1 1.0 GO:0006614 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 0.3 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.1 0.8 GO:0000032 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.1 0.4 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.1 0.6 GO:0006276 plasmid maintenance(GO:0006276)
0.1 0.2 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.6 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.1 4.0 GO:0007124 pseudohyphal growth(GO:0007124)
0.1 0.6 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.1 0.4 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 1.9 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 1.7 GO:0042594 response to starvation(GO:0042594)
0.1 2.6 GO:0044744 protein targeting to nucleus(GO:0044744)
0.1 0.1 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.1 0.3 GO:0030497 fatty acid elongation(GO:0030497)
0.1 1.2 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 1.0 GO:0006415 translational termination(GO:0006415)
0.1 0.1 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.1 0.4 GO:0034063 stress granule assembly(GO:0034063)
0.1 1.0 GO:0030473 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.1 1.2 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094)
0.1 0.2 GO:0007329 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.1 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.2 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.1 0.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 0.2 GO:0000296 spermine transport(GO:0000296)
0.1 0.1 GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.1 0.2 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.1 0.2 GO:0015883 FAD transport(GO:0015883)
0.1 0.3 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.1 0.1 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.1 0.5 GO:0072507 cellular divalent inorganic cation homeostasis(GO:0072503) divalent inorganic cation homeostasis(GO:0072507)
0.1 0.4 GO:0052803 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.1 0.1 GO:1902223 L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.0 0.8 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0015809 arginine transport(GO:0015809)
0.0 0.1 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.0 0.1 GO:0045860 positive regulation of protein kinase activity(GO:0045860)
0.0 0.1 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.0 0.2 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.4 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.1 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.0 0.4 GO:0000921 septin ring assembly(GO:0000921)
0.0 0.3 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.0 0.5 GO:0000011 vacuole inheritance(GO:0000011)
0.0 0.2 GO:0048255 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.0 0.1 GO:0001109 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.0 0.2 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.0 0.5 GO:0007004 telomere maintenance via telomerase(GO:0007004) telomere maintenance via telomere lengthening(GO:0010833)
0.0 4.8 GO:0006364 rRNA processing(GO:0006364)
0.0 0.4 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.3 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound biosynthetic process(GO:0042559)
0.0 0.5 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 1.2 GO:0008033 tRNA processing(GO:0008033)
0.0 0.1 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.1 GO:0060491 regulation of cell projection organization(GO:0031344) mating projection assembly(GO:0031382) regulation of mating projection assembly(GO:0031383) regulation of termination of mating projection growth(GO:0031385) regulation of cell projection assembly(GO:0060491)
0.0 0.2 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.3 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.4 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.7 GO:0006414 translational elongation(GO:0006414)
0.0 0.4 GO:0033753 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753)
0.0 0.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.0 1.1 GO:0006413 translational initiation(GO:0006413)
0.0 0.1 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.0 0.1 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.0 0.8 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.1 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.0 GO:0007232 osmosensory signaling pathway via Sho1 osmosensor(GO:0007232)
0.0 0.8 GO:0009266 response to temperature stimulus(GO:0009266)
0.0 0.1 GO:0007157 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.0 0.1 GO:1903051 negative regulation of protein catabolic process(GO:0042177) negative regulation of proteolysis involved in cellular protein catabolic process(GO:1903051) negative regulation of cellular protein catabolic process(GO:1903363)
0.0 0.3 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.4 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 0.2 GO:0007323 peptide pheromone maturation(GO:0007323)
0.0 0.4 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.0 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.2 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.0 0.3 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.2 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0048313 Golgi inheritance(GO:0048313)
0.0 0.1 GO:0042435 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.0 0.1 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.0 0.1 GO:0034470 ncRNA processing(GO:0034470)
0.0 0.3 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0030042 actin filament depolymerization(GO:0030042) Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.1 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) nucleus localization(GO:0051647)
0.0 0.1 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.0 0.0 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.0 1.2 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.1 GO:0006734 NADH metabolic process(GO:0006734)
0.0 0.2 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.1 GO:0008299 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.0 0.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.1 GO:0031647 regulation of protein stability(GO:0031647)
0.0 0.2 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.2 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.0 0.1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.1 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244) spliceosomal snRNP assembly(GO:0000387)
0.0 0.0 GO:0046348 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0 0.1 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.1 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.2 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.1 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.0 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.1 GO:0051666 actin cortical patch localization(GO:0051666)
0.0 0.1 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.0 GO:0006816 calcium ion transport(GO:0006816)
0.0 0.3 GO:0040020 regulation of meiotic nuclear division(GO:0040020)
0.0 0.1 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.1 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.4 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.3 GO:0071900 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of protein serine/threonine kinase activity(GO:0071900) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.2 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.0 GO:0035493 SNARE complex assembly(GO:0035493) regulation of SNARE complex assembly(GO:0035542)
0.0 0.0 GO:0031047 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.0 0.2 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.1 GO:0045116 protein neddylation(GO:0045116)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 1.4 GO:0044427 chromatin(GO:0000785) chromosomal part(GO:0044427)
1.0 3.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.5 3.1 GO:0005871 kinesin complex(GO:0005871)
0.4 1.5 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.3 1.7 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.3 0.9 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 0.8 GO:0031415 NatA complex(GO:0031415)
0.3 3.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.3 0.8 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.2 1.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 0.7 GO:0034457 Mpp10 complex(GO:0034457)
0.2 1.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 0.6 GO:0070545 PeBoW complex(GO:0070545)
0.2 0.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 0.6 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.2 1.3 GO:0016272 prefoldin complex(GO:0016272)
0.2 15.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 0.5 GO:0031417 NatC complex(GO:0031417)
0.2 1.1 GO:0000136 alpha-1,6-mannosyltransferase complex(GO:0000136)
0.2 2.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.2 0.6 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.2 0.8 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 0.4 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.1 0.4 GO:0035649 Nrd1 complex(GO:0035649)
0.1 0.6 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.1 1.0 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.1 1.3 GO:0005655 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.1 1.1 GO:0051233 spindle midzone(GO:0051233)
0.1 1.1 GO:0005720 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.1 0.6 GO:0044697 HICS complex(GO:0044697)
0.1 0.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 1.0 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.4 GO:0030869 RENT complex(GO:0030869)
0.1 0.9 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.4 GO:0030428 cell septum(GO:0030428)
0.1 0.7 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.5 GO:0016587 Isw1 complex(GO:0016587)
0.1 0.9 GO:0030008 TRAPP complex(GO:0030008)
0.1 0.4 GO:0034448 EGO complex(GO:0034448)
0.1 0.3 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.1 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.2 GO:0005771 multivesicular body(GO:0005771)
0.1 0.3 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.1 GO:0032155 actomyosin contractile ring(GO:0005826) cell division site(GO:0032153) cell division site part(GO:0032155) contractile ring(GO:0070938)
0.1 0.4 GO:0032160 septin filament array(GO:0032160)
0.1 5.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.8 GO:0005791 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.1 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.3 GO:0000811 GINS complex(GO:0000811)
0.1 1.2 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.1 2.6 GO:0030686 90S preribosome(GO:0030686)
0.1 1.2 GO:0016586 RSC complex(GO:0016586)
0.1 0.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.3 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.1 0.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.4 GO:0016459 myosin complex(GO:0016459)
0.1 0.3 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.1 0.4 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.3 GO:0070772 PAS complex(GO:0070772)
0.0 0.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 1.8 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 8.4 GO:0005933 cellular bud(GO:0005933)
0.0 0.3 GO:0000798 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.0 0.1 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.0 0.7 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.5 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 0.1 GO:0097344 Rix1 complex(GO:0097344)
0.0 0.1 GO:0005828 polar microtubule(GO:0005827) kinetochore microtubule(GO:0005828) tubulin complex(GO:0045298)
0.0 0.4 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.4 GO:0071782 cortical endoplasmic reticulum(GO:0032541) endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 1.1 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.1 GO:0035770 ribonucleoprotein granule(GO:0035770) cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 0.2 GO:0000346 transcription export complex(GO:0000346)
0.0 0.1 GO:0044426 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.0 1.2 GO:0030479 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.0 0.1 GO:0070985 TFIIK complex(GO:0070985)
0.0 0.2 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 1.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.4 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.3 GO:0000786 nucleosome(GO:0000786)
0.0 0.2 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.1 GO:1990904 intracellular ribonucleoprotein complex(GO:0030529) ribonucleoprotein complex(GO:1990904)
0.0 0.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.4 GO:0005844 polysome(GO:0005844)
0.0 0.1 GO:0030130 AP-1 adaptor complex(GO:0030121) clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.1 GO:0030907 MBF transcription complex(GO:0030907)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.3 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.1 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 1.8 GO:0005840 ribosome(GO:0005840)
0.0 0.1 GO:0031499 TRAMP complex(GO:0031499)
0.0 0.2 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152) anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.1 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 16.1 GO:0005634 nucleus(GO:0005634)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.6 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
1.1 3.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.8 4.7 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.7 3.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.5 3.2 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.5 2.1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.5 1.5 GO:0070568 guanylyltransferase activity(GO:0070568)
0.5 1.5 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.5 2.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.5 2.8 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.5 2.3 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.4 1.3 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.4 1.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.3 1.6 GO:0032451 demethylase activity(GO:0032451)
0.3 3.1 GO:0003777 microtubule motor activity(GO:0003777)
0.3 1.2 GO:0019206 nucleoside kinase activity(GO:0019206)
0.3 4.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 0.9 GO:0016504 peptidase activator activity(GO:0016504)
0.3 1.4 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.3 0.8 GO:0000339 RNA cap binding(GO:0000339)
0.3 1.3 GO:0004707 MAP kinase activity(GO:0004707)
0.2 0.7 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.2 0.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 0.7 GO:0005262 calcium channel activity(GO:0005262)
0.2 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 0.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.2 0.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 0.6 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.2 1.2 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 0.6 GO:0008097 5S rRNA binding(GO:0008097)
0.2 0.7 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.2 0.5 GO:0004100 chitin synthase activity(GO:0004100)
0.2 0.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 1.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 0.9 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.2 1.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 0.4 GO:0019003 GDP binding(GO:0019003)
0.1 1.6 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 1.2 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.1 2.6 GO:0030515 snoRNA binding(GO:0030515)
0.1 1.3 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 0.4 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 0.5 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.1 0.7 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 0.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.1 GO:0051213 dioxygenase activity(GO:0051213)
0.1 1.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.9 GO:0031072 heat shock protein binding(GO:0031072)
0.1 0.3 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.1 1.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 1.3 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 0.3 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 1.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 1.1 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 0.3 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.6 GO:0016408 C-acyltransferase activity(GO:0016408)
0.1 1.1 GO:0019904 protein domain specific binding(GO:0019904)
0.1 18.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 1.1 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.4 GO:0005034 osmosensor activity(GO:0005034)
0.1 5.6 GO:0003924 GTPase activity(GO:0003924)
0.1 0.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.3 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 0.6 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.1 2.6 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.9 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.2 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.1 0.9 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.1 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 1.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.8 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.6 GO:0019239 deaminase activity(GO:0019239)
0.1 2.1 GO:0042393 histone binding(GO:0042393)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.5 GO:1901681 sulfur compound binding(GO:1901681)
0.1 0.2 GO:0008252 nucleotidase activity(GO:0008252)
0.1 1.1 GO:0019001 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.1 0.2 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.1 1.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.2 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.1 0.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.2 GO:0009922 fatty acid elongase activity(GO:0009922)
0.1 0.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 1.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.4 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.1 GO:0019202 amino acid kinase activity(GO:0019202)
0.0 0.3 GO:0030145 manganese ion binding(GO:0030145)
0.0 1.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.7 GO:0090484 drug transporter activity(GO:0090484)
0.0 1.2 GO:0015631 tubulin binding(GO:0015631)
0.0 0.1 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0000146 microfilament motor activity(GO:0000146)
0.0 1.3 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.5 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.2 GO:0019201 nucleotide kinase activity(GO:0019201)
0.0 0.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.2 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 0.1 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.6 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.1 GO:0017022 myosin binding(GO:0017022)
0.0 2.4 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.3 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.1 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 1.1 GO:0003779 actin binding(GO:0003779)
0.0 0.3 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0001671 ATPase activator activity(GO:0001671) ATPase regulator activity(GO:0060590)
0.0 1.4 GO:0003682 chromatin binding(GO:0003682)
0.0 0.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.2 GO:0004529 exodeoxyribonuclease activity(GO:0004529)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.4 GO:0051087 chaperone binding(GO:0051087)
0.0 0.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 1.5 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.6 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.2 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0008443 phosphofructokinase activity(GO:0008443)
0.0 0.3 GO:0008289 lipid binding(GO:0008289)
0.0 0.1 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.0 0.2 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 0.2 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.1 GO:0030276 clathrin binding(GO:0030276)
0.0 0.3 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.3 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0004497 monooxygenase activity(GO:0004497)
0.0 0.1 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.1 GO:0015266 protein channel activity(GO:0015266)
0.0 0.1 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 PID P73PATHWAY p73 transcription factor network
0.1 0.1 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 0.3 PID E2F PATHWAY E2F transcription factor network
0.1 0.2 PID SHP2 PATHWAY SHP2 signaling
0.0 0.1 PID MYC PATHWAY C-MYC pathway
0.0 0.0 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.1 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.9 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.4 0.7 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.4 1.4 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.2 0.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 3.3 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 0.6 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 0.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.2 REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR Genes involved in Downstream signaling of activated FGFR
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.1 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.0 0.2 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.0 0.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.1 REACTOME HIV LIFE CYCLE Genes involved in HIV Life Cycle
0.0 0.1 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.1 REACTOME GPCR LIGAND BINDING Genes involved in GPCR ligand binding