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Results for YKL222C

Z-value: 1.46

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Transcription factors associated with YKL222C

Gene Symbol Gene ID Gene Info
S000001705 Protein of unknown function that may interact with ribosomes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
YKL222C0.792.0e-06Click!

Activity profile of YKL222C motif

Sorted Z-values of YKL222C motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YIL057C 20.21 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YML042W 18.89
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YJR095W 16.09
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YLR174W 13.63
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YPL171C 13.26
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YAR053W 12.96 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR048W 12.35
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YOR343C 12.35 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YNL194C 11.77 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YDL244W 11.57
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YNR002C 11.00
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YKL221W 10.60
MCH2
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YNR034W-A 10.53 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YHR048W 10.10
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YMR103C 10.02 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL135W 9.97
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YPR010C-A 9.94 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YNL202W 9.64
SPS19
Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
YAR060C 9.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCL001W-B 8.82 Putative protein of unknown function; identified by homology
YDR277C 8.34
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YNL117W 8.20
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YMR017W 8.20
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YAR050W 8.16
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YOR348C 8.01
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YML089C 7.77 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YDR536W 7.66
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YHR212C 7.54 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL089W 7.28
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YHR212W-A 7.25 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPR026W 7.05
ATH1
Acid trehalase required for utilization of extracellular trehalose
YLR142W 7.02
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YNL274C 6.95
GOR1
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFL030W 6.87
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YKL109W 6.78
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YLR377C 6.68
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YLR332W 6.59
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YDL245C 6.56
HXT15
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YAR047C 6.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL045W 6.44 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YPL181W 6.42
CTI6
Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
YLR331C 6.32
JIP3
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YLR327C 6.26
TMA10
Protein of unknown function that associates with ribosomes
YPL182C 6.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
YCR005C 5.93
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YFL054C 5.88 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YLR346C 5.79 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YOR100C 5.65
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YMR244W 5.52 Putative protein of unknown function
YEL028W 5.50 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR072W 5.49
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YDL138W 5.38
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YDR343C 5.25
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YJR150C 5.25
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YOR065W 5.15
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YFR053C 5.05
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YOR382W 5.00
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YGR197C 4.96
SNG1
Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance
YJL116C 4.92
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YCR068W 4.91
ATG15
Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YML090W 4.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YKL044W 4.89 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR139C 4.87
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YDR342C 4.82
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YDR070C 4.79
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL084W 4.78
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YAR035W 4.73
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YDR259C 4.68
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YGR087C 4.66
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YEL070W 4.61
DSF1
Deletion suppressor of mpt5 mutation
YDL130W-A 4.57
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YMR206W 4.48 Putative protein of unknown function; YMR206W is not an essential gene
YPL250C 4.43
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YPR191W 4.41
QCR2
Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YEL009C 4.31
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YKR009C 4.27
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YOL157C 4.24 Putative protein of unknown function
YEL008W 4.21 Hypothetical protein predicted to be involved in metabolism
YPL222C-A 4.19 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLR304C 4.14
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YLR122C 4.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YKL163W 4.12
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YMR107W 4.08
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YEL024W 4.04
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YHR096C 4.04
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YNL144C 3.94 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YML091C 3.91
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YIL160C 3.88
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YLR366W 3.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YFL053W 3.85
DAK2
Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YHR001W-A 3.84
QCR10
Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YLR111W 3.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL015W 3.79
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YCR007C 3.74 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YGR213C 3.72
RTA1
Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions
YAL039C 3.68
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YBL064C 3.68
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YBR179C 3.64
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YNL305C 3.64 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YDR043C 3.60
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YLR149C 3.58 Putative protein of unknown function; YLR149C is not an essential gene
YKL043W 3.57
PHD1
Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YOL156W 3.54
HXT11
Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance
YOR152C 3.53 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YIL077C 3.50 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YBR296C 3.49
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YLR123C 3.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YOL081W 3.43
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YJL133C-A 3.42 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHL024W 3.42
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YFL052W 3.39 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YNR050C 3.39
LYS9
Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway
YAL054C 3.38
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YBR116C 3.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YDR010C 3.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL210W 3.32
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YDR092W 3.28
UBC13
Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
YER024W 3.26
YAT2
Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
YLR307C-A 3.26 Putative protein of unknown function
YJL088W 3.18
ARG3
Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
YJL220W 3.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2
YKL161C 3.15 Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p
YBR035C 3.12
PDX3
Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YFR022W 3.11
ROG3
Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YLL053C 3.10 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YPR013C 3.09 Putative zinc finger protein; YPR013C is not an essential gene
YHR211W 3.04
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YGR110W 3.01 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YHR160C 3.00
PEX18
Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p
YKL217W 2.95
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YFL011W 2.95
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YER014C-A 2.92
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YPR111W 2.90
DBF20
Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis
YMR040W 2.90
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YNL142W 2.88
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YLL019C 2.87
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YEL012W 2.82
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YCR010C 2.82
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YGR088W 2.82
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YLL052C 2.81
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YLL041C 2.81
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YJL221C 2.81
FSP2
Protein of unknown function, expression is induced during nitrogen limitation
YDR455C 2.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
YDL246C 2.79
SOR2
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YIL162W 2.79
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YKR102W 2.78
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YFL024C 2.78
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YJR115W 2.78 Putative protein of unknown function
YDR406W 2.77
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YMR118C 2.76 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YJL219W 2.75
HXT9
Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p
YDR456W 2.73
NHX1
Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock
YML128C 2.73
MSC1
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YJR148W 2.71
BAT2
Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase
YDR216W 2.70
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YPL248C 2.70
GAL4
DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p
YKL026C 2.70
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YDL139C 2.69
SCM3
Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p
YHR054W-A 2.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2
YER158C 2.65 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YLR124W 2.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR019W-A 2.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR217C 2.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YPL024W 2.64
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YDL218W 2.63 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YLR046C 2.63 Putative membrane protein, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YBR180W 2.63
DTR1
Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
YBR297W 2.62
MAL33
MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YDR251W 2.57
PAM1
Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
YGL215W 2.56
CLG1
Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
YDR250C 2.56 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YDR096W 2.56
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YDL020C 2.55
RPN4
Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
YAR019C 2.55
CDC15
Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
YJR159W 2.54
SOR1
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol
YLL018C-A 2.49
COX19
Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase
YJR146W 2.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YOR228C 2.48 Protein of unknown function, localized to the mitochondrial outer membrane
YJL166W 2.45
QCR8
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YDL149W 2.43
ATG9
Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes; forms a complex with Atg23p and Atg27p
YOR346W 2.43
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YOL128C 2.43
YGK3
Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YDR441C 2.41
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YBR054W 2.40
YRO2
Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YPL058C 2.40
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YMR302C 2.39
YME2
Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
YHR079C-A 2.39
SAE3
Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p
YAR023C 2.38 Putative integral membrane protein, member of DUP240 gene family
YNL322C 2.38
KRE1
Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
YLR365W 2.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
YHR055C 2.36
CUP1-2
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YMR280C 2.36
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YGL096W 2.35
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YFL063W 2.35 Dubious open reading frame, based on available experimental and comparative sequence data
YHR150W 2.34
PEX28
Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
YMR181C 2.33 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YPR196W 2.32 Putative maltose activator
YLR356W 2.31 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YPL026C 2.31
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YFL064C 2.30 Putative protein of unknown function

Network of associatons between targets according to the STRING database.

First level regulatory network of YKL222C

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.0 26.9 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
5.4 16.1 GO:0015740 C4-dicarboxylate transport(GO:0015740)
3.6 7.3 GO:0061413 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
3.6 36.3 GO:0046487 glyoxylate metabolic process(GO:0046487)
3.2 32.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
3.0 9.1 GO:0005993 trehalose catabolic process(GO:0005993)
2.3 9.4 GO:0015804 neutral amino acid transport(GO:0015804)
2.3 7.0 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
2.3 7.0 GO:0006545 glycine biosynthetic process(GO:0006545)
2.2 13.0 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
2.0 8.0 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
2.0 3.9 GO:0015755 fructose transport(GO:0015755)
1.8 5.4 GO:0051594 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
1.6 6.6 GO:0070054 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
1.6 4.9 GO:0006624 vacuolar protein processing(GO:0006624) multivesicular body organization(GO:0036257)
1.6 4.8 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
1.5 1.5 GO:0034224 cellular response to zinc ion starvation(GO:0034224) regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation(GO:0034225)
1.4 7.2 GO:0006083 acetate metabolic process(GO:0006083)
1.4 4.2 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
1.4 4.1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.4 2.7 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
1.3 21.4 GO:0009062 fatty acid catabolic process(GO:0009062)
1.2 3.7 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.2 4.9 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
1.2 4.8 GO:0006848 pyruvate transport(GO:0006848)
1.2 17.9 GO:0015696 ammonium transport(GO:0015696)
1.2 5.8 GO:0008053 mitochondrial fusion(GO:0008053)
1.1 5.7 GO:0015793 glycerol transport(GO:0015793)
1.1 3.3 GO:0006538 glutamate catabolic process(GO:0006538)
1.1 3.3 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
1.1 4.3 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
1.1 5.3 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.1 3.2 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
1.0 7.3 GO:0000023 maltose metabolic process(GO:0000023)
1.0 3.0 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
1.0 4.0 GO:0046688 response to copper ion(GO:0046688)
1.0 1.0 GO:0032780 negative regulation of ATPase activity(GO:0032780)
1.0 4.8 GO:0051099 positive regulation of binding(GO:0051099)
1.0 3.8 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.9 2.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.9 6.5 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.9 2.7 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.9 15.2 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.9 6.1 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.8 2.4 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.7 4.4 GO:0051260 protein homooligomerization(GO:0051260)
0.7 10.3 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.7 7.1 GO:0046686 response to cadmium ion(GO:0046686)
0.7 2.8 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.7 0.7 GO:0051238 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.7 2.0 GO:0042843 D-xylose catabolic process(GO:0042843)
0.7 2.7 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.7 13.4 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.7 6.6 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.6 1.9 GO:0071396 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.6 5.2 GO:0015891 siderophore transport(GO:0015891)
0.6 2.6 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.6 5.1 GO:0006591 ornithine metabolic process(GO:0006591)
0.6 1.9 GO:0044209 AMP salvage(GO:0044209)
0.6 8.0 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.6 4.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.6 3.6 GO:0006279 premeiotic DNA replication(GO:0006279)
0.6 6.9 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.6 1.7 GO:0043335 protein unfolding(GO:0043335)
0.6 2.3 GO:0071333 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.6 2.8 GO:0034487 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.5 8.2 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.5 1.6 GO:0019748 secondary metabolic process(GO:0019748)
0.5 4.7 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.5 3.1 GO:0050821 protein stabilization(GO:0050821)
0.5 7.6 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.5 3.5 GO:0061013 regulation of mRNA catabolic process(GO:0061013)
0.5 1.5 GO:1902751 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.5 1.4 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.5 3.2 GO:0015908 fatty acid transport(GO:0015908)
0.5 2.3 GO:0044070 regulation of anion transport(GO:0044070)
0.5 1.4 GO:0031098 stress-activated protein kinase signaling cascade(GO:0031098) regulation of stress-activated MAPK cascade(GO:0032872) stress-activated MAPK cascade(GO:0051403) regulation of stress-activated protein kinase signaling cascade(GO:0070302)
0.4 1.6 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.4 3.6 GO:0046777 protein autophosphorylation(GO:0046777)
0.4 1.2 GO:0090630 activation of GTPase activity(GO:0090630)
0.4 1.5 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.4 0.4 GO:0043270 positive regulation of ion transport(GO:0043270)
0.4 1.5 GO:0015846 polyamine transport(GO:0015846)
0.4 8.2 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.4 5.2 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.4 2.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4 1.1 GO:0006111 regulation of gluconeogenesis(GO:0006111)
0.4 1.8 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.4 1.8 GO:0000730 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.4 3.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.3 2.8 GO:0006817 phosphate ion transport(GO:0006817)
0.3 1.7 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.3 6.0 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.3 0.6 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of fatty acid metabolic process(GO:0045923)
0.3 4.5 GO:0000209 protein polyubiquitination(GO:0000209)
0.3 0.6 GO:0042148 strand invasion(GO:0042148)
0.3 7.0 GO:0008219 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.3 0.6 GO:0005980 glycogen catabolic process(GO:0005980)
0.3 2.5 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.3 2.7 GO:0006814 sodium ion transport(GO:0006814)
0.3 1.2 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.3 0.6 GO:0046033 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.3 0.3 GO:0052652 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.3 1.1 GO:0032102 regulation of macroautophagy(GO:0016241) negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.3 2.0 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.3 0.8 GO:0015851 nucleobase transport(GO:0015851)
0.3 1.1 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.3 2.2 GO:0018345 protein palmitoylation(GO:0018345)
0.3 3.3 GO:0045144 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.3 1.4 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.3 1.1 GO:0072367 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.3 1.1 GO:0031297 replication fork processing(GO:0031297)
0.3 0.8 GO:0019323 pentose metabolic process(GO:0019321) pentose catabolic process(GO:0019323)
0.3 1.3 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.3 1.3 GO:0019388 galactose catabolic process(GO:0019388)
0.3 0.5 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.3 0.5 GO:0032006 regulation of TOR signaling(GO:0032006)
0.3 1.3 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.3 1.0 GO:0031507 heterochromatin assembly(GO:0031507)
0.3 2.8 GO:0015893 drug transport(GO:0015893)
0.2 1.7 GO:0045332 phospholipid translocation(GO:0045332)
0.2 11.8 GO:0007031 peroxisome organization(GO:0007031)
0.2 1.7 GO:0009306 protein secretion(GO:0009306)
0.2 0.9 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.2 0.4 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.2 3.7 GO:0015918 sterol transport(GO:0015918)
0.2 0.2 GO:0090399 replicative senescence(GO:0090399)
0.2 0.4 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.2 1.3 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.2 1.3 GO:0045117 azole transport(GO:0045117)
0.2 0.2 GO:0000729 meiotic DNA double-strand break processing(GO:0000706) DNA double-strand break processing(GO:0000729)
0.2 0.4 GO:0000409 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.2 0.2 GO:0006740 NADPH regeneration(GO:0006740)
0.2 0.6 GO:0043954 cellular component maintenance(GO:0043954)
0.2 1.2 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.2 0.4 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.2 0.6 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.2 0.9 GO:0035601 protein deacetylation(GO:0006476) protein deacylation(GO:0035601) macromolecule deacylation(GO:0098732)
0.2 2.3 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.2 1.7 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.2 0.8 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.2 1.2 GO:0070058 tRNA gene clustering(GO:0070058)
0.2 1.0 GO:0072348 sulfur compound transport(GO:0072348)
0.2 6.1 GO:0042244 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.2 0.5 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.2 2.0 GO:0042026 protein refolding(GO:0042026)
0.2 1.8 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.2 0.3 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.2 0.5 GO:0042407 cristae formation(GO:0042407)
0.2 0.6 GO:0043200 response to amino acid(GO:0043200)
0.2 0.5 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.1 0.3 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178) negative regulation of histone modification(GO:0031057) histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.1 0.7 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.4 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.1 0.4 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 2.7 GO:0016579 protein deubiquitination(GO:0016579)
0.1 1.1 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 2.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 2.2 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 0.4 GO:0032069 regulation of nuclease activity(GO:0032069) positive regulation of nuclease activity(GO:0032075)
0.1 0.4 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.1 5.5 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 1.6 GO:0006094 gluconeogenesis(GO:0006094)
0.1 1.6 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 1.5 GO:0042493 response to drug(GO:0042493)
0.1 0.4 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 1.5 GO:0034401 chromatin organization involved in regulation of transcription(GO:0034401)
0.1 0.5 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.6 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.3 GO:0046471 phosphatidylglycerol metabolic process(GO:0046471)
0.1 1.0 GO:1901661 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.1 0.2 GO:0071456 cellular response to hypoxia(GO:0071456)
0.1 0.3 GO:0042173 regulation of sporulation resulting in formation of a cellular spore(GO:0042173)
0.1 0.7 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.1 0.3 GO:0009106 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.1 0.4 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.1 0.3 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 0.3 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.4 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.1 0.9 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.5 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.7 GO:0000103 sulfate assimilation(GO:0000103)
0.1 0.5 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)
0.1 1.1 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.1 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.9 GO:0001300 chronological cell aging(GO:0001300)
0.1 0.2 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.6 GO:0000755 cytogamy(GO:0000755)
0.1 0.3 GO:0006071 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.1 0.2 GO:0051230 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.1 0.2 GO:0023056 positive regulation of signal transduction(GO:0009967) positive regulation of signaling(GO:0023056)
0.1 0.9 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 0.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.1 0.2 GO:0001927 exocyst assembly(GO:0001927) exocyst localization(GO:0051601)
0.1 0.1 GO:0000821 regulation of glutamine family amino acid metabolic process(GO:0000820) regulation of arginine metabolic process(GO:0000821)
0.1 0.2 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.1 0.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.6 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.1 0.8 GO:0032258 CVT pathway(GO:0032258)
0.1 0.3 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.3 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.1 0.2 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 0.3 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.6 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.1 0.3 GO:0016574 histone ubiquitination(GO:0016574)
0.1 0.4 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.6 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.6 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.1 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.0 0.1 GO:0090527 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.0 0.2 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.3 GO:0006112 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.0 0.4 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.2 GO:0009250 glucan biosynthetic process(GO:0009250)
0.0 0.4 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.2 GO:0030866 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) cortical cytoskeleton organization(GO:0030865) cortical actin cytoskeleton organization(GO:0030866) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.0 0.3 GO:0046173 polyol biosynthetic process(GO:0046173)
0.0 1.4 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.2 GO:0015802 basic amino acid transport(GO:0015802)
0.0 0.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.3 GO:0090114 COPII-coated vesicle budding(GO:0090114)
0.0 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.0 0.6 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.1 GO:0045116 protein neddylation(GO:0045116)
0.0 0.5 GO:0006289 nucleotide-excision repair(GO:0006289)
0.0 0.0 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.0 0.4 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.1 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 1.6 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.2 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.0 0.1 GO:2000142 regulation of transcription initiation from RNA polymerase II promoter(GO:0060260) regulation of DNA-templated transcription, initiation(GO:2000142)
0.0 0.1 GO:0034968 histone lysine methylation(GO:0034968)
0.0 0.1 GO:0006298 mismatch repair(GO:0006298)
0.0 0.1 GO:0015677 copper ion import(GO:0015677)
0.0 0.1 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.1 GO:0006301 postreplication repair(GO:0006301)
0.0 0.4 GO:0051304 chromosome separation(GO:0051304)
0.0 0.0 GO:0042762 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of sulfur metabolic process(GO:0042762)
0.0 0.1 GO:0030474 spindle pole body duplication(GO:0030474)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 19.9 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
2.1 25.1 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.7 6.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.7 5.0 GO:0032585 multivesicular body membrane(GO:0032585)
1.4 11.2 GO:0042597 periplasmic space(GO:0042597)
1.1 20.5 GO:0070469 respiratory chain(GO:0070469)
0.9 2.7 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.9 2.6 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.9 2.6 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.8 3.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.8 2.3 GO:0046930 pore complex(GO:0046930)
0.7 4.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.7 39.8 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.7 3.9 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.6 9.7 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.6 1.2 GO:0030061 mitochondrial crista(GO:0030061)
0.5 6.6 GO:0005619 ascospore wall(GO:0005619)
0.5 5.4 GO:0005769 early endosome(GO:0005769)
0.5 1.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 3.0 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.4 1.5 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.4 6.3 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.3 1.7 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.3 7.7 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.3 2.1 GO:0033101 cellular bud membrane(GO:0033101)
0.3 0.9 GO:0034967 Set3 complex(GO:0034967)
0.3 0.6 GO:0032126 eisosome(GO:0032126)
0.3 2.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 2.0 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.3 1.9 GO:0034657 GID complex(GO:0034657)
0.3 0.8 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.3 12.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 4.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.2 0.7 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.2 27.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 0.9 GO:0000813 ESCRT I complex(GO:0000813)
0.2 1.1 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.2 2.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 2.1 GO:0005643 nuclear pore(GO:0005643)
0.2 1.6 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.2 0.9 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.2 7.9 GO:0031225 anchored component of membrane(GO:0031225)
0.2 0.7 GO:0032116 SMC loading complex(GO:0032116)
0.2 1.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 0.3 GO:0070211 Snt2C complex(GO:0070211)
0.2 0.6 GO:0033309 SBF transcription complex(GO:0033309)
0.2 0.5 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 0.2 GO:0005871 kinesin complex(GO:0005871)
0.2 2.1 GO:0000812 Swr1 complex(GO:0000812)
0.2 0.5 GO:0032301 MutSalpha complex(GO:0032301)
0.1 0.8 GO:0030008 TRAPP complex(GO:0030008)
0.1 2.4 GO:0098798 mitochondrial protein complex(GO:0098798)
0.1 0.7 GO:0044233 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.8 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 1.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 2.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.6 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 0.4 GO:0097196 Shu complex(GO:0097196)
0.1 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.3 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 0.5 GO:0005875 microtubule associated complex(GO:0005875)
0.1 1.7 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.1 0.4 GO:0008623 CHRAC(GO:0008623)
0.1 0.3 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.4 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.3 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 53.2 GO:0005739 mitochondrion(GO:0005739)
0.1 0.2 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 0.2 GO:0071013 U2-type catalytic step 2 spliceosome(GO:0071007) catalytic step 2 spliceosome(GO:0071013)
0.1 0.3 GO:0000243 commitment complex(GO:0000243)
0.1 0.4 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.8 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.3 GO:0071819 DUBm complex(GO:0071819)
0.1 0.4 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.5 GO:0031211 palmitoyltransferase complex(GO:0002178) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.4 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.2 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.0 0.1 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784)
0.0 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.3 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.3 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.1 GO:0070772 PAS complex(GO:0070772)
0.0 20.8 GO:0031224 intrinsic component of membrane(GO:0031224)
0.0 0.2 GO:0000133 polarisome(GO:0000133)
0.0 2.2 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.4 GO:0005682 U5 snRNP(GO:0005682)
0.0 1.2 GO:0005815 microtubule organizing center(GO:0005815) spindle pole body(GO:0005816)
0.0 0.1 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0000145 exocyst(GO:0000145)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.0 26.9 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
4.5 13.6 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
4.5 18.0 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
3.6 14.3 GO:0005537 mannose binding(GO:0005537)
3.0 9.1 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
2.8 14.2 GO:0015295 solute:proton symporter activity(GO:0015295)
2.5 12.3 GO:0008198 ferrous iron binding(GO:0008198)
2.4 7.1 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
2.4 9.4 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
1.8 14.7 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.8 5.4 GO:0005536 glucose binding(GO:0005536)
1.6 17.3 GO:0015293 symporter activity(GO:0015293)
1.5 14.5 GO:0015297 antiporter activity(GO:0015297)
1.4 4.2 GO:0016289 CoA hydrolase activity(GO:0016289)
1.3 5.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.3 3.9 GO:0015385 sodium:proton antiporter activity(GO:0015385)
1.3 10.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.2 3.7 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
1.2 4.9 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
1.2 3.6 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
1.1 4.6 GO:0004396 hexokinase activity(GO:0004396)
1.1 5.3 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.0 4.9 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
1.0 14.3 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.9 3.7 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.9 5.5 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.9 4.5 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.9 2.7 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.9 2.7 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.9 12.3 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.9 2.6 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.8 8.3 GO:0035064 methylated histone binding(GO:0035064)
0.8 2.3 GO:0022829 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.7 2.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.7 7.8 GO:0004888 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.7 5.0 GO:0051920 thioredoxin peroxidase activity(GO:0008379) peroxiredoxin activity(GO:0051920)
0.6 3.2 GO:0016408 C-acyltransferase activity(GO:0016408)
0.6 2.5 GO:0016531 copper chaperone activity(GO:0016531)
0.6 1.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.6 4.2 GO:0016597 amino acid binding(GO:0016597)
0.6 5.7 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.6 9.0 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.5 0.5 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.5 2.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.5 2.6 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.5 3.0 GO:0000400 four-way junction DNA binding(GO:0000400)
0.5 1.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.5 1.4 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 22.5 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.5 1.4 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.4 7.3 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.4 2.1 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.4 2.1 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.4 1.3 GO:0008169 C-methyltransferase activity(GO:0008169)
0.4 4.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.4 7.6 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 1.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.4 1.2 GO:0031072 heat shock protein binding(GO:0031072)
0.4 9.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.4 3.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.4 2.9 GO:0010181 FMN binding(GO:0010181)
0.4 2.1 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.4 1.1 GO:0000150 recombinase activity(GO:0000150)
0.4 1.4 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.3 1.4 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.3 2.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.3 1.4 GO:0019776 Atg8 ligase activity(GO:0019776)
0.3 1.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.3 1.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 4.1 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.3 2.4 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.3 0.9 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.3 5.0 GO:0051287 NAD binding(GO:0051287)
0.3 3.5 GO:0050661 NADP binding(GO:0050661)
0.3 2.0 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.3 2.5 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 0.8 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.3 2.3 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 2.2 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.2 1.2 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.2 5.8 GO:0003684 damaged DNA binding(GO:0003684)
0.2 5.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 0.7 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.2 0.5 GO:0015038 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.2 1.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 2.1 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.2 0.9 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.2 0.7 GO:0016417 S-acyltransferase activity(GO:0016417)
0.2 4.6 GO:0042802 identical protein binding(GO:0042802)
0.2 1.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 1.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 1.1 GO:0045118 azole transporter activity(GO:0045118)
0.2 1.0 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.2 3.7 GO:0008301 DNA binding, bending(GO:0008301)
0.2 0.5 GO:0032183 SUMO binding(GO:0032183)
0.2 1.6 GO:0001671 ATPase activator activity(GO:0001671)
0.2 4.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 2.0 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.2 0.5 GO:0030060 malate dehydrogenase activity(GO:0016615) L-malate dehydrogenase activity(GO:0030060)
0.2 1.1 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.2 5.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 2.1 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.1 1.0 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.4 GO:0004458 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.1 0.6 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.1 0.1 GO:0016530 metallochaperone activity(GO:0016530)
0.1 2.2 GO:0031491 nucleosome binding(GO:0031491)
0.1 9.8 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.5 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.1 0.4 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 1.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 1.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 1.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.4 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 1.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 1.3 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.8 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.9 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.2 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 1.2 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.3 GO:0004629 phospholipase C activity(GO:0004629)
0.1 0.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 2.0 GO:0019901 kinase binding(GO:0019900) protein kinase binding(GO:0019901)
0.1 1.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.3 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 0.3 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.1 1.8 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 8.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 0.2 GO:0003951 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.1 0.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 1.6 GO:0005509 calcium ion binding(GO:0005509)
0.1 0.3 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.1 0.2 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.1 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.5 GO:0005548 phospholipid transporter activity(GO:0005548)
0.1 2.3 GO:0043130 ubiquitin binding(GO:0043130)
0.1 0.2 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.1 4.9 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 1.1 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 0.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.3 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 0.4 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 1.0 GO:0050662 coenzyme binding(GO:0050662)
0.1 0.9 GO:0008374 O-acyltransferase activity(GO:0008374)
0.1 0.3 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.3 GO:0005507 copper ion binding(GO:0005507)
0.0 1.0 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.3 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.2 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.4 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.0 0.1 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 1.2 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 0.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.4 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.2 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 1.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.0 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.0 0.1 GO:0004672 protein kinase activity(GO:0004672)
0.0 0.1 GO:0005102 receptor binding(GO:0005102)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.3 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.9 3.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.7 2.0 PID AP1 PATHWAY AP-1 transcription factor network
0.5 2.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.4 0.7 PID ATF2 PATHWAY ATF-2 transcription factor network
0.3 1.0 PID FOXO PATHWAY FoxO family signaling
0.3 0.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.3 2.0 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 0.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 0.2 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1 0.4 PID AURORA B PATHWAY Aurora B signaling
0.1 0.7 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 175.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 0.3 PID P73PATHWAY p73 transcription factor network
0.1 0.2 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 0.1 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.0 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.4 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
1.6 4.9 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.9 7.8 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.8 2.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.5 0.9 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.2 1.4 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.2 0.2 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.1 1.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.8 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 172.0 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 1.0 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.3 REACTOME INNATE IMMUNE SYSTEM Genes involved in Innate Immune System
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.0 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.3 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.0 0.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein