Results for YKL222C
Z-value: 1.46
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Transcription factors associated with YKL222C
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| S000001705 | Protein of unknown function that may interact with ribosomes |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YIL057C Show fit | 20.21 |
Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose |
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| YML042W Show fit | 18.89 |
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes |
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| YJR095W Show fit | 16.09 |
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization |
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| YLR174W Show fit | 13.63 |
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose |
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| YPL171C Show fit | 13.26 |
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism |
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| YAR053W Show fit | 12.96 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YJR048W Show fit | 12.35 |
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration |
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| YOR343C Show fit | 12.35 |
Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data |
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| YNL194C Show fit | 11.77 |
Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS |
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| YDL244W Show fit | 11.57 |
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 |
Network of associatons between targets according to the STRING database.
First level regulatory network of YKL222C
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 36.3 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
| 3.2 | 32.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 9.0 | 26.9 | GO:0009437 | amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437) |
| 1.3 | 21.4 | GO:0009062 | fatty acid catabolic process(GO:0009062) |
| 1.2 | 17.9 | GO:0015696 | ammonium transport(GO:0015696) |
| 5.4 | 16.1 | GO:0015740 | C4-dicarboxylate transport(GO:0015740) |
| 0.9 | 15.2 | GO:0042724 | thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724) |
| 0.7 | 13.4 | GO:0015749 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 2.2 | 13.0 | GO:0000128 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
| 0.2 | 11.8 | GO:0007031 | peroxisome organization(GO:0007031) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 53.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.7 | 39.8 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.2 | 27.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 2.1 | 25.1 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 20.8 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 1.1 | 20.5 | GO:0070469 | respiratory chain(GO:0070469) |
| 2.2 | 19.9 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.3 | 12.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 1.4 | 11.2 | GO:0042597 | periplasmic space(GO:0042597) |
| 0.6 | 9.7 | GO:0005753 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.0 | 26.9 | GO:0016406 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 0.5 | 22.5 | GO:0001228 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 4.5 | 18.0 | GO:0015556 | C4-dicarboxylate transmembrane transporter activity(GO:0015556) |
| 1.6 | 17.3 | GO:0015293 | symporter activity(GO:0015293) |
| 1.8 | 14.7 | GO:0016679 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 1.5 | 14.5 | GO:0015297 | antiporter activity(GO:0015297) |
| 3.6 | 14.3 | GO:0005537 | mannose binding(GO:0005537) |
| 1.0 | 14.3 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 2.8 | 14.2 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 4.5 | 13.6 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 175.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 1.3 | 3.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.9 | 3.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.5 | 2.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.7 | 2.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.3 | 2.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.3 | 1.0 | PID FOXO PATHWAY | FoxO family signaling |
| 0.4 | 0.7 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 0.7 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.2 | 0.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 172.0 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 4.1 | 12.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.9 | 7.8 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 1.6 | 4.9 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.8 | 2.4 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 1.4 | REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | Genes involved in Transmembrane transport of small molecules |
| 0.1 | 1.2 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.1 | 1.0 | REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.5 | 0.9 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.1 | 0.8 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |