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Results for YJL103C

Z-value: 0.76

Activity profile of YJL103C motif

Sorted Z-values of YJL103C motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YOR348C 13.52
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YER065C 8.92
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YNL144C 8.81 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YLR377C 8.75
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YJR048W 8.17
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YKR097W 7.74
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YPL024W 7.42
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YMR206W 6.99 Putative protein of unknown function; YMR206W is not an essential gene
YNL142W 6.81
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YLR122C 6.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YNL117W 6.71
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YPL026C 6.07
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YIL057C 6.04 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YLR174W 6.01
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YLR312C 5.95
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YAR035W 5.91
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YFR053C 5.88
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YLR356W 5.87 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YKL109W 5.60
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YLR123C 5.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YCR005C 5.52
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YHR096C 5.46
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YAR053W 4.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL043W 4.86
ECM13
Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YNL305C 4.83 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YBL064C 4.82
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YNL190W 4.75 Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YNL143C 4.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR095W 4.65
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YPL250C 4.53
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YDR298C 4.51
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YJL045W 4.42 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YDL210W 4.28
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YPR007C 4.23
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YDR343C 4.20
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YLR124W 4.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR327C 4.02
TMA10
Protein of unknown function that associates with ribosomes
YER067C-A 3.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
YMR090W 3.81 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YEL012W 3.78
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YAR060C 3.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL085W 3.66
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YGL191W 3.65
COX13
Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YPR036W-A 3.64 Protein of unknown function; transcription is regulated by Pdr1p
YDR216W 3.58
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YER158C 3.55 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YKL217W 3.48
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YOR343C 3.40 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YBR105C 3.28
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YLR125W 3.26 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YAL039C 3.21
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YHR212C 3.17 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL223C 3.15
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YER150W 3.13
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YGR045C 3.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR120W 3.09
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YPR030W 3.09
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YPL017C 3.06
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YAL054C 3.03
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YER033C 2.99
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YBL049W 2.99
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YKL171W 2.89 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YGR243W 2.89
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL082W 2.88
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YOL051W 2.84
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YNR034W-A 2.84 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YGR032W 2.82
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YFL054C 2.81 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YHR212W-A 2.81 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YMR191W 2.80
SPG5
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YPR026W 2.77
ATH1
Acid trehalase required for utilization of extracellular trehalose
YDR178W 2.77
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YGL192W 2.73
IME4
Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YMR256C 2.70
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YGL193C 2.68 Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YEL049W 2.66
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YKL163W 2.65
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YEL060C 2.64
PRB1
Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YLL029W 2.62
FRA1
Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
YEL008W 2.61 Hypothetical protein predicted to be involved in metabolism
YLL053C 2.58 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YMR135C 2.53
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YEL009C 2.48
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YPL025C 2.48 Hypothetical protein
YMR107W 2.47
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YDR277C 2.47
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YER066W 2.43 Putative protein of unknown function; YER066W is not an essential gene
YFR033C 2.40
QCR6
Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
YAR050W 2.40
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YJL133C-A 2.33 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER088C 2.32
DOT6
Protein of unknown function, involved in telomeric gene silencing and filamentation
YLL052C 2.31
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YOR139C 2.31 Hypothetical protein
YML081C-A 2.30
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YEL039C 2.30
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YCL054W 2.29
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YLR304C 2.29
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YDR070C 2.28
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL183C 2.26
MND1
Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks
YDL194W 2.25
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YJL116C 2.23
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YDR096W 2.23
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YDR036C 2.22
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YKL148C 2.21
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YDL223C 2.20
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YML089C 2.20 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YOR140W 2.20
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YCR021C 2.20
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YPL262W 2.19
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YPL089C 2.17
RLM1
MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YBR179C 2.16
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YBR230C 2.16
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YJR146W 2.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YMR272C 2.13
SCS7
Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YBL015W 2.10
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YJL152W 2.08 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR040W 2.08
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YLL041C 2.08
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YOL052C-A 2.04
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YKL093W 2.03
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YGL072C 2.02 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YLR402W 2.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL180C 2.00
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YLR403W 1.98
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YPR001W 1.98
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YMR244W 1.97 Putative protein of unknown function
YFR017C 1.91 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YAR047C 1.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML042W 1.89
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YBR021W 1.87
FUR4
Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues
YER015W 1.86
FAA2
Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids
YCL001W-B 1.85 Putative protein of unknown function; identified by homology
YPR006C 1.85
ICL2
2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YOR381W 1.84
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YLL009C 1.84
COX17
Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase
YMR271C 1.83
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YIL125W 1.83
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YBL078C 1.81
ATG8
Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YML120C 1.78
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YKR101W 1.77
SIR1
Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
YMR250W 1.77
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YHR015W 1.77
MIP6
Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YIR029W 1.76
DAL2
Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YBR117C 1.75
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YBR047W 1.75
FMP23
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL248W 1.74
PDE1
Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
YER014C-A 1.74
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YBR145W 1.73
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YDR313C 1.73
PIB1
RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YBR116C 1.73 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YPL156C 1.73
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YNL179C 1.72 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YPL229W 1.70 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene
YJR078W 1.69
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YDR173C 1.68
ARG82
Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
YIL162W 1.68
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YGL062W 1.67
PYC1
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YMR081C 1.66
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YOR374W 1.64
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YFL053W 1.63
DAK2
Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YDR406W 1.62
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YPR002W 1.61
PDH1
Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YCR007C 1.61 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YIL023C 1.59
YKE4
Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
YDR342C 1.59
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YPR061C 1.58
JID1
Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
YKR100C 1.58
SKG1
Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
YDR452W 1.57
PPN1
Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
YJR138W 1.57
IML1
Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YGL045W 1.55
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YMR280C 1.54
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YPL088W 1.53 Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YMR165C 1.52
PAH1
Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1
YFL052W 1.52 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YIL024C 1.52 Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
YLR259C 1.51
HSP60
Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YFL021W 1.51
GAT1
Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
YDR536W 1.51
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YMR311C 1.51
GLC8
Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2
YLR004C 1.50
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YOR382W 1.50
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YMR056C 1.50
AAC1
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YOR100C 1.49
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YKL031W 1.49 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YBR046C 1.47
ZTA1
Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity
YMR175W 1.47
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YGL134W 1.46
PCL10
Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
YNL240C 1.44
NAR1
Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf
YNL277W-A 1.43 Putative protein of unknown function
YMR068W 1.43
AVO2
Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YJR085C 1.43 Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL045C 1.42
COR1
Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
YBR076C-A 1.41 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR
YKR009C 1.41
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YGL056C 1.40
SDS23
One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation
YCR068W 1.40
ATG15
Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YBR297W 1.37
MAL33
MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YBR180W 1.37
DTR1
Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
YML090W 1.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YDR102C 1.36 Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index

Network of associatons between targets according to the STRING database.

First level regulatory network of YJL103C

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 13.1 GO:0015804 neutral amino acid transport(GO:0015804)
3.2 28.4 GO:0006097 glyoxylate cycle(GO:0006097)
2.6 7.8 GO:0015755 fructose transport(GO:0015755)
2.6 7.8 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
2.3 6.9 GO:0072488 ammonium transmembrane transport(GO:0072488)
1.9 7.7 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
1.8 5.4 GO:0019629 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
1.6 6.4 GO:0006848 pyruvate transport(GO:0006848)
1.5 13.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
1.4 4.3 GO:0046321 regulation of fatty acid beta-oxidation(GO:0031998) positive regulation of fatty acid beta-oxidation(GO:0032000) regulation of fatty acid oxidation(GO:0046320) positive regulation of fatty acid oxidation(GO:0046321)
1.4 7.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.2 9.5 GO:0015758 glucose transport(GO:0015758)
1.1 3.3 GO:0015740 C4-dicarboxylate transport(GO:0015740)
1.1 3.3 GO:0051469 vesicle fusion with vacuole(GO:0051469)
1.1 3.2 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
1.1 3.2 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.0 3.1 GO:0006740 NADPH regeneration(GO:0006740)
1.0 3.1 GO:0042843 D-xylose catabolic process(GO:0042843)
1.0 2.9 GO:0005993 trehalose catabolic process(GO:0005993)
1.0 2.9 GO:0010039 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.9 2.8 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.9 9.7 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.9 12.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.9 25.7 GO:0006094 gluconeogenesis(GO:0006094)
0.8 3.2 GO:0015847 putrescine transport(GO:0015847)
0.8 3.8 GO:0006083 acetate metabolic process(GO:0006083)
0.8 0.8 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.7 2.8 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.7 4.2 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.6 5.6 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.6 4.8 GO:0015891 siderophore transport(GO:0015891)
0.6 4.1 GO:0000023 maltose metabolic process(GO:0000023)
0.6 1.8 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.6 1.8 GO:0006538 glutamate catabolic process(GO:0006538)
0.6 1.8 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.6 1.7 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.6 1.1 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.6 2.2 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.6 7.2 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.5 2.7 GO:0043605 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.5 3.2 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.5 1.6 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.5 1.6 GO:0036257 multivesicular body organization(GO:0036257)
0.5 4.0 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.5 7.5 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.5 2.0 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.5 4.9 GO:0042773 respiratory electron transport chain(GO:0022904) ATP synthesis coupled electron transport(GO:0042773) mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.5 1.5 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.5 2.9 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.5 2.4 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.5 2.4 GO:0072523 purine-containing compound catabolic process(GO:0072523)
0.5 3.3 GO:0006007 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.5 5.6 GO:0046686 response to cadmium ion(GO:0046686)
0.5 1.4 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.5 1.8 GO:0015680 intracellular copper ion transport(GO:0015680)
0.4 0.9 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.4 2.2 GO:0008053 mitochondrial fusion(GO:0008053)
0.4 1.3 GO:0006545 glycine biosynthetic process(GO:0006545)
0.4 1.7 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.4 2.1 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.4 1.2 GO:0015888 thiamine transport(GO:0015888)
0.4 1.6 GO:0015886 heme transport(GO:0015886)
0.4 1.6 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.4 2.4 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.4 4.5 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.4 13.4 GO:0009060 aerobic respiration(GO:0009060)
0.4 1.5 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.4 1.1 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.4 1.8 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.3 1.4 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.3 8.3 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.3 0.7 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.3 1.3 GO:0043200 response to amino acid(GO:0043200)
0.3 1.3 GO:0044070 regulation of anion transport(GO:0044070)
0.3 2.3 GO:0006829 zinc II ion transport(GO:0006829)
0.3 1.0 GO:0043270 positive regulation of ion transport(GO:0043270)
0.3 0.9 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.3 0.6 GO:0071241 cellular response to inorganic substance(GO:0071241)
0.3 0.3 GO:0019627 urea metabolic process(GO:0019627)
0.3 0.6 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.3 1.4 GO:0010255 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.3 0.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.3 1.1 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.3 0.8 GO:0006598 polyamine catabolic process(GO:0006598)
0.3 0.8 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.2 2.2 GO:0071709 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.2 1.5 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.2 0.7 GO:0008216 spermidine metabolic process(GO:0008216)
0.2 0.7 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.2 0.7 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.2 1.2 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.2 0.9 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.2 1.8 GO:0031167 rRNA methylation(GO:0031167)
0.2 0.5 GO:0045128 negative regulation of reciprocal meiotic recombination(GO:0045128)
0.2 0.4 GO:0006687 glycosphingolipid metabolic process(GO:0006687) glycosphingolipid biosynthetic process(GO:0006688)
0.2 0.4 GO:0009251 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.2 1.1 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.2 0.4 GO:0071456 cellular response to hypoxia(GO:0071456)
0.2 0.2 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.2 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.2 2.3 GO:0000767 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753) cell morphogenesis involved in conjugation(GO:0000767)
0.2 0.8 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 0.8 GO:0072529 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357) pyrimidine-containing compound catabolic process(GO:0072529)
0.2 0.4 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.2 0.8 GO:0032373 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.2 1.1 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.2 0.2 GO:0043970 histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.2 0.6 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.2 3.9 GO:0016579 protein deubiquitination(GO:0016579)
0.2 0.2 GO:0034440 fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
0.2 0.9 GO:0044746 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.2 0.9 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.2 0.5 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.2 0.7 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.2 0.2 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.2 1.3 GO:0045332 phospholipid translocation(GO:0045332)
0.2 0.6 GO:0060194 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.2 0.5 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.2 0.2 GO:0050685 positive regulation of mRNA processing(GO:0050685)
0.2 0.3 GO:0006311 meiotic gene conversion(GO:0006311)
0.2 0.8 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.1 0.4 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 1.0 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.7 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 2.0 GO:0001101 response to acid chemical(GO:0001101)
0.1 1.8 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.1 2.8 GO:0031503 protein complex localization(GO:0031503)
0.1 0.8 GO:0010969 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0010969) regulation of signal transduction involved in conjugation with cellular fusion(GO:0060238)
0.1 2.9 GO:0008361 regulation of cell size(GO:0008361)
0.1 0.5 GO:0015793 glycerol transport(GO:0015793)
0.1 2.9 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.6 GO:0070941 eisosome assembly(GO:0070941)
0.1 0.4 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.1 1.3 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 0.5 GO:0098630 aggregation of unicellular organisms(GO:0098630) cell aggregation(GO:0098743)
0.1 1.1 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 0.5 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.2 GO:0042148 strand invasion(GO:0042148)
0.1 0.3 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 0.2 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 0.2 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 0.6 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.5 GO:0009209 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.1 0.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.1 0.5 GO:0043954 cellular component maintenance(GO:0043954)
0.1 0.3 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.4 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.1 0.3 GO:0042407 cristae formation(GO:0042407)
0.1 1.2 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.1 0.3 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.1 0.1 GO:0007032 endosome organization(GO:0007032)
0.1 0.4 GO:0051274 beta-glucan biosynthetic process(GO:0051274)
0.1 4.4 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 0.6 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.1 0.1 GO:0006265 DNA topological change(GO:0006265)
0.1 0.7 GO:0042819 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1 0.1 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.1 3.0 GO:0070726 cell wall assembly(GO:0070726)
0.1 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 1.2 GO:0000902 cell morphogenesis(GO:0000902)
0.1 1.2 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.4 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 0.1 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.1 0.6 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.1 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.1 0.1 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.1 0.3 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.1 0.1 GO:0051098 regulation of binding(GO:0051098)
0.1 1.2 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.1 0.3 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.1 0.1 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 1.0 GO:0001558 regulation of cell growth(GO:0001558)
0.1 0.3 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) peptidyl-histidine modification(GO:0018202)
0.1 0.4 GO:0070058 tRNA gene clustering(GO:0070058)
0.1 0.5 GO:0051294 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.1 0.3 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 1.4 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.1 0.3 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 0.3 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.2 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.1 0.2 GO:0006048 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.3 GO:0015677 copper ion import(GO:0015677)
0.1 0.1 GO:0042743 hydrogen peroxide metabolic process(GO:0042743)
0.1 0.1 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.1 0.9 GO:0006915 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.1 0.5 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.1 0.3 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.0 0.1 GO:0071168 protein localization to chromatin(GO:0071168)
0.0 0.5 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.0 0.3 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.6 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.3 GO:2000242 negative regulation of reproductive process(GO:2000242)
0.0 0.3 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.7 GO:0030474 spindle pole body duplication(GO:0030474)
0.0 0.1 GO:0045117 azole transport(GO:0045117)
0.0 0.2 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.0 0.2 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.0 0.2 GO:0006816 calcium ion transport(GO:0006816)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.2 GO:0043461 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.0 0.1 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.0 0.2 GO:0048209 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport(GO:0060628) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 0.1 GO:0035690 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.0 0.1 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.0 0.1 GO:0019933 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.0 0.4 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.2 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856) 'de novo' UMP biosynthetic process(GO:0044205)
0.0 0.1 GO:0043007 maintenance of rDNA(GO:0043007)
0.0 0.2 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.6 GO:0098660 inorganic ion transmembrane transport(GO:0098660)
0.0 0.5 GO:0042493 response to drug(GO:0042493)
0.0 0.1 GO:0000348 mRNA branch site recognition(GO:0000348)
0.0 0.1 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.2 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.1 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.3 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.0 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.1 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.0 0.2 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.5 GO:0007031 peroxisome organization(GO:0007031)
0.0 0.1 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.1 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.2 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627) mitochondrial protein processing(GO:0034982)
0.0 0.0 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of sulfur metabolic process(GO:0042762)
0.0 0.0 GO:0009106 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.0 0.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.0 GO:0015786 pyrimidine nucleotide-sugar transport(GO:0015781) UDP-glucose transport(GO:0015786)
0.0 0.0 GO:0090527 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.0 0.4 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
1.9 5.8 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
1.6 6.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.4 11.3 GO:0042597 periplasmic space(GO:0042597)
1.4 7.1 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.0 21.4 GO:0070469 respiratory chain(GO:0070469)
1.0 2.9 GO:0045252 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.8 2.5 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.8 5.8 GO:0034657 GID complex(GO:0034657)
0.7 4.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.7 2.8 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.6 7.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.5 1.6 GO:0032585 multivesicular body membrane(GO:0032585)
0.5 1.5 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.5 3.0 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.5 1.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 1.3 GO:0046930 pore complex(GO:0046930)
0.4 1.2 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.4 1.2 GO:0032807 DNA ligase IV complex(GO:0032807)
0.4 3.2 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.4 2.5 GO:0034967 Set3 complex(GO:0034967)
0.3 5.2 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.3 1.3 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.3 14.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 1.8 GO:0031932 TORC2 complex(GO:0031932)
0.3 0.9 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.2 1.5 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.2 0.5 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 0.2 GO:0000974 Prp19 complex(GO:0000974)
0.2 1.6 GO:0033101 cellular bud membrane(GO:0033101)
0.2 1.4 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 0.7 GO:0031901 early endosome membrane(GO:0031901)
0.2 0.5 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.2 1.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.2 1.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 0.3 GO:0001400 mating projection base(GO:0001400)
0.2 0.6 GO:0030666 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.2 22.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 1.1 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.1 4.0 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 2.9 GO:0070847 core mediator complex(GO:0070847)
0.1 0.7 GO:0032221 Rpd3S complex(GO:0032221)
0.1 0.6 GO:0098797 plasma membrane protein complex(GO:0098797)
0.1 0.7 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.9 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 6.9 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.8 GO:0032126 eisosome(GO:0032126)
0.1 0.2 GO:0070211 Snt2C complex(GO:0070211)
0.1 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 5.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.0 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.3 GO:0032301 MutSalpha complex(GO:0032301)
0.1 0.6 GO:0033263 CORVET complex(GO:0033263)
0.1 0.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.3 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.1 1.4 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 1.8 GO:0005811 lipid particle(GO:0005811)
0.1 1.0 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 0.4 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.1 0.3 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.3 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.1 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.3 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.1 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.4 GO:0031160 ascospore wall(GO:0005619) spore wall(GO:0031160)
0.1 1.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.2 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 0.9 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 0.9 GO:0098798 mitochondrial protein complex(GO:0098798)
0.0 2.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.3 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.2 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.0 0.2 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 3.8 GO:0042995 mating projection(GO:0005937) cell projection(GO:0042995)
0.0 0.5 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.2 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784)
0.0 0.1 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 5.0 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.0 0.2 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0005769 early endosome(GO:0005769)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 0.1 GO:0043291 RAVE complex(GO:0043291)
0.0 0.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 1.7 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.2 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.0 0.1 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.1 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 0.0 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 7.5 GO:0005739 mitochondrion(GO:0005739)
0.0 0.1 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.0 0.1 GO:0033698 Rpd3L complex(GO:0033698)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 14.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
2.8 8.3 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
2.6 7.8 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
2.0 10.2 GO:0015295 solute:proton symporter activity(GO:0015295)
2.0 6.1 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
2.0 5.9 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.7 8.6 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.5 10.8 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.4 4.3 GO:0016289 CoA hydrolase activity(GO:0016289)
1.4 7.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.4 5.6 GO:0004396 hexokinase activity(GO:0004396)
1.3 7.8 GO:0000400 four-way junction DNA binding(GO:0000400)
1.1 3.3 GO:0016208 AMP binding(GO:0016208)
1.0 4.0 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
1.0 11.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.0 2.9 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.0 2.9 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.9 2.8 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.9 2.8 GO:0005536 glucose binding(GO:0005536)
0.9 7.0 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.8 3.3 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.8 2.5 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.8 3.3 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091) TFIIH-class transcription factor binding(GO:0001097)
0.8 3.2 GO:0005537 mannose binding(GO:0005537)
0.8 3.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.8 1.5 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.7 2.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.7 1.5 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.7 2.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.6 6.4 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.6 1.7 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.6 2.3 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.5 3.0 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.5 3.8 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.5 8.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.5 1.8 GO:0016531 copper chaperone activity(GO:0016531)
0.4 1.3 GO:0015288 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.4 3.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.4 1.7 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.4 1.3 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.4 1.3 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.4 1.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.4 1.7 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.4 1.6 GO:0005471 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.4 2.0 GO:0015294 solute:cation symporter activity(GO:0015294)
0.4 6.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.4 1.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.4 6.7 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.4 1.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.4 1.1 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.4 1.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.4 3.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 3.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.3 2.6 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.3 4.1 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.3 2.8 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.3 2.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 2.3 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.3 1.1 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.3 1.4 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.3 2.7 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.3 0.8 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.3 0.8 GO:0015658 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.2 0.7 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.2 2.2 GO:0022838 substrate-specific channel activity(GO:0022838)
0.2 0.7 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.2 1.6 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.2 0.9 GO:0008198 ferrous iron binding(GO:0008198)
0.2 0.4 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.2 0.2 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.2 0.4 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.2 1.0 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.2 1.9 GO:0004177 aminopeptidase activity(GO:0004177)
0.2 0.7 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.2 2.4 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.2 0.9 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.2 0.4 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.2 0.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 0.3 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.2 1.3 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.2 1.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 1.5 GO:0015297 antiporter activity(GO:0015297)
0.2 1.0 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.2 1.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 3.8 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.2 0.5 GO:0008169 C-methyltransferase activity(GO:0008169)
0.2 0.6 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.2 2.1 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.1 0.4 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.1 1.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 0.4 GO:0032183 SUMO binding(GO:0032183)
0.1 0.5 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 0.5 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.4 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 0.5 GO:0045118 azole transporter activity(GO:0045118)
0.1 1.0 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.1 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.1 2.0 GO:0050661 NADP binding(GO:0050661)
0.1 0.5 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.5 GO:0051213 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) dioxygenase activity(GO:0051213)
0.1 0.2 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 0.3 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.1 0.5 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 2.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.1 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.1 1.8 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 0.1 GO:0016530 metallochaperone activity(GO:0016530)
0.1 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.6 GO:0042887 amide transmembrane transporter activity(GO:0042887)
0.1 2.7 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 3.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.3 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 1.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.2 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.8 GO:0008374 O-acyltransferase activity(GO:0008374)
0.1 0.2 GO:0005034 osmosensor activity(GO:0005034)
0.1 2.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 0.8 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 4.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 1.0 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.3 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.2 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 0.4 GO:0038023 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.1 0.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 1.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 1.4 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 0.7 GO:0046961 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 0.5 GO:0043140 3'-5' DNA helicase activity(GO:0043138) ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.3 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.7 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 1.3 GO:0030674 protein binding, bridging(GO:0030674) binding, bridging(GO:0060090)
0.0 0.1 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.0 0.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.6 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.1 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.1 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.0 0.1 GO:0005102 receptor binding(GO:0005102)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.0 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.0 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.9 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.1 GO:0019239 deaminase activity(GO:0019239)
0.0 0.0 GO:0046527 glucosyltransferase activity(GO:0046527)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.2 3.5 PID IL4 2PATHWAY IL4-mediated signaling events
0.9 2.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.9 7.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.4 1.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 1.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 0.3 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 0.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 0.3 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.1 0.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 0.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.0 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 52.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.2 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
2.0 17.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.4 4.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.5 1.4 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.4 1.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.4 0.7 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.3 2.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.3 0.3 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.2 0.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 0.3 REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
0.1 1.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 0.3 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.1 0.9 REACTOME DNA REPAIR Genes involved in DNA Repair
0.1 0.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.1 REACTOME SIGNALING BY NOTCH Genes involved in Signaling by NOTCH
0.0 52.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME MEMBRANE TRAFFICKING Genes involved in Membrane Trafficking
0.0 0.0 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C