Results for YJL103C
Z-value: 0.76
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YOR348C Show fit | 13.52 |
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells |
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| YER065C Show fit | 8.92 |
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose |
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| YNL144C Show fit | 8.81 |
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene |
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| YLR377C Show fit | 8.75 |
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism |
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| YJR048W Show fit | 8.17 |
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration |
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| YKR097W Show fit | 7.74 |
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
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| YPL024W Show fit | 7.42 |
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III) |
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| YMR206W Show fit | 6.99 |
Putative protein of unknown function; YMR206W is not an essential gene |
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| YNL142W Show fit | 6.81 |
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation |
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| YLR122C Show fit | 6.75 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C |
Network of associatons between targets according to the STRING database.
First level regulatory network of YJL103C
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 28.4 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.9 | 25.7 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 0.4 | 13.4 | GO:0009060 | aerobic respiration(GO:0009060) |
| 1.5 | 13.2 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 3.3 | 13.1 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.9 | 12.3 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.9 | 9.7 | GO:0006101 | tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101) |
| 1.2 | 9.5 | GO:0015758 | glucose transport(GO:0015758) |
| 0.3 | 8.3 | GO:0000422 | mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726) |
| 2.6 | 7.8 | GO:0015755 | fructose transport(GO:0015755) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 22.6 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 1.0 | 21.4 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.3 | 14.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 1.4 | 11.3 | GO:0042597 | periplasmic space(GO:0042597) |
| 2.6 | 7.9 | GO:0031422 | RecQ helicase-Topo III complex(GO:0031422) |
| 0.0 | 7.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.4 | 7.1 | GO:0045273 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.6 | 7.1 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 6.9 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 1.6 | 6.3 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 14.0 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 1.0 | 11.0 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 1.5 | 10.8 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 2.0 | 10.2 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.5 | 8.8 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 1.7 | 8.6 | GO:0050308 | sugar-phosphatase activity(GO:0050308) |
| 2.8 | 8.3 | GO:0036440 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 2.6 | 7.8 | GO:0016406 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 1.3 | 7.8 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 1.4 | 7.1 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 52.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 2.8 | 8.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.9 | 7.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 1.2 | 3.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.9 | 2.6 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.2 | 1.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 1.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 0.3 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.1 | 0.3 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 0.3 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 52.4 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 2.0 | 17.7 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 2.7 | 8.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 1.4 | 4.2 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.3 | 2.5 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.4 | 1.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.5 | 1.4 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 1.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 0.9 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.4 | 0.7 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |