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Results for YER184C

Z-value: 0.80

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Transcription factors associated with YER184C

Gene Symbol Gene ID Gene Info
S000000986 Putative zinc cluster protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
YER184C0.572.6e-03Click!

Activity profile of YER184C motif

Sorted Z-values of YER184C motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YOR348C 7.23
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YAR035W 6.37
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YER065C 5.87
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YLR377C 4.96
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YPL026C 4.94
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YLR402W 4.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL024W 4.79
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YLR122C 4.79 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YBL043W 4.55
ECM13
Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YAR053W 4.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR403W 4.26
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YLR123C 4.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YDR343C 3.94
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YOL084W 3.91
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YAL062W 3.73
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YMR244W 3.68 Putative protein of unknown function
YIL057C 3.64 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YBL064C 3.62
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YKR097W 3.60
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YLR174W 3.45
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YNL180C 3.43
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YNL179C 3.38 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YJL045W 3.36 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YML089C 3.30 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YMR206W 3.29 Putative protein of unknown function; YMR206W is not an essential gene
YOL085W-A 3.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YAL039C 3.28
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YPR036W-A 3.28 Protein of unknown function; transcription is regulated by Pdr1p
YLR124W 3.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR096C 3.11
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YNL305C 3.00 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YKL217W 2.94
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YJR048W 2.86
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YNL117W 2.66
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YCR005C 2.65
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YDR277C 2.62
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YDR216W 2.58
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YMR135C 2.57
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YAR060C 2.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL210W 2.52
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YPL171C 2.51
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YDR096W 2.49
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YLL053C 2.47 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YDR178W 2.46
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YFL052W 2.45 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YFR053C 2.42
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YDR406W 2.40
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YPL017C 2.38
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YPR001W 2.36
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YEL012W 2.34
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YMR090W 2.31 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YAL054C 2.28
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YBL015W 2.27
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YBR105C 2.26
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YKL109W 2.23
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YAR050W 2.18
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YLR125W 2.18 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YPR027C 2.16 Putative protein of unknown function
YGR258C 2.13
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YGR045C 2.12 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR191W 2.08
SPG5
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YJR078W 2.08
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YPL223C 2.08
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YPR030W 2.07
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YML090W 2.05 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YLL041C 2.03
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YLL052C 2.02
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YDR036C 1.98
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YGL193C 1.96 Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YLR312C 1.95
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YKL171W 1.93 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YOL082W 1.91
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YJL116C 1.91
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YKL031W 1.90 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YBR116C 1.90 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YLR296W 1.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR378W 1.88 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YGL192W 1.88
IME4
Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YHR048W 1.87
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YOR139C 1.85 Hypothetical protein
YGR236C 1.85
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR272C 1.84
SCS7
Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YIL023C 1.81
YKE4
Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
YMR194C-B 1.80 Putative protein of unknown function
YGL191W 1.80
COX13
Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YGR032W 1.79
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YNL144C 1.77 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YDL223C 1.74
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YOR140W 1.74
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YLR295C 1.74
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YDR259C 1.72
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YOR192C 1.69
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YER014C-A 1.68
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YBL049W 1.67
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YML091C 1.67
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YNR002C 1.67
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YGL163C 1.66
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YAR047C 1.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR452W 1.59
PPN1
Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
YDR536W 1.58
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YLR004C 1.58
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YMR256C 1.57
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YPL134C 1.56
ODC1
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YBR047W 1.54
FMP23
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL085W 1.54
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YCR010C 1.54
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YPL262W 1.54
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YPR006C 1.53
ICL2
2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YMR271C 1.52
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YLR346C 1.51 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YDR043C 1.51
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YNL125C 1.51
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YKL093W 1.49
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YOR343C 1.49 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YBL078C 1.48
ATG8
Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YEL011W 1.47
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBR269C 1.46
FMP21
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR015C 1.45 Putative protein of unknown function
YHR139C 1.43
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YOL051W 1.43
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YPR026W 1.40
ATH1
Acid trehalase required for utilization of extracellular trehalose
YER158C 1.39 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YMR017W 1.39
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YPL250C 1.38
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YMR040W 1.38
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YOL052C-A 1.38
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YMR103C 1.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER067C-A 1.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
YDR173C 1.36
ARG82
Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
YLL060C 1.34
GTT2
Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YGR243W 1.34
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNR034W-A 1.34 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YMR195W 1.34
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YJL152W 1.33 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL229W 1.33 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene
YDR010C 1.32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL194W 1.31
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YPL025C 1.29 Hypothetical protein
YOR381W 1.28
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YOR138C 1.28
RUP1
Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain
YGR046W 1.27
TAM41
Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud
YOR192C-C 1.26 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YOR120W 1.26
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YDR441C 1.25
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YBR046C 1.25
ZTA1
Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity
YEL049W 1.24
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YLR327C 1.23
TMA10
Protein of unknown function that associates with ribosomes
YDL182W 1.22
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YGL072C 1.21 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YIR029W 1.21
DAL2
Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YPL092W 1.20
SSU1
Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YHR212W-A 1.20 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YKR101W 1.18
SIR1
Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
YCL001W-B 1.18 Putative protein of unknown function; identified by homology
YKR009C 1.18
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YHR212C 1.17 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL208W 1.17
SIP2
One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane
YBR076C-A 1.16 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR
YMR081C 1.15
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YMR056C 1.15
AAC1
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YOL100W 1.15
PKH2
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YLR111W 1.15 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR182C 1.14
RGM1
Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth
YKL198C 1.14
PTK1
Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein
YFR022W 1.13
ROG3
Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YMR110C 1.13
HFD1
Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome
YDR313C 1.12
PIB1
RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YNL240C 1.12
NAR1
Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf
YPL015C 1.12
HST2
Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YMR002W 1.12
MIC17
Mitochondrial intermembrane space cysteine motif protein; MIC17 is not an essential gene
YGL205W 1.11
POX1
Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YDR102C 1.11 Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YKL133C 1.09 Putative protein of unknown function
YFL021W 1.09
GAT1
Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
YHR015W 1.09
MIP6
Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YPR007C 1.08
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YMR135W-A 1.08 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKR100C 1.08
SKG1
Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
YCR007C 1.08 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YGL146C 1.08 Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YPL054W 1.07
LEE1
Zinc-finger protein of unknown function
YPR150W 1.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YGR201C 1.06 Putative protein of unknown function
YGL183C 1.06
MND1
Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks
YDR530C 1.06
APA2
Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YER039C-A 1.06 Putative protein of unknown function; YER039C-A is not an essential gene
YER084W 1.03 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR044C 1.02
RME1
Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-a2 regulator; mediates cell type control of sporulation
YMR107W 1.02
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YPL027W 1.01
SMA1
Protein of unknown function involved in the assembly of the prospore membrane during sporulation
YHR189W 1.00
PTH1
One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth and for mitochondrial respiration
YLL009C 0.99
COX17
Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase
YNL142W 0.99
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YIL154C 0.99
IMP2'
Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
YER150W 0.98
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YAL060W 0.97
BDH1
NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
YMR306W 0.97
FKS3
Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCR025C 0.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YFL011W 0.96
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YOR062C 0.96 Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS

Network of associatons between targets according to the STRING database.

First level regulatory network of YER184C

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.4 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
1.6 14.5 GO:0006097 glyoxylate cycle(GO:0006097)
1.5 6.1 GO:0015804 neutral amino acid transport(GO:0015804)
1.3 5.2 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
1.3 3.9 GO:0019543 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
1.1 3.4 GO:0015755 fructose transport(GO:0015755)
1.1 3.3 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.1 4.3 GO:0006848 pyruvate transport(GO:0006848)
1.1 3.2 GO:0046320 regulation of fatty acid beta-oxidation(GO:0031998) positive regulation of fatty acid beta-oxidation(GO:0032000) regulation of fatty acid oxidation(GO:0046320) positive regulation of fatty acid oxidation(GO:0046321)
1.0 3.0 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.9 4.5 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.9 2.6 GO:0015888 thiamine transport(GO:0015888)
0.8 7.2 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.7 6.6 GO:0034284 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.7 5.1 GO:0006083 acetate metabolic process(GO:0006083)
0.7 2.8 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.7 2.6 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.6 1.7 GO:0005993 trehalose catabolic process(GO:0005993)
0.5 1.6 GO:0006538 glutamate catabolic process(GO:0006538)
0.5 0.5 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.5 3.1 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.5 1.6 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.5 4.2 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.5 1.6 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.5 2.1 GO:0032079 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.5 1.0 GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.5 4.6 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.5 1.5 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.5 3.0 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.5 4.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 1.5 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.5 1.4 GO:0042744 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.5 1.4 GO:0042843 D-xylose catabolic process(GO:0042843)
0.4 1.7 GO:0015847 putrescine transport(GO:0015847)
0.4 2.2 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.4 2.1 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.4 1.3 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.4 2.5 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.4 0.8 GO:0042775 respiratory electron transport chain(GO:0022904) ATP synthesis coupled electron transport(GO:0042773) mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.4 1.2 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.4 4.5 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.4 1.2 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.4 1.2 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.4 1.1 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.4 1.9 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.4 5.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.4 1.4 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.4 4.3 GO:0046686 response to cadmium ion(GO:0046686)
0.3 1.0 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.3 1.4 GO:0015886 heme transport(GO:0015886)
0.3 0.7 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.3 0.7 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.3 1.0 GO:0015680 intracellular copper ion transport(GO:0015680)
0.3 1.3 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.3 3.0 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.3 3.3 GO:0015893 drug transport(GO:0015893)
0.3 2.3 GO:0015891 siderophore transport(GO:0015891)
0.3 3.7 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.3 2.0 GO:0000023 maltose metabolic process(GO:0000023)
0.3 0.8 GO:0071456 cellular response to hypoxia(GO:0071456)
0.3 0.8 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.3 0.6 GO:0043270 positive regulation of ion transport(GO:0043270)
0.3 1.9 GO:0006829 zinc II ion transport(GO:0006829)
0.3 1.3 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.3 1.0 GO:0060195 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.3 1.0 GO:2000909 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.2 2.6 GO:0019740 nitrogen utilization(GO:0019740)
0.2 0.5 GO:0046323 glucose import(GO:0046323)
0.2 0.7 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.2 3.4 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.2 1.6 GO:0071241 cellular response to inorganic substance(GO:0071241)
0.2 0.7 GO:0006545 glycine biosynthetic process(GO:0006545)
0.2 0.4 GO:0032006 regulation of TOR signaling(GO:0032006)
0.2 1.1 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 0.7 GO:0034389 lipid particle organization(GO:0034389)
0.2 1.3 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.2 0.2 GO:0044109 cellular alcohol catabolic process(GO:0044109)
0.2 0.2 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.2 0.8 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.2 1.0 GO:1902222 L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.2 0.8 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 0.6 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.2 0.9 GO:0015793 glycerol transport(GO:0015793)
0.2 0.7 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.2 3.9 GO:0007266 Rho protein signal transduction(GO:0007266)
0.2 0.5 GO:0036257 multivesicular body organization(GO:0036257)
0.2 0.3 GO:0006527 arginine catabolic process(GO:0006527)
0.2 0.3 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.2 0.5 GO:0046113 nucleobase catabolic process(GO:0046113)
0.2 2.4 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.2 7.1 GO:0009060 aerobic respiration(GO:0009060)
0.2 1.8 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
0.2 0.5 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.2 0.5 GO:0033993 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.2 2.1 GO:0042493 response to drug(GO:0042493)
0.2 0.8 GO:0008053 mitochondrial fusion(GO:0008053)
0.2 0.8 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.2 1.0 GO:0051274 (1->6)-beta-D-glucan biosynthetic process(GO:0006078) beta-glucan biosynthetic process(GO:0051274)
0.2 0.6 GO:0032105 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.1 0.6 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.4 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 3.3 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 0.3 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.1 0.4 GO:0071168 protein localization to chromatin(GO:0071168)
0.1 0.8 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 2.9 GO:0012501 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.1 0.3 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 0.8 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.4 GO:0033499 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.8 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.1 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.1 0.4 GO:0090180 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.1 0.4 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.1 0.2 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.1 0.1 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.1 0.4 GO:0045128 negative regulation of reciprocal meiotic recombination(GO:0045128)
0.1 0.5 GO:0090220 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 0.7 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 1.1 GO:0032120 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 0.4 GO:0070475 rRNA base methylation(GO:0070475)
0.1 0.7 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.5 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.1 0.2 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.1 1.4 GO:0009084 glutamine family amino acid biosynthetic process(GO:0009084)
0.1 0.2 GO:0072529 pyrimidine-containing compound catabolic process(GO:0072529)
0.1 0.1 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.1 2.3 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.2 GO:0006688 glycosphingolipid metabolic process(GO:0006687) glycosphingolipid biosynthetic process(GO:0006688)
0.1 0.1 GO:0032069 regulation of nuclease activity(GO:0032069)
0.1 0.5 GO:1901072 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.1 0.4 GO:0006598 polyamine catabolic process(GO:0006598)
0.1 0.5 GO:0032974 amino acid export(GO:0032973) amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.1 0.9 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.1 0.5 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.5 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 0.9 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.3 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.1 0.6 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.4 GO:0006465 signal peptide processing(GO:0006465)
0.1 1.9 GO:0016485 protein processing(GO:0016485)
0.1 0.3 GO:0044209 AMP salvage(GO:0044209)
0.1 1.3 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.2 GO:0090527 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.1 0.7 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 0.2 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 0.3 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.1 1.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.8 GO:0016575 histone deacetylation(GO:0016575)
0.1 0.2 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.4 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.1 0.1 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.1 0.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.1 GO:0043966 negative regulation of histone modification(GO:0031057) histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.1 0.3 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.1 0.4 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.1 0.2 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.1 0.3 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.1 0.8 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 0.6 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 0.4 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 0.1 GO:0097271 protein localization to bud neck(GO:0097271)
0.1 0.1 GO:0051193 regulation of glycolytic process(GO:0006110) regulation of nucleoside metabolic process(GO:0009118) regulation of nucleotide catabolic process(GO:0030811) regulation of cofactor metabolic process(GO:0051193) regulation of coenzyme metabolic process(GO:0051196) regulation of ATP metabolic process(GO:1903578)
0.1 0.7 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 0.2 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.1 0.2 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.1 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.3 GO:0019933 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.1 0.4 GO:0070058 tRNA gene clustering(GO:0070058)
0.1 0.1 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) DNA double-strand break processing(GO:0000729)
0.1 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 2.2 GO:0070591 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 0.2 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.1 0.2 GO:0016574 histone ubiquitination(GO:0016574)
0.1 0.4 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.2 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.1 0.1 GO:0006311 meiotic gene conversion(GO:0006311)
0.1 0.2 GO:0010927 cellular component assembly involved in morphogenesis(GO:0010927)
0.1 0.2 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 2.1 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 0.2 GO:0016239 positive regulation of macroautophagy(GO:0016239) regulation of macroautophagy(GO:0016241)
0.1 0.2 GO:0046160 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.1 0.2 GO:0009106 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.1 0.2 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
0.1 0.2 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 0.2 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 0.9 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.7 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.0 0.3 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.8 GO:0006094 gluconeogenesis(GO:0006094)
0.0 0.2 GO:0043007 maintenance of rDNA(GO:0043007)
0.0 0.4 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.0 0.2 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.0 0.2 GO:0001881 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.0 0.5 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.0 1.2 GO:1902408 cellular bud site selection(GO:0000282) mitotic cytokinesis, site selection(GO:1902408)
0.0 0.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.2 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.2 GO:0023014 signal transduction by protein phosphorylation(GO:0023014)
0.0 0.0 GO:0055075 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.0 0.4 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.1 GO:0019433 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0 0.2 GO:0019932 second-messenger-mediated signaling(GO:0019932)
0.0 0.1 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.0 0.4 GO:0030474 spindle pole body duplication(GO:0030474)
0.0 0.3 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.9 GO:0006839 mitochondrial transport(GO:0006839)
0.0 0.8 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.4 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.3 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.4 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:0001301 progressive alteration of chromatin involved in cell aging(GO:0001301) progressive alteration of chromatin involved in replicative cell aging(GO:0001304) negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.0 0.3 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.3 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.1 GO:0044275 cellular carbohydrate catabolic process(GO:0044275)
0.0 0.2 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.3 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.1 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.0 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 0.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.0 0.1 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.0 0.0 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.4 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.5 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.6 GO:0006289 nucleotide-excision repair(GO:0006289)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.2 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.3 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.1 GO:0009209 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.0 0.2 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.3 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.1 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.0 0.1 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.3 GO:0007031 peroxisome organization(GO:0007031)
0.0 0.1 GO:0000132 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.0 0.1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.0 GO:0090110 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.9 4.5 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.8 6.1 GO:0042597 periplasmic space(GO:0042597)
0.7 3.0 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.7 2.8 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.7 4.8 GO:0034657 GID complex(GO:0034657)
0.6 3.5 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.4 1.3 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.4 3.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.4 3.4 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.4 2.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.4 4.4 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.4 2.5 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.3 2.3 GO:0034967 Set3 complex(GO:0034967)
0.3 4.2 GO:0070469 respiratory chain(GO:0070469)
0.3 0.9 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.2 0.7 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.2 2.7 GO:0005619 ascospore wall(GO:0005619)
0.2 0.6 GO:0032807 DNA ligase IV complex(GO:0032807)
0.2 1.0 GO:0032221 Rpd3S complex(GO:0032221)
0.2 9.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 1.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 1.4 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.2 0.6 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.2 0.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.2 0.5 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.2 2.7 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.2 1.1 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.4 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.6 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 0.8 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.4 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 1.1 GO:0030677 ribonuclease P complex(GO:0030677)
0.1 0.6 GO:0032126 eisosome(GO:0032126)
0.1 0.4 GO:0030669 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.2 GO:0070211 Snt2C complex(GO:0070211)
0.1 2.3 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 11.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 0.5 GO:0031932 TORC2 complex(GO:0031932)
0.1 2.0 GO:0016592 mediator complex(GO:0016592)
0.1 0.9 GO:0005769 early endosome(GO:0005769)
0.1 0.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.4 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 0.2 GO:0016363 nuclear matrix(GO:0016363)
0.1 0.4 GO:0000796 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.1 0.4 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 3.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.5 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.1 7.8 GO:0000323 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.0 0.2 GO:0097196 Shu complex(GO:0097196)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0030874 nucleolar chromatin(GO:0030874)
0.0 0.9 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.1 GO:0098562 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.0 0.7 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.4 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 0.3 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.2 GO:0031207 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.0 0.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.1 GO:0033309 SBF transcription complex(GO:0033309)
0.0 0.1 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.0 0.2 GO:0000974 Prp19 complex(GO:0000974)
0.0 22.9 GO:0005739 mitochondrion(GO:0005739)
0.0 0.1 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.0 GO:0031970 organelle envelope lumen(GO:0031970)
0.0 0.1 GO:0033551 monopolin complex(GO:0033551)
0.0 0.4 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.1 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.0 GO:0001400 mating projection base(GO:0001400)
0.0 0.4 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 1.4 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.0 0.0 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.4 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
1.7 5.2 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.5 7.7 GO:0015295 solute:proton symporter activity(GO:0015295)
1.5 5.8 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.4 4.2 GO:0016289 CoA hydrolase activity(GO:0016289)
1.2 3.7 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.0 3.1 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
1.0 5.0 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.0 6.8 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.9 2.8 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.9 4.5 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.9 3.5 GO:0005537 mannose binding(GO:0005537)
0.8 2.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.8 2.4 GO:0005536 glucose binding(GO:0005536)
0.8 4.8 GO:0000400 four-way junction DNA binding(GO:0000400)
0.8 3.1 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.7 2.1 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.6 2.3 GO:0004396 hexokinase activity(GO:0004396)
0.6 2.3 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.6 4.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.6 2.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.6 1.7 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.5 1.1 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.5 5.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.4 1.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.4 1.3 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.4 0.4 GO:0016208 AMP binding(GO:0016208)
0.4 3.4 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 1.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 3.6 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.4 1.4 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.3 2.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 2.0 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 2.3 GO:0051213 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) dioxygenase activity(GO:0051213)
0.3 2.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.3 3.5 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.3 1.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3 0.9 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.3 0.9 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.3 3.6 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.3 2.2 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.3 2.7 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.3 1.0 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.3 0.8 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.2 1.0 GO:0016531 copper chaperone activity(GO:0016531)
0.2 1.0 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.2 0.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 0.2 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.2 1.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 1.1 GO:0016783 sulfurtransferase activity(GO:0016783)
0.2 1.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 0.4 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.2 0.4 GO:0016530 metallochaperone activity(GO:0016530)
0.2 10.2 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.2 1.0 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 1.0 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 0.6 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.2 0.6 GO:0032183 SUMO binding(GO:0032183)
0.2 3.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 0.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.2 0.9 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.2 0.7 GO:0004180 carboxypeptidase activity(GO:0004180)
0.2 1.6 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.2 0.7 GO:0005261 cation channel activity(GO:0005261)
0.2 0.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 1.0 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.1 0.6 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.1 0.7 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.9 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 0.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 3.0 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 1.0 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.4 GO:0008198 ferrous iron binding(GO:0008198)
0.1 0.4 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 1.1 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.1 1.1 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.3 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 1.8 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 1.1 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 1.2 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors(GO:0016903)
0.1 0.9 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 1.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 0.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.2 GO:0000150 recombinase activity(GO:0000150)
0.1 2.3 GO:0003684 damaged DNA binding(GO:0003684)
0.1 4.1 GO:0016820 primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 1.3 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.3 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.1 1.1 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 0.3 GO:0015288 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.1 0.4 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.1 0.3 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.1 1.3 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.1 0.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.2 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.1 0.5 GO:0022838 substrate-specific channel activity(GO:0022838)
0.1 0.2 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 0.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.2 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.1 0.1 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.1 0.3 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.1 0.3 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.1 1.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 1.4 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 1.1 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 1.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.4 GO:0001031 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.1 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 0.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.8 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.1 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.2 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.1 0.3 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.2 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 0.6 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.1 0.2 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 0.5 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 0.1 GO:0005034 osmosensor activity(GO:0005034)
0.0 0.9 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.4 GO:0019239 deaminase activity(GO:0019239)
0.0 0.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 2.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 4.2 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.5 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.4 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.9 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.6 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 2.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.1 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.0 0.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.1 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.2 GO:0050661 NADP binding(GO:0050661)
0.0 0.1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.1 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.0 0.1 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.0 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.2 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.0 GO:0070717 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.0 0.0 GO:0000171 ribonuclease MRP activity(GO:0000171)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.5 4.9 PID FANCONI PATHWAY Fanconi anemia pathway
0.4 1.3 PID ERBB4 PATHWAY ErbB4 signaling events
0.4 1.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 0.2 PID AP1 PATHWAY AP-1 transcription factor network
0.1 0.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 0.2 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.1 0.4 PID P73PATHWAY p73 transcription factor network
0.1 0.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 0.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 57.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.1 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.7 5.9 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.5 1.5 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.4 1.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.3 1.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 0.4 REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
0.2 0.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.2 0.7 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.2 0.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 0.2 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 0.4 REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE Genes involved in NFkB and MAP kinases activation mediated by TLR4 signaling repertoire
0.1 1.0 REACTOME MEIOSIS Genes involved in Meiosis
0.1 0.1 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.1 0.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.4 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.0 57.0 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.2 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.0 0.0 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.1 REACTOME DNA REPAIR Genes involved in DNA Repair