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Results for YER130C

Z-value: 0.88

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Transcription factors associated with YER130C

Gene Symbol Gene ID Gene Info
S000000932 Protein of unknown function

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
YER130C-0.242.3e-01Click!

Activity profile of YER130C motif

Sorted Z-values of YER130C motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YMR107W 10.39
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YOL052C-A 9.30
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YHR096C 7.61
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YMR175W 7.28
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YNR034W-A 6.55 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YGR256W 6.33
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YHL040C 6.24
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YHR139C 6.02
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YPL054W 5.88
LEE1
Zinc-finger protein of unknown function
YAR053W 5.72 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR117C 5.60
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YIL099W 5.57
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YBR072W 5.08
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YFR017C 4.91 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YLR149C 4.83 Putative protein of unknown function; YLR149C is not an essential gene
YEL039C 4.74
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YMR081C 4.68
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YIL101C 4.38
XBP1
Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YAR060C 4.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR050W 3.98
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YKL163W 3.92
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YDR258C 3.89
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YKL107W 3.89 Putative protein of unknown function
YOR348C 3.88
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YLR312C 3.85
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YPR002W 3.79
PDH1
Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YGR087C 3.71
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YMR105C 3.57
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YGR243W 3.56
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR211W 3.55
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YKL103C 3.55
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YPL223C 3.52
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YLR174W 3.50
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YDR277C 3.38
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YKL148C 3.38
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YKL217W 3.35
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YBR201C-A 3.34 Putative protein of unknown function
YAR047C 3.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR250W 3.30
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YDL210W 3.28
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YDL204W 3.28
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YOR393W 3.27
ERR1
Protein of unknown function, has similarity to enolases
YDR343C 3.15
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YNL117W 3.13
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YFL030W 3.10
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YER103W 3.08
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YMR118C 3.02 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YML089C 3.01 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YKL102C 3.01 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YLR080W 2.92
EMP46
Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YBL049W 2.87
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YMR206W 2.80 Putative protein of unknown function; YMR206W is not an essential gene
YMR174C 2.80
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YOR120W 2.79
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YIL136W 2.75
OM45
Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YML131W 2.74 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YJR095W 2.73
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YGL205W 2.72
POX1
Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YAL054C 2.70
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YOR394W 2.65
PAU21
Hypothetical protein
YPL240C 2.65
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YGR067C 2.63 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YEL008W 2.60 Hypothetical protein predicted to be involved in metabolism
YDL130W-A 2.59
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YNR002C 2.57
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YGR144W 2.57
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YDL085W 2.55
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YLR356W 2.54 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YPL282C 2.53
PAU22
Hypothetical protein
YHR212C 2.52 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKR102W 2.50
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YNL305C 2.47 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YMR196W 2.39 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
YBL078C 2.38
ATG8
Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YPR027C 2.38 Putative protein of unknown function
YEL009C 2.36
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YFL019C 2.33 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YHR212W-A 2.30 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YMR280C 2.27
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YAL034C 2.20
FUN19
Non-essential protein of unknown function
YPR007C 2.14
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YIL100C-A 2.13 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL014W 2.12
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YIL107C 2.12
PFK26
6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A
YOR347C 2.12
PYK2
Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux
YJL144W 2.12 Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS
YJL045W 2.11 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YPR001W 2.08
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YOR391C 2.07
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YEL011W 2.03
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YIR027C 2.00
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YGR043C 2.00
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YOL082W 1.99
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YPR010C-A 1.97 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YPL036W 1.95
PMA2
Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YHR087W 1.94
RTC3
Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity
YOL163W 1.93 Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
YGR088W 1.93
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YPL147W 1.92
PXA1
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YOR374W 1.90
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YER067W 1.89 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YPL271W 1.89
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YIL155C 1.86
GUT2
Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YHR139C-A 1.85 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR150C 1.83
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YIL122W 1.82
POG1
Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YOR173W 1.81
DCS2
Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YIL055C 1.79 Putative protein of unknown function
YML090W 1.79 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YOR152C 1.78 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YHR210C 1.78 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YJL066C 1.77
MPM1
Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches
YNR001C 1.74
CIT1
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YDL222C 1.73
FMP45
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YAL039C 1.73
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YOR211C 1.71
MGM1
Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YBR280C 1.69
SAF1
F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
YGL183C 1.68
MND1
Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks
YKL010C 1.67
UFD4
Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins
YIL100W 1.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YAL061W 1.66
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YLR377C 1.64
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YJL133C-A 1.64 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFR053C 1.64
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YIL162W 1.63
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YGR268C 1.61
HUA1
Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YHR138C 1.60 Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YEL070W 1.60
DSF1
Deletion suppressor of mpt5 mutation
YNL055C 1.59
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YOR346W 1.58
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YJR091C 1.56
JSN1
Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells
YKL050C 1.55 Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p
YJR115W 1.54 Putative protein of unknown function
YLR337C 1.54
VRP1
Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)
YBR214W 1.52
SDS24
One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis
YDR505C 1.52
PSP1
Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition
YDL021W 1.52
GPM2
Homolog of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YDR313C 1.50
PIB1
RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YPL186C 1.50
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YOR178C 1.50
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YLR327C 1.50
TMA10
Protein of unknown function that associates with ribosomes
YLL041C 1.50
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YLR030W 1.50 Putative protein of unknown function
YDR119W-A 1.49 Putative protein of unknown function
YMR135C 1.46
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YNL180C 1.46
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YCR010C 1.46
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YOR345C 1.45 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YML091C 1.45
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YKL093W 1.45
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YDL113C 1.45
ATG20
Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
YFL020C 1.44
PAU5
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YLR178C 1.44
TFS1
Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway
YOR100C 1.43
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YHR007C-A 1.42 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YDR476C 1.42 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YGR110W 1.42 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YGL045W 1.41
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YJL020C 1.40
BBC1
Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
YNL144C 1.40 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YPL222W 1.40
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER096W 1.39
SHC1
Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
YJR038C 1.38 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL181W 1.38
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YML128C 1.37
MSC1
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YJR004C 1.36
SAG1
Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
YML120C 1.36
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YJL135W 1.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
YJL070C 1.35 Putative protein of unknown function with similarity to AMP deaminases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YJL070C is a non-essential gene
YKR033C 1.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80
YNL179C 1.32 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YBR051W 1.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YIL146C 1.31
ECM37
Non-essential protein of unknown function
YPL185W 1.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YFL051C 1.30 Putative protein of unknown function; YFL051C is not an essential gene
YJL116C 1.30
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YJL037W 1.29
IRC18
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YAL060W 1.28
BDH1
NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
YLR122C 1.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YLR395C 1.28
COX8
Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YOL118C 1.26 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YER121W 1.26 Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YBL101C 1.26
ECM21
Non-essential protein of unknown function; promoter contains several Gcn4p binding elements
YER033C 1.25
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YKL067W 1.25
YNK1
Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
YKL177W 1.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YKL146W 1.24
AVT3
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YJL161W 1.24
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR050C 1.24
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YIL113W 1.23
SDP1
Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
YGR258C 1.23
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YAL028W 1.22
FRT2
Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate
YGR059W 1.22
SPR3
Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI
YOL047C 1.19 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YPL058C 1.19
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YNL015W 1.18
PBI2
Cytosolic inhibitor of vacuolar proteinase B, required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion
YPL087W 1.17
YDC1
Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity
YCR025C 1.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YJL149W 1.17
DAS1
Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C; null mutant suppresses dst1delta sensitivity for 6-azauracil
YKL147C 1.17 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3

Network of associatons between targets according to the STRING database.

First level regulatory network of YER130C

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0019629 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
1.8 5.4 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
1.8 7.1 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
1.7 6.9 GO:0006848 pyruvate transport(GO:0006848)
1.6 9.8 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.5 4.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
1.5 7.5 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
1.4 4.2 GO:0043335 protein unfolding(GO:0043335)
1.3 11.4 GO:0006097 glyoxylate cycle(GO:0006097)
1.2 6.1 GO:0005980 glycogen catabolic process(GO:0005980)
1.2 2.3 GO:0006740 NADPH regeneration(GO:0006740)
1.2 3.5 GO:0006538 glutamate catabolic process(GO:0006538)
1.1 12.2 GO:0015758 glucose transport(GO:0015758)
1.1 5.4 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.0 4.2 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
1.0 3.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
1.0 3.1 GO:0006545 glycine biosynthetic process(GO:0006545)
1.0 3.0 GO:0042843 D-xylose catabolic process(GO:0042843)
0.9 7.6 GO:0015891 siderophore transport(GO:0015891)
0.9 2.6 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.8 3.3 GO:0015804 neutral amino acid transport(GO:0015804)
0.8 7.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.8 10.1 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.7 2.1 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.6 2.6 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.6 0.6 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.6 3.1 GO:0043954 cellular component maintenance(GO:0043954)
0.6 2.4 GO:0015847 putrescine transport(GO:0015847)
0.6 1.8 GO:0042148 strand invasion(GO:0042148)
0.6 3.5 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.6 1.7 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.5 1.6 GO:0005993 trehalose catabolic process(GO:0005993)
0.5 1.6 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.5 4.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.5 1.8 GO:1903138 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.5 1.4 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.4 2.2 GO:0006007 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.4 4.7 GO:0015696 ammonium transport(GO:0015696)
0.4 2.6 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.4 2.1 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.4 1.3 GO:0006183 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.4 6.2 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.4 2.0 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.4 2.3 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.4 1.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.4 3.3 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.4 3.3 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.4 4.3 GO:0006099 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.4 1.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.3 2.4 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.3 1.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 5.2 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.3 7.7 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.3 1.3 GO:0015976 carbon utilization(GO:0015976)
0.3 0.9 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.3 0.6 GO:0042732 D-xylose metabolic process(GO:0042732)
0.3 1.2 GO:0007157 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.3 2.5 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.3 1.9 GO:0015908 fatty acid transport(GO:0015908)
0.3 1.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.3 4.1 GO:0009206 ATP biosynthetic process(GO:0006754) purine nucleoside triphosphate biosynthetic process(GO:0009145) purine ribonucleoside triphosphate biosynthetic process(GO:0009206)
0.3 1.0 GO:0006598 polyamine catabolic process(GO:0006598)
0.3 0.5 GO:0019320 hexose catabolic process(GO:0019320)
0.2 0.7 GO:0015888 thiamine transport(GO:0015888)
0.2 1.2 GO:0032974 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.2 1.2 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.2 1.7 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.2 0.5 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.2 0.5 GO:0045895 positive regulation of mating-type specific transcription, DNA-templated(GO:0045895)
0.2 0.7 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.2 0.7 GO:0015691 cadmium ion transport(GO:0015691)
0.2 1.7 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.2 0.6 GO:0006311 meiotic gene conversion(GO:0006311)
0.2 1.1 GO:0051260 protein homooligomerization(GO:0051260)
0.2 2.1 GO:0006119 oxidative phosphorylation(GO:0006119)
0.2 0.6 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.2 1.8 GO:0070987 error-free translesion synthesis(GO:0070987)
0.2 0.2 GO:0009730 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.2 0.8 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.2 2.1 GO:0016925 protein sumoylation(GO:0016925)
0.2 0.8 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.2 0.7 GO:0016242 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.2 0.5 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.2 0.7 GO:0043462 regulation of ATPase activity(GO:0043462)
0.2 3.3 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.2 0.9 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.2 1.7 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.2 0.2 GO:0045923 positive regulation of fatty acid metabolic process(GO:0045923)
0.2 0.8 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.2 0.9 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.2 0.6 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.1 0.1 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.1 5.6 GO:0070590 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 0.4 GO:0001198 regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001196) negative regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001198) negative regulation of mating-type specific transcription, DNA-templated(GO:0045894)
0.1 0.5 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.1 0.4 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.1 0.5 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.1 0.6 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.1 0.1 GO:0018209 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.1 0.5 GO:0015846 polyamine transport(GO:0015846)
0.1 0.6 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.1 0.8 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.8 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.8 GO:0010508 positive regulation of autophagy(GO:0010508)
0.1 0.3 GO:0009190 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.1 0.3 GO:0009438 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 1.9 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 1.1 GO:0045144 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.1 3.0 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.1 1.3 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.1 0.8 GO:0000755 cytogamy(GO:0000755)
0.1 3.8 GO:0009060 aerobic respiration(GO:0009060)
0.1 0.6 GO:0006452 translational frameshifting(GO:0006452)
0.1 0.9 GO:0043488 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.1 0.6 GO:0007129 synapsis(GO:0007129)
0.1 0.4 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.1 1.1 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.1 0.4 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.3 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.1 1.6 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 0.5 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 0.7 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 0.5 GO:0046578 regulation of Ras protein signal transduction(GO:0046578)
0.1 0.6 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 0.4 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.1 0.4 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.1 0.5 GO:0051598 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.1 0.2 GO:0042407 cristae formation(GO:0042407)
0.1 0.2 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.1 0.2 GO:0051503 adenine nucleotide transport(GO:0051503)
0.1 0.2 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.1 1.4 GO:0031503 protein complex localization(GO:0031503)
0.1 0.5 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.1 0.8 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 0.2 GO:0043096 purine nucleobase salvage(GO:0043096)
0.1 0.6 GO:0044091 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 0.1 GO:0001323 age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324)
0.1 0.5 GO:0006639 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.1 0.6 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.3 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.1 0.3 GO:0032373 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.1 1.0 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.1 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.1 0.5 GO:0009306 protein secretion(GO:0009306)
0.1 0.7 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.1 0.3 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.1 0.7 GO:0000011 vacuole inheritance(GO:0000011)
0.1 0.1 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.3 GO:0051099 positive regulation of binding(GO:0051099)
0.1 0.4 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 0.5 GO:0055070 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.1 0.2 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 0.9 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.2 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.1 0.3 GO:0030100 regulation of endocytosis(GO:0030100)
0.1 0.2 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.3 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 0.2 GO:0071469 response to alkaline pH(GO:0010446) cellular response to pH(GO:0071467) cellular response to alkaline pH(GO:0071469)
0.1 0.1 GO:0034091 regulation of sister chromatid cohesion(GO:0007063) maintenance of sister chromatid cohesion(GO:0034086) regulation of maintenance of sister chromatid cohesion(GO:0034091)
0.1 0.1 GO:0000304 response to singlet oxygen(GO:0000304)
0.0 0.1 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.0 0.2 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.1 GO:0051228 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.0 0.1 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.0 0.2 GO:0046337 phosphatidylethanolamine metabolic process(GO:0046337)
0.0 0.0 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.1 GO:0032079 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736) positive regulation of nuclease activity(GO:0032075) positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.0 0.2 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.3 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.0 1.5 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.1 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.0 0.3 GO:0070272 proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.1 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.0 0.2 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.0 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.1 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.0 0.1 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.0 0.4 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.3 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.2 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 0.2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.1 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:0045117 azole transport(GO:0045117)
0.0 0.1 GO:0045033 peroxisome inheritance(GO:0045033)
0.0 0.5 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.1 GO:0000754 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion(GO:0000754) adaptation of signaling pathway(GO:0023058)
0.0 0.1 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.1 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.1 GO:0015809 arginine transport(GO:0015809)
0.0 0.1 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.2 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.1 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.0 0.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.1 GO:0071033 nuclear retention of pre-mRNA at the site of transcription(GO:0071033)
0.0 0.0 GO:0090110 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.0 GO:0034033 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.0 0.1 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.1 5.4 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.6 1.9 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.6 1.7 GO:0030061 mitochondrial crista(GO:0030061)
0.5 6.9 GO:0005619 ascospore wall(GO:0005619)
0.5 5.8 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.4 9.0 GO:0070469 respiratory chain(GO:0070469)
0.4 1.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.4 3.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.4 2.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.4 2.5 GO:0034657 GID complex(GO:0034657)
0.4 6.4 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.4 2.8 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.3 0.9 GO:0001400 mating projection base(GO:0001400)
0.3 0.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.3 2.4 GO:0042597 periplasmic space(GO:0042597)
0.3 5.8 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.2 1.0 GO:0045334 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.2 1.5 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.2 2.9 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.2 0.8 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.2 1.2 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.2 7.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 1.9 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.2 2.2 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 4.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 0.9 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.6 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.3 GO:0033263 CORVET complex(GO:0033263)
0.1 2.7 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.1 1.1 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.1 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.1 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.4 GO:0033255 SAS acetyltransferase complex(GO:0033255)
0.1 0.2 GO:0044284 mitochondrial crista junction(GO:0044284)
0.1 0.7 GO:0031499 TRAMP complex(GO:0031499)
0.1 0.4 GO:0032177 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.1 5.5 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.6 GO:0005869 dynactin complex(GO:0005869)
0.1 4.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 17.2 GO:0000322 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 0.9 GO:0005769 early endosome(GO:0005769)
0.1 0.5 GO:0044233 ERMES complex(GO:0032865) organelle membrane contact site(GO:0044232) ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.3 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.1 0.4 GO:0033551 monopolin complex(GO:0033551)
0.1 1.3 GO:0070822 Sin3-type complex(GO:0070822)
0.1 0.4 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 1.2 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.6 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.7 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 3.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 2.1 GO:0005774 vacuolar membrane(GO:0005774)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 0.6 GO:0097346 INO80-type complex(GO:0097346)
0.0 0.1 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.0 0.5 GO:0098573 intrinsic component of mitochondrial membrane(GO:0098573)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.7 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.1 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.1 GO:0030478 actin cap(GO:0030478)
0.0 0.0 GO:0030123 AP-3 adaptor complex(GO:0030123)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 10.0 GO:0005537 mannose binding(GO:0005537)
1.8 5.4 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
1.6 6.2 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
1.5 4.5 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.5 4.4 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.3 6.6 GO:0015295 solute:proton symporter activity(GO:0015295)
1.3 3.9 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.3 5.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.2 3.6 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.2 7.0 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
1.1 3.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.1 5.4 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.0 4.2 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
1.0 3.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.9 2.7 GO:0016208 AMP binding(GO:0016208)
0.7 3.0 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.7 2.7 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.6 2.6 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.6 0.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.5 1.6 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.5 1.6 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.5 1.6 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.5 1.5 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.5 2.5 GO:0008198 ferrous iron binding(GO:0008198)
0.5 6.4 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.5 1.4 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.4 3.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.4 1.7 GO:0004396 hexokinase activity(GO:0004396)
0.4 1.2 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.4 1.2 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.4 2.0 GO:0017022 myosin binding(GO:0017022)
0.4 1.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.4 1.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.4 1.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 2.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.4 6.1 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.4 1.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.3 2.0 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.3 1.0 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.3 1.2 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.3 0.8 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.3 0.8 GO:0070336 flap-structured DNA binding(GO:0070336)
0.3 4.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.3 0.8 GO:0004629 phospholipase C activity(GO:0004629)
0.3 1.0 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.3 2.3 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.3 3.8 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.3 1.3 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.3 0.8 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.2 2.2 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 1.4 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 2.3 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.2 0.7 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.2 2.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.2 0.6 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.2 3.9 GO:0050661 NADP binding(GO:0050661)
0.2 0.6 GO:0016872 intramolecular lyase activity(GO:0016872)
0.2 2.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 1.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 0.8 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.2 0.9 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.2 0.9 GO:0015294 solute:cation symporter activity(GO:0015294)
0.2 1.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 0.5 GO:0070569 uridylyltransferase activity(GO:0070569)
0.2 1.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 0.2 GO:0019902 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.2 1.0 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.2 0.5 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.2 0.8 GO:0004075 biotin carboxylase activity(GO:0004075)
0.2 0.8 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.2 0.6 GO:0004180 carboxypeptidase activity(GO:0004180)
0.2 0.5 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 5.0 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 0.7 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 1.1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 1.9 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 2.8 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.1 1.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.8 GO:0015293 symporter activity(GO:0015293)
0.1 2.3 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.6 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.2 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.1 1.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 8.9 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.3 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.1 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691) G-quadruplex DNA binding(GO:0051880)
0.1 0.9 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 0.2 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.1 0.8 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 0.4 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.1 0.4 GO:0045118 azole transporter activity(GO:0045118)
0.1 0.3 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.1 1.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.2 GO:0048029 monosaccharide binding(GO:0048029)
0.1 1.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.4 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.6 GO:0004872 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.1 5.9 GO:0019787 ubiquitin-like protein transferase activity(GO:0019787)
0.1 0.3 GO:0015665 alcohol transmembrane transporter activity(GO:0015665) organic hydroxy compound transmembrane transporter activity(GO:1901618)
0.1 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.8 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.7 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.1 GO:0030332 cyclin binding(GO:0030332)
0.1 0.2 GO:0042887 amide transmembrane transporter activity(GO:0042887)
0.1 0.5 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 1.8 GO:0043492 ATPase activity, coupled to movement of substances(GO:0043492)
0.1 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.4 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.8 GO:0032947 protein complex scaffold(GO:0032947)
0.0 2.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.8 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0 0.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.5 GO:0051087 chaperone binding(GO:0051087)
0.0 0.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.1 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106) ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.5 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 0.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.1 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.0 0.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.4 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.1 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.6 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.2 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 0.3 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.1 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.3 GO:0000049 tRNA binding(GO:0000049)
0.0 0.1 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 0.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.1 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 0.1 GO:0031369 translation initiation factor binding(GO:0031369)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.8 2.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.6 1.7 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.2 0.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 48.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.0 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.7 2.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.6 6.5 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.2 1.6 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 0.5 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 0.2 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.1 0.1 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 0.2 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.1 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.5 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.1 REACTOME SIGNALING BY NOTCH Genes involved in Signaling by NOTCH
0.0 47.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME INNATE IMMUNE SYSTEM Genes involved in Innate Immune System