Results for YDR520C
Z-value: 1.30
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Transcription factors associated with YDR520C
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
URC2
|
S000002928 | Putative Zn(II)2Cys6 motif containing transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YJR095W Show fit | 18.19 |
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization |
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| YPL171C Show fit | 13.61 |
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism |
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| YNR034W-A Show fit | 12.17 |
Putative protein of unknown function; expression is regulated by Msn2p/Msn4p |
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| YIL057C Show fit | 11.95 |
Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose |
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| YLR174W Show fit | 10.90 |
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose |
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| YAR053W Show fit | 9.91 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YFL030W Show fit | 9.81 |
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases |
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| YDL244W Show fit | 9.33 |
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 |
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| YKR009C Show fit | 9.22 |
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities |
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| YJL045W Show fit | 8.93 |
Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner |
Network of associatons between targets according to the STRING database.
First level regulatory network of YDR520C
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 28.3 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
| 6.1 | 18.2 | GO:0015740 | C4-dicarboxylate transport(GO:0015740) |
| 1.7 | 17.0 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.7 | 15.8 | GO:0012501 | apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501) |
| 1.3 | 14.4 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.7 | 12.0 | GO:0042724 | thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724) |
| 0.8 | 10.9 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 3.4 | 10.3 | GO:0015755 | fructose transport(GO:0015755) |
| 1.2 | 9.9 | GO:0015891 | siderophore transport(GO:0015891) |
| 3.3 | 9.8 | GO:0006545 | glycine biosynthetic process(GO:0006545) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 49.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.3 | 41.7 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.6 | 35.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 1.7 | 20.2 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.9 | 14.2 | GO:0045259 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259) |
| 1.5 | 13.9 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.5 | 9.5 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.4 | 5.3 | GO:0005619 | ascospore wall(GO:0005619) |
| 0.6 | 5.1 | GO:0042597 | periplasmic space(GO:0042597) |
| 0.3 | 5.0 | GO:0033698 | Rpd3L complex(GO:0033698) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 18.5 | GO:0015556 | C4-dicarboxylate transmembrane transporter activity(GO:0015556) |
| 0.3 | 12.9 | GO:0016820 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.2 | 12.8 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 2.9 | 11.7 | GO:0016661 | oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) |
| 0.6 | 11.4 | GO:0016769 | transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769) |
| 3.6 | 10.9 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 1.0 | 10.9 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.9 | 10.1 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.1 | 9.4 | GO:0004672 | protein kinase activity(GO:0004672) |
| 2.8 | 8.4 | GO:0016406 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 116.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.4 | 3.5 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.5 | 2.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.5 | 1.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.5 | 1.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 0.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 0.6 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 0.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 0.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 112.2 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.9 | 7.8 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 1.8 | 5.3 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 1.7 | 5.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 1.0 | REACTOME HEMOSTASIS | Genes involved in Hemostasis |
| 0.2 | 0.7 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 0.6 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.1 | 0.4 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.2 | 0.3 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.0 | 0.3 | REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | Genes involved in Transmembrane transport of small molecules |