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Results for YDR520C

Z-value: 1.30

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Transcription factors associated with YDR520C

Gene Symbol Gene ID Gene Info
URC2
S000002928 Putative Zn(II)2Cys6 motif containing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
URC2YDR520C0.653.5e-04Click!

Activity profile of YDR520C motif

Sorted Z-values of YDR520C motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YJR095W 18.19
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YPL171C 13.61
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YNR034W-A 12.17 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YIL057C 11.95 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YLR174W 10.90
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YAR053W 9.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFL030W 9.81
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YDL244W 9.33
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YKR009C 9.22
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YJL045W 8.93 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YLR377C 8.91
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YML042W 8.45
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YOR348C 8.30
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YDR277C 8.01
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YFR053C 7.96
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YNR002C 7.93
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YNL117W 7.89
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YAL039C 7.84
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YAR060C 7.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL220W 6.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2
YJL116C 6.67
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YNL274C 6.62
GOR1
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR096C 6.59
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YOR065W 6.28
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YHR211W 6.08
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YJL221C 6.03
FSP2
Protein of unknown function, expression is induced during nitrogen limitation
YJL219W 5.96
HXT9
Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p
YML089C 5.95 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YOR343C 5.80 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YOR139C 5.78 Hypothetical protein
YFL054C 5.72 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YMR206W 5.61 Putative protein of unknown function; YMR206W is not an essential gene
YOR140W 5.57
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YGR243W 5.48
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR212C 5.41 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR007C 5.30 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YPL135W 5.09
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YLR307C-A 5.09 Putative protein of unknown function
YDR119W-A 5.06 Putative protein of unknown function
YOL157C 5.00 Putative protein of unknown function
YHR212W-A 4.99 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR139C 4.98
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YHR048W 4.97
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YOR382W 4.83
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YKL109W 4.77
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YEL028W 4.76 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL127C-B 4.72 Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
YDL245C 4.68
HXT15
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YIL077C 4.65 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YPL181W 4.59
CTI6
Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
YPR191W 4.57
QCR2
Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YMR244W 4.53 Putative protein of unknown function
YDR342C 4.41
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YLR122C 4.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YGR087C 4.34
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YPL182C 4.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
YOL156W 4.30
HXT11
Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance
YPL017C 4.29
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YPR196W 4.28 Putative maltose activator
YDR171W 4.24
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YOL084W 4.22
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YIL160C 4.20
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YNL202W 4.16
SPS19
Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
YDL222C 4.03
FMP45
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YPL147W 4.01
PXA1
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YKL188C 3.98
PXA2
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YOR393W 3.92
ERR1
Protein of unknown function, has similarity to enolases
YLL019C 3.87
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YML081C-A 3.87
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YFL053W 3.85
DAK2
Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YDR536W 3.83
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YGR197C 3.73
SNG1
Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance
YLR123C 3.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YEL070W 3.61
DSF1
Deletion suppressor of mpt5 mutation
YHL024W 3.61
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YGR110W 3.59 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YBL015W 3.59
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YEL008W 3.56 Hypothetical protein predicted to be involved in metabolism
YFR022W 3.54
ROG3
Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YBR072W 3.53
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YML090W 3.51 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YPL024W 3.48
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YOR072W 3.47 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YOR138C 3.40
RUP1
Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain
YER015W 3.38
FAA2
Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids
YDL130W-A 3.37
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YJL089W 3.34
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YFR029W 3.33
PTR3
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YEL009C 3.32
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YJL133C-A 3.28 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL052C-A 3.24
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YGR067C 3.24 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YHR095W 3.23 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR327C 3.13
TMA10
Protein of unknown function that associates with ribosomes
YDL246C 3.12
SOR2
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YOR192C 3.12
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YFL024C 3.11
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YGL258W-A 3.10 Putative protein of unknown function
YJR048W 3.10
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YOR381W 3.09
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YLR152C 3.08 Putative protein of unknown function; YLR152C is not an essential gene
YFL052W 3.06 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YBR179C 3.05
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YHR160C 3.04
PEX18
Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p
YHR001W-A 3.03
QCR10
Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YNL144C 3.01 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YPL026C 3.01
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YLR332W 2.98
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YOR072W-A 2.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YMR103C 2.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR192C-C 2.95 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YHR210C 2.94 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YOR084W 2.92
LPX1
Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
YLR331C 2.91
JIP3
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YOR071C 2.91
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YJR159W 2.89
SOR1
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol
YOL100W 2.86
PKH2
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YJL217W 2.82 Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YPR013C 2.79 Putative zinc finger protein; YPR013C is not an essential gene
YAR069C 2.77 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR090W 2.75 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YML091C 2.70
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YEL065W 2.66
SIT1
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YCR091W 2.61
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YLR124W 2.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR070C 2.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIR027C 2.57
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YER033C 2.57
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YBR180W 2.54
DTR1
Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
YKL217W 2.52
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YOR391C 2.52
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YLL056C 2.50 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YLR334C 2.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
YKR046C 2.46
PET10
Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
YDR406W 2.43
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YGR088W 2.41
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YJR160C 2.41
MPH3
Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication
YLL053C 2.40 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YBL096C 2.37 Non-essential protein of unknown function
YDL194W 2.33
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YKR015C 2.31 Putative protein of unknown function
YPR151C 2.31
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YBR037C 2.30
SCO1
Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins
YKL026C 2.29
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YLR125W 2.24 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YOL044W 2.24
PEX15
Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly
YNL142W 2.22
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YBL095W 2.20 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLL055W 2.19
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YDR247W 2.17
VHS1
Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YJR148W 2.17
BAT2
Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase
YEL011W 2.14
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YPL201C 2.13
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YLL052C 2.13
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YPL271W 2.11
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YMR135C 2.08
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YCR005C 2.08
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YNL013C 2.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
YOL085W-A 2.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YHR092C 2.05
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YBR203W 2.04
COS111
Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL277W-A 2.03 Putative protein of unknown function
YPR027C 2.01 Putative protein of unknown function
YAR068W 2.01 Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YNR050C 2.00
LYS9
Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway
YFL051C 1.96 Putative protein of unknown function; YFL051C is not an essential gene
YMR107W 1.96
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YFL055W 1.96
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YLR304C 1.95
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YBR169C 1.95
SSE2
Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p
YNL052W 1.92
COX5A
Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YAL054C 1.92
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YDR441C 1.92
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YER158C 1.91 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YIR039C 1.89
YPS6
Putative GPI-anchored aspartic protease
YMR280C 1.88
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YLR431C 1.88
ATG23
Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway; cycles between the pre-autophagosome (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p
YLR366W 1.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YNL276C 1.83 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W
YER014C-A 1.83
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YHR052W-A 1.79 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-1
YGR043C 1.79
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YPR061C 1.78
JID1
Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
YAR050W 1.78
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YBR269C 1.78
FMP21
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR096W 1.76
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YLR296W 1.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL214W 1.75
HXT8
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YKR103W 1.75
NFT1
Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
YOR363C 1.75
PIP2
Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes
YGR142W 1.74
BTN2
v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YMR141C 1.73 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR070C 1.72
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR533C 1.69
HSP31
Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YNL055C 1.68
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YNL133C 1.66
FYV6
Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining
YOR120W 1.65
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YMR081C 1.64
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YJR152W 1.64
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YBR212W 1.64
NGR1
RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase

Network of associatons between targets according to the STRING database.

First level regulatory network of YDR520C

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.2 GO:0015740 C4-dicarboxylate transport(GO:0015740)
3.4 10.3 GO:0015755 fructose transport(GO:0015755)
3.3 9.8 GO:0006545 glycine biosynthetic process(GO:0006545)
2.8 28.3 GO:0046487 glyoxylate metabolic process(GO:0046487)
2.8 8.4 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
2.6 7.8 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
2.4 9.6 GO:0015804 neutral amino acid transport(GO:0015804)
2.1 6.3 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
2.0 6.0 GO:0015888 thiamine transport(GO:0015888)
2.0 8.0 GO:0006848 pyruvate transport(GO:0006848)
1.7 17.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.7 3.3 GO:0061413 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
1.5 1.5 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
1.3 14.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
1.2 9.9 GO:0015891 siderophore transport(GO:0015891)
1.2 7.0 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.1 4.6 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
1.1 3.4 GO:0032780 negative regulation of ATPase activity(GO:0032780)
1.1 4.4 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
1.0 7.2 GO:0006083 acetate metabolic process(GO:0006083)
1.0 4.8 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
1.0 2.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.9 3.7 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.9 4.4 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.8 3.3 GO:0043200 response to amino acid(GO:0043200)
0.8 2.4 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.8 10.9 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.8 5.3 GO:0015908 fatty acid transport(GO:0015908)
0.7 0.7 GO:0051099 positive regulation of binding(GO:0051099)
0.7 3.0 GO:0036498 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.7 3.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.7 3.6 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.7 2.1 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.7 2.8 GO:0015793 glycerol transport(GO:0015793)
0.7 1.4 GO:0009730 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.7 12.0 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.7 2.1 GO:0005993 trehalose catabolic process(GO:0005993)
0.7 4.2 GO:0009062 fatty acid catabolic process(GO:0009062)
0.7 4.9 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.7 4.8 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.7 15.8 GO:0012501 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.7 9.2 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.6 3.6 GO:0006279 premeiotic DNA replication(GO:0006279)
0.6 3.4 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.6 1.7 GO:0042843 D-xylose catabolic process(GO:0042843)
0.5 8.7 GO:0019740 nitrogen utilization(GO:0019740)
0.5 3.8 GO:0000023 maltose metabolic process(GO:0000023)
0.5 4.7 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.5 3.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 2.0 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.5 1.5 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.5 1.9 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.5 3.8 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.5 9.3 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.4 0.4 GO:0034440 fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
0.4 5.5 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.4 1.7 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.4 6.3 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.4 0.8 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.4 1.2 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.4 1.9 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.4 2.8 GO:0045332 phospholipid translocation(GO:0045332)
0.3 2.4 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.3 1.0 GO:2001247 positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
0.3 1.0 GO:0006111 regulation of gluconeogenesis(GO:0006111)
0.3 1.0 GO:0070583 spore membrane bending pathway(GO:0070583)
0.3 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.3 1.0 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.3 3.2 GO:0046686 response to cadmium ion(GO:0046686)
0.3 4.7 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.3 0.9 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.3 0.9 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.3 0.6 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.3 2.8 GO:0015893 drug transport(GO:0015893)
0.3 1.7 GO:0051260 protein homooligomerization(GO:0051260)
0.3 5.0 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.3 0.8 GO:0015693 magnesium ion transport(GO:0015693)
0.3 0.5 GO:0045912 negative regulation of cellular carbohydrate metabolic process(GO:0010677) negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of carbohydrate metabolic process(GO:0045912) negative regulation of glycogen metabolic process(GO:0070874)
0.3 2.6 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.3 0.8 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.3 0.5 GO:0071941 urea metabolic process(GO:0019627) nitrogen cycle metabolic process(GO:0071941)
0.2 1.0 GO:0032105 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.2 0.7 GO:0043335 protein unfolding(GO:0043335)
0.2 0.7 GO:0051093 negative regulation of cell differentiation(GO:0045596) negative regulation of developmental process(GO:0051093)
0.2 1.7 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.2 1.5 GO:0072337 modified amino acid transport(GO:0072337)
0.2 0.7 GO:0036257 multivesicular body organization(GO:0036257)
0.2 2.8 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.2 1.1 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.2 1.7 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.2 2.8 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.2 1.2 GO:0018065 protein-cofactor linkage(GO:0018065)
0.2 2.0 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.2 0.4 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.2 3.9 GO:0016579 protein deubiquitination(GO:0016579)
0.2 0.6 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.2 0.6 GO:0019323 pentose metabolic process(GO:0019321) pentose catabolic process(GO:0019323)
0.2 0.2 GO:0043902 positive regulation of multi-organism process(GO:0043902)
0.2 0.8 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.2 6.0 GO:0007031 peroxisome organization(GO:0007031)
0.2 0.6 GO:0031297 replication fork processing(GO:0031297)
0.2 0.2 GO:0006740 NADPH regeneration(GO:0006740)
0.2 0.4 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.2 0.5 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.2 0.5 GO:0071281 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.2 0.3 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.2 0.5 GO:0045117 azole transport(GO:0045117)
0.2 0.7 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.2 2.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.2 1.0 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.2 0.5 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.2 0.8 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.2 0.5 GO:0051503 adenine nucleotide transport(GO:0051503)
0.2 5.2 GO:0009060 aerobic respiration(GO:0009060)
0.2 0.2 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.2 2.1 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.1 0.1 GO:0051238 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.1 6.0 GO:0042244 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 2.0 GO:0042026 protein refolding(GO:0042026)
0.1 0.8 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.9 GO:0009306 protein secretion(GO:0009306)
0.1 0.8 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.4 GO:1902751 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 0.5 GO:0071709 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 0.6 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.2 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1 0.3 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.1 1.7 GO:0007129 synapsis(GO:0007129)
0.1 0.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.5 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.3 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.6 GO:0006276 plasmid maintenance(GO:0006276)
0.1 0.1 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.1 0.3 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.1 0.8 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.3 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.1 0.3 GO:0034059 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 2.3 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.1 0.3 GO:0070542 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.1 0.3 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 0.7 GO:0043488 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.1 0.5 GO:0015677 copper ion import(GO:0015677)
0.1 0.8 GO:0006513 protein monoubiquitination(GO:0006513)
0.1 0.7 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 0.6 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.5 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.1 0.8 GO:0006817 phosphate ion transport(GO:0006817)
0.1 0.2 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.1 0.3 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.1 0.2 GO:2000217 regulation of invasive growth in response to glucose limitation(GO:2000217)
0.1 0.5 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.2 GO:0071850 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.1 0.4 GO:0006591 ornithine metabolic process(GO:0006591)
0.1 0.6 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.1 1.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.3 GO:0032973 amino acid export(GO:0032973)
0.1 0.2 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 0.8 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 0.6 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.1 0.2 GO:0042407 cristae formation(GO:0042407)
0.1 0.1 GO:0010676 positive regulation of cellular carbohydrate metabolic process(GO:0010676) positive regulation of carbohydrate metabolic process(GO:0045913)
0.1 0.2 GO:0006596 polyamine biosynthetic process(GO:0006596) spermidine metabolic process(GO:0008216)
0.1 0.2 GO:0001308 progressive alteration of chromatin involved in replicative cell aging(GO:0001304) negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.1 0.2 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1 0.7 GO:0008360 regulation of cell shape(GO:0008360)
0.1 0.2 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.1 0.2 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.1 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.2 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.0 0.6 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.1 GO:0042148 strand invasion(GO:0042148)
0.0 0.6 GO:0000902 cell morphogenesis(GO:0000902)
0.0 0.3 GO:0051322 anaphase(GO:0051322)
0.0 0.7 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.2 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.7 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.2 GO:0000729 meiotic DNA double-strand break processing(GO:0000706) DNA double-strand break processing(GO:0000729)
0.0 0.1 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.0 0.6 GO:0031503 protein complex localization(GO:0031503)
0.0 0.1 GO:0065005 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.0 0.3 GO:0005977 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.0 0.2 GO:0009967 positive regulation of signal transduction(GO:0009967) positive regulation of signaling(GO:0023056)
0.0 0.1 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.6 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.4 GO:0006301 postreplication repair(GO:0006301)
0.0 0.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.3 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.0 0.1 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.0 0.0 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.0 0.1 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.1 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.2 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.0 0.3 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.1 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.0 0.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.1 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.0 0.1 GO:0072367 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.0 1.1 GO:0031505 fungal-type cell wall organization(GO:0031505)
0.0 0.0 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.0 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 0.0 GO:0035690 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.0 0.0 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.0 0.1 GO:0042181 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 20.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.5 13.9 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.2 4.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.2 3.5 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.9 14.2 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.8 4.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.6 5.1 GO:0042597 periplasmic space(GO:0042597)
0.6 35.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.6 1.7 GO:0046930 pore complex(GO:0046930)
0.5 9.5 GO:0070469 respiratory chain(GO:0070469)
0.5 3.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.5 3.1 GO:0032126 eisosome(GO:0032126)
0.4 1.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 5.3 GO:0005619 ascospore wall(GO:0005619)
0.4 1.2 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.4 1.6 GO:0008623 CHRAC(GO:0008623)
0.4 4.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.3 2.4 GO:0034657 GID complex(GO:0034657)
0.3 5.0 GO:0033698 Rpd3L complex(GO:0033698)
0.3 0.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 1.4 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.3 41.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 1.0 GO:0031932 TORC2 complex(GO:0031932)
0.2 1.8 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.2 0.7 GO:0032585 multivesicular body membrane(GO:0032585)
0.2 0.7 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 3.3 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.2 0.9 GO:0005770 late endosome(GO:0005770)
0.2 0.6 GO:0030128 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.2 1.1 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.1 0.4 GO:0032177 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.1 0.4 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.1 0.8 GO:0033263 CORVET complex(GO:0033263)
0.1 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.3 GO:0035649 Nrd1 complex(GO:0035649)
0.1 0.6 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 0.6 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 0.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.3 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 1.0 GO:0000795 synaptonemal complex(GO:0000795)
0.1 3.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.7 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.4 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.1 1.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 1.5 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.1 0.3 GO:0019867 outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.1 0.4 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.1 1.5 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 1.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 49.0 GO:0005739 mitochondrion(GO:0005739)
0.1 1.7 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 4.1 GO:0009277 fungal-type cell wall(GO:0009277)
0.1 0.7 GO:0005769 early endosome(GO:0005769)
0.1 1.2 GO:0005811 lipid particle(GO:0005811)
0.1 0.2 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.1 0.7 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.2 GO:0033309 SBF transcription complex(GO:0033309)
0.1 0.6 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0097196 Shu complex(GO:0097196)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.2 GO:0019866 organelle inner membrane(GO:0019866)
0.0 1.3 GO:0044440 endosomal part(GO:0044440)
0.0 0.1 GO:0032545 CURI complex(GO:0032545)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153) ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 18.5 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
3.6 10.9 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
2.9 11.7 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
2.8 8.4 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
2.0 8.0 GO:0004396 hexokinase activity(GO:0004396)
2.0 7.9 GO:0005537 mannose binding(GO:0005537)
1.8 5.5 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.8 7.3 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.7 8.3 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.4 6.8 GO:0015295 solute:proton symporter activity(GO:0015295)
1.3 6.7 GO:0008198 ferrous iron binding(GO:0008198)
1.2 3.7 GO:0005536 glucose binding(GO:0005536)
1.2 2.4 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.2 3.6 GO:0016289 CoA hydrolase activity(GO:0016289)
1.1 4.4 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
1.0 10.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.9 7.6 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.9 10.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.9 0.9 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.8 2.3 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.8 2.3 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.8 7.6 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.7 3.6 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.7 2.1 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.7 2.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.7 2.7 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.6 1.3 GO:0015038 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.6 6.0 GO:0035064 methylated histone binding(GO:0035064)
0.6 11.4 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.6 3.5 GO:0000400 four-way junction DNA binding(GO:0000400)
0.6 1.7 GO:0022829 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.6 1.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.5 7.1 GO:0015297 antiporter activity(GO:0015297)
0.5 4.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 0.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.5 4.3 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.5 2.8 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.5 4.2 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.5 4.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.4 3.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379) peroxiredoxin activity(GO:0051920)
0.4 3.8 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.4 1.3 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.4 0.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 1.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 2.1 GO:0016408 C-acyltransferase activity(GO:0016408)
0.4 2.1 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.4 2.9 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.4 3.2 GO:0015293 symporter activity(GO:0015293)
0.4 5.2 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.4 4.8 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.4 1.9 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.4 1.1 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.4 4.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.4 5.3 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.3 4.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 1.3 GO:0008172 S-methyltransferase activity(GO:0008172)
0.3 0.9 GO:0070569 uridylyltransferase activity(GO:0070569)
0.3 3.1 GO:0004888 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.3 3.0 GO:0043495 protein anchor(GO:0043495)
0.3 5.4 GO:0016836 hydro-lyase activity(GO:0016836)
0.3 12.9 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.3 5.8 GO:0051287 NAD binding(GO:0051287)
0.3 1.6 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 0.8 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.2 1.7 GO:0000149 SNARE binding(GO:0000149)
0.2 2.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 0.7 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 1.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 3.4 GO:0042803 protein homodimerization activity(GO:0042803)
0.2 1.8 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 0.6 GO:0016417 S-acyltransferase activity(GO:0016417)
0.2 2.4 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.2 2.6 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.2 1.2 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 1.0 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.2 1.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 12.8 GO:0051082 unfolded protein binding(GO:0051082)
0.2 0.3 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.2 0.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 0.5 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.2 0.5 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.2 3.5 GO:0016298 lipase activity(GO:0016298)
0.2 2.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.2 0.6 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.1 0.6 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 1.7 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.1 1.2 GO:0005548 phospholipid transporter activity(GO:0005548)
0.1 1.4 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.1 0.4 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 1.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.6 GO:0004075 biotin carboxylase activity(GO:0004075)
0.1 0.5 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 1.4 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 4.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.3 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 0.5 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.1 9.4 GO:0004672 protein kinase activity(GO:0004672)
0.1 2.1 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.4 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 0.3 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.4 GO:0016597 amino acid binding(GO:0016597)
0.1 0.2 GO:0043812 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 0.2 GO:0045118 azole transporter activity(GO:0045118)
0.1 2.2 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.1 0.3 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 1.8 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.2 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.1 0.4 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 2.2 GO:0046983 protein dimerization activity(GO:0046983)
0.1 0.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.3 GO:0046970 NAD-dependent histone deacetylase activity(GO:0017136) histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H3-K9 specific)(GO:0032129) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent protein deacetylase activity(GO:0034979) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.1 1.1 GO:0008374 O-acyltransferase activity(GO:0008374)
0.1 0.5 GO:0001671 ATPase activator activity(GO:0001671) ATPase regulator activity(GO:0060590)
0.1 0.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 1.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.3 GO:0015103 inorganic anion transmembrane transporter activity(GO:0015103)
0.0 0.1 GO:0070336 flap-structured DNA binding(GO:0070336)
0.0 0.3 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.1 GO:0032183 SUMO binding(GO:0032183)
0.0 0.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.4 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.3 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 0.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.2 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.0 0.1 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.3 GO:0015926 glucosidase activity(GO:0015926)
0.0 0.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.2 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0022804 active transmembrane transporter activity(GO:0022804)
0.0 0.1 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.5 1.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5 2.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.4 3.5 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 0.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 0.6 PID NOTCH PATHWAY Notch signaling pathway
0.1 0.3 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 116.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 0.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
1.7 5.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.9 7.8 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 0.7 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 1.0 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.2 0.6 REACTOME DNA REPAIR Genes involved in DNA Repair
0.2 0.3 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.1 0.4 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.1 112.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.3 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.0 0.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein