Results for YBL054W

Z-value: 0.90

Activity profile of YBL054W motif

Sorted Z-values of YBL054W motif

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 11.02 Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 9.37 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YOR096W 5.93 Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YER102W 5.79 Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YDR345C 5.47 Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YDR385W 5.30 Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YMR246W 5.12 Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YLR154W-B 4.52 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154C 4.52 Ribonuclease H2 subunit, required for RNase H2 activity
YLR154W-A 4.50 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YPR148C 4.47 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YFR031C-A 4.10 Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YDR384C 3.93 Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
YJR105W 3.73 Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YDR399W 3.61 Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YOR101W 3.58 GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YJL148W 3.40 RNA polymerase I subunit A34.5
YMR123W 3.14 V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YAL033W 3.12 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YOR340C 2.98 RNA polymerase I subunit A43
YER146W 2.98 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YOL124C 2.97 Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YNL112W 2.97 Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing
YLR333C 2.88 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YIL133C 2.86 N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YPL090C 2.86 Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YEL053W-A 2.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YIL091C 2.77 Protein required for cell viability
YCR018C 2.67 Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YJL011C 2.66 RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YEL027W 2.58 Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YLR154W-C 2.58 Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YER131W 2.55 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YHR070C-A 2.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W
YER074W 2.46 Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YNL248C 2.44 RNA polymerase I subunit A49
YFR054C 2.44 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR349W 2.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YIL158W 2.36 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YKL209C 2.34 Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YOL109W 2.32 Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria
YLR348C 2.30 Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YBL092W 2.29 Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YKR074W 2.26 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YOR226C 2.26 Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YKL153W 2.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YPL250W-A 2.24 Identified by fungal homology and RT-PCR
YEL029C 2.22 Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YLR449W 2.18 Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YKR092C 2.17 Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YNL178W 2.16 Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YNR001W-A 2.16 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YKL009W 2.13 Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YMR049C 2.12 Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YCR016W 2.08 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene
YJR070C 2.07 Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YNL175C 2.06 Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA
YMR217W 2.02 GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YNR016C 2.02 Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YIR021W 2.00 Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YBR084W 1.98 Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
YNR043W 1.97 Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer
YDR037W 1.96 Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YMR199W 1.96 G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YOL123W 1.95 Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YPR163C 1.95 Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
YLR300W 1.94 Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YDR087C 1.93 Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
YNR053C 1.92 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YAL059W 1.91 Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export
YJR071W 1.91 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL162C 1.89 Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YDR033W 1.88 Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YDR450W 1.87 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YIR026C 1.87 Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; transcription induced by low temperature and nitrogen starvation; member of the dual-specificity family of protein phosphatases
YDR183C-A 1.87 Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR
YIL078W 1.87 Threonyl-tRNA synthetase, essential cytoplasmic protein
YIL056W 1.86 Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YLR325C 1.82 Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YNL065W 1.82 Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YMR032W 1.82 Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YBR092C 1.80 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YPL112C 1.79 Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YDR454C 1.78 Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
YGR151C 1.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C
YDL208W 1.77 Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
YER073W 1.77 Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YOL041C 1.77 Nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe
YCR031C 1.77 Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YEL068C 1.76 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL096C 1.76 Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit
YGR123C 1.76 Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YPL108W 1.76 Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YLR002C 1.76 Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation
YKL164C 1.75 O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YGR159C 1.75 Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YNL113W 1.73 RNA polymerase subunit, common to RNA polymerases I and III
YDR083W 1.72 Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation
YKL110C 1.72 Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YPL211W 1.71 Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
YIL053W 1.70 Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YHR148W 1.70 Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
YPL143W 1.67 N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
YNL141W 1.65 Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
YDL148C 1.64 Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
YOR004W 1.62 Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function
YOR063W 1.61 Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YNL114C 1.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
YMR011W 1.60 High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YLR185W 1.60 Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YBR084C-A 1.59 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YER003C 1.59 Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YLR196W 1.58 Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YIR012W 1.56 Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay
YOL077C 1.56 Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
YNL182C 1.55 Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YDL051W 1.55 RNA binding protein required for maturation of tRNA and snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
YLR420W 1.54 Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YAL025C 1.53 Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
YGR121W-A 1.52 Putative protein of unknown function
YLR183C 1.52 Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YDR321W 1.50 Cytosolic L-asparaginase, involved in asparagine catabolism
YLL034C 1.50 Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
YBL027W 1.49 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YDL055C 1.48 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YOR153W 1.48 Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YOR243C 1.48 Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates
YDR002W 1.47 Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YJR145C 1.45 Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YJL200C 1.45 Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YKR079C 1.44 tRNase Z, involved in RNA processing, has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif, homolog of the human candidate prostate cancer susceptibility gene ELAC2
YDR120C 1.44 tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
YNL251C 1.43 RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs
YIL110W 1.43 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; deletion mutant exhibits a weak vacuolar protein sorting defect, enhanced resistance to caspofungin, and is synthetically lethal with MEN mutants
YKL099C 1.42 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YHR197W 1.41 Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YLR129W 1.40 Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
YKL182W 1.40 Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YGR200C 1.39 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
YLR068W 1.39 Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts
YNL234W 1.39 Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p
YEL020C-B 1.39 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YGR124W 1.37 Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YDL167C 1.36 Protein of unknown function, rich in asparagine residues
YLR180W 1.35 S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YNL247W 1.35 Essential protein of unknown function; may interact with ribosomes, based on co-purification experiments
YDR021W 1.34 Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
YKL014C 1.34 Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
YDR144C 1.34 GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p
YER107W-A 1.33 Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C
YBR182C-A 1.33 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YEL066W 1.33 D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YBL028C 1.32 Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
YKL181W 1.32 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YOR234C 1.31 Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
YJR094W-A 1.31 Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YDR279W 1.31 Ribonuclease H2 subunit, required for RNase H2 activity
YBL031W 1.31 Cytoskeletal protein of unknown function; overexpression causes growth arrest
YDR091C 1.31 Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YPL010W 1.30 Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YPR043W 1.29 Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype
YER107C 1.28 Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p
YBR118W 1.28 Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YPL037C 1.27 Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YOR108W 1.27 Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YHR052W 1.26 Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
YBR187W 1.26 Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis
YPL141C 1.25 Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YFR021W 1.25 Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
YDR060W 1.24 Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
YPL266W 1.24 Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
YML026C 1.23 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YOR287C 1.23 Putative protein of unknown function; may play a role in the ribosome and rRNA biosynthesis based on expression profiles and mutant phenotype
YHR149C 1.23 Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YCR057C 1.21 Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis
YCL036W 1.21 Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
YBR061C 1.21 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop
YGL050W 1.21 tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YGL078C 1.20 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
YPL239W 1.20 Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
YPR051W 1.20 Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus
YGL055W 1.19 Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YER001W 1.19 Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YKR081C 1.17 Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
YDR276C 1.17 Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YGL028C 1.16 Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
YBR104W 1.16 Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YAL053W 1.16 Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YJL025W 1.15 Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn6p and TATA-binding protein
YBR154C 1.15 RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
YPL212C 1.13 tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA
YPL062W 1.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YDL211C 1.12 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YBR142W 1.12 Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
YDR429C 1.12 Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation
YHR085W 1.11 Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YAL036C 1.11 Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46p
YKR060W 1.10 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YIL127C 1.10 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YDL112W 1.10 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs

Network of associatons between targets according to the STRING database.

First level regulatory network of YBL054W

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.0 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
1.8 7.3 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
1.8 5.3 GO:0045901 positive regulation of translational elongation(GO:0045901)
1.5 1.5 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
1.3 8.1 GO:0046037 GMP metabolic process(GO:0046037)
1.2 3.6 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
1.0 2.1 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
1.0 3.1 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.9 3.5 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.8 5.8 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.8 1.7 GO:0046083 adenine metabolic process(GO:0046083)
0.8 3.2 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.8 2.4 GO:0044209 AMP salvage(GO:0044209)
0.8 3.1 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.7 23.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.7 3.5 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.7 2.8 GO:0006528 asparagine metabolic process(GO:0006528)
0.7 2.7 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.7 0.7 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.7 11.8 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.6 11.6 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.6 18.4 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472)
0.6 1.8 GO:0071049 nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription(GO:0071049)
0.6 3.0 GO:0046656 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.6 5.4 GO:0031070 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.6 1.7 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.5 10.1 GO:0030488 tRNA methylation(GO:0030488)
0.5 24.0 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.5 40.7 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.5 2.0 GO:0031057 negative regulation of histone modification(GO:0031057)
0.5 3.8 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.5 1.4 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.4 1.3 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.4 1.3 GO:0046831 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.4 1.3 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.4 1.3 GO:0006624 vacuolar protein processing(GO:0006624)
0.4 2.0 GO:0042710 biofilm formation(GO:0042710)
0.4 39.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.4 0.4 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.4 1.9 GO:0042435 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.4 4.6 GO:0071047 nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.4 1.5 GO:0000296 spermine transport(GO:0000296)
0.4 1.9 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.4 2.6 GO:0009098 leucine biosynthetic process(GO:0009098)
0.4 1.1 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.4 2.2 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.4 4.1 GO:0006817 phosphate ion transport(GO:0006817)
0.4 1.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.3 8.4 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.3 1.0 GO:0009221 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) 2'-deoxyribonucleotide biosynthetic process(GO:0009265) 2'-deoxyribonucleotide metabolic process(GO:0009394) deoxyribose phosphate biosynthetic process(GO:0046385)
0.3 0.3 GO:0033967 box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963)
0.3 1.0 GO:1902101 positive regulation of mitotic nuclear division(GO:0045840) positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101) positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.3 0.7 GO:0033866 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.3 1.3 GO:0031167 rRNA methylation(GO:0031167)
0.3 15.5 GO:0006364 rRNA processing(GO:0006364)
0.3 0.3 GO:0042304 regulation of fatty acid biosynthetic process(GO:0042304)
0.3 0.9 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
0.3 1.2 GO:0048313 Golgi inheritance(GO:0048313)
0.3 1.2 GO:0044206 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.3 0.8 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.3 1.1 GO:0017157 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.3 1.1 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.3 0.5 GO:0071850 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.3 0.8 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
0.3 0.8 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.3 3.8 GO:0015833 peptide transport(GO:0015833)
0.3 2.0 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.3 1.8 GO:0006855 drug transmembrane transport(GO:0006855)
0.3 0.8 GO:0071545 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.3 2.5 GO:0006415 translational termination(GO:0006415)
0.2 0.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 1.0 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.2 1.4 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.2 1.0 GO:0009099 valine biosynthetic process(GO:0009099)
0.2 0.7 GO:0000912 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.2 1.6 GO:0007000 nucleolus organization(GO:0007000)
0.2 0.7 GO:0018195 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.2 0.9 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.2 2.5 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.2 1.5 GO:0043457 regulation of cellular respiration(GO:0043457)
0.2 1.3 GO:0006491 N-glycan processing(GO:0006491)
0.2 1.5 GO:0032447 protein urmylation(GO:0032447)
0.2 3.2 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.2 1.0 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.2 3.0 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.2 1.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.2 1.0 GO:0007535 donor selection(GO:0007535)
0.2 0.6 GO:2001057 reactive nitrogen species metabolic process(GO:2001057)
0.2 0.4 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.2 0.8 GO:0006448 regulation of translational elongation(GO:0006448)
0.2 0.4 GO:0016077 snRNA catabolic process(GO:0016076) snoRNA catabolic process(GO:0016077) nuclear polyadenylation-dependent snoRNA catabolic process(GO:0071036) nuclear polyadenylation-dependent snRNA catabolic process(GO:0071037)
0.2 0.7 GO:0015883 FAD transport(GO:0015883)
0.2 0.7 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) isoleucine biosynthetic process(GO:0009097)
0.2 0.2 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.2 0.5 GO:0042256 mature ribosome assembly(GO:0042256)
0.2 1.4 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.2 0.8 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.1 0.9 GO:0016559 peroxisome fission(GO:0016559)
0.1 0.6 GO:0045896 regulation of transcription during mitosis(GO:0045896)
0.1 0.1 GO:0061647 histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.1 0.3 GO:0032261 purine nucleotide salvage(GO:0032261)
0.1 0.1 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.1 0.1 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.1 0.6 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.1 3.4 GO:0006184 obsolete GTP catabolic process(GO:0006184)
0.1 0.9 GO:0006116 NADH oxidation(GO:0006116)
0.1 0.3 GO:0042992 negative regulation of transcription factor import into nucleus(GO:0042992)
0.1 0.5 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.1 0.5 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.2 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.1 1.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.5 GO:0035065 regulation of histone acetylation(GO:0035065) positive regulation of histone acetylation(GO:0035066) regulation of protein acetylation(GO:1901983) positive regulation of protein acetylation(GO:1901985) regulation of peptidyl-lysine acetylation(GO:2000756) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.1 2.0 GO:0019740 nitrogen utilization(GO:0019740)
0.1 0.5 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 0.8 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.1 0.8 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.1 0.3 GO:1902707 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.1 0.2 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 0.8 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 3.2 GO:0008033 tRNA processing(GO:0008033)
0.1 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.4 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.4 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.1 0.9 GO:0009303 rRNA transcription(GO:0009303)
0.1 2.5 GO:0016129 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.1 0.1 GO:1903322 positive regulation of protein ubiquitination(GO:0031398) positive regulation of protein modification by small protein conjugation or removal(GO:1903322)
0.1 3.2 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 0.1 GO:0006952 defense response(GO:0006952)
0.1 0.8 GO:0046040 IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.1 0.3 GO:0048211 Golgi vesicle docking(GO:0048211)
0.1 0.6 GO:0071267 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.1 0.9 GO:0055074 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)
0.1 0.6 GO:0045116 protein neddylation(GO:0045116)
0.1 0.6 GO:0000279 mitotic M phase(GO:0000087) M phase(GO:0000279)
0.1 0.6 GO:0006720 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.1 2.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 0.6 GO:0031134 sister chromatid biorientation(GO:0031134)
0.1 2.1 GO:0006334 nucleosome assembly(GO:0006334)
0.1 0.3 GO:0046495 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.1 0.9 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.1 1.6 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 0.2 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111) regulation of microtubule depolymerization(GO:0031114)
0.1 0.3 GO:0030834 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.1 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.6 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.1 0.9 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.1 0.2 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.1 1.1 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.1 0.4 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 0.2 GO:0036213 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.1 1.2 GO:0010383 cell wall polysaccharide metabolic process(GO:0010383)
0.1 0.3 GO:0036010 protein localization to endosome(GO:0036010)
0.1 0.2 GO:0070417 response to cold(GO:0009409) positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422) cellular response to cold(GO:0070417) cellular response to ethanol(GO:0071361) regulation of cell aging(GO:0090342) cellular response to alcohol(GO:0097306) regulation of replicative cell aging(GO:1900062)
0.1 0.2 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 0.2 GO:0046348 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.1 0.1 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.1 0.5 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.1 0.6 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.3 GO:0009088 threonine biosynthetic process(GO:0009088)
0.1 0.3 GO:0015680 intracellular copper ion transport(GO:0015680)
0.1 0.3 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 0.8 GO:0006999 nuclear pore organization(GO:0006999)
0.1 0.2 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.1 0.2 GO:0098609 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.1 0.2 GO:0090399 replicative senescence(GO:0090399)
0.1 0.2 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1 0.1 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.1 0.2 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 0.2 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1 1.8 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 1.3 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 0.3 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.1 0.2 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.3 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.1 0.4 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.1 0.1 GO:0006816 calcium ion transport(GO:0006816)
0.1 0.2 GO:0090002 protein localization to plasma membrane(GO:0072659) establishment of protein localization to plasma membrane(GO:0090002) protein localization to cell periphery(GO:1990778)
0.1 0.6 GO:0016074 snoRNA metabolic process(GO:0016074)
0.0 0.1 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.0 0.1 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 0.1 GO:0052646 alditol phosphate metabolic process(GO:0052646)
0.0 1.5 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.1 GO:0051093 negative regulation of cell differentiation(GO:0045596) negative regulation of developmental process(GO:0051093)
0.0 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.7 GO:0007020 microtubule nucleation(GO:0007020) microtubule polymerization(GO:0046785)
0.0 0.8 GO:0012501 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.0 0.1 GO:0007009 plasma membrane organization(GO:0007009)
0.0 0.1 GO:0006734 NADH metabolic process(GO:0006734)
0.0 0.4 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 2.5 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.3 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.2 GO:0000032 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.0 0.2 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.1 GO:0097549 heterochromatin organization involved in chromatin silencing(GO:0070868) chromatin organization involved in negative regulation of transcription(GO:0097549)
0.0 0.1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054) negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.1 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.0 0.1 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.1 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.0 0.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.1 GO:0051785 positive regulation of nuclear division(GO:0051785)
0.0 0.1 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.0 0.1 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.0 0.4 GO:0030261 chromosome condensation(GO:0030261)
0.0 0.1 GO:0043007 maintenance of rDNA(GO:0043007)
0.0 0.8 GO:0070590 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.0 0.0 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.1 GO:0005992 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.0 0.1 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.0 0.1 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:0032988 ribonucleoprotein complex disassembly(GO:0032988)
0.0 0.1 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.0 0.1 GO:0032042 mitochondrial DNA metabolic process(GO:0032042)
0.0 1.0 GO:0006913 nucleocytoplasmic transport(GO:0006913)
0.0 0.1 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.0 0.1 GO:0030491 heteroduplex formation(GO:0030491)
0.0 0.1 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.0 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.2 GO:0015918 sterol transport(GO:0015918)
0.0 0.3 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.1 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.2 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.4 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0 0.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.2 GO:0007051 spindle organization(GO:0007051)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.4 4.1 GO:0097344 Rix1 complex(GO:0097344)
1.1 5.4 GO:0030689 Noc complex(GO:0030689)
1.0 3.1 GO:0070545 PeBoW complex(GO:0070545)
1.0 13.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.9 5.4 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.8 8.0 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.8 2.4 GO:0034457 Mpp10 complex(GO:0034457)
0.7 21.8 GO:0032040 small-subunit processome(GO:0032040)
0.7 2.0 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.6 25.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.6 5.4 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.6 2.4 GO:0042788 polysomal ribosome(GO:0042788)
0.6 2.8 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.6 2.2 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.5 3.3 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.5 20.8 GO:0030684 preribosome(GO:0030684)
0.5 1.5 GO:0000928 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.5 1.8 GO:0044697 HICS complex(GO:0044697)
0.4 1.3 GO:0035649 Nrd1 complex(GO:0035649)
0.4 1.3 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.4 32.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 1.2 GO:0031417 NatC complex(GO:0031417)
0.4 3.1 GO:0005688 U6 snRNP(GO:0005688)
0.4 14.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 1.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.4 3.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.3 1.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.3 1.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.3 1.2 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.3 0.9 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 33.6 GO:0005730 nucleolus(GO:0005730)
0.3 1.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.3 1.0 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 0.8 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 1.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 1.0 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.2 2.0 GO:0030126 COPI vesicle coat(GO:0030126)
0.2 0.9 GO:0000938 GARP complex(GO:0000938)
0.2 1.3 GO:0005880 nuclear microtubule(GO:0005880)
0.2 1.3 GO:0070772 PAS complex(GO:0070772)
0.2 1.4 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.2 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 0.8 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.2 0.8 GO:0034448 EGO complex(GO:0034448)
0.2 0.9 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.2 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 0.7 GO:0042597 periplasmic space(GO:0042597)
0.2 0.8 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.2 1.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.2 0.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 2.4 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.4 GO:0051286 cell tip(GO:0051286)
0.1 0.4 GO:0070939 Dsl1p complex(GO:0070939)
0.1 0.3 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.5 GO:0034990 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.1 0.9 GO:0016459 myosin complex(GO:0016459)
0.1 1.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.9 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.4 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 1.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.2 GO:0000786 nucleosome(GO:0000786)
0.1 0.7 GO:0051233 spindle midzone(GO:0051233)
0.1 0.4 GO:0030907 MBF transcription complex(GO:0030907)
0.1 3.9 GO:0005811 lipid particle(GO:0005811)
0.1 1.1 GO:0000243 commitment complex(GO:0000243)
0.1 1.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.8 GO:0017119 Golgi transport complex(GO:0017119)
0.1 0.3 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.1 0.7 GO:0000144 cellular bud neck septin ring(GO:0000144)
0.1 0.4 GO:0000133 polarisome(GO:0000133)
0.1 0.2 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.1 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.4 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 0.3 GO:0000811 GINS complex(GO:0000811)
0.1 0.4 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.1 0.6 GO:0000142 cellular bud neck contractile ring(GO:0000142)
0.1 1.4 GO:0005844 polysome(GO:0005844)
0.1 2.3 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 0.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 7.7 GO:0005840 ribosome(GO:0005840)
0.1 0.6 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 0.2 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.1 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.3 GO:0005940 septin ring(GO:0005940)
0.1 0.3 GO:0000136 alpha-1,6-mannosyltransferase complex(GO:0000136)
0.1 0.5 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 0.3 GO:0031389 DNA replication factor C complex(GO:0005663) Rad17 RFC-like complex(GO:0031389) Elg1 RFC-like complex(GO:0031391)
0.1 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 1.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.6 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.0 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.2 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.3 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.1 GO:0000798 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.3 GO:0036452 ESCRT complex(GO:0036452)
0.0 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.1 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.0 1.1 GO:0005643 nuclear pore(GO:0005643)
0.0 0.1 GO:0000417 HIR complex(GO:0000417)
0.0 0.1 GO:0005824 outer plaque of spindle pole body(GO:0005824)
0.0 0.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.4 GO:0016586 RSC complex(GO:0016586)
0.0 0.4 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.1 GO:0070209 ASTRA complex(GO:0070209)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.1 GO:0005884 actin filament(GO:0005884)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.3 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.2 GO:0000346 transcription export complex(GO:0000346)
0.0 0.7 GO:0044445 cytosolic part(GO:0044445)
0.0 0.1 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0000796 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.0 0.2 GO:0030118 clathrin coat(GO:0030118)
0.0 0.1 GO:0034044 exomer complex(GO:0034044)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.0 GO:0033179 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 9.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
1.5 5.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.4 4.2 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
1.3 5.2 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
1.0 4.1 GO:0019206 nucleoside kinase activity(GO:0019206)
1.0 3.0 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
1.0 13.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.9 2.7 GO:0008097 5S rRNA binding(GO:0008097)
0.8 2.5 GO:0019003 GDP binding(GO:0019003)
0.8 3.4 GO:1904680 peptide transmembrane transporter activity(GO:1904680)
0.8 15.0 GO:0030515 snoRNA binding(GO:0030515)
0.7 2.1 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.6 1.9 GO:0097617 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.6 9.2 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.6 1.8 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.6 2.3 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.6 2.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.5 2.1 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.5 21.4 GO:0019843 rRNA binding(GO:0019843)
0.5 3.5 GO:0016778 diphosphotransferase activity(GO:0016778)
0.5 1.5 GO:0070568 guanylyltransferase activity(GO:0070568)
0.5 2.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.4 1.3 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.4 2.4 GO:0003993 acid phosphatase activity(GO:0003993)
0.4 3.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.4 1.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.4 1.9 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.4 1.5 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.4 1.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.4 3.7 GO:0001056 RNA polymerase III activity(GO:0001056)
0.4 3.3 GO:0004497 monooxygenase activity(GO:0004497)
0.4 2.2 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.4 1.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.4 1.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.3 3.9 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.3 1.6 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.3 0.9 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.3 1.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.3 11.4 GO:0003724 RNA helicase activity(GO:0003724)
0.3 54.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 0.9 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.3 0.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 0.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 0.9 GO:0016882 cyclo-ligase activity(GO:0016882)
0.3 2.6 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.3 0.8 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.3 2.7 GO:0019239 deaminase activity(GO:0019239)
0.3 1.1 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.3 1.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.3 1.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.3 1.0 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 1.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.2 4.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.2 0.7 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 0.7 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.2 0.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 2.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 0.7 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.2 0.5 GO:0001082 transcription factor activity, RNA polymerase I transcription factor binding(GO:0001082) RNA polymerase I transcription factor binding(GO:0001179) transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.2 1.5 GO:0019201 nucleotide kinase activity(GO:0019201)
0.2 1.7 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 0.6 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 0.8 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 0.8 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.2 2.0 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.2 0.7 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.2 1.1 GO:0016408 C-acyltransferase activity(GO:0016408)
0.2 0.5 GO:0008242 omega peptidase activity(GO:0008242)
0.2 0.7 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.2 0.7 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.2 2.2 GO:0045182 translation regulator activity(GO:0045182)
0.2 4.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 0.5 GO:0009922 fatty acid elongase activity(GO:0009922)
0.2 0.3 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.2 0.5 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.2 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 0.8 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.2 5.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 0.5 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.1 5.1 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.1 GO:0015248 sterol transporter activity(GO:0015248)
0.1 9.2 GO:0003924 GTPase activity(GO:0003924)
0.1 0.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.4 GO:0004100 chitin synthase activity(GO:0004100)
0.1 1.2 GO:0010181 FMN binding(GO:0010181)
0.1 0.5 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 0.7 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1 0.9 GO:0000049 tRNA binding(GO:0000049)
0.1 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.6 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 0.6 GO:0017022 myosin binding(GO:0017022)
0.1 1.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.3 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.1 0.4 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.1 0.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.4 GO:0052744 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.1 1.1 GO:0019904 protein domain specific binding(GO:0019904)
0.1 0.3 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.1 0.6 GO:0004529 exodeoxyribonuclease activity(GO:0004529)
0.1 0.2 GO:0072341 modified amino acid binding(GO:0072341)
0.1 20.5 GO:0003723 RNA binding(GO:0003723)
0.1 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 0.4 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.1 1.4 GO:0005525 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.1 0.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.7 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.1 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.1 2.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.5 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 0.4 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 1.2 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 0.8 GO:0034061 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.1 0.7 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 1.3 GO:0008017 microtubule binding(GO:0008017)
0.1 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.4 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 0.3 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 5.2 GO:0003682 chromatin binding(GO:0003682)
0.1 0.2 GO:0005262 calcium channel activity(GO:0005262)
0.1 0.6 GO:0000182 rDNA binding(GO:0000182)
0.1 0.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 0.2 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.1 0.2 GO:0016504 peptidase activator activity(GO:0016504)
0.1 0.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.6 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.3 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.3 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.1 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.0 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.2 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 0.2 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.4 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.0 0.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.2 GO:0031072 heat shock protein binding(GO:0031072)
0.0 1.2 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.3 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.0 0.4 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.3 GO:0005048 signal sequence binding(GO:0005048)
0.0 0.3 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.3 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.6 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.1 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.2 GO:0043022 ribosome binding(GO:0043022)
0.0 0.1 GO:0008762 UDP-N-acetylmuramate dehydrogenase activity(GO:0008762)
0.0 0.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0015631 tubulin binding(GO:0015631)
0.0 0.9 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.0 0.7 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.3 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0008144 drug binding(GO:0008144)
0.0 0.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.1 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0008252 nucleotidase activity(GO:0008252)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0 0.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.2 GO:0015926 glucosidase activity(GO:0015926)
0.0 0.2 GO:0008170 N-methyltransferase activity(GO:0008170)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.3 1.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 1.1 PID PLK1 PATHWAY PLK1 signaling events
0.2 0.4 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 0.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 0.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 0.2 PID E2F PATHWAY E2F transcription factor network
0.1 0.2 PID MYC PATHWAY C-MYC pathway
0.0 0.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.3 PID ATR PATHWAY ATR signaling pathway
0.0 0.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.5 1.0 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.5 3.7 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.4 10.0 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.3 1.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.3 0.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 2.0 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.2 0.8 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.2 1.4 REACTOME AXON GUIDANCE Genes involved in Axon guidance
0.1 0.1 REACTOME HIV LIFE CYCLE Genes involved in HIV Life Cycle
0.1 0.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.3 REACTOME PROTEIN FOLDING Genes involved in Protein folding
0.0 0.2 REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0 0.1 REACTOME APOPTOSIS Genes involved in Apoptosis
0.0 0.4 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.0 0.1 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.2 REACTOME TRANSCRIPTION Genes involved in Transcription
0.0 0.1 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane