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Results for YAP7

Z-value: 1.46

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Transcription factors associated with YAP7

Gene Symbol Gene ID Gene Info
YAP7
S000005388 Putative basic leucine zipper (bZIP) transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
YAP7YOL028C-0.572.5e-03Click!

Activity profile of YAP7 motif

Sorted Z-values of YAP7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YPL171C 16.81
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YDR343C 11.97
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YLR307C-A 9.57 Putative protein of unknown function
YCR021C 9.20
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YDR453C 8.53
TSA2
Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YDR277C 7.89
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YFL030W 7.75
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YHL040C 7.74
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YNR034W-A 7.54 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YER065C 6.69
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YKL071W 6.23 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBR117C 6.16
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YFL055W 6.00
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YLL053C 5.90 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YKL086W 5.51
SRX1
Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes
YJR146W 5.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YNL195C 5.41 Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL016C 5.39
ATP7
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YLL052C 5.18
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YFL052W 5.06 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YER150W 5.03
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YOR152C 5.00 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YMR096W 4.85
SNZ1
Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
YDL204W 4.79
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YNL134C 4.73 Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
YPL250C 4.71
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YHR139C 4.66
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YCR007C 4.50 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YLR149C 4.38 Putative protein of unknown function; YLR149C is not an essential gene
YAL002W 4.35
VPS8
Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif
YML087C 4.28
AIM33
Putative protein of unknown function; highly conserved across species and orthologous to human CYB5R4; null mutant shows increased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YDL170W 4.26
UGA3
Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YGL184C 4.17
STR3
Cystathionine beta-lyase, converts cystathionine into homocysteine
YJR048W 4.15
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YER024W 4.09
YAT2
Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
YPR078C 4.02 Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YAR050W 3.96
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YDL218W 3.87 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YDL182W 3.87
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YMR271C 3.86
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YER141W 3.84
COX15
Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
YBR008C 3.84
FLR1
Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs
YJR095W 3.74
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YLR294C 3.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14
YDR533C 3.56
HSP31
Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YJL130C 3.48
URA2
Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YAR047C 3.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR111W 3.10
DBF20
Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis
YLR312C 3.08
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YDR055W 3.02
PST1
Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
YMR095C 2.99
SNO1
Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
YHR048W 2.98
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YLL060C 2.90
GTT2
Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YGR225W 2.84
AMA1
Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis
YKL067W 2.76
YNK1
Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
YIL057C 2.75 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YDR010C 2.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL162C 2.74 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YLR047C 2.74
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YDR542W 2.65
PAU10
Hypothetical protein
YDL183C 2.64 Putative protein of unknown function; YDL183C is not an essential gene
YLL055W 2.61
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YLL056C 2.60 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YOR394W 2.56
PAU21
Hypothetical protein
YLR296W 2.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL114W 2.52 Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YHR008C 2.52
SOD2
Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
YJL088W 2.51
ARG3
Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
YML131W 2.50 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YPR007C 2.50
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YPL222C-A 2.48 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YOR173W 2.44
DCS2
Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YEL049W 2.44
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YHR199C 2.43
AIM46
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YAR035W 2.42
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YDR032C 2.41
PST2
Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL008W 2.40 Hypothetical protein predicted to be involved in metabolism
YOR072W 2.40 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YGR087C 2.32
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YBR179C 2.31
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YBL049W 2.29
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YGR209C 2.29
TRX2
Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance
YJL100W 2.28
LSB6
Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YGL188C 2.28 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHL046W-A 2.28 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL009C 2.28
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YLR295C 2.27
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YNR050C 2.23
LYS9
Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway
YKR067W 2.21
GPT2
Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YPL017C 2.21
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YNR069C 2.20
BSC5
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YGR191W 2.19
HIP1
High-affinity histidine permease, also involved in the transport of manganese ions
YPR023C 2.18
EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YER147C 2.17
SCC4
Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
YER066W 2.12 Putative protein of unknown function; YER066W is not an essential gene
YOR072W-A 2.12 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YOR120W 2.11
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YPR013C 2.10 Putative zinc finger protein; YPR013C is not an essential gene
YOR071C 2.06
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YLR135W 2.05
SLX4
Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
YJR046W 2.02
TAH11
DNA replication licensing factor, required for pre-replication complex assembly
YJR147W 2.02
HMS2
Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YNL176C 2.01 Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p
YMR118C 1.99 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YOR346W 1.99
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YCL017C 1.99
NFS1
Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria
YHL047C 1.98
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YNL240C 1.94
NAR1
Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf
YJR045C 1.94
SSC1
Mitochondrial matrix ATPase, subunit of the presequence translocase-associated protein import motor (PAM) and of SceI endonuclease; involved in protein folding and translocation into the matrix; phosphorylated; member of HSP70 family
YLR402W 1.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR066C 1.91
CCP1
Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YDL020C 1.91
RPN4
Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
YGR190C 1.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YGR065C 1.88
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YPL216W 1.87 Putative protein of unknown function; YPL216W is not an essential gene
YDR541C 1.86 Putative dihydrokaempferol 4-reductase
YOR221C 1.85
MCT1
Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling
YLR403W 1.84
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YCL048W 1.83
SPS22
Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
YKL103C 1.83
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YDR306C 1.78 F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
YMR250W 1.76
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YOL050C 1.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YGR019W 1.75
UGA1
Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization
YHR180W 1.73 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL025C 1.72
SSN8
Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance
YBL039W-B 1.69 Putative protein of unknown function
YEL072W 1.68
RMD6
Protein required for sporulation
YOR345C 1.67 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YOL159C 1.67 Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA
YBR180W 1.67
DTR1
Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
YOR227W 1.67 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR036W-A 1.66 Protein of unknown function; transcription is regulated by Pdr1p
YOR303W 1.66
CPA1
Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader
YLR247C 1.65
IRC20
Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
YMR194C-B 1.65 Putative protein of unknown function
YDL124W 1.64 NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family
YLR038C 1.63
COX12
Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated
YLR258W 1.63
GSY2
Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YHL016C 1.63
DUR3
Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
YGL090W 1.62
LIF1
Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
YGR053C 1.62 Putative protein of unknown function
YJR154W 1.61 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YAR053W 1.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCL065W 1.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps HMLALPHA1
YDR186C 1.57 Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YAL067C 1.57
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YJL199C 1.55
MBB1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YER185W 1.54
PUG1
Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions
YMR284W 1.54
YKU70
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YOL154W 1.51
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YJL103C 1.51
GSM1
Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YGR088W 1.51
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YOR100C 1.50
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YDR259C 1.50
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YGL096W 1.50
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YDL223C 1.50
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YJL089W 1.50
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YJL213W 1.50 Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YBR292C 1.49 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YDL243C 1.49
AAD4
Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YNR063W 1.48 Putative zinc-cluster protein of unknown function
YDL169C 1.47
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YOR285W 1.47 Protein of unknown function, localized to the mitochondrial outer membrane
YJR122W 1.44
IBA57
Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system
YER069W 1.44
ARG5,6
Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p
YKL148C 1.42
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YKL161C 1.42 Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p
YGL015C 1.42 Hypothetical protein
YGR110W 1.41 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YER167W 1.39
BCK2
Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YOR292C 1.38 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
YPR201W 1.38
ARR3
Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
YER068C-A 1.37 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL019C 1.37 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YJR138W 1.36
IML1
Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YKL102C 1.35 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YJR109C 1.35
CPA2
Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor
YPR191W 1.34
QCR2
Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YOR223W 1.33 Putative protein of unknown function
YER096W 1.32
SHC1
Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
YMR103C 1.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL101C 1.30
ECM21
Non-essential protein of unknown function; promoter contains several Gcn4p binding elements
YEL009C-A 1.28 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL180W 1.26 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YER184C 1.24 Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source
YLR346C 1.23 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YBR019C 1.22
GAL10
UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
YAR060C 1.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL087C 1.20
CYT2
Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
YLR297W 1.18 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YJR137C 1.18
ECM17
Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
YCL054W 1.17
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YDR132C 1.16 Putative protein of unknown function
YKR071C 1.16
DRE2
Protein of unknown function required for sister chromatid cohesion; mutation displays synthetic lethal interaction with the pol3-13 allele of CDC2
YOR290C 1.16
SNF2
Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
YNL018C 1.16 Putative protein of unknown function
YBR001C 1.15
NTH2
Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses
YMR040W 1.15
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YLR015W 1.14
BRE2
Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L

Network of associatons between targets according to the STRING database.

First level regulatory network of YAP7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.2 GO:0032780 negative regulation of ATPase activity(GO:0032780)
2.6 7.8 GO:0006545 glycine biosynthetic process(GO:0006545)
2.2 6.5 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
1.5 6.0 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
1.5 4.4 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
1.3 3.9 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
1.2 9.8 GO:0015891 siderophore transport(GO:0015891)
1.2 6.9 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
1.1 3.2 GO:0015740 C4-dicarboxylate transport(GO:0015740)
1.0 8.4 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
1.0 1.9 GO:0043335 protein unfolding(GO:0043335)
1.0 4.8 GO:0043954 cellular component maintenance(GO:0043954)
0.9 2.8 GO:0006183 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.9 2.7 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.9 21.5 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.9 1.8 GO:0006538 glutamate catabolic process(GO:0006538)
0.9 1.7 GO:0043419 urea catabolic process(GO:0043419)
0.9 2.6 GO:0015888 thiamine transport(GO:0015888)
0.8 7.2 GO:0006097 glyoxylate cycle(GO:0006097)
0.8 4.6 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.7 1.5 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.7 2.2 GO:0045117 azole transport(GO:0045117)
0.7 2.2 GO:0071169 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.7 2.1 GO:0042843 D-xylose catabolic process(GO:0042843)
0.7 3.5 GO:0006559 L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.7 2.7 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.7 2.0 GO:0001315 age-dependent response to reactive oxygen species(GO:0001315) cellular age-dependent response to reactive oxygen species(GO:0072353)
0.6 6.4 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.6 7.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.6 1.9 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.6 8.4 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.6 1.1 GO:0006740 NADPH regeneration(GO:0006740)
0.6 2.2 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.5 2.2 GO:0060194 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.5 2.0 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.5 2.6 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.5 5.0 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.5 3.4 GO:0006855 drug transmembrane transport(GO:0006855)
0.5 0.5 GO:0019627 urea metabolic process(GO:0019627)
0.5 2.3 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.4 3.1 GO:0061013 regulation of mRNA catabolic process(GO:0061013)
0.4 0.4 GO:0042743 hydrogen peroxide metabolic process(GO:0042743)
0.4 5.8 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.4 2.8 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.4 1.2 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.4 4.3 GO:0072348 sulfur compound transport(GO:0072348)
0.4 2.0 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.4 5.0 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.4 1.5 GO:0015886 heme transport(GO:0015886)
0.4 1.2 GO:0042148 strand invasion(GO:0042148)
0.4 1.2 GO:0005993 trehalose catabolic process(GO:0005993)
0.4 1.1 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.4 1.5 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.4 1.8 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.4 1.8 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 0.7 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.3 1.2 GO:2001247 positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
0.3 3.1 GO:0071265 L-methionine biosynthetic process(GO:0071265)
0.3 0.6 GO:0042732 D-xylose metabolic process(GO:0042732)
0.3 7.4 GO:0006915 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.3 1.4 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.3 1.4 GO:0010672 regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010672)
0.3 2.4 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.3 1.6 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.3 0.5 GO:0045471 response to ethanol(GO:0045471)
0.3 1.0 GO:0006598 polyamine catabolic process(GO:0006598)
0.2 0.7 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.2 4.6 GO:0001101 response to acid chemical(GO:0001101)
0.2 0.7 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.2 5.8 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.2 0.9 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.2 0.6 GO:0051101 regulation of sulfur amino acid metabolic process(GO:0031335) positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.2 1.9 GO:0070987 error-free translesion synthesis(GO:0070987)
0.2 0.4 GO:1903313 positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.2 0.8 GO:0098743 aggregation of unicellular organisms(GO:0098630) cell aggregation(GO:0098743)
0.2 1.0 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.2 1.4 GO:0000023 maltose metabolic process(GO:0000023)
0.2 0.8 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 0.6 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.2 1.2 GO:0015802 basic amino acid transport(GO:0015802)
0.2 1.1 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.2 4.2 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.2 2.2 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.2 7.5 GO:0071940 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.2 0.7 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.2 4.2 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.2 1.6 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.2 1.5 GO:0006119 oxidative phosphorylation(GO:0006119)
0.2 0.5 GO:0006824 cobalt ion transport(GO:0006824)
0.2 0.5 GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.2 0.7 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993)
0.2 1.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.2 0.6 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.2 0.8 GO:0043605 cellular amide catabolic process(GO:0043605)
0.1 0.4 GO:0046113 nucleobase catabolic process(GO:0046113)
0.1 0.4 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.1 1.8 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.1 0.9 GO:0010508 positive regulation of autophagy(GO:0010508)
0.1 0.4 GO:0006108 malate metabolic process(GO:0006108)
0.1 2.5 GO:0022900 electron transport chain(GO:0022900)
0.1 1.2 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.4 GO:1905039 organic acid transmembrane transport(GO:1903825) carboxylic acid transmembrane transport(GO:1905039)
0.1 1.4 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.1 0.5 GO:0015893 drug transport(GO:0015893)
0.1 0.5 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.1 1.4 GO:0008360 regulation of cell shape(GO:0008360)
0.1 0.5 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.1 0.7 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.1 0.4 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.1 0.8 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 0.4 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 0.3 GO:0018209 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.1 0.9 GO:0046015 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) regulation of transcription by glucose(GO:0046015)
0.1 0.1 GO:0032070 regulation of nuclease activity(GO:0032069) regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.1 0.4 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.1 0.3 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.8 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.1 0.5 GO:0051322 anaphase(GO:0051322)
0.1 1.1 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 0.3 GO:0032365 intracellular lipid transport(GO:0032365)
0.1 0.3 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.1 0.3 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.1 1.1 GO:0006071 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.1 1.9 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.1 0.2 GO:0001111 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.1 1.0 GO:0043486 histone exchange(GO:0043486)
0.1 0.1 GO:0043470 regulation of glycolytic process(GO:0006110) regulation of nucleoside metabolic process(GO:0009118) regulation of nucleotide catabolic process(GO:0030811) regulation of carbohydrate catabolic process(GO:0043470) regulation of cellular carbohydrate catabolic process(GO:0043471) positive regulation of nucleotide metabolic process(GO:0045981) regulation of cofactor metabolic process(GO:0051193) regulation of coenzyme metabolic process(GO:0051196) positive regulation of purine nucleotide metabolic process(GO:1900544) regulation of ATP metabolic process(GO:1903578)
0.1 0.9 GO:0006513 protein monoubiquitination(GO:0006513)
0.1 0.3 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 0.4 GO:0006465 signal peptide processing(GO:0006465)
0.1 1.2 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.1 0.4 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.1 0.7 GO:0034401 chromatin organization involved in regulation of transcription(GO:0034401)
0.1 0.2 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1 0.3 GO:0046185 aldehyde catabolic process(GO:0046185)
0.1 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.2 GO:0019433 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.1 1.3 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.1 0.2 GO:0072396 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.1 0.6 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.4 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.1 0.8 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.7 GO:0051653 establishment of spindle localization(GO:0051293) spindle localization(GO:0051653)
0.1 0.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.2 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.9 GO:0008361 regulation of cell size(GO:0008361)
0.0 0.4 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0 0.2 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.0 0.1 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.0 0.3 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.6 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.3 GO:0001009 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.0 0.3 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.7 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.0 0.4 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.1 GO:0015851 nucleobase transport(GO:0015851)
0.0 0.2 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.7 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.4 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.0 0.3 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.2 GO:0043461 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.0 1.2 GO:0030437 ascospore formation(GO:0030437) cell development(GO:0048468)
0.0 0.8 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.0 0.1 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.7 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.6 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.4 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.1 GO:0045338 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.0 0.0 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.8 GO:0030435 sporulation resulting in formation of a cellular spore(GO:0030435)
0.0 0.4 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.0 0.0 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.8 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.1 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.0 0.1 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.2 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.1 GO:0031578 mitotic spindle orientation checkpoint(GO:0031578)
0.0 0.5 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.5 GO:0007124 pseudohyphal growth(GO:0007124)
0.0 0.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320) re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.0 0.1 GO:0000429 carbon catabolite regulation of transcription from RNA polymerase II promoter(GO:0000429)
0.0 0.0 GO:0042868 antisense RNA metabolic process(GO:0042868)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.7 4.4 GO:0033263 CORVET complex(GO:0033263)
0.5 2.2 GO:0032116 SMC loading complex(GO:0032116)
0.5 1.6 GO:0032807 DNA ligase IV complex(GO:0032807)
0.4 1.3 GO:0030061 mitochondrial crista(GO:0030061)
0.4 2.2 GO:0032221 Rpd3S complex(GO:0032221)
0.4 2.1 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.4 5.0 GO:0005619 ascospore wall(GO:0005619)
0.4 2.3 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.3 8.6 GO:0070469 respiratory chain(GO:0070469)
0.3 1.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.3 1.8 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306)
0.3 1.1 GO:0033551 monopolin complex(GO:0033551)
0.3 1.1 GO:0031901 early endosome membrane(GO:0031901)
0.3 12.6 GO:0031225 anchored component of membrane(GO:0031225)
0.3 1.0 GO:0008623 CHRAC(GO:0008623)
0.2 0.9 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271)
0.2 1.5 GO:0005720 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.2 2.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 1.2 GO:0000439 nucleotide-excision repair factor 3 complex(GO:0000112) core TFIIH complex(GO:0000439)
0.1 6.5 GO:0000322 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 0.4 GO:0045252 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.7 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 3.4 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 1.1 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.1 0.4 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.4 GO:0001400 mating projection base(GO:0001400)
0.1 0.2 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.3 GO:0033255 SAS acetyltransferase complex(GO:0033255)
0.1 1.4 GO:0000812 Swr1 complex(GO:0000812)
0.1 1.9 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 7.4 GO:0044440 endosome membrane(GO:0010008) endosomal part(GO:0044440)
0.1 1.1 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.3 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 1.0 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.5 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 3.8 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.3 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 1.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.5 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.7 GO:0005802 trans-Golgi network(GO:0005802)
0.1 0.2 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.5 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 1.6 GO:0005576 extracellular region(GO:0005576)
0.0 1.0 GO:0098800 inner mitochondrial membrane protein complex(GO:0098800)
0.0 5.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 3.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.3 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0070274 RES complex(GO:0070274)
0.0 0.1 GO:0031201 SNARE complex(GO:0031201)
0.0 20.5 GO:0016021 integral component of membrane(GO:0016021)
0.0 0.2 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.0 GO:0035649 Nrd1 complex(GO:0035649)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)
0.0 0.4 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 14.0 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
2.4 9.7 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
2.2 6.5 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
2.2 6.5 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
1.2 6.0 GO:0045118 azole transporter activity(GO:0045118)
1.2 4.6 GO:0005537 mannose binding(GO:0005537)
0.9 12.8 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.8 2.4 GO:0016872 intramolecular lyase activity(GO:0016872)
0.8 3.2 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.8 4.7 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.8 8.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.6 3.9 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.6 4.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.6 0.6 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.6 2.3 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.6 2.8 GO:0016783 sulfurtransferase activity(GO:0016783)
0.5 2.2 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.5 1.6 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.5 3.8 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.5 2.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.5 1.8 GO:0016417 S-acyltransferase activity(GO:0016417)
0.5 3.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 1.8 GO:0051183 vitamin transporter activity(GO:0051183)
0.4 2.7 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.4 3.5 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.4 4.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.4 4.4 GO:0043495 protein anchor(GO:0043495)
0.4 1.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 1.2 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.4 1.9 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.4 6.8 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 0.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.4 1.4 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.4 2.5 GO:0015294 solute:cation symporter activity(GO:0015294)
0.4 1.8 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.3 0.9 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.3 0.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 1.2 GO:0016854 racemase and epimerase activity(GO:0016854)
0.3 2.6 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.3 1.2 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.3 2.6 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.3 0.9 GO:0032183 SUMO binding(GO:0032183)
0.3 1.4 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.3 1.7 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.3 0.8 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.3 0.5 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.3 8.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.3 0.8 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.3 1.3 GO:0016597 amino acid binding(GO:0016597)
0.2 6.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.2 6.7 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.2 1.8 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 0.9 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.2 0.4 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 1.0 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.2 10.0 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 3.2 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.2 3.1 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.2 0.8 GO:0004396 hexokinase activity(GO:0004396)
0.2 2.0 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.2 1.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.5 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.2 1.4 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.2 0.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 1.9 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 1.9 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.1 2.0 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 3.6 GO:0003684 damaged DNA binding(GO:0003684)
0.1 2.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.7 GO:0015293 symporter activity(GO:0015293)
0.1 0.6 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.1 1.2 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 0.3 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.1 0.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 0.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 1.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.4 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 0.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.2 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.1 1.1 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.3 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.1 0.4 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.1 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.1 0.4 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 1.9 GO:0015291 secondary active transmembrane transporter activity(GO:0015291)
0.1 0.2 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.1 0.9 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 0.3 GO:0004075 biotin carboxylase activity(GO:0004075) ligase activity, forming carbon-carbon bonds(GO:0016885)
0.1 0.9 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.4 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 0.3 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 0.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.7 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 0.9 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.1 2.2 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.1 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.2 GO:0017022 myosin binding(GO:0017022)
0.0 0.3 GO:0001008 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.0 0.7 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.3 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.1 GO:0004458 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.0 0.2 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.2 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.3 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.0 1.7 GO:0003682 chromatin binding(GO:0003682)
0.0 0.4 GO:0017171 serine hydrolase activity(GO:0017171)
0.0 0.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0042171 triglyceride lipase activity(GO:0004806) lysophosphatidic acid acyltransferase activity(GO:0042171) retinyl-palmitate esterase activity(GO:0050253)
0.0 0.3 GO:0022838 substrate-specific channel activity(GO:0022838)
0.0 0.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.4 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 1.3 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0000156 phosphorelay response regulator activity(GO:0000156) osmosensor activity(GO:0005034)
0.0 0.1 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.0 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.0 0.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102) activating transcription factor binding(GO:0033613)
0.0 0.2 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.1 GO:0000149 SNARE binding(GO:0000149)
0.0 0.1 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.1 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0031369 translation initiation factor binding(GO:0031369)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.8 2.5 PID FOXO PATHWAY FoxO family signaling
0.7 2.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.4 0.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.4 1.2 PID AP1 PATHWAY AP-1 transcription factor network
0.3 1.4 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.2 0.7 PID CMYB PATHWAY C-MYB transcription factor network
0.1 0.3 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 0.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 82.1 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.1 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.6 1.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.5 1.6 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.2 1.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 2.1 REACTOME DNA REPAIR Genes involved in DNA Repair
0.1 0.6 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.1 0.3 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.1 82.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis