Results for XBP1

Z-value: 4.11

Motif logo

Transcription factors associated with XBP1

Gene Symbol Gene ID Gene Info
S000001363 Transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of XBP1 motif

Sorted Z-values of XBP1 motif

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 37.95 Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 33.38 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YDR033W 24.13 Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YGR108W 22.26 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YML052W 20.50 Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
YDR044W 20.23 Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YPR119W 19.83 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YJL158C 18.55 Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YCR018C 18.52 Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YMR032W 17.46 Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YKR038C 16.71 Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YLR180W 15.74 S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YLR328W 14.91 Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YKR013W 14.49 Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YMR199W 13.93 G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YKL128C 13.67 Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YJR094W-A 13.11 Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YIR021W 13.06 Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YHR163W 12.72 6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p
YBR011C 12.65 Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YGL157W 12.40 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YMR307W 12.34 Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
YKR012C 12.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YGR185C 12.23 Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyr
YDR047W 12.18 Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YJR105W 11.98 Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YGL097W 11.71 Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YKR092C 11.53 Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YMR001C-A 11.47 Putative protein of unknown function
YLL045C 11.42 Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YLR257W 11.24 Putative protein of unknown function
YDR098C 11.23 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YPL245W 11.14 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YDR046C 11.10 Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
YBR084W 10.89 Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
YKL127W 10.71 Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YNL066W 10.50 Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YOR101W 10.36 GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YHR162W 10.19 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YPR074C 10.08 Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YLR179C 10.06 Protein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential
YOR315W 10.06 Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YOR222W 10.04 Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
YGR040W 9.93 Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YNL010W 9.76 Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
YGL202W 9.63 Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YPL273W 9.59 S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
YOR226C 9.57 Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YER043C 9.50 S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
YAL003W 9.42 Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YDL055C 9.35 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YGR279C 9.20 Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YDR502C 9.17 S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YDR133C 9.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YOL086C 8.93 Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YDR023W 8.93 Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YNR001W-A 8.87 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YLR110C 8.70 Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YLR314C 8.67 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YGL179C 8.65 Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YGR234W 8.63 Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YEL040W 8.51 Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YJL011C 8.48 RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YPR170W-B 8.43 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YDR261C 8.38 Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YIL121W 8.29 Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake
YGR264C 8.27 Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YBR121C 8.16 Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation
YLR372W 8.14 Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YHR094C 7.98 Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YBR162C 7.90 Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
YDR345C 7.85 Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YGR249W 7.82 Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YHR216W 7.80 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YHR201C 7.63 Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
YGR265W 7.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YBR012C 7.56 Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
YOL039W 7.55 Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YFR054C 7.51 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR123W 7.51 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability
YML056C 7.38 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YPL246C 7.37 Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
YHR144C 7.35 Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YER124C 7.28 Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YKL218C 7.28 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YLR367W 7.23 Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YOR312C 7.14 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
YPR157W 7.11 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YPL075W 7.09 Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YAL012W 7.09 Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine
YPR170W-A 7.00 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YER137C 6.87 Putative protein of unknown function
YHR043C 6.84 2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed
YNL160W 6.80 Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YHR182C-A 6.76 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR183W 6.71 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
YHR089C 6.70 Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YGR106C 6.68 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YKL164C 6.63 O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YDR309C 6.57 Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
YBR067C 6.55 Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
YNL141W 6.51 Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
YGR107W 6.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR096W 6.39 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER
YDR497C 6.35 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
YAL029C 6.32 One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p
YKL219W 6.30 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YCR087C-A 6.28 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
YBR066C 6.28 Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YBR023C 6.24 Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YBR158W 6.14 Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YMR319C 6.05 Low-affinity Fe(II) transporter of the plasma membrane
YLR042C 6.03 Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YKR093W 6.01 Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YMR318C 6.00 NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YPL037C 5.99 Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YKL096W 5.92 Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization
YMR202W 5.90 C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
YKL068W-A 5.89 Putative protein of unknown function; identified by homology to Ashbya gossypii
YGL255W 5.76 High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YDR257C 5.72 Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins
YJR069C 5.69 Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine
YIL158W 5.68 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YHR063C 5.63 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
YMR083W 5.60 Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YNL162W 5.59 Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein
YOR153W 5.55 Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YLR132C 5.51 Protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene
YKL119C 5.49 Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
YNR043W 5.46 Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer
YHR063W-A 5.44 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR242W 5.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YBR252W 5.39 dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability
YLR285W 5.36 Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination
YGR138C 5.36 Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YOL040C 5.34 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YGR266W 5.33 Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane
YBR177C 5.32 Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YDR321W 5.31 Cytosolic L-asparaginase, involved in asparagine catabolism
YML063W 5.31 Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YMR177W 5.31 Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YER134C 5.25 Putative protein of unknown function; non-essential gene
YNL169C 5.17 Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine
YPL263C 5.15 Cytoplasmic protein of unknown function
YNL234W 5.14 Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p
YDR032C 5.10 Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR082C 5.09 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL085C 5.08 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YMR208W 5.07 Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YDR099W 5.07 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YOR092W 5.07 Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation
YDR353W 5.04 Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress
YOL104C 5.02 Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes
YDL211C 5.02 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YDR211W 5.01 Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YOR342C 4.97 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YMR305C 4.96 Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YKL153W 4.94 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YMR320W 4.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL124C 4.91 Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YDL236W 4.91 Alkaline phosphatase specific for p-nitrophenyl phosphate, involved in dephosphorylation of histone II-A and casein
YHR070C-A 4.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W
YGR241C 4.86 Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YGL001C 4.83 C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YPR010C 4.80 RNA polymerase I subunit A135
YOL103W 4.79 Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YPR060C 4.76 Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
YDR279W 4.74 Ribonuclease H2 subunit, required for RNase H2 activity
YPL211W 4.73 Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
YKR003W 4.73 Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery
YBR210W 4.73 Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YOL136C 4.70 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YMR012W 4.70 eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
YKL033W-A 4.69 Putative protein of unknown function; similar to uncharacterized proteins from other fungi
YDR072C 4.68 Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YLL024C 4.65 ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall
YDR276C 4.63 Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YMR003W 4.62 Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YNL028W 4.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL162W 4.60 Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YIR020C 4.55 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR517W 4.54 Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
YOR087W 4.53 Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
YHR010W 4.52 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YEL001C 4.52 Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YFL017C 4.51 Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
YNL044W 4.45 Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
YHR108W 4.43 Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
YER056C-A 4.41 Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein
YPR033C 4.40 Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence
YFR025C 4.38 Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YGR177C 4.38 Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing
YHL028W 4.34 ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YIL118W 4.34 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YLR089C 4.34 Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAL023C 4.33 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals
YLR428C 4.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1
YCL036W 4.32 Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
YOR108C-A 4.32 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YER001W 4.31 Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family

Network of associatons between targets according to the STRING database.

First level regulatory network of XBP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.7 38.0 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
8.6 34.5 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
6.0 42.3 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
4.9 34.3 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
4.8 14.4 GO:0009094 tyrosine biosynthetic process(GO:0006571) L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
4.2 12.7 GO:0009176 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
4.0 12.0 GO:0044209 AMP salvage(GO:0044209)
3.9 19.4 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
3.8 7.5 GO:0046083 adenine metabolic process(GO:0046083)
3.5 17.7 GO:0006177 GMP biosynthetic process(GO:0006177)
3.5 10.4 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
3.4 13.7 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
3.1 9.4 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
3.1 12.5 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
3.0 11.8 GO:0000296 spermine transport(GO:0000296)
2.8 5.7 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
2.7 16.5 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
2.7 2.7 GO:0046037 GMP metabolic process(GO:0046037)
2.7 8.0 GO:0006798 polyphosphate catabolic process(GO:0006798)
2.7 2.7 GO:0019413 acetate biosynthetic process(GO:0019413)
2.5 29.5 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
2.4 7.1 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
2.4 7.1 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
2.3 9.3 GO:0030497 fatty acid elongation(GO:0030497)
2.3 11.3 GO:0035434 copper ion transmembrane transport(GO:0035434)
2.3 4.5 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
2.2 9.0 GO:0006528 asparagine metabolic process(GO:0006528)
2.2 8.7 GO:0098610 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
2.1 10.7 GO:0046655 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
2.1 18.5 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
2.0 14.3 GO:0005992 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
2.0 4.1 GO:0006110 regulation of glycolytic process(GO:0006110)
2.0 6.0 GO:0015680 intracellular copper ion transport(GO:0015680)
2.0 68.5 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
1.9 9.6 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
1.9 7.6 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
1.9 5.6 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
1.9 13.1 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
1.8 23.6 GO:0009636 response to toxic substance(GO:0009636)
1.7 5.2 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
1.7 5.1 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
1.7 22.0 GO:0030011 maintenance of cell polarity(GO:0030011)
1.7 6.7 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
1.7 30.1 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
1.6 14.8 GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947)
1.6 9.7 GO:0007030 Golgi organization(GO:0007030)
1.5 7.7 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
1.5 12.3 GO:0015940 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
1.4 2.9 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
1.4 4.3 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
1.4 5.7 GO:0050667 homocysteine metabolic process(GO:0050667)
1.4 2.8 GO:0006531 aspartate metabolic process(GO:0006531)
1.4 5.6 GO:0070588 calcium ion transmembrane transport(GO:0070588)
1.4 19.6 GO:0006037 cell wall chitin metabolic process(GO:0006037)
1.3 5.1 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
1.3 15.3 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
1.3 6.3 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
1.2 10.7 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
1.2 2.4 GO:0042992 regulation of transcription factor import into nucleus(GO:0042990) negative regulation of transcription factor import into nucleus(GO:0042992)
1.2 9.4 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
1.2 8.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
1.1 8.0 GO:0006797 polyphosphate metabolic process(GO:0006797)
1.1 2.2 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
1.1 3.2 GO:0043171 peptide catabolic process(GO:0043171)
1.1 5.4 GO:0042401 tryptophan biosynthetic process(GO:0000162) amine biosynthetic process(GO:0009309) cellular biogenic amine biosynthetic process(GO:0042401) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
1.1 4.3 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
1.1 4.3 GO:0008299 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
1.1 141.6 GO:0002181 cytoplasmic translation(GO:0002181)
1.0 6.2 GO:0072337 modified amino acid transport(GO:0072337)
1.0 2.0 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
1.0 9.0 GO:0009435 NAD biosynthetic process(GO:0009435)
1.0 3.9 GO:1900434 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
1.0 1.9 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
1.0 6.8 GO:0040031 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
1.0 1.9 GO:0006688 glycosphingolipid metabolic process(GO:0006687) glycosphingolipid biosynthetic process(GO:0006688)
1.0 6.7 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.9 5.7 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.9 4.7 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.9 7.3 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.9 20.0 GO:0097384 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.9 3.6 GO:0007050 cell cycle arrest(GO:0007050)
0.9 7.1 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.9 2.6 GO:2000879 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.9 2.6 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.8 5.8 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.8 2.5 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.8 2.5 GO:0016114 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.8 1.6 GO:0071478 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.8 4.1 GO:0009092 homoserine metabolic process(GO:0009092)
0.8 24.3 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.8 3.2 GO:0042938 dipeptide transport(GO:0042938)
0.8 4.0 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.8 4.0 GO:0006491 N-glycan processing(GO:0006491)
0.8 1.6 GO:0015786 pyrimidine nucleotide-sugar transport(GO:0015781) UDP-glucose transport(GO:0015786)
0.8 3.9 GO:0044070 regulation of anion transport(GO:0044070)
0.8 11.6 GO:0015918 sterol transport(GO:0015918)
0.8 3.1 GO:0030030 cell projection organization(GO:0030030) cell projection assembly(GO:0030031)
0.7 8.1 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.7 21.3 GO:0006414 translational elongation(GO:0006414)
0.7 2.2 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.7 3.6 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.7 2.2 GO:0060988 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.7 1.4 GO:0031032 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.7 3.5 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.7 6.9 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.7 2.7 GO:0006857 oligopeptide transport(GO:0006857)
0.7 2.1 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.7 0.7 GO:0070592 cell wall polysaccharide biosynthetic process(GO:0070592)
0.7 3.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.7 11.5 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.7 2.7 GO:0009371 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.7 3.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.7 16.7 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.7 2.0 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.6 1.3 GO:0006023 aminoglycan biosynthetic process(GO:0006023) chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.6 1.3 GO:0010672 regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010672) negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.6 4.4 GO:0015791 polyol transport(GO:0015791)
0.6 1.9 GO:0031532 actin filament reorganization involved in cell cycle(GO:0030037) actin cytoskeleton reorganization(GO:0031532) actin filament reorganization(GO:0090527)
0.6 5.0 GO:0006829 zinc II ion transport(GO:0006829)
0.6 5.5 GO:0032120 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.6 1.2 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.6 1.8 GO:0048194 Golgi vesicle budding(GO:0048194)
0.6 3.0 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.6 3.0 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.6 1.8 GO:0019419 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.6 3.4 GO:0030042 actin filament depolymerization(GO:0030042)
0.6 2.8 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.6 1.1 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.6 2.8 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.6 7.2 GO:0007120 axial cellular bud site selection(GO:0007120)
0.5 2.1 GO:0051446 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.5 9.6 GO:0030488 tRNA methylation(GO:0030488)
0.5 2.1 GO:0015886 heme transport(GO:0015886)
0.5 3.1 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.5 2.1 GO:0032262 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.5 1.0 GO:0031292 gene conversion at mating-type locus, DNA double-strand break processing(GO:0031292)
0.5 6.2 GO:0006555 methionine metabolic process(GO:0006555)
0.5 7.1 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.5 1.0 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.5 3.5 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.5 8.3 GO:0006446 regulation of translational initiation(GO:0006446)
0.5 4.4 GO:0000105 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.5 1.5 GO:0015693 magnesium ion transport(GO:0015693)
0.5 2.9 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.5 1.0 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.5 2.3 GO:0006551 leucine metabolic process(GO:0006551) leucine biosynthetic process(GO:0009098)
0.5 4.7 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.5 1.4 GO:0010978 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.5 2.3 GO:0007535 donor selection(GO:0007535)
0.5 3.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.4 2.7 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.4 1.3 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.4 0.9 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.4 0.9 GO:0009088 threonine biosynthetic process(GO:0009088)
0.4 2.1 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.4 1.7 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.4 0.8 GO:0035494 SNARE complex disassembly(GO:0035494)
0.4 0.8 GO:0090069 negative regulation of DNA-templated transcription, elongation(GO:0032785) regulation of ribosome biogenesis(GO:0090069) regulation of rRNA processing(GO:2000232)
0.4 1.7 GO:0015809 arginine transport(GO:0015809)
0.4 1.2 GO:0015867 ATP transport(GO:0015867)
0.4 8.2 GO:0008219 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.4 1.6 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.4 0.8 GO:0000101 sulfur amino acid transport(GO:0000101)
0.4 1.2 GO:0000092 mitotic anaphase B(GO:0000092)
0.4 3.6 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.4 8.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.4 1.6 GO:0006778 porphyrin-containing compound metabolic process(GO:0006778) porphyrin-containing compound biosynthetic process(GO:0006779) heme biosynthetic process(GO:0006783) tetrapyrrole metabolic process(GO:0033013) tetrapyrrole biosynthetic process(GO:0033014) heme metabolic process(GO:0042168)
0.4 3.0 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.4 0.7 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.4 1.5 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.4 1.1 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.4 0.7 GO:0034198 regulation of TOR signaling(GO:0032006) cellular response to amino acid starvation(GO:0034198)
0.4 10.8 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.4 0.4 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.3 55.5 GO:0006364 rRNA processing(GO:0006364)
0.3 0.3 GO:0000916 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.3 2.4 GO:0009306 protein secretion(GO:0009306)
0.3 1.7 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.3 6.1 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.3 1.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.3 5.4 GO:0032508 DNA duplex unwinding(GO:0032508)
0.3 2.6 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.3 1.6 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.3 0.6 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.3 4.1 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.3 0.9 GO:0015677 copper ion import(GO:0015677)
0.3 0.9 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.3 1.5 GO:0031081 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.3 3.6 GO:0006999 nuclear pore organization(GO:0006999)
0.3 1.2 GO:0015883 FAD transport(GO:0015883)
0.3 0.6 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.3 2.3 GO:0006734 NADH metabolic process(GO:0006734)
0.3 1.4 GO:1901985 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.3 3.1 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.3 0.8 GO:0008272 sulfate transport(GO:0008272)
0.3 0.8 GO:0090110 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.3 0.3 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.3 1.1 GO:0006021 inositol biosynthetic process(GO:0006021)
0.3 1.6 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.3 0.5 GO:0001927 exocyst assembly(GO:0001927)
0.3 7.2 GO:0006612 protein targeting to membrane(GO:0006612)
0.3 1.6 GO:0009130 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) UMP biosynthetic process(GO:0006222) pyrimidine nucleoside monophosphate metabolic process(GO:0009129) pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) 'de novo' UMP biosynthetic process(GO:0044205) UMP metabolic process(GO:0046049)
0.3 1.0 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.3 3.4 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.3 0.8 GO:1901977 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.3 2.0 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.3 2.0 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.2 1.5 GO:0042991 transcription factor import into nucleus(GO:0042991)
0.2 0.5 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.2 1.6 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.2 3.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 3.1 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.2 1.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 12.5 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.2 1.2 GO:0006855 drug transmembrane transport(GO:0006855)
0.2 2.6 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.2 0.6 GO:0019748 secondary metabolic process(GO:0019748)
0.2 0.6 GO:0046174 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563) polyol catabolic process(GO:0046174)
0.2 0.8 GO:0031134 sister chromatid biorientation(GO:0031134)
0.2 0.6 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.2 1.2 GO:0016125 steroid metabolic process(GO:0008202) sterol metabolic process(GO:0016125)
0.2 1.0 GO:0043457 regulation of cellular respiration(GO:0043457)
0.2 0.4 GO:0051320 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.2 3.5 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.2 1.5 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 0.4 GO:0051666 actin cortical patch localization(GO:0051666)
0.2 8.0 GO:0016311 dephosphorylation(GO:0016311)
0.2 1.3 GO:0006415 translational termination(GO:0006415)
0.2 11.4 GO:0006897 endocytosis(GO:0006897)
0.2 0.9 GO:0000011 vacuole inheritance(GO:0000011)
0.2 0.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 5.4 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.2 1.6 GO:0006356 regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.2 0.9 GO:0006828 manganese ion transport(GO:0006828)
0.2 2.1 GO:0001300 chronological cell aging(GO:0001300)
0.1 1.0 GO:0007323 peptide pheromone maturation(GO:0007323)
0.1 0.6 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.1 0.3 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990) regulation of protein desumoylation(GO:0060188)
0.1 0.5 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.1 0.7 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 4.0 GO:0072524 pyridine-containing compound metabolic process(GO:0072524)
0.1 0.5 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.1 0.3 GO:0051781 positive regulation of cell division(GO:0051781)
0.1 1.0 GO:0006012 galactose metabolic process(GO:0006012)
0.1 0.6 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.1 0.2 GO:0018342 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.1 0.3 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 1.1 GO:0006272 leading strand elongation(GO:0006272)
0.1 1.8 GO:0070085 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413) glycosylation(GO:0070085)
0.1 0.7 GO:0006814 sodium ion transport(GO:0006814)
0.1 1.3 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.1 1.0 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.1 GO:0042439 ethanolamine-containing compound metabolic process(GO:0042439)
0.1 0.4 GO:0097035 lipid translocation(GO:0034204) regulation of membrane lipid distribution(GO:0097035)
0.1 0.4 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.1 1.0 GO:0051338 regulation of transferase activity(GO:0051338)
0.1 2.2 GO:0006413 translational initiation(GO:0006413)
0.1 0.2 GO:0006825 copper ion transport(GO:0006825)
0.1 4.2 GO:0006913 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.1 0.1 GO:2000243 positive regulation of cell fate commitment(GO:0010455) positive regulation of mating type switching(GO:0031496) positive regulation of cell differentiation(GO:0045597) positive regulation of developmental process(GO:0051094) positive regulation of reproductive process(GO:2000243)
0.1 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.3 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 1.8 GO:0007088 regulation of mitotic nuclear division(GO:0007088)
0.1 0.8 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 1.4 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 0.1 GO:0030541 plasmid partitioning(GO:0030541)
0.1 0.2 GO:0006276 plasmid maintenance(GO:0006276)
0.0 0.3 GO:0042559 folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound biosynthetic process(GO:0042559)
0.0 0.1 GO:0043087 regulation of GTPase activity(GO:0043087)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.3 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.3 GO:0048278 vesicle docking(GO:0048278)
0.0 0.3 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.0 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.1 GO:0015856 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.0 0.2 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.2 GO:0043007 maintenance of rDNA(GO:0043007)
0.0 0.6 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.3 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.2 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.1 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.0 0.1 GO:0048478 replication fork protection(GO:0048478)
0.0 0.9 GO:0006839 mitochondrial transport(GO:0006839)
0.0 0.0 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.1 GO:0045116 protein neddylation(GO:0045116)
0.0 0.4 GO:0006400 tRNA modification(GO:0006400)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 39.9 GO:0000144 cellular bud neck septin ring(GO:0000144)
4.1 12.3 GO:0030428 cell septum(GO:0030428)
3.6 10.8 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
3.4 20.3 GO:0032126 eisosome(GO:0032126)
3.3 16.7 GO:0000408 EKC/KEOPS complex(GO:0000408)
2.8 14.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
2.2 6.7 GO:0070545 PeBoW complex(GO:0070545)
2.2 6.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
2.0 6.1 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
2.0 8.1 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
2.0 6.0 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
1.8 7.4 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
1.7 8.6 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
1.7 6.7 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
1.6 6.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
1.6 12.7 GO:0042597 periplasmic space(GO:0042597)
1.4 5.7 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
1.4 9.9 GO:0016459 myosin complex(GO:0016459)
1.3 4.0 GO:0005697 telomerase holoenzyme complex(GO:0005697)
1.3 3.9 GO:0046930 pore complex(GO:0046930)
1.3 110.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.2 4.9 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
1.2 20.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.0 61.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.0 4.8 GO:0030478 actin cap(GO:0030478)
0.9 3.7 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.9 7.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.9 2.7 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.9 4.4 GO:0034044 exomer complex(GO:0034044)
0.9 2.6 GO:0016363 nuclear matrix(GO:0016363)
0.8 2.5 GO:0032301 MutSalpha complex(GO:0032301)
0.8 15.7 GO:0030137 COPI-coated vesicle(GO:0030137)
0.8 4.9 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.8 8.0 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.8 3.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.8 3.2 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.8 13.5 GO:0022626 cytosolic ribosome(GO:0022626)
0.8 17.4 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.8 13.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.8 54.9 GO:0005576 extracellular region(GO:0005576)
0.7 4.4 GO:0035339 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.7 18.7 GO:0005887 integral component of plasma membrane(GO:0005887)
0.7 2.7 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.7 4.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.7 5.3 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.6 1.9 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.6 5.1 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.6 2.5 GO:0000938 GARP complex(GO:0000938)
0.6 9.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.6 1.8 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.6 2.3 GO:0044611 nuclear pore inner ring(GO:0044611)
0.6 10.8 GO:0030118 clathrin coat(GO:0030118)
0.6 1.1 GO:0005771 multivesicular body(GO:0005771)
0.5 4.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.5 7.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.5 15.7 GO:0005844 polysome(GO:0005844)
0.5 7.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.5 2.0 GO:0030907 MBF transcription complex(GO:0030907)
0.5 3.0 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.5 3.4 GO:0000346 transcription export complex(GO:0000346)
0.5 3.3 GO:0034455 t-UTP complex(GO:0034455)
0.5 3.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.5 1.4 GO:0070823 HDA1 complex(GO:0070823)
0.4 3.6 GO:0005688 U6 snRNP(GO:0005688)
0.4 1.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.4 3.7 GO:0031225 anchored component of membrane(GO:0031225)
0.4 1.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.4 1.6 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.4 4.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 0.4 GO:0000837 Doa10p ubiquitin ligase complex(GO:0000837)
0.4 2.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.4 1.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.4 2.2 GO:0042555 MCM complex(GO:0042555)
0.4 1.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.4 1.4 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.4 0.7 GO:0030869 RENT complex(GO:0030869)
0.3 1.7 GO:0030689 Noc complex(GO:0030689)
0.3 12.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.3 0.3 GO:0005869 dynactin complex(GO:0005869)
0.3 2.1 GO:0016471 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase complex(GO:0033176) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.3 0.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 20.3 GO:0005815 microtubule organizing center(GO:0005815) spindle pole body(GO:0005816)
0.3 10.4 GO:0005811 lipid particle(GO:0005811)
0.3 2.8 GO:0000243 commitment complex(GO:0000243)
0.3 1.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 60.2 GO:0005829 cytosol(GO:0005829)
0.3 1.3 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.3 1.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 0.7 GO:0043529 GET complex(GO:0043529)
0.2 41.7 GO:0005730 nucleolus(GO:0005730)
0.2 0.7 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.2 2.0 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.2 1.1 GO:0031391 DNA replication factor C complex(GO:0005663) Rad17 RFC-like complex(GO:0031389) Elg1 RFC-like complex(GO:0031391)
0.2 42.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 3.2 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.2 1.2 GO:0032432 actin filament bundle(GO:0032432)
0.2 50.6 GO:0005783 endoplasmic reticulum(GO:0005783)
0.2 1.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.2 6.7 GO:0031965 nuclear membrane(GO:0031965)
0.2 0.7 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.2 1.7 GO:0000781 chromosome, telomeric region(GO:0000781)
0.2 5.3 GO:0005635 nuclear envelope(GO:0005635)
0.2 0.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 1.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 1.9 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 16.8 GO:0005933 cellular bud(GO:0005933)
0.1 0.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.3 GO:0005685 U1 snRNP(GO:0005685)
0.1 2.1 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.1 0.2 GO:0005796 Golgi lumen(GO:0005796)
0.1 4.4 GO:0000139 Golgi membrane(GO:0000139)
0.1 0.4 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.6 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.1 0.4 GO:0055087 Ski complex(GO:0055087)
0.1 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.9 GO:0043332 mating projection tip(GO:0043332)
0.1 0.9 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.3 GO:0031201 SNARE complex(GO:0031201)
0.0 0.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 8.5 GO:0005886 plasma membrane(GO:0005886)
0.0 0.1 GO:0071819 DUBm complex(GO:0071819)
0.0 0.2 GO:0005775 vacuolar lumen(GO:0005775)
0.0 0.1 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.0 0.2 GO:0031261 DNA replication preinitiation complex(GO:0031261)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 42.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
5.1 20.5 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
5.1 15.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
4.1 12.2 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
3.9 15.7 GO:0019206 nucleoside kinase activity(GO:0019206)
3.6 10.7 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
3.2 19.3 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
3.2 31.8 GO:0005216 ion channel activity(GO:0005216)
3.1 9.4 GO:0070568 guanylyltransferase activity(GO:0070568)
3.1 9.3 GO:0009922 fatty acid elongase activity(GO:0009922)
3.0 12.2 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
3.0 9.1 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
3.0 11.8 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
2.8 17.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
2.7 16.0 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
2.5 9.9 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
2.5 14.8 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
2.4 9.6 GO:0008172 S-methyltransferase activity(GO:0008172)
2.4 23.9 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
2.4 11.9 GO:0004707 MAP kinase activity(GO:0004707)
2.3 11.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
2.3 11.3 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
2.2 6.5 GO:0004100 chitin synthase activity(GO:0004100)
2.2 6.5 GO:0051219 phosphoprotein binding(GO:0051219)
2.0 53.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
2.0 68.5 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
1.9 7.7 GO:0016841 ammonia-lyase activity(GO:0016841)
1.9 9.6 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
1.9 7.7 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
1.9 7.7 GO:0004614 phosphoglucomutase activity(GO:0004614)
1.8 5.5 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
1.8 5.5 GO:0019203 carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
1.7 1.7 GO:0004805 trehalose-phosphatase activity(GO:0004805)
1.7 6.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.7 6.7 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
1.6 4.9 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
1.6 8.1 GO:0000146 microfilament motor activity(GO:0000146)
1.6 4.7 GO:0019003 GDP binding(GO:0019003)
1.5 4.6 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
1.5 7.5 GO:0003993 acid phosphatase activity(GO:0003993)
1.4 4.3 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
1.4 7.1 GO:0017048 Rho GTPase binding(GO:0017048)
1.4 7.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.4 14.1 GO:0031490 chromatin DNA binding(GO:0031490)
1.4 4.1 GO:0019202 amino acid kinase activity(GO:0019202)
1.4 8.1 GO:0030145 manganese ion binding(GO:0030145)
1.4 20.3 GO:0015926 glucosidase activity(GO:0015926)
1.3 8.0 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
1.3 4.0 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.3 4.0 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
1.3 6.6 GO:0008443 phosphofructokinase activity(GO:0008443)
1.3 3.8 GO:0008097 5S rRNA binding(GO:0008097)
1.2 1.2 GO:0015248 sterol transporter activity(GO:0015248)
1.2 6.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
1.2 7.4 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
1.2 15.8 GO:0003746 translation elongation factor activity(GO:0003746)
1.1 6.5 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
1.1 10.6 GO:0009982 pseudouridine synthase activity(GO:0009982)
1.0 2.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
1.0 3.1 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
1.0 10.3 GO:0019239 deaminase activity(GO:0019239)
1.0 12.0 GO:0005199 structural constituent of cell wall(GO:0005199)
1.0 5.9 GO:0015198 oligopeptide transporter activity(GO:0015198)
1.0 5.9 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
1.0 3.9 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
1.0 4.9 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.0 19.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.9 10.3 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.9 11.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035) disulfide oxidoreductase activity(GO:0015036)
0.9 2.7 GO:0001169 transcription factor activity, RNA polymerase I CORE element sequence-specific binding(GO:0001169) transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting(GO:0001187)
0.9 6.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.8 2.5 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.8 169.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.8 4.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.8 3.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.8 8.0 GO:0001056 RNA polymerase III activity(GO:0001056)
0.8 3.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.8 6.8 GO:0010181 FMN binding(GO:0010181)
0.8 3.0 GO:0008242 omega peptidase activity(GO:0008242)
0.8 5.3 GO:0016866 intramolecular transferase activity(GO:0016866)
0.7 27.5 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.7 2.9 GO:0004622 lysophospholipase activity(GO:0004622)
0.7 2.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.7 1.4 GO:0015216 purine nucleotide transmembrane transporter activity(GO:0015216)
0.7 10.0 GO:0070566 adenylyltransferase activity(GO:0070566)
0.7 10.6 GO:0050661 NADP binding(GO:0050661)
0.7 4.9 GO:0015211 purine nucleoside transmembrane transporter activity(GO:0015211)
0.7 42.4 GO:0003924 GTPase activity(GO:0003924)
0.7 10.8 GO:0042803 protein homodimerization activity(GO:0042803)
0.6 6.5 GO:0005516 calmodulin binding(GO:0005516)
0.6 5.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.6 5.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.6 1.8 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.6 1.8 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.6 16.5 GO:0016853 isomerase activity(GO:0016853)
0.6 1.8 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.6 6.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.6 3.6 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.6 3.4 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.5 3.8 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.5 4.4 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.5 7.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.5 2.1 GO:0008312 7S RNA binding(GO:0008312)
0.5 1.5 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.5 2.4 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.5 1.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.5 2.9 GO:0019201 nucleotide kinase activity(GO:0019201)
0.5 1.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.5 5.7 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.5 1.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.5 12.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.4 0.9 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.4 1.3 GO:0019205 nucleobase-containing compound kinase activity(GO:0019205)
0.4 0.9 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.4 1.3 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.4 1.7 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.4 6.2 GO:0008170 N-methyltransferase activity(GO:0008170)
0.4 4.4 GO:0051015 actin filament binding(GO:0051015)
0.4 1.6 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.4 0.8 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.4 1.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.4 0.8 GO:0001163 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163)
0.4 1.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.4 1.4 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.4 5.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.4 3.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.4 1.8 GO:0017022 myosin binding(GO:0017022)
0.3 18.7 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.3 9.7 GO:0008135 translation initiation factor activity(GO:0003743) translation factor activity, RNA binding(GO:0008135)
0.3 3.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.3 1.7 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.3 0.7 GO:0001167 RNA polymerase I transcription factor activity, sequence-specific DNA binding(GO:0001167)
0.3 2.0 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.3 1.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.3 2.2 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.3 3.1 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.3 3.9 GO:0005048 signal sequence binding(GO:0005048) peptide binding(GO:0042277)
0.3 0.8 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.3 0.8 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.3 0.3 GO:0015605 organophosphate ester transmembrane transporter activity(GO:0015605)
0.3 1.4 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.3 12.4 GO:0016791 phosphatase activity(GO:0016791)
0.3 1.8 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.3 2.3 GO:0030276 clathrin binding(GO:0030276)
0.3 1.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 1.2 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.2 1.9 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2 2.9 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.2 1.9 GO:0043022 ribosome binding(GO:0043022)
0.2 3.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 0.7 GO:0004629 phospholipase C activity(GO:0004629)
0.2 1.7 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 1.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.2 0.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 1.0 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.2 11.7 GO:0008565 protein transporter activity(GO:0008565)
0.2 4.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 0.9 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.2 1.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 3.1 GO:0030515 snoRNA binding(GO:0030515)
0.2 0.5 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 0.7 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 5.4 GO:0000030 mannosyltransferase activity(GO:0000030)
0.2 6.2 GO:0016410 N-acyltransferase activity(GO:0016410)
0.2 5.7 GO:0003724 RNA helicase activity(GO:0003724)
0.2 0.5 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 2.5 GO:0032561 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.1 1.1 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 1.1 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 1.7 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.5 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.1 6.5 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.6 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 1.3 GO:0051087 chaperone binding(GO:0051087)
0.1 2.8 GO:0030674 protein binding, bridging(GO:0030674)
0.1 0.3 GO:0004497 monooxygenase activity(GO:0004497)
0.1 0.3 GO:0015103 inorganic anion transmembrane transporter activity(GO:0015103)
0.1 2.6 GO:0043130 ubiquitin binding(GO:0043130)
0.1 0.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.7 GO:0043495 protein anchor(GO:0043495)
0.1 0.7 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 2.1 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 0.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 2.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 0.1 GO:0008144 drug binding(GO:0008144)
0.1 0.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 1.1 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 0.3 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.4 GO:0004175 endopeptidase activity(GO:0004175)
0.0 1.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.9 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.3 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.4 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.2 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.0 0.4 GO:0005319 lipid transporter activity(GO:0005319)
0.0 0.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.5 GO:0016757 transferase activity, transferring glycosyl groups(GO:0016757)
0.0 0.0 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.1 GO:0072509 divalent inorganic cation transmembrane transporter activity(GO:0072509)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
2.8 8.4 PID CDC42 PATHWAY CDC42 signaling events
1.5 3.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
1.0 2.0 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.5 1.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.5 2.3 PID PLK1 PATHWAY PLK1 signaling events
0.5 1.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 0.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.3 0.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 0.7 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 0.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 0.6 PID E2F PATHWAY E2F transcription factor network
0.2 0.6 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.2 1.7 PID ATR PATHWAY ATR signaling pathway
0.1 0.3 PID MYC PATHWAY C-MYC pathway
0.1 0.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 0.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
2.1 8.5 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
2.1 6.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
1.4 5.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.3 4.0 REACTOME ACTIVATED TLR4 SIGNALLING Genes involved in Activated TLR4 signalling
1.2 8.6 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
1.2 3.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.9 7.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.9 2.6 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.7 3.6 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.7 2.0 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.6 1.9 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.6 9.2 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.5 2.0 REACTOME APOPTOSIS Genes involved in Apoptosis
0.5 1.8 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.4 3.0 REACTOME PROTEIN FOLDING Genes involved in Protein folding
0.4 1.7 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.4 2.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 3.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.3 1.1 REACTOME NUCLEOTIDE EXCISION REPAIR Genes involved in Nucleotide Excision Repair
0.2 1.4 REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM Genes involved in Cytokine Signaling in Immune system
0.2 1.2 REACTOME TRANSLATION Genes involved in Translation
0.1 0.7 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 0.3 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.2 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.1 0.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane