Results for UPC2
Z-value: 0.99
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Transcription factors associated with UPC2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
UPC2
|
S000002621 | Sterol regulatory element binding protein |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YIL162W Show fit | 5.22 |
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively |
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| YDR541C Show fit | 2.54 |
Putative dihydrokaempferol 4-reductase |
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| YOR382W Show fit | 2.47 |
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall |
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| YOL154W Show fit | 2.42 |
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH |
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| YLR295C Show fit | 2.40 |
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis |
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| YLR056W Show fit | 2.30 |
C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources |
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| YIL012W Show fit | 2.29 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YGR279C Show fit | 2.27 |
Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating |
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| YFL051C Show fit | 2.04 |
Putative protein of unknown function; YFL051C is not an essential gene |
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| YMR316C-B Show fit | 1.87 |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
Network of associatons between targets according to the STRING database.
First level regulatory network of UPC2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 7.3 | GO:0015891 | siderophore transport(GO:0015891) |
| 0.4 | 6.0 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.7 | 5.5 | GO:0005985 | sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987) |
| 0.1 | 4.0 | GO:0044108 | ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384) |
| 0.2 | 3.6 | GO:0051156 | glucose 6-phosphate metabolic process(GO:0051156) |
| 0.4 | 3.4 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.0 | 2.7 | GO:0045229 | external encapsulating structure organization(GO:0045229) cell wall organization(GO:0071555) |
| 0.1 | 2.6 | GO:0022900 | electron transport chain(GO:0022900) |
| 0.4 | 2.2 | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205) |
| 0.4 | 2.1 | GO:0005980 | glycogen catabolic process(GO:0005980) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.5 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.2 | 15.9 | GO:0005576 | extracellular region(GO:0005576) |
| 0.2 | 4.3 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.4 | 3.9 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.4 | 3.7 | GO:0000328 | fungal-type vacuole lumen(GO:0000328) |
| 0.1 | 3.5 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 3.0 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.1 | 2.5 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 2.3 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 2.3 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.0 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 1.8 | 5.4 | GO:0004564 | beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575) |
| 0.3 | 4.6 | GO:0015926 | glucosidase activity(GO:0015926) |
| 1.0 | 3.9 | GO:0015343 | siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927) |
| 0.7 | 3.0 | GO:0016661 | oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) |
| 0.1 | 2.5 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 0.6 | 2.4 | GO:0004396 | hexokinase activity(GO:0004396) |
| 0.2 | 2.4 | GO:0022838 | substrate-specific channel activity(GO:0022838) |
| 0.1 | 2.4 | GO:0015297 | antiporter activity(GO:0015297) |
| 0.5 | 2.2 | GO:0004180 | carboxypeptidase activity(GO:0004180) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 36.4 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.4 | 1.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 1.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 0.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 0.4 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.2 | 0.2 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.1 | 0.2 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.1 | 0.1 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.0 | 0.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.1 | PID CDC42 PATHWAY | CDC42 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 36.4 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 1.6 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.3 | 1.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 0.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 0.7 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 0.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 0.4 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.1 | 0.3 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.1 | 0.3 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 0.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |