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Results for TYE7

Z-value: 0.39

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Transcription factors associated with TYE7

Gene Symbol Gene ID Gene Info
TYE7
S000005871 Serine-rich protein that contains a bHLH DNA binding motif

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TYE7YOR344C-0.635.4e-04Click!

Activity profile of TYE7 motif

Sorted Z-values of TYE7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YCR021C 2.28
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YJL133C-A 2.25 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL016C 2.19
ATP7
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YML089C 2.07 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YJR095W 1.99
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YJR115W 1.98 Putative protein of unknown function
YPR001W 1.71
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YJR138W 1.70
IML1
Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YNL036W 1.60
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YKL163W 1.56
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YFL024C 1.54
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YPL250C 1.53
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YMR206W 1.46 Putative protein of unknown function; YMR206W is not an essential gene
YNL063W 1.39
MTQ1
S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene
YHL036W 1.35
MUP3
Low affinity methionine permease, similar to Mup1p
YAL054C 1.34
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YCL042W 1.32 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YCL040W 1.30
GLK1
Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YBR296C 1.26
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YHR001W-A 1.23
QCR10
Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YML090W 1.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YJR137C 1.22
ECM17
Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
YIL107C 1.21
PFK26
6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A
YML120C 1.21
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YLR307C-A 1.15 Putative protein of unknown function
YJR146W 1.12 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YCL001W-B 1.11 Putative protein of unknown function; identified by homology
YMR081C 1.08
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YJL116C 1.06
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YOR152C 1.04 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YNL037C 1.03
IDH1
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YAL062W 1.00
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YLR149C 0.99 Putative protein of unknown function; YLR149C is not an essential gene
YLR356W 0.91 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YAL018C 0.91 Putative protein of unknown function
YBR145W 0.90
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YKL085W 0.88
MDH1
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YOR346W 0.86
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YPL024W 0.86
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YGR065C 0.85
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YML091C 0.84
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YEL024W 0.84
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YGR289C 0.84
MAL11
Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; broad substrate specificity that includes maltotriose
YLR092W 0.83
SUL2
High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
YOR328W 0.83
PDR10
ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p
YGL187C 0.81
COX4
Subunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; N-terminal 25 residues of precursor are cleaved during mitochondrial import; phosphorylated
YLR267W 0.80
BOP2
Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation
YMR271C 0.80
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YPL026C 0.80
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YOR345C 0.78 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YCR007C 0.77 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YJL166W 0.76
QCR8
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YPL018W 0.76
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YER004W 0.75
FMP52
Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDR022C 0.75
CIS1
Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YOR378W 0.75 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YMR165C 0.74
PAH1
Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1
YDR281C 0.73
PHM6
Protein of unknown function, expression is regulated by phosphate levels
YGR290W 0.73 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)
YJR150C 0.73
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YOL081W 0.71
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YGL073W 0.71
HSF1
Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
YDR504C 0.70
SPG3
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YHR211W 0.69
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YFR049W 0.69
YMR31
Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
YDR034C 0.67
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YDR381C-A 0.67 Protein of unknown function, localized to the mitochondrial outer membrane
YCR011C 0.67
ADP1
Putative ATP-dependent permease of the ABC transporter family of proteins
YFR030W 0.67
MET10
Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide
YOR054C 0.67
VHS3
Functionally redundant (see also SIS2) inhibitory subunit of Ppz1p, a PP1c-related ser/thr protein phosphatase Z isoform; synthetically lethal with sis2; putative phosphopantothenoylcysteine decarboxylase involved in coenzyme A biosynthesis
YAL039C 0.66
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YOR065W 0.65
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YAR069C 0.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR070C 0.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL078C 0.61
ATG8
Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YDR530C 0.60
APA2
Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YHR176W 0.59
FMO1
Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
YEL044W 0.59
IES6
Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YPL206C 0.59
PGC1
Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs
YIL033C 0.59
BCY1
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YBR255C-A 0.58 Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YBR250W 0.58
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YKL192C 0.58
ACP1
Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p
YDL113C 0.58
ATG20
Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
YIL047C 0.58
SYG1
Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
YPR023C 0.57
EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YOR298C-A 0.57
MBF1
Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations
YLR023C 0.57
IZH3
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YOR055W 0.57 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGR045C 0.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR011C 0.55 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YFL055W 0.54
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YPR196W 0.54 Putative maltose activator
YOR147W 0.54
MDM32
Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
YIR039C 0.53
YPS6
Putative GPI-anchored aspartic protease
YKL109W 0.53
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YOR208W 0.53
PTP2
Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus
YGR110W 0.53 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YNL220W 0.50
ADE12
Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
YJR147W 0.49
HMS2
Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YPL189C-A 0.49
COA2
Putative cytochrome oxidase assembly factor; identified by homology to Ashbya gossypii; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity
YGR292W 0.48
MAL12
Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus
YBR039W 0.48
ATP3
Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YGL072C 0.48 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YAR053W 0.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL277W 0.47
MET2
L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway
YGL074C 0.47 Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
YDR277C 0.46
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YFR026C 0.46 Putative protein of unknown function
YHR082C 0.46
KSP1
Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation
YDR114C 0.46 Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
YPR010C-A 0.46 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YNL283C 0.45
WSC2
Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
YCL057C-A 0.45 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAR068W 0.45 Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YCR088W 0.45
ABP1
Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization
YKL198C 0.45
PTK1
Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein
YLR374C 0.45 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
YLR375W 0.44
STP3
Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YER091C-A 0.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL236C 0.44 Putative protein kinase that exhibits Akr1p-dependent palmitoylation
YNL104C 0.44
LEU4
Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YLL056C 0.43 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YIL125W 0.43
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YDR542W 0.43
PAU10
Hypothetical protein
YMR216C 0.43
SKY1
SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
YDR055W 0.42
PST1
Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
YHR096C 0.42
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YCL048W-A 0.42 Putative protein of unknown function
YEL059W 0.42 Dubious open reading frame unlikely to encode a functional protein
YER060W-A 0.42
FCY22
Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
YMR196W 0.42 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
YBR284W 0.42 Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YPR007C 0.42
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YJR120W 0.42 Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YPL223C 0.42
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YKL031W 0.41 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YOR381W 0.41
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YJL045W 0.41 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YLR326W 0.41 Hypothetical protein
YCL041C 0.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
YMR017W 0.41
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YLL055W 0.40
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YGR087C 0.39
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YDR124W 0.39 Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
YLL060C 0.39
GTT2
Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YPR013C 0.39 Putative zinc finger protein; YPR013C is not an essential gene
YDR115W 0.39 Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins
YDR014W-A 0.39
HED1
Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase
YPL187W 0.38
MF(ALPHA)1
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
YOR072W 0.38 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YDL026W 0.37 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YER111C 0.37
SWI4
DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
YDR441C 0.37
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YOL163W 0.37 Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
YOR289W 0.36 Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YGL256W 0.36
ADH4
Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
YNL240C 0.36
NAR1
Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf
YEL028W 0.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL079C 0.36
MRK1
Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YNL094W 0.36
APP1
Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization
YCL035C 0.35
GRX1
Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage
YAL017W 0.35
PSK1
One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
YDR541C 0.35 Putative dihydrokaempferol 4-reductase
YHR204W 0.35
MNL1
Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides
YIL088C 0.34
AVT7
Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YML017W 0.34
PSP2
Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing
YNL282W 0.34
POP3
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YHR159W 0.34 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate
YML012C-A 0.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1
YAR060C 0.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL055C 0.33
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YOR071C 0.33
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YNL180C 0.33
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YBR117C 0.33
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YDR406W 0.32
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YDL020C 0.32
RPN4
Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
YPR103W 0.32
PRE2
Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
YLR438W 0.32
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YHR210C 0.32 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YNL179C 0.31 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YLR410W 0.31
VIP1
Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of IP7 by Vip1p is important for phosphate signaling; likely involved in cortical actin cytoskeleton function, by analogy with S. pombe ortholog asp1
YLR402W 0.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL027C 0.30 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene
YER187W 0.30 Putative protein of unknown function; induced in respiratory-deficient cells
YDR338C 0.30 Hypothetical protein
YHR138C 0.30 Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YLR403W 0.30
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YMR291W 0.29 Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential gene
YNL095C 0.29 Putative protein of unknown function predicted to contain a transmembrane domain; YNL095C is not an essential gene
YEL043W 0.29 Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold
YER125W 0.29
RSP5
Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain
YJR152W 0.29
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YFL018C 0.29
LPD1
Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
YOR072W-A 0.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YLR004C 0.28
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YPL190C 0.28
NAB3
Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p
YKR009C 0.28
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YJR089W 0.28
BIR1
Essential chromosomal passenger protein involved in coordinating cell cycle events for proper chromosome segregation; C-terminal region binds Sli15p, and the middle region, upon phosphorylation, localizes Cbf2p to the spindle at anaphase
YGR256W 0.27
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone

Network of associatons between targets according to the STRING database.

First level regulatory network of TYE7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.7 2.0 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.6 1.7 GO:0019629 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.4 1.3 GO:0010942 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.4 0.8 GO:0008272 sulfate transport(GO:0008272)
0.4 1.6 GO:0015976 carbon utilization(GO:0015976)
0.4 0.8 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.4 1.5 GO:0046323 glucose import(GO:0046323)
0.4 3.6 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.3 0.9 GO:0006000 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3 1.1 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.2 0.7 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.2 0.7 GO:0032006 regulation of TOR signaling(GO:0032006)
0.2 1.6 GO:0015758 glucose transport(GO:0015758)
0.2 1.3 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.2 3.1 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 0.9 GO:0006108 malate metabolic process(GO:0006108)
0.2 1.3 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.2 1.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.2 0.4 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.2 0.6 GO:0009106 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.2 0.6 GO:0060195 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.2 1.3 GO:0000023 maltose metabolic process(GO:0000023)
0.2 0.7 GO:0034389 lipid particle organization(GO:0034389)
0.2 1.3 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.2 0.7 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.2 0.9 GO:0006167 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.2 0.5 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.2 1.2 GO:0019660 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.2 1.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 0.6 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.1 1.2 GO:0051180 vitamin transport(GO:0051180)
0.1 0.4 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.1 0.4 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.1 0.4 GO:0072530 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.1 0.3 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.1 0.8 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.1 0.4 GO:0015804 sulfur amino acid transport(GO:0000101) neutral amino acid transport(GO:0015804)
0.1 0.5 GO:0000200 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.1 0.5 GO:0015937 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.1 0.4 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.1 3.0 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 0.4 GO:0006527 arginine catabolic process(GO:0006527)
0.1 0.5 GO:0032105 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.1 1.6 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.1 0.3 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.1 0.8 GO:0006855 drug transmembrane transport(GO:0006855)
0.1 0.4 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.1 0.9 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.4 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.1 0.4 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.4 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.6 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.4 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 0.2 GO:0042843 D-xylose catabolic process(GO:0042843)
0.1 2.2 GO:0098656 anion transmembrane transport(GO:0098656)
0.1 0.1 GO:0031564 transcriptional attenuation(GO:0031555) transcription antitermination(GO:0031564)
0.1 0.6 GO:0015891 siderophore transport(GO:0015891)
0.1 0.2 GO:0071168 protein localization to chromatin(GO:0071168)
0.1 0.2 GO:0042743 hydrogen peroxide metabolic process(GO:0042743)
0.1 0.2 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.1 0.4 GO:0009098 leucine biosynthetic process(GO:0009098)
0.1 0.1 GO:0051099 positive regulation of binding(GO:0051099)
0.1 0.2 GO:0015886 heme transport(GO:0015886)
0.1 0.3 GO:0044070 regulation of anion transport(GO:0044070)
0.1 0.3 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048)
0.0 0.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.1 GO:0046058 cAMP metabolic process(GO:0046058)
0.0 0.3 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.0 0.3 GO:0031134 sister chromatid biorientation(GO:0031134)
0.0 0.2 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.0 0.1 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.0 0.2 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.0 0.4 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.0 0.3 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.2 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 0.1 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.0 0.2 GO:0032079 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.0 0.1 GO:0005993 trehalose catabolic process(GO:0005993)
0.0 0.1 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.0 0.7 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.5 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.2 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.0 GO:0033523 histone H2B ubiquitination(GO:0033523) histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.0 0.3 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.5 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.0 0.1 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.0 0.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.0 0.1 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.1 GO:0046503 glycerolipid catabolic process(GO:0046503)
0.0 0.1 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.0 0.8 GO:0022900 electron transport chain(GO:0022900)
0.0 0.4 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.1 GO:0015793 glycerol transport(GO:0015793)
0.0 0.4 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.0 0.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.2 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.2 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.0 0.2 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.2 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.0 0.1 GO:0006545 glycine biosynthetic process(GO:0006545) threonine catabolic process(GO:0006567)
0.0 0.1 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.0 0.1 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.0 0.2 GO:0006826 iron ion transport(GO:0006826)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.1 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.0 0.8 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.1 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.0 0.2 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.2 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.0 0.1 GO:1902532 negative regulation of intracellular signal transduction(GO:1902532)
0.0 0.8 GO:0006479 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.0 0.5 GO:0035966 response to topologically incorrect protein(GO:0035966)
0.0 0.1 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.1 GO:0051225 spindle assembly(GO:0051225)
0.0 0.1 GO:0071241 cellular response to inorganic substance(GO:0071241)
0.0 0.2 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.3 GO:0042168 porphyrin-containing compound metabolic process(GO:0006778) tetrapyrrole metabolic process(GO:0033013) heme metabolic process(GO:0042168)
0.0 0.2 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.4 GO:0000001 mitochondrion inheritance(GO:0000001) mitochondrion distribution(GO:0048311)
0.0 0.1 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.0 0.1 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.1 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.0 0.1 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.1 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.0 0.0 GO:0019627 urea metabolic process(GO:0019627)
0.0 0.1 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.0 0.1 GO:0045912 negative regulation of cellular carbohydrate metabolic process(GO:0010677) negative regulation of gluconeogenesis(GO:0045721) negative regulation of carbohydrate metabolic process(GO:0045912)
0.0 0.1 GO:0034965 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.0 0.2 GO:0044088 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.1 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.0 0.1 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.0 GO:1903727 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513) positive regulation of phospholipid biosynthetic process(GO:0071073) positive regulation of phospholipid metabolic process(GO:1903727)
0.0 0.0 GO:0000090 mitotic anaphase(GO:0000090)
0.0 0.0 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 0.1 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.1 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0006452 translational frameshifting(GO:0006452)
0.0 0.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.2 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.0 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.4 1.7 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.4 3.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.4 1.8 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.3 0.9 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.3 1.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.2 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 0.8 GO:0000817 COMA complex(GO:0000817)
0.2 0.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 0.5 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.1 0.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.1 GO:0070069 cytochrome complex(GO:0070069)
0.1 0.6 GO:0032221 Rpd3S complex(GO:0032221)
0.1 0.3 GO:0046930 pore complex(GO:0046930)
0.1 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.1 1.0 GO:0030677 ribonuclease P complex(GO:0030677)
0.1 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.3 GO:0035649 Nrd1 complex(GO:0035649)
0.1 0.4 GO:0033309 SBF transcription complex(GO:0033309)
0.1 0.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.7 GO:0070469 respiratory chain(GO:0070469)
0.1 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.2 GO:0044426 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.1 2.5 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 1.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 2.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.2 GO:0032126 eisosome(GO:0032126)
0.0 4.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.2 GO:0034657 GID complex(GO:0034657)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.1 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.0 0.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.2 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.1 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.0 0.1 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.1 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112) core TFIIH complex(GO:0000439)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.9 GO:0030479 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.0 0.4 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.0 1.3 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.5 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 0.0 GO:0005740 mitochondrial envelope(GO:0005740)
0.0 0.6 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.1 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 0.0 GO:0030874 nucleolar chromatin(GO:0030874)
0.0 0.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 3.5 GO:0005886 plasma membrane(GO:0005886)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.5 2.0 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.5 1.5 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 1.3 GO:0016208 AMP binding(GO:0016208) acid-ammonia (or amide) ligase activity(GO:0016880)
0.4 0.8 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.4 1.6 GO:0004396 hexokinase activity(GO:0004396)
0.4 2.8 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.4 1.8 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.3 1.7 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.3 0.9 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.3 0.9 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.3 3.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3 1.1 GO:0005537 mannose binding(GO:0005537)
0.3 0.8 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.2 2.3 GO:0005216 ion channel activity(GO:0005216)
0.2 0.9 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 1.1 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.2 0.2 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.2 0.6 GO:0004629 phospholipase C activity(GO:0004629)
0.2 0.6 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 0.6 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.2 0.7 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1 0.8 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 0.8 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.6 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 0.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 1.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.4 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.1 0.4 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.1 0.4 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.1 1.0 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.7 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 0.6 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1 0.3 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 2.1 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 0.6 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.1 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.3 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.2 GO:0032452 histone demethylase activity(GO:0032452)
0.1 0.2 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.7 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.2 GO:0005471 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.1 0.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.2 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.6 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.5 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 0.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0032183 SUMO binding(GO:0032183)
0.0 1.0 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.3 GO:0042887 amide transmembrane transporter activity(GO:0042887)
0.0 0.1 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.0 0.9 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.0 0.2 GO:0015295 solute:proton symporter activity(GO:0015295)
0.0 0.2 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.1 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.5 GO:0004888 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.0 0.4 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.0 1.7 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.3 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.0 0.1 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.0 0.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.3 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.4 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.0 0.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.1 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.0 0.1 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0015293 symporter activity(GO:0015293)
0.0 0.4 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.1 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.0 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.0 0.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.1 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.0 0.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.2 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.1 GO:0001004 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.0 0.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.0 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.0 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.0 0.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.0 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.2 0.8 PID P73PATHWAY p73 transcription factor network
0.1 0.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 0.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 0.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 0.2 PID NOTCH PATHWAY Notch signaling pathway
0.1 0.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 19.6 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.2 1.0 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.1 0.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.0 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.1 REACTOME DNA REPAIR Genes involved in DNA Repair
0.1 0.2 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.0 19.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules