Results for TOS8
Z-value: 1.34
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Transcription factors associated with TOS8
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
TOS8
|
S000003064 | Homeodomain-containing protein and putative transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YAL062W Show fit | 18.53 |
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources |
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| YAR053W Show fit | 14.38 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YBR117C Show fit | 13.78 |
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids |
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| YFL051C Show fit | 13.66 |
Putative protein of unknown function; YFL051C is not an essential gene |
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| YMR107W Show fit | 10.76 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YAR060C Show fit | 9.99 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YHR212C Show fit | 8.69 |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
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| YKL163W Show fit | 8.44 |
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway |
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| YHR212W-A Show fit | 8.12 |
Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
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| YNL195C Show fit | 8.07 |
Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
Network of associatons between targets according to the STRING database.
First level regulatory network of TOS8
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 20.1 | GO:0000128 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
| 1.9 | 17.2 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 5.6 | 16.8 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 1.0 | 15.4 | GO:0006098 | pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682) |
| 0.4 | 15.0 | GO:0070591 | ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940) |
| 1.1 | 9.5 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 2.3 | 9.1 | GO:0015847 | putrescine transport(GO:0015847) |
| 0.9 | 7.8 | GO:0070873 | regulation of glycogen biosynthetic process(GO:0005979) regulation of glycogen metabolic process(GO:0070873) |
| 0.4 | 7.8 | GO:0015749 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 1.1 | 7.7 | GO:0042816 | pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 21.0 | GO:0031160 | spore wall(GO:0031160) |
| 2.4 | 19.3 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 16.3 | GO:0005774 | vacuolar membrane(GO:0005774) |
| 0.3 | 15.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 14.6 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.3 | 14.4 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 1.0 | 11.9 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 1.0 | 8.6 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277) |
| 0.1 | 8.0 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.3 | 7.0 | GO:0042764 | prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 20.5 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
| 4.7 | 18.6 | GO:0005537 | mannose binding(GO:0005537) |
| 4.5 | 18.0 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 0.5 | 17.3 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 3.1 | 15.6 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.6 | 12.7 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 2.0 | 12.0 | GO:0016744 | transferase activity, transferring aldehyde or ketonic groups(GO:0016744) |
| 0.2 | 9.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 1.2 | 9.7 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 1.8 | 9.1 | GO:0005315 | inorganic phosphate transmembrane transporter activity(GO:0005315) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 182.1 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 2.5 | 10.0 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 1.5 | 3.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.7 | 2.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.1 | 2.1 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.3 | 2.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 1.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.8 | 1.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 0.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 0.6 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 182.1 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 3.3 | 9.9 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.8 | 2.3 | REACTOME SIGNALING BY NOTCH | Genes involved in Signaling by NOTCH |
| 0.2 | 1.9 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 0.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 0.9 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.2 | 0.7 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.1 | 0.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 0.6 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 0.6 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |