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Results for TOS8

Z-value: 1.34

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Transcription factors associated with TOS8

Gene Symbol Gene ID Gene Info
TOS8
S000003064 Homeodomain-containing protein and putative transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TOS8YGL096W0.971.0e-15Click!

Activity profile of TOS8 motif

Sorted Z-values of TOS8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YAL062W 18.53
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YAR053W 14.38 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR117C 13.78
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YFL051C 13.66 Putative protein of unknown function; YFL051C is not an essential gene
YMR107W 10.76
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YAR060C 9.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR212C 8.69 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL163W 8.44
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YHR212W-A 8.12 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YNL195C 8.07 Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL210W 7.93
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YOR343C 7.31 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YNL117W 7.19
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YHR139C 7.19
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YMR090W 6.63 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YBR145W 6.63
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YLR307W 6.58
CDA1
Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YLR307C-A 6.53 Putative protein of unknown function
YJR095W 6.52
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YKR102W 6.51
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YDR043C 6.24
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YDR342C 6.24
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YMR256C 6.21
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YPL223C 5.92
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YAL063C 5.50
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YLR273C 5.45
PIG1
Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
YOR178C 5.42
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YMR206W 5.36 Putative protein of unknown function; YMR206W is not an essential gene
YFL011W 5.34
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YOR100C 5.17
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YMR081C 5.14
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YOL052C-A 5.11
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YBR051W 5.02 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YCR005C 4.99
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YBR296C 4.94
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YJR078W 4.89
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YBR050C 4.85
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YOL060C 4.81
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YDR536W 4.54
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YDL085W 4.41
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YMR306C-A 4.36 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR072W 4.32
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YHL040C 4.14
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YPL171C 4.12
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YLR366W 4.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YHR211W 4.08
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YER096W 4.06
SHC1
Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
YKL038W 4.00
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YGL205W 3.93
POX1
Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YDR540C 3.87
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YBR144C 3.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
YNR034W-A 3.83 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YJL133C-A 3.78 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR235W 3.68
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YBR045C 3.67
GIP1
Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
YKL103C 3.66
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YLR402W 3.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL102C 3.62 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YER065C 3.59
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YJL116C 3.55
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YMR013C 3.53
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YLR403W 3.52
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YJR150C 3.49
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YPR013C 3.47 Putative zinc finger protein; YPR013C is not an essential gene
YPR078C 3.43 Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YLR365W 3.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
YGL193C 3.39 Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YMR096W 3.39
SNZ1
Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
YNR064C 3.37 Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
YGR087C 3.36
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YGL192W 3.35
IME4
Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YKL217W 3.30
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YNR073C 3.27 Putative mannitol dehydrogenase
YMR118C 3.25 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YBR292C 3.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YOR348C 3.16
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YNL125C 3.08
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YLR312C 3.08
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YIL077C 3.00 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YPL222C-A 3.00 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YER150W 2.95
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YMR169C 2.95
ALD3
Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
YOR190W 2.93
SPR1
Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
YEL008W 2.92 Hypothetical protein predicted to be involved in metabolism
YCR021C 2.84
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YCR007C 2.84 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YEL009C 2.83
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YFL012W 2.78 Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin
YER014C-A 2.74
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YMR316C-B 2.70 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR147W 2.66
RTC2
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YPR027C 2.65 Putative protein of unknown function
YCR091W 2.65
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YKL177W 2.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YHR033W 2.61 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YJR152W 2.60
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YOR289W 2.59 Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YIL055C 2.54 Putative protein of unknown function
YCL001W-B 2.53 Putative protein of unknown function; identified by homology
YER053C 2.53
PIC2
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
YCL048W 2.52
SPS22
Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
YAR050W 2.50
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YOL100W 2.49
PKH2
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YDR277C 2.48
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YMR317W 2.47 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YPL258C 2.44
THI21
Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
YGR144W 2.43
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YNL104C 2.39
LEU4
Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YOL118C 2.39 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YHR095W 2.38 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR005C 2.37
HAL1
Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
YPL240C 2.36
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YPL222W 2.36
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER187W 2.35 Putative protein of unknown function; induced in respiratory-deficient cells
YOR237W 2.34
HES1
Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP)
YGL045W 2.33
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YNL091W 2.31
NST1
Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
YJR151C 2.31
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YNL103W 2.30
MET4
Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
YBR035C 2.29
PDX3
Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YOR072W 2.27 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YLR334C 2.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
YOR255W 2.25
OSW1
Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p
YPR145C-A 2.25 Putative protein of unknown function
YPL230W 2.25
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YPL250C 2.24
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YHL035C 2.23
VMR1
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ATP-binding cassette (ABC) family; potential Cdc28p substrate; detected in purified mitochondria in high-throughput studies
YLR356W 2.21 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YBR250W 2.19
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YLR311C 2.18 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL067C 2.18
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YDR542W 2.18
PAU10
Hypothetical protein
YMR017W 2.16
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YLR087C 2.15
CSF1
Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL180W 2.14 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YCR010C 2.12
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YNL036W 2.12
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YEL049W 2.10
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YPL134C 2.07
ODC1
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YER166W 2.07
DNF1
Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
YNR063W 2.06 Putative zinc-cluster protein of unknown function
YMR095C 2.06
SNO1
Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
YAL018C 2.06 Putative protein of unknown function
YJR077C 2.06
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YML120C 2.06
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YNL144C 2.06 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YLR327C 2.05
TMA10
Protein of unknown function that associates with ribosomes
YGL163C 2.04
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YAR047C 2.02 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR122C 2.02 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YHR125W 2.01 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR183C 2.01
QCR9
Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YDR022C 2.01
CIS1
Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YPL021W 2.01
ECM23
Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
YMR194C-B 1.97 Putative protein of unknown function
YGR256W 1.96
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YMR014W 1.96
BUD22
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YDR281C 1.95
PHM6
Protein of unknown function, expression is regulated by phosphate levels
YKL178C 1.94
STE3
Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YNL180C 1.94
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YEL028W 1.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL278W 1.92
CAF120
Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
YHR051W 1.91
COX6
Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels
YLR270W 1.89
DCS1
Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p
YHR206W 1.89
SKN7
Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation
YPR169W-A 1.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B
YDR034C 1.88
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YGL117W 1.88 Putative protein of unknown function
YDR263C 1.87
DIN7
Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination
YHR210C 1.86 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YGR191W 1.85
HIP1
High-affinity histidine permease, also involved in the transport of manganese ions
YCR068W 1.84
ATG15
Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YGR213C 1.84
RTA1
Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions
YOR394W 1.83
PAU21
Hypothetical protein
YOL075C 1.83 Putative ABC transporter
YOR381W 1.82
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YFR015C 1.82
GSY1
Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
YNL179C 1.82 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YDR461C-A 1.81 Putative protein of unknown function
YOL082W 1.81
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YPL033C 1.81 Putative protein of unknown function; may be involved in DNA metabolism; expression is induced by Kar4p
YPR106W 1.80
ISR1
Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C
YDR310C 1.78
SUM1
Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; involved in telomere maintenance, regulated by the pachytene checkpoint
YOR071C 1.77
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YHR139C-A 1.77 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR387C 1.77 Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction
YHR048W 1.76
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YFR029W 1.76
PTR3
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YEL072W 1.76
RMD6
Protein required for sporulation
YDL194W 1.75
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YFL050C 1.75
ALR2
Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition
YGR248W 1.73
SOL4
6-phosphogluconolactonase with similarity to Sol3p
YLR123C 1.73 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YGR065C 1.72
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YOR382W 1.72
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YNL006W 1.71
LST8
Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
YIL134C-A 1.71 Putative protein of unknown function, identified by fungal homology and RT-PCR
YBL015W 1.70
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YOR066W 1.70
MSA1
Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YGR088W 1.68
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide

Network of associatons between targets according to the STRING database.

First level regulatory network of TOS8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 16.8 GO:0019676 ammonia assimilation cycle(GO:0019676)
3.3 20.1 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
2.3 9.1 GO:0015847 putrescine transport(GO:0015847)
2.2 6.6 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
1.9 17.2 GO:0006097 glyoxylate cycle(GO:0006097)
1.8 5.5 GO:0015740 C4-dicarboxylate transport(GO:0015740)
1.8 3.6 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
1.8 1.8 GO:0015755 fructose transport(GO:0015755)
1.6 1.6 GO:0046487 glyoxylate metabolic process(GO:0046487)
1.3 5.3 GO:0046323 glucose import(GO:0046323)
1.1 7.7 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
1.1 7.6 GO:1902707 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
1.1 9.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
1.0 15.4 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
1.0 4.1 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
1.0 4.0 GO:0006598 polyamine catabolic process(GO:0006598)
1.0 4.8 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.9 2.8 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.9 7.5 GO:0015891 siderophore transport(GO:0015891)
0.9 3.7 GO:0042357 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.9 4.6 GO:0032974 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.9 1.8 GO:0061413 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.9 7.8 GO:0070873 regulation of glycogen biosynthetic process(GO:0005979) regulation of glycogen metabolic process(GO:0070873)
0.8 4.0 GO:0015793 glycerol transport(GO:0015793)
0.8 4.0 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.8 3.2 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.8 3.1 GO:0015804 neutral amino acid transport(GO:0015804)
0.8 1.5 GO:0043419 urea catabolic process(GO:0043419)
0.7 2.2 GO:0042743 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.7 2.9 GO:0006848 pyruvate transport(GO:0006848)
0.7 3.5 GO:0006032 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.7 2.1 GO:0006545 glycine biosynthetic process(GO:0006545)
0.7 2.7 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.7 2.0 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.7 5.3 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.7 2.6 GO:0046688 response to copper ion(GO:0046688)
0.7 7.2 GO:0006817 phosphate ion transport(GO:0006817)
0.6 5.8 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.6 3.2 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.6 2.5 GO:0015976 carbon utilization(GO:0015976)
0.6 1.9 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.6 3.7 GO:0045117 azole transport(GO:0045117)
0.6 0.6 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.6 1.8 GO:0036257 multivesicular body organization(GO:0036257)
0.6 4.3 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.6 3.7 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.6 4.3 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.6 1.2 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.6 3.5 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.6 0.6 GO:0019627 urea metabolic process(GO:0019627)
0.6 6.3 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.6 1.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.6 1.7 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.6 1.1 GO:0044070 regulation of anion transport(GO:0044070)
0.5 1.6 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.5 4.9 GO:0045332 phospholipid translocation(GO:0045332)
0.5 2.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.5 1.6 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.5 1.0 GO:0006538 glutamate catabolic process(GO:0006538)
0.5 1.5 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.5 1.0 GO:0006740 NADPH regeneration(GO:0006740)
0.5 2.5 GO:0006083 acetate metabolic process(GO:0006083)
0.5 1.5 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.5 4.4 GO:0006829 zinc II ion transport(GO:0006829)
0.5 0.5 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.5 3.8 GO:0072348 sulfur compound transport(GO:0072348)
0.5 1.9 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.5 5.0 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.4 1.8 GO:0043200 response to amino acid(GO:0043200)
0.4 2.2 GO:0046058 cAMP metabolic process(GO:0046058)
0.4 15.0 GO:0070591 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.4 7.8 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.4 2.0 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.4 2.0 GO:0051099 positive regulation of binding(GO:0051099)
0.4 1.2 GO:0090630 activation of GTPase activity(GO:0090630)
0.4 1.6 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.4 1.2 GO:0090399 replicative senescence(GO:0090399)
0.4 2.3 GO:0009098 leucine biosynthetic process(GO:0009098)
0.4 1.5 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.4 3.2 GO:0046686 response to cadmium ion(GO:0046686)
0.4 1.1 GO:0006003 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3 1.0 GO:0044209 AMP salvage(GO:0044209)
0.3 1.7 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.3 2.4 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.3 2.0 GO:0006089 lactate metabolic process(GO:0006089)
0.3 2.7 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.3 1.3 GO:0033993 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.3 1.0 GO:0005993 trehalose catabolic process(GO:0005993)
0.3 1.0 GO:0046113 nucleobase catabolic process(GO:0046113)
0.3 1.6 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.3 1.2 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.3 2.8 GO:0000755 cytogamy(GO:0000755)
0.3 1.8 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.3 3.0 GO:0001101 response to acid chemical(GO:0001101)
0.3 2.9 GO:0019740 nitrogen utilization(GO:0019740)
0.3 0.3 GO:0043270 positive regulation of ion transport(GO:0043270)
0.3 1.9 GO:0000023 maltose metabolic process(GO:0000023)
0.3 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.3 1.1 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.3 1.3 GO:0018202 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) peptidyl-histidine modification(GO:0018202)
0.3 1.3 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
0.3 0.5 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.3 1.5 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.2 1.0 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.2 3.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 1.0 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.2 0.2 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.2 1.7 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.2 0.7 GO:1902533 positive regulation of intracellular signal transduction(GO:1902533)
0.2 0.7 GO:0032147 activation of protein kinase activity(GO:0032147)
0.2 0.7 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.2 0.9 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.2 1.4 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.2 0.9 GO:1903513 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.2 0.7 GO:0015693 magnesium ion transport(GO:0015693)
0.2 0.5 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.2 1.8 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.2 2.2 GO:0010038 response to metal ion(GO:0010038)
0.2 0.2 GO:0009409 response to cold(GO:0009409) cellular response to cold(GO:0070417)
0.2 1.5 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.2 1.0 GO:0051260 protein homooligomerization(GO:0051260)
0.2 0.8 GO:0033866 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.2 1.2 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.2 0.6 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.2 0.6 GO:0051238 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.2 0.6 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.2 3.7 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.2 1.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 0.4 GO:0044154 negative regulation of histone modification(GO:0031057) histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.2 1.1 GO:0000266 mitochondrial fission(GO:0000266)
0.2 0.5 GO:1902751 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 0.5 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.2 0.3 GO:0000078 obsolete cytokinesis after mitosis checkpoint(GO:0000078)
0.2 0.3 GO:0036297 interstrand cross-link repair(GO:0036297)
0.2 0.8 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.2 0.5 GO:0009107 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.2 0.7 GO:0019388 galactose catabolic process(GO:0019388)
0.2 1.7 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.2 0.8 GO:0045033 peroxisome inheritance(GO:0045033)
0.2 0.6 GO:0071495 cellular response to endogenous stimulus(GO:0071495)
0.2 0.5 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.2 0.9 GO:0006591 ornithine metabolic process(GO:0006591)
0.2 0.5 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.2 1.2 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.1 7.3 GO:0009060 aerobic respiration(GO:0009060)
0.1 0.6 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.4 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.1 2.0 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.1 0.4 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 0.5 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.1 0.3 GO:0034755 high-affinity iron ion transmembrane transport(GO:0006827) iron ion transmembrane transport(GO:0034755)
0.1 0.8 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 2.0 GO:0006023 aminoglycan biosynthetic process(GO:0006023) chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.1 0.8 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 0.5 GO:0015809 arginine transport(GO:0015809)
0.1 0.6 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 0.6 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.1 1.1 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.1 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061395) cellular response to arsenic-containing substance(GO:0071243)
0.1 0.7 GO:0000733 DNA strand renaturation(GO:0000733)
0.1 0.8 GO:0006641 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.1 0.5 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.6 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 2.7 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 0.3 GO:2000002 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.1 1.1 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.1 0.7 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987) disaccharide catabolic process(GO:0046352)
0.1 0.1 GO:0043937 regulation of sporulation(GO:0043937)
0.1 0.1 GO:0060195 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.1 0.1 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 0.1 GO:0000821 regulation of glutamine family amino acid metabolic process(GO:0000820) regulation of arginine metabolic process(GO:0000821)
0.1 0.3 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712) DNA topological change(GO:0006265)
0.1 0.9 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.1 3.0 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 0.9 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 2.0 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.6 GO:0006449 regulation of translational termination(GO:0006449)
0.1 0.3 GO:0000042 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1 0.3 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.6 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.5 GO:0015802 basic amino acid transport(GO:0015802)
0.1 0.6 GO:0001009 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.1 0.8 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753) cell morphogenesis involved in conjugation(GO:0000767)
0.1 0.3 GO:0018065 protein-cofactor linkage(GO:0018065)
0.1 0.3 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.1 GO:0046185 aldehyde catabolic process(GO:0046185)
0.1 1.2 GO:0016571 histone methylation(GO:0016571)
0.1 0.7 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.2 GO:0051259 protein oligomerization(GO:0051259)
0.1 1.1 GO:0016575 histone deacetylation(GO:0016575)
0.1 0.3 GO:0030835 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.1 1.4 GO:0031503 protein complex localization(GO:0031503)
0.1 0.2 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 0.8 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.1 0.4 GO:0003400 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport(GO:0060628) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.1 5.2 GO:0048646 anatomical structure formation involved in morphogenesis(GO:0048646)
0.1 0.6 GO:0009272 fungal-type cell wall biogenesis(GO:0009272)
0.1 0.4 GO:0019321 pentose metabolic process(GO:0019321) pentose catabolic process(GO:0019323)
0.1 0.3 GO:0051180 vitamin transport(GO:0051180)
0.1 0.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.8 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 0.2 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.1 0.5 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.5 GO:0051181 cofactor transport(GO:0051181)
0.1 0.1 GO:0008105 asymmetric protein localization(GO:0008105)
0.1 0.6 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.0 0.4 GO:0006826 iron ion transport(GO:0006826)
0.0 0.3 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.0 0.3 GO:0046337 phosphatidylethanolamine metabolic process(GO:0046337)
0.0 0.4 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.0 0.1 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546)
0.0 0.3 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.0 0.0 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.0 0.2 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.2 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.3 GO:0015893 drug transport(GO:0015893)
0.0 0.2 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.0 0.2 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.0 0.1 GO:2001023 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.0 0.1 GO:0019748 secondary metabolic process(GO:0019748)
0.0 1.3 GO:0070585 protein localization to mitochondrion(GO:0070585) establishment of protein localization to mitochondrion(GO:0072655)
0.0 0.2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.1 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.0 GO:0043096 purine nucleobase salvage(GO:0043096)
0.0 0.1 GO:0072367 regulation of lipid transport(GO:0032368) positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.0 0.1 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.0 0.1 GO:0006525 arginine metabolic process(GO:0006525)
0.0 0.1 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.2 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.1 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.1 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.3 GO:0008219 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.0 0.3 GO:0000741 karyogamy(GO:0000741)
0.0 0.0 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 0.0 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:0048278 vesicle docking(GO:0048278)
0.0 0.1 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.1 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.2 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.2 GO:0000001 mitochondrion inheritance(GO:0000001) mitochondrion distribution(GO:0048311)
0.0 0.4 GO:0043254 regulation of protein complex assembly(GO:0043254)
0.0 0.0 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 19.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.5 21.0 GO:0031160 spore wall(GO:0031160)
1.4 4.3 GO:0031166 integral component of vacuolar membrane(GO:0031166)
1.0 11.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.0 8.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.7 2.7 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.7 2.0 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.7 2.0 GO:0032585 multivesicular body membrane(GO:0032585)
0.6 0.6 GO:0030061 mitochondrial crista(GO:0030061)
0.6 1.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.5 1.6 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.5 1.6 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.5 2.1 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.5 0.5 GO:0070469 respiratory chain(GO:0070469)
0.5 1.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.5 2.5 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.5 2.8 GO:0032126 eisosome(GO:0032126)
0.4 2.2 GO:0031931 TORC1 complex(GO:0031931)
0.4 2.9 GO:0034967 Set3 complex(GO:0034967)
0.4 1.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.4 1.1 GO:0046930 pore complex(GO:0046930)
0.3 15.9 GO:0031225 anchored component of membrane(GO:0031225)
0.3 7.0 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.3 1.3 GO:0016587 Isw1 complex(GO:0016587)
0.3 1.0 GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.3 14.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 0.9 GO:0005784 Sec61 translocon complex(GO:0005784)
0.3 2.0 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.3 1.8 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.3 0.8 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 1.6 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.2 0.7 GO:0030896 checkpoint clamp complex(GO:0030896)
0.2 1.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 3.4 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.2 3.1 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.2 1.0 GO:0070772 PAS complex(GO:0070772)
0.2 0.5 GO:0032176 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.2 1.8 GO:0005769 early endosome(GO:0005769)
0.2 2.0 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 1.9 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.3 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.3 GO:0001400 mating projection base(GO:0001400)
0.1 8.0 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.7 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.9 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 0.8 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.1 14.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 2.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.2 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 1.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.2 GO:0033263 CORVET complex(GO:0033263)
0.1 0.6 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 16.3 GO:0005774 vacuolar membrane(GO:0005774)
0.1 0.4 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 0.6 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.3 GO:0071013 U2-type catalytic step 2 spliceosome(GO:0071007) catalytic step 2 spliceosome(GO:0071013)
0.1 0.3 GO:0031499 TRAMP complex(GO:0031499)
0.1 0.2 GO:0035649 Nrd1 complex(GO:0035649)
0.1 0.3 GO:0005884 actin filament(GO:0005884)
0.1 0.2 GO:0000818 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.6 GO:0000322 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.0 0.3 GO:0034657 GID complex(GO:0034657)
0.0 0.2 GO:0031518 CBF3 complex(GO:0031518)
0.0 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0071819 DUBm complex(GO:0071819)
0.0 0.2 GO:0033551 monopolin complex(GO:0033551)
0.0 0.2 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.0 0.1 GO:0005960 glycine cleavage complex(GO:0005960)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.6 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.1 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.4 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.2 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.1 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.1 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)
0.0 0.1 GO:0000145 exocyst(GO:0000145)
0.0 0.1 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.0 GO:0032133 chromosome passenger complex(GO:0032133)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 18.6 GO:0005537 mannose binding(GO:0005537)
4.5 18.0 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
3.1 15.6 GO:0015295 solute:proton symporter activity(GO:0015295)
2.2 6.5 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
2.0 6.0 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
2.0 12.0 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
1.8 9.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
1.7 20.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
1.6 1.6 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.4 5.5 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
1.2 4.8 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
1.2 9.7 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.0 3.1 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
1.0 1.9 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.9 2.7 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.9 8.7 GO:0015293 symporter activity(GO:0015293)
0.9 3.4 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.9 8.6 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.8 2.5 GO:0005536 glucose binding(GO:0005536)
0.7 3.0 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.7 7.3 GO:0010181 FMN binding(GO:0010181)
0.7 0.7 GO:0043177 amino acid binding(GO:0016597) carboxylic acid binding(GO:0031406) organic acid binding(GO:0043177)
0.7 4.1 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.6 12.7 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.6 5.0 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.6 4.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.6 1.8 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.6 1.1 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.6 1.7 GO:0016289 CoA hydrolase activity(GO:0016289)
0.5 17.3 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.5 2.4 GO:0008198 ferrous iron binding(GO:0008198)
0.5 2.9 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.5 1.4 GO:0032183 SUMO binding(GO:0032183)
0.5 3.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.4 3.6 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.4 4.0 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.4 2.6 GO:0042887 amide transmembrane transporter activity(GO:0042887)
0.4 1.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.4 6.9 GO:0015297 antiporter activity(GO:0015297)
0.4 1.6 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.4 1.6 GO:0008169 C-methyltransferase activity(GO:0008169)
0.4 2.0 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.4 1.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.4 1.9 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.4 1.2 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.4 2.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 1.1 GO:0015288 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.4 1.1 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.4 1.8 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.3 2.7 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3 3.0 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.3 1.0 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.3 0.9 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.3 1.3 GO:0004396 hexokinase activity(GO:0004396)
0.3 2.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 1.8 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.3 3.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3 1.5 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.3 2.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 1.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.3 3.3 GO:0005199 structural constituent of cell wall(GO:0005199)
0.3 0.5 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.3 1.6 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 0.7 GO:0016898 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.2 1.0 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.2 0.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 0.7 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.2 0.7 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.2 1.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.2 2.9 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.2 2.2 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.2 0.4 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.2 3.0 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.2 1.3 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.2 1.1 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.2 0.8 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 9.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 0.8 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.2 0.8 GO:0016209 antioxidant activity(GO:0016209)
0.2 1.9 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.2 3.0 GO:0015145 monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149) sugar transmembrane transporter activity(GO:0051119)
0.2 0.9 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.2 0.7 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.2 4.1 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.2 0.7 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.2 0.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 0.6 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.2 0.5 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.2 0.5 GO:0070569 uridylyltransferase activity(GO:0070569)
0.2 0.2 GO:0016530 metallochaperone activity(GO:0016530)
0.1 0.7 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.1 0.6 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 1.0 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 1.6 GO:0042054 histone methyltransferase activity(GO:0042054)
0.1 0.6 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.1 0.6 GO:0072509 divalent inorganic cation transmembrane transporter activity(GO:0072509)
0.1 1.4 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 1.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.3 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 0.5 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.1 1.4 GO:0005507 copper ion binding(GO:0005507)
0.1 0.3 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.1 0.3 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 0.4 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 0.6 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 1.0 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.9 GO:0000149 SNARE binding(GO:0000149)
0.1 1.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 2.9 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 0.7 GO:0051184 cofactor transporter activity(GO:0051184)
0.1 1.4 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.1 0.3 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 0.6 GO:0001005 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.1 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.4 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.1 2.7 GO:0003712 transcription cofactor activity(GO:0003712)
0.1 0.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 1.4 GO:0005509 calcium ion binding(GO:0005509)
0.1 1.5 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 1.0 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.9 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.2 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1 0.2 GO:0000150 recombinase activity(GO:0000150)
0.1 0.5 GO:0022838 substrate-specific channel activity(GO:0022838)
0.1 0.4 GO:0008374 O-acyltransferase activity(GO:0008374)
0.1 0.3 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 0.2 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.1 0.5 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.1 GO:0019902 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.1 0.4 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.3 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.1 1.0 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 0.3 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 1.0 GO:0031491 nucleosome binding(GO:0031491)
0.1 5.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 0.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.1 GO:0045118 azole transporter activity(GO:0045118)
0.0 0.5 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.8 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.6 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 0.0 GO:0019842 vitamin binding(GO:0019842)
0.0 0.1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.0 0.1 GO:0070336 flap-structured DNA binding(GO:0070336)
0.0 0.6 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.3 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.2 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.5 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.1 GO:0001168 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.0 0.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.0 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 0.0 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.0 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 10.0 PID ERBB4 PATHWAY ErbB4 signaling events
1.5 3.0 PID IL4 2PATHWAY IL4-mediated signaling events
1.1 2.1 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.8 1.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.7 2.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6 1.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.3 2.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.3 0.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.3 0.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 0.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 182.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.1 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.9 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.8 2.3 REACTOME SIGNALING BY NOTCH Genes involved in Signaling by NOTCH
0.5 0.5 REACTOME DNA REPLICATION Genes involved in DNA Replication
0.2 0.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.2 0.7 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.2 1.9 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 0.9 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 0.6 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.1 0.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 182.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.2 REACTOME MEIOSIS Genes involved in Meiosis
0.1 0.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.0 0.1 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.1 REACTOME RNA POL II TRANSCRIPTION Genes involved in RNA Polymerase II Transcription
0.0 0.1 REACTOME HEMOSTASIS Genes involved in Hemostasis