Results for THI2
Z-value: 1.17
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Transcription factors associated with THI2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
THI2
|
S000000444 | Transcriptional activator of thiamine biosynthetic genes |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 23.12 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 20.15 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YER131W Show fit | 7.37 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein |
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| YOL127W Show fit | 7.15 |
Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif |
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| YJL115W Show fit | 5.95 |
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition |
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| YPL250W-A Show fit | 5.82 |
Identified by fungal homology and RT-PCR |
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| YLR154C Show fit | 5.47 |
Ribonuclease H2 subunit, required for RNase H2 activity |
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| YLR154W-B Show fit | 4.73 |
Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand |
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| YLR154W-A Show fit | 4.73 |
Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand |
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| YMR290W-A Show fit | 4.67 |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase |
Network of associatons between targets according to the STRING database.
First level regulatory network of THI2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 23.7 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 7.7 | 23.1 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.6 | 10.9 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 0.3 | 10.9 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.1 | 8.8 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.4 | 8.5 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 1.4 | 7.1 | GO:2000758 | positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758) |
| 0.5 | 7.0 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 7.0 | GO:0016311 | dephosphorylation(GO:0016311) |
| 0.2 | 6.0 | GO:0006694 | steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 33.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.4 | 21.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.7 | 8.0 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 7.9 | GO:0005730 | nucleolus(GO:0005730) |
| 0.2 | 6.2 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 5.9 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 1.8 | 5.5 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.3 | 4.7 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 1.1 | 4.5 | GO:0030287 | cell wall-bounded periplasmic space(GO:0030287) |
| 0.0 | 4.2 | GO:0005933 | cellular bud(GO:0005933) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 34.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 3.4 | 20.5 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.3 | 13.4 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.3 | 7.8 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.2 | 6.5 | GO:0042393 | histone binding(GO:0042393) |
| 1.0 | 5.7 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 1.4 | 5.5 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.0 | 5.5 | GO:0003723 | RNA binding(GO:0003723) |
| 0.2 | 5.4 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.5 | 5.2 | GO:0005216 | ion channel activity(GO:0005216) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.3 | 1.7 | PID FGF PATHWAY | FGF signaling pathway |
| 0.3 | 0.9 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.1 | 0.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 0.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 0.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 0.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 0.1 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.4 | 2.9 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.5 | 2.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.3 | 2.0 | REACTOME SIGNALING BY GPCR | Genes involved in Signaling by GPCR |
| 0.6 | 1.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.4 | 1.8 | REACTOME NUCLEOTIDE EXCISION REPAIR | Genes involved in Nucleotide Excision Repair |
| 0.3 | 1.8 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.3 | 0.9 | REACTOME SIGNALLING TO ERKS | Genes involved in Signalling to ERKs |
| 0.3 | 0.9 | REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT | Genes involved in SLC-mediated transmembrane transport |
| 0.2 | 0.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |