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Results for TEC1

Z-value: 1.52

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Transcription factors associated with TEC1

Gene Symbol Gene ID Gene Info
TEC1
S000000287 Transcription factor targeting filamentation genes and Ty1 expression

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TEC1YBR083W0.115.8e-01Click!

Activity profile of TEC1 motif

Sorted Z-values of TEC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YKR102W 10.32
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YAR053W 7.77 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR382W 7.58
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YKL217W 7.05
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YFL051C 7.00 Putative protein of unknown function; YFL051C is not an essential gene
YPR077C 7.00 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1
YER065C 5.52
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YAR060C 5.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL161C 5.27 Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p
YHR096C 5.08
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YPL026C 4.99
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YDL127W 4.92
PCL2
G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle, essential for cell morphogenesis; localizes to sites of polarized cell growth
YDR342C 4.81
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YBL049W 4.76
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YAR069C 4.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR078C 4.71 Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YHR212W-A 4.67 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPL024W 4.65
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YMR081C 4.65
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YBR083W 4.65
TEC1
Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member
YOR346W 4.59
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YFL030W 4.58
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YFR053C 4.58
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YOR345C 4.52 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YPR005C 4.52
HAL1
Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
YHR212C 4.36 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL244W 4.35
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YML042W 4.30
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YBL075C 4.18
SSA3
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YJL045W 4.14 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YKL026C 4.00
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YBL066C 3.89
SEF1
Putative transcription factor, has homolog in Kluyveromyces lactis
YPL271W 3.89
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YER067C-A 3.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
YAR070C 3.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFL019C 3.76 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YPR075C 3.72
OPY2
Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone
YDR528W 3.71
HLR1
Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YPR076W 3.67 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL282W 3.61
POP3
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YNL322C 3.58
KRE1
Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
YER103W 3.51
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YKL086W 3.46
SRX1
Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes
YDR034C 3.45
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YER014C-A 3.41
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YGL166W 3.38
CUP2
Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations
YDR542W 3.37
PAU10
Hypothetical protein
YLR327C 3.34
TMA10
Protein of unknown function that associates with ribosomes
YGL096W 3.31
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YJR153W 3.24
PGU1
Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
YLR136C 3.22
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YPR002W 3.22
PDH1
Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YAR019W-A 3.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR206W 3.21 Putative protein of unknown function; YMR206W is not an essential gene
YLR346C 3.20 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YKR091W 3.18
SRL3
Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate
YOL163W 3.17 Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
YBL065W 3.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
YPL054W 3.13
LEE1
Zinc-finger protein of unknown function
YGR144W 3.12
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YDR250C 3.10 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YPL150W 3.04 Putative protein kinase of unknown cellular role
YCR005C 3.04
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YML047W-A 3.03 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR311C 3.03 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR150C 3.00
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YKL177W 2.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YNL283C 2.96
WSC2
Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
YGR039W 2.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YKR011C 2.95 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YIL057C 2.90 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YPL058C 2.87
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YPR027C 2.86 Putative protein of unknown function
YDR251W 2.85
PAM1
Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
YDR379W 2.83
RGA2
GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
YNL144C 2.82 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YAL062W 2.81
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YAR019C 2.78
CDC15
Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
YGR146C 2.78 Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation
YFL020C 2.71
PAU5
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YAR068W 2.71 Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YBR094W 2.67
PBY1
Putative tubulin tyrosine ligase associated with P-bodies
YDR077W 2.67
SED1
Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
YAL067C 2.62
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YLL042C 2.56
ATG10
E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy
YDR043C 2.54
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YBR292C 2.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YMR194C-B 2.52 Putative protein of unknown function
YEL009C-A 2.50 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR127W 2.46 Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YDL114W 2.45 Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene
YDL214C 2.45
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YJR149W 2.45 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLR307W 2.42
CDA1
Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YOR393W 2.40
ERR1
Protein of unknown function, has similarity to enolases
YDR249C 2.38 Putative protein of unknown function
YKR040C 2.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
YDR022C 2.36
CIS1
Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YHR211W 2.33
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YNL142W 2.33
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YDL204W 2.30
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YJR138W 2.28
IML1
Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YPR192W 2.27
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YIR029W 2.26
DAL2
Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YKR069W 2.25
MET1
S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
YDL245C 2.22
HXT15
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YOR152C 2.18 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YKL178C 2.18
STE3
Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YDL218W 2.17 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YDR036C 2.17
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YNL053W 2.15
MSG5
Dual-specificity protein phosphatase required for maintenance of a low level of signaling through the cell integrity pathway; regulates and is regulated by Slt2p; dephosphorylates Fus3p; required for adaptive response to pheromone
YPL134C 2.13
ODC1
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YJR151C 2.12
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YGR286C 2.12
BIO2
Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YOL084W 2.09
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YLR402W 2.03 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL240C 2.02
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YFL036W 2.01
RPO41
Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
YDL210W 2.00
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YOR381W 1.97
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YJR137C 1.96
ECM17
Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
YBL093C 1.96
ROX3
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme
YDR374C 1.94 Putative protein of unknown function
YPL057C 1.93
SUR1
Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p
YOR072W 1.93 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YBR082C 1.92
UBC4
Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response
YGL167C 1.92
PMR1
High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
YPR191W 1.88
QCR2
Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YLR403W 1.88
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YNL091W 1.86
NST1
Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
YNL143C 1.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL102C 1.85 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YKL163W 1.84
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YEL010W 1.83 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL118C 1.83 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YLR107W 1.82
REX3
RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases
YMR306W 1.81
FKS3
Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR387C 1.81 Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction
YNL133C 1.80
FYV6
Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining
YEL049W 1.77
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YGL089C 1.75
MF(ALPHA)2
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
YPL186C 1.74
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YNR034W-A 1.74 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YPR169W-A 1.73 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B
YPL025C 1.73 Hypothetical protein
YKL103C 1.72
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YOR391C 1.70
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YDR231C 1.69
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YJL161W 1.69
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR213C 1.67
RTA1
Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions
YAR023C 1.66 Putative integral membrane protein, member of DUP240 gene family
YGR043C 1.66
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YHR159W 1.66 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate
YBL001C 1.66
ECM15
Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
YJL088W 1.65
ARG3
Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
YGL230C 1.63 Putative protein of unknown function; non-essential gene
YGL163C 1.63
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YNR063W 1.62 Putative zinc-cluster protein of unknown function
YDR381C-A 1.61 Protein of unknown function, localized to the mitochondrial outer membrane
YPR015C 1.60 Putative protein of unknown function
YER150W 1.59
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YOR027W 1.59
STI1
Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein
YOR072W-A 1.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YKR015C 1.59 Putative protein of unknown function
YPL185W 1.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YDR019C 1.57
GCV1
T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
YMR158W-B 1.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C
YOR211C 1.57
MGM1
Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YPL151C 1.56
PRP46
Splicing factor that is found in the Cef1p subcomplex of the spliceosome
YAL066W 1.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL064C 1.53
AVT2
Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YHR095W 1.52 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR208C 1.52
DUR1,2
Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YGR221C 1.52
TOS2
Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p
YNL321W 1.50
VNX1
Low affinity vacuolar membrane localized monovalent cation/H+ antiporter; member of the calcium exchanger (CAX) family; potential Cdc28p substrate
YLR122C 1.49 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YFL034W 1.48 Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
YJR078W 1.48
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YMR195W 1.47
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YKL093W 1.47
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YPL114W 1.47 Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index
YHL024W 1.45
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YOR071C 1.44
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YJL084C 1.42
ALY2
Cytoplasmic protein of unknown function that interacts with the cyclin Pcl7p; phosphorylated in vitro by the cyclin-CDK complex, Pcl7p-Pho85p; identified as a potential Cdc28p substrate; mRNA is cell cycle regulated, peaking in M phase
YJL176C 1.42
SWI3
Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
YLR270W 1.42
DCS1
Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p
YNL013C 1.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
YER084W 1.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNR069C 1.40
BSC5
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YOR066W 1.40
MSA1
Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YKL044W 1.39 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR001W-A 1.39
QCR10
Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YDL128W 1.38
VCX1
Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
YLL061W 1.38
MMP1
High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p
YGR153W 1.38 Putative protein of unknown function
YMR118C 1.36 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YDR369C 1.36
XRS2
Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
YLR037C 1.35
DAN2
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YOR348C 1.35
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YDL085W 1.33
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain

Network of associatons between targets according to the STRING database.

First level regulatory network of TEC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 13.3 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.8 7.0 GO:0006848 pyruvate transport(GO:0006848)
1.6 4.9 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
1.6 4.8 GO:0006545 glycine biosynthetic process(GO:0006545)
1.5 4.6 GO:0015755 fructose transport(GO:0015755)
1.3 5.2 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
1.3 10.1 GO:0015891 siderophore transport(GO:0015891)
1.2 3.7 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
1.2 4.7 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
1.1 3.2 GO:0019626 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
1.1 10.6 GO:0046487 glyoxylate metabolic process(GO:0046487)
1.0 3.0 GO:0015888 thiamine transport(GO:0015888)
0.9 2.6 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.8 3.4 GO:0046688 response to copper ion(GO:0046688)
0.8 0.8 GO:0071361 positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) cellular response to ethanol(GO:0071361) cellular response to alcohol(GO:0097306)
0.8 2.3 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.8 0.8 GO:0043633 polyadenylation-dependent RNA catabolic process(GO:0043633)
0.7 4.2 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.7 2.0 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.7 3.3 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.6 1.9 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.6 1.9 GO:0042128 nitrate metabolic process(GO:0042126) nitrate assimilation(GO:0042128)
0.6 2.5 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.6 5.5 GO:0009746 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.6 5.5 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.6 3.0 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.6 2.3 GO:0034764 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.6 1.2 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
0.6 1.1 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.5 1.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.5 8.7 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.5 4.6 GO:0070987 error-free translesion synthesis(GO:0070987)
0.5 2.0 GO:0006598 polyamine catabolic process(GO:0006598)
0.5 2.0 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.5 1.4 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.5 1.4 GO:0044109 cellular alcohol catabolic process(GO:0044109)
0.5 3.3 GO:0071467 cellular response to pH(GO:0071467)
0.5 4.1 GO:0051318 mitotic G1 phase(GO:0000080) G1 phase(GO:0051318)
0.5 2.3 GO:0043954 cellular component maintenance(GO:0043954)
0.5 4.6 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.5 1.4 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.4 2.6 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.4 1.3 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.4 1.3 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.4 0.9 GO:0070417 response to cold(GO:0009409) cellular response to cold(GO:0070417)
0.4 1.3 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.4 1.2 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.4 1.6 GO:0006546 glycine catabolic process(GO:0006546)
0.4 1.2 GO:0044209 AMP salvage(GO:0044209)
0.4 0.8 GO:0042148 strand invasion(GO:0042148)
0.4 1.6 GO:0051180 vitamin transport(GO:0051180)
0.4 3.2 GO:0006828 manganese ion transport(GO:0006828)
0.4 4.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.4 1.1 GO:0006538 glutamate catabolic process(GO:0006538)
0.4 5.2 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.4 1.1 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.4 3.6 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.4 2.1 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.3 1.4 GO:0043200 response to amino acid(GO:0043200)
0.3 1.0 GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.3 1.4 GO:0072337 modified amino acid transport(GO:0072337)
0.3 1.4 GO:0015804 neutral amino acid transport(GO:0015804)
0.3 2.0 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.3 1.0 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.3 2.0 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.3 2.9 GO:0000755 cytogamy(GO:0000755)
0.3 1.6 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.3 2.2 GO:0051322 anaphase(GO:0051322)
0.3 1.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 1.2 GO:0015847 putrescine transport(GO:0015847)
0.3 0.6 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.3 0.9 GO:0019748 secondary metabolic process(GO:0019748)
0.3 0.9 GO:0042843 D-xylose catabolic process(GO:0042843)
0.3 1.7 GO:0006279 premeiotic DNA replication(GO:0006279)
0.3 0.9 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.3 2.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.3 1.4 GO:0034487 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.3 0.9 GO:0006740 NADPH regeneration(GO:0006740)
0.3 0.8 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.3 2.4 GO:0034965 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.3 1.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 1.3 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.3 5.0 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.3 0.8 GO:0070583 spore membrane bending pathway(GO:0070583)
0.3 1.0 GO:0000435 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.3 2.0 GO:0000103 sulfate assimilation(GO:0000103)
0.2 13.5 GO:0009060 aerobic respiration(GO:0009060)
0.2 1.0 GO:0098869 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.2 1.2 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.2 1.0 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.2 5.7 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.2 0.7 GO:0042744 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.2 0.7 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.2 2.8 GO:0001101 response to acid chemical(GO:0001101)
0.2 2.0 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.2 1.8 GO:0006591 ornithine metabolic process(GO:0006591)
0.2 1.8 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.2 1.8 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.2 0.7 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.2 1.5 GO:0006814 sodium ion transport(GO:0006814)
0.2 0.2 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.2 0.6 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.2 0.4 GO:0015893 drug transport(GO:0015893)
0.2 0.9 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.2 0.5 GO:0051569 positive regulation of histone methylation(GO:0031062) regulation of histone H3-K4 methylation(GO:0051569)
0.2 0.9 GO:0015793 glycerol transport(GO:0015793)
0.2 0.7 GO:0060195 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.2 0.7 GO:0042173 regulation of sporulation resulting in formation of a cellular spore(GO:0042173)
0.2 0.5 GO:0007019 microtubule depolymerization(GO:0007019)
0.2 1.6 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.2 3.1 GO:0000209 protein polyubiquitination(GO:0000209)
0.2 0.7 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.2 0.3 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.2 0.8 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.2 0.7 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.2 0.3 GO:2001038 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.2 0.3 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.2 0.8 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 1.3 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.1 0.1 GO:0019568 arabinose metabolic process(GO:0019566) arabinose catabolic process(GO:0019568)
0.1 0.3 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.1 1.7 GO:0009651 response to salt stress(GO:0009651)
0.1 0.7 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 0.4 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.1 0.3 GO:0045980 regulation of cyclic nucleotide metabolic process(GO:0030799) regulation of cyclic nucleotide biosynthetic process(GO:0030802) regulation of nucleotide biosynthetic process(GO:0030808) regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) negative regulation of nucleotide metabolic process(GO:0045980) regulation of purine nucleotide biosynthetic process(GO:1900371)
0.1 0.8 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 0.7 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.3 GO:0001315 age-dependent response to reactive oxygen species(GO:0001315)
0.1 0.8 GO:0000266 mitochondrial fission(GO:0000266)
0.1 3.0 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.1 0.5 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glycogen metabolic process(GO:0070873)
0.1 0.7 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 0.6 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.4 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.1 1.0 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.4 GO:0070988 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.1 0.7 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.1 0.9 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 0.2 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.1 0.5 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 1.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.9 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.2 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.1 0.4 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.1 1.7 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.1 2.2 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.1 0.4 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.1 0.3 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.4 GO:0031297 replication fork processing(GO:0031297)
0.1 0.2 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.1 0.2 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.1 0.4 GO:0016241 regulation of macroautophagy(GO:0016241)
0.1 0.4 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.3 GO:0006276 plasmid maintenance(GO:0006276)
0.1 1.6 GO:0010821 regulation of mitochondrion organization(GO:0010821)
0.1 0.7 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.1 0.6 GO:0006855 drug transmembrane transport(GO:0006855)
0.1 3.9 GO:0007031 peroxisome organization(GO:0007031)
0.1 0.2 GO:1902751 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 0.6 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 0.2 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.2 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 0.3 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.1 0.1 GO:0070192 chromosome organization involved in meiotic cell cycle(GO:0070192)
0.1 0.2 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.1 0.3 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.1 0.6 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.1 1.4 GO:0022900 electron transport chain(GO:0022900)
0.1 0.3 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.2 GO:0001927 exocyst assembly(GO:0001927)
0.1 0.1 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 0.5 GO:0006817 phosphate ion transport(GO:0006817)
0.1 0.3 GO:0015976 carbon utilization(GO:0015976)
0.1 2.1 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.1 0.4 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 0.2 GO:1901977 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.1 0.5 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.5 GO:0015802 basic amino acid transport(GO:0015802)
0.1 1.9 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 0.4 GO:0007265 Ras protein signal transduction(GO:0007265)
0.1 0.1 GO:0009268 response to pH(GO:0009268)
0.1 0.2 GO:0031058 positive regulation of histone modification(GO:0031058)
0.1 0.2 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.1 0.3 GO:0000023 maltose metabolic process(GO:0000023)
0.1 0.1 GO:0051098 regulation of binding(GO:0051098)
0.0 0.9 GO:0000902 cell morphogenesis(GO:0000902)
0.0 0.5 GO:0032258 CVT pathway(GO:0032258)
0.0 0.1 GO:0000409 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.0 0.5 GO:0007533 mating type switching(GO:0007533)
0.0 0.1 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151)
0.0 0.1 GO:0016076 snRNA catabolic process(GO:0016076) snoRNA catabolic process(GO:0016077) nuclear polyadenylation-dependent snoRNA catabolic process(GO:0071036) nuclear polyadenylation-dependent snRNA catabolic process(GO:0071037)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.3 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.2 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.8 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.9 GO:0006865 amino acid transport(GO:0006865)
0.0 2.5 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.0 0.6 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.2 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.0 0.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.1 GO:0036257 multivesicular body organization(GO:0036257)
0.0 0.1 GO:0051225 spindle assembly(GO:0051225)
0.0 0.2 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.1 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.0 0.2 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.3 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.0 0.7 GO:0045132 meiotic chromosome segregation(GO:0045132)
0.0 0.9 GO:0030466 chromatin silencing at silent mating-type cassette(GO:0030466)
0.0 0.2 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.1 GO:0000042 protein targeting to Golgi(GO:0000042) retrograde transport, vesicle recycling within Golgi(GO:0000301) establishment of protein localization to Golgi(GO:0072600)
0.0 0.2 GO:0031134 sister chromatid biorientation(GO:0031134)
0.0 0.1 GO:0046464 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0 0.3 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.5 GO:1902534 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.0 0.1 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.0 0.0 GO:0032186 cellular bud neck septin ring organization(GO:0032186) protein autoubiquitination(GO:0051865)
0.0 0.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.1 GO:0051707 immune effector process(GO:0002252) immune system process(GO:0002376) response to virus(GO:0009615) response to external biotic stimulus(GO:0043207) defense response to virus(GO:0051607) response to other organism(GO:0051707) defense response to other organism(GO:0098542)
0.0 0.1 GO:0034476 U5 snRNA 3'-end processing(GO:0034476)
0.0 0.6 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.0 GO:0006952 defense response(GO:0006952)
0.0 0.1 GO:0016233 telomere capping(GO:0016233)
0.0 0.1 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.4 GO:0051304 chromosome separation(GO:0051304)
0.0 1.6 GO:0048646 anatomical structure formation involved in morphogenesis(GO:0048646)
0.0 0.1 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.1 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.2 GO:0030474 spindle pole body duplication(GO:0030474)
0.0 0.4 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.1 GO:0001041 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.0 0.2 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 1.1 GO:0000398 mRNA splicing, via spliceosome(GO:0000398)
0.0 0.1 GO:0015846 polyamine transport(GO:0015846)
0.0 0.0 GO:0071902 positive regulation of protein serine/threonine kinase activity(GO:0071902)
0.0 0.2 GO:0043085 positive regulation of catalytic activity(GO:0043085) positive regulation of molecular function(GO:0044093)
0.0 0.1 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.0 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
1.4 4.3 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
1.2 3.5 GO:0030061 mitochondrial crista(GO:0030061)
1.0 4.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
1.0 2.9 GO:0032177 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.8 2.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.6 2.3 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.5 1.5 GO:0030870 Mre11 complex(GO:0030870)
0.4 1.6 GO:0005960 glycine cleavage complex(GO:0005960)
0.4 4.8 GO:0005619 ascospore wall(GO:0005619)
0.4 2.9 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.3 0.9 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.3 1.5 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.3 2.4 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.3 0.5 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 1.0 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.3 7.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 1.2 GO:0032865 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.2 1.6 GO:0034657 GID complex(GO:0034657)
0.2 2.4 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 1.9 GO:0070069 cytochrome complex(GO:0070069)
0.2 1.8 GO:0000795 synaptonemal complex(GO:0000795)
0.2 1.9 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.2 4.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 0.5 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 0.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 0.5 GO:0035649 Nrd1 complex(GO:0035649)
0.2 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.2 1.9 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.2 1.5 GO:0000974 Prp19 complex(GO:0000974)
0.1 3.2 GO:0016592 mediator complex(GO:0016592)
0.1 1.6 GO:0005769 early endosome(GO:0005769)
0.1 0.7 GO:0032221 Rpd3S complex(GO:0032221)
0.1 0.7 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 0.4 GO:0001400 mating projection base(GO:0001400)
0.1 0.8 GO:0008180 COP9 signalosome(GO:0008180)
0.1 3.1 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 0.7 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 6.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.9 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.7 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.1 2.1 GO:0098798 mitochondrial protein complex(GO:0098798)
0.1 0.3 GO:0031261 DNA replication preinitiation complex(GO:0031261)
0.1 1.3 GO:0016586 RSC complex(GO:0016586)
0.1 0.3 GO:0070274 RES complex(GO:0070274)
0.1 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.3 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.1 0.4 GO:0034448 EGO complex(GO:0034448)
0.1 0.2 GO:0033263 CORVET complex(GO:0033263)
0.1 0.3 GO:0033309 SBF transcription complex(GO:0033309)
0.1 0.3 GO:0070390 transcription export complex 2(GO:0070390)
0.1 0.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.3 GO:0098803 mitochondrial respiratory chain(GO:0005746) respiratory chain complex(GO:0098803)
0.1 0.3 GO:0044697 HICS complex(GO:0044697)
0.1 0.2 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.4 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.7 GO:0070822 Sin3-type complex(GO:0070822)
0.1 0.5 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.2 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.2 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.1 0.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.3 GO:0051233 spindle midzone(GO:0051233)
0.1 1.0 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.1 3.3 GO:0005741 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.1 2.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.4 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 0.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.2 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 2.7 GO:0000131 incipient cellular bud site(GO:0000131)
0.1 6.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 0.2 GO:0032126 eisosome(GO:0032126)
0.0 1.3 GO:0044459 plasma membrane part(GO:0044459)
0.0 5.2 GO:0000329 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.0 2.6 GO:0005657 replication fork(GO:0005657)
0.0 0.3 GO:0034967 Set3 complex(GO:0034967)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.4 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 2.2 GO:0043332 mating projection tip(GO:0043332)
0.0 1.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0016363 nuclear matrix(GO:0016363)
0.0 7.8 GO:0005886 plasma membrane(GO:0005886)
0.0 0.2 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.8 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 0.1 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.0 0.1 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.1 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 0.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.0 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 14.1 GO:0005537 mannose binding(GO:0005537)
1.9 9.6 GO:0015295 solute:proton symporter activity(GO:0015295)
1.6 4.9 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
1.3 4.0 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
1.1 3.4 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.1 4.5 GO:0004396 hexokinase activity(GO:0004396)
0.9 0.9 GO:0001005 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.8 2.5 GO:0016289 CoA hydrolase activity(GO:0016289)
0.8 2.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.8 2.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.8 4.7 GO:0000400 four-way junction DNA binding(GO:0000400)
0.8 5.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.8 2.3 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.7 2.9 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.7 2.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.7 2.9 GO:0022821 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.7 2.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.7 2.1 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.6 3.1 GO:0008198 ferrous iron binding(GO:0008198)
0.6 4.8 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.6 2.3 GO:0008169 C-methyltransferase activity(GO:0008169)
0.6 8.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.6 5.1 GO:0038023 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.6 2.2 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.5 1.5 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.5 1.9 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.5 1.4 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.5 2.3 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782) sulfurtransferase activity(GO:0016783)
0.5 5.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.5 1.8 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.4 1.3 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.4 3.7 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.4 4.1 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.4 1.2 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.4 0.4 GO:0016208 AMP binding(GO:0016208)
0.4 1.6 GO:0004375 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.4 1.2 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.4 1.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.3 0.3 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.3 1.4 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.3 1.4 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.3 1.1 GO:0051183 vitamin transporter activity(GO:0051183)
0.3 1.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.3 2.1 GO:0031072 heat shock protein binding(GO:0031072)
0.3 1.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 3.1 GO:0022838 substrate-specific channel activity(GO:0022838)
0.3 4.4 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.3 1.5 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 7.1 GO:0016209 antioxidant activity(GO:0016209)
0.3 2.5 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.3 1.3 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.2 3.4 GO:0005507 copper ion binding(GO:0005507)
0.2 2.4 GO:0000171 ribonuclease MRP activity(GO:0000171) ribonuclease P activity(GO:0004526)
0.2 0.2 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.2 0.7 GO:0070336 flap-structured DNA binding(GO:0070336)
0.2 6.1 GO:0003684 damaged DNA binding(GO:0003684)
0.2 0.9 GO:0008172 S-methyltransferase activity(GO:0008172)
0.2 0.5 GO:0005536 glucose binding(GO:0005536)
0.2 1.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.2 0.4 GO:0032452 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) histone demethylase activity(GO:0032452) histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 3.1 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.2 0.7 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 5.2 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.2 0.9 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 0.8 GO:0016417 S-acyltransferase activity(GO:0016417)
0.2 0.6 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.2 1.0 GO:0070403 NAD+ binding(GO:0070403)
0.2 1.0 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 0.6 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.2 0.8 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.2 1.9 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.7 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.2 2.5 GO:0019213 deacetylase activity(GO:0019213)
0.2 1.3 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 0.2 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.2 0.5 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.2 1.6 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.2 0.8 GO:0016408 C-acyltransferase activity(GO:0016408)
0.1 1.0 GO:0015293 symporter activity(GO:0015293)
0.1 1.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 1.2 GO:0000149 SNARE binding(GO:0000149)
0.1 0.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.4 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.1 0.4 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 2.1 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.5 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 3.4 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 0.8 GO:0016597 amino acid binding(GO:0016597) carboxylic acid binding(GO:0031406) organic acid binding(GO:0043177)
0.1 8.6 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.7 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.1 0.5 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.1 0.5 GO:0016435 O-methyltransferase activity(GO:0008171) rRNA (guanine) methyltransferase activity(GO:0016435)
0.1 1.4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 0.6 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 2.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 3.8 GO:0005342 organic acid transmembrane transporter activity(GO:0005342)
0.1 4.5 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.3 GO:0032183 SUMO binding(GO:0032183)
0.1 0.4 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 2.1 GO:0005509 calcium ion binding(GO:0005509)
0.1 1.0 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 0.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.4 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 0.3 GO:0017022 myosin binding(GO:0017022)
0.1 1.5 GO:0050661 NADP binding(GO:0050661)
0.1 1.0 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.5 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 8.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 0.4 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.1 0.4 GO:0004620 phospholipase activity(GO:0004620)
0.1 1.1 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 1.0 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.8 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.3 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 0.2 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.1 0.7 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 0.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 4.5 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 0.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 1.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.2 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 0.2 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.1 0.3 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 0.7 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.1 0.4 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.6 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 0.2 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.2 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 1.0 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.2 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.9 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.0 0.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 1.8 GO:0019787 ubiquitin-like protein transferase activity(GO:0019787)
0.0 0.7 GO:0042393 histone binding(GO:0042393)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.2 GO:0033613 RNA polymerase II activating transcription factor binding(GO:0001102) activating transcription factor binding(GO:0033613)
0.0 0.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 1.1 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.4 GO:0043022 ribosome binding(GO:0043022)
0.0 0.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.3 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.0 0.0 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.2 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.1 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.2 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.3 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.0 GO:0008409 5'-3' exonuclease activity(GO:0008409)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 1.6 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.7 2.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.6 4.9 PID FANCONI PATHWAY Fanconi anemia pathway
0.5 1.6 PID AP1 PATHWAY AP-1 transcription factor network
0.4 0.4 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.4 1.1 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.3 2.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.3 0.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 0.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 142.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 0.3 PID E2F PATHWAY E2F transcription factor network
0.1 0.3 PID FOXO PATHWAY FoxO family signaling
0.1 0.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 0.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 0.1 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.1 REACTOME DNA REPAIR Genes involved in DNA Repair
0.4 1.3 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.4 1.9 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.4 1.1 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.3 1.5 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.3 0.8 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.2 1.6 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 1.0 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 0.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 138.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 0.1 REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE Genes involved in NFkB and MAP kinases activation mediated by TLR4 signaling repertoire
0.0 0.1 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.1 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.0 0.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.0 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing