Results for TBS1
Z-value: 0.99
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Transcription factors associated with TBS1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
TBS1
|
S000000354 | Putative protein of unknown function |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YLR349W Show fit | 2.61 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C |
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| YNL134C Show fit | 2.59 |
Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS |
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| YLR348C Show fit | 2.42 |
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix |
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| YER088C-A Show fit | 2.34 |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
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| YEL001C Show fit | 2.20 |
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci |
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| YDR345C Show fit | 1.94 |
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions |
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| YCL018W Show fit | 1.93 |
Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway |
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| YLR350W Show fit | 1.74 |
Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum |
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| YOL086C Show fit | 1.70 |
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway |
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| YBR177C Show fit | 1.68 |
Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBS1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.4 | GO:0009098 | leucine biosynthetic process(GO:0009098) |
| 0.0 | 3.6 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.8 | 3.1 | GO:0000296 | spermine transport(GO:0000296) |
| 0.1 | 2.6 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.4 | 2.5 | GO:0006835 | dicarboxylic acid transport(GO:0006835) |
| 0.5 | 2.0 | GO:0009099 | valine biosynthetic process(GO:0009099) |
| 0.1 | 1.9 | GO:0006633 | fatty acid biosynthetic process(GO:0006633) |
| 0.6 | 1.7 | GO:0090153 | regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038) |
| 0.2 | 1.6 | GO:0019655 | glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707) |
| 0.0 | 1.6 | GO:0032543 | mitochondrial translation(GO:0032543) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | GO:0044445 | cytosolic part(GO:0044445) |
| 0.0 | 3.7 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 3.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 3.3 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.0 | 3.2 | GO:0005576 | extracellular region(GO:0005576) |
| 0.0 | 2.7 | GO:0000329 | fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852) |
| 0.0 | 2.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 2.6 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.1 | 2.5 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.3 | 2.2 | GO:0033101 | cellular bud membrane(GO:0033101) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.8 | 3.1 | GO:0000297 | spermine transmembrane transporter activity(GO:0000297) |
| 0.3 | 2.5 | GO:0005310 | dicarboxylic acid transmembrane transporter activity(GO:0005310) |
| 0.1 | 2.3 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.1 | 2.0 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.3 | 1.9 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.3 | 1.7 | GO:0034318 | alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318) |
| 0.0 | 1.7 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 0.1 | 1.6 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.2 | 1.5 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 0.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 0.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 0.2 | PID SHP2 PATHWAY | SHP2 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.2 | 0.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 0.5 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 0.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 0.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 0.4 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.3 | REACTOME SIGNALING BY GPCR | Genes involved in Signaling by GPCR |
| 0.0 | 0.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 0.2 | REACTOME INSULIN RECEPTOR SIGNALLING CASCADE | Genes involved in Insulin receptor signalling cascade |
| 0.0 | 0.1 | REACTOME PROTEIN FOLDING | Genes involved in Protein folding |