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Results for TBS1

Z-value: 0.99

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Transcription factors associated with TBS1

Gene Symbol Gene ID Gene Info
TBS1
S000000354 Putative protein of unknown function

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBS1YBR150C-0.758.5e-06Click!

Activity profile of TBS1 motif

Sorted Z-values of TBS1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YLR349W 2.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YNL134C 2.59 Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
YLR348C 2.42
DIC1
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YER088C-A 2.34 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL001C 2.20
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YDR345C 1.94
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YCL018W 1.93
LEU2
Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YLR350W 1.74
ORM2
Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YOL086C 1.70
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YBR177C 1.68
EHT1
Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YGL157W 1.53 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YPR157W 1.52 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YOR028C 1.46
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YFR055W 1.45
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YJR016C 1.40
ILV3
Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
YOL085C 1.40 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YLR110C 1.37
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YLL028W 1.35
TPO1
Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
YDR133C 1.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YOR273C 1.31
TPO4
Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YKL096W 1.26
CWP1
Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization
YNR014W 1.25 Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
YDR046C 1.19
BAP3
Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
YDR047W 1.18
HEM12
Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YFL014W 1.17
HSP12
Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways
YFL015C 1.17 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YDR033W 1.14
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YLR154W-A 1.12 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGR234W 1.10
YHB1
Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YLR154W-B 1.09 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGL009C 1.09
LEU1
Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YCR102C 1.08 Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene
YMR318C 1.07
ADH6
NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YBL100C 1.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YGR055W 1.05
MUP1
High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
YCL064C 1.00
CHA1
Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YGR279C 0.98
SCW4
Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YCR102W-A 0.98 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR251W-A 0.98
HOR7
Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor
YBR178W 0.96 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C
YDR309C 0.95
GIC2
Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
YHL003C 0.92
LAG1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YMR243C 0.87
ZRC1
Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm
YER001W 0.87
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YHR208W 0.87
BAT1
Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase
YCR024C-B 0.84 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YNL327W 0.83
EGT2
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YDL125C 0.82
HNT1
Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint
YIL123W 0.81
SIM1
Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
YPR149W 0.81
NCE102
Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
YKL219W 0.81
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YFL022C 0.80
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YOR029W 0.79 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YER134C 0.79 Putative protein of unknown function; non-essential gene
YBR032W 0.78 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YLR212C 0.78
TUB4
Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
YLR411W 0.75
CTR3
High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YPR063C 0.75 ER-localized protein of unknown function
YOR376W-A 0.75 Putative protein of unknown function; identified by fungal homology and RT-PCR
YBL006C 0.75
LDB7
Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
YOR272W 0.74
YTM1
Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YBL099W 0.72
ATP1
Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YOR247W 0.72
SRL1
Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YER117W 0.72
RPL23B
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YFR056C 0.69 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YKL209C 0.64
STE6
Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YML127W 0.64
RSC9
Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YMR246W 0.63
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YGR254W 0.61
ENO1
Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YDL174C 0.58
DLD1
D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
YNL104C 0.56
LEU4
Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YGL202W 0.56
ARO8
Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YOR012W 0.55 Putative protein of unknown function
YFL016C 0.55
MDJ1
Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YLR258W 0.54
GSY2
Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YGR251W 0.54 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YER010C 0.53 Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction
YNL055C 0.53
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YHR140W 0.52 Putative integral membrane protein of unknown function
YDR385W 0.52
EFT2
Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YKR075C 0.52 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YIL051C 0.51
MMF1
Mitochondrial protein involved in maintenance of the mitochondrial genome
YOR092W 0.51
ECM3
Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation
YOR271C 0.51
FSF1
Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YMR304C-A 0.51 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10
YOL052C 0.50
SPE2
S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
YPR156C 0.49
TPO3
Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YLR312W-A 0.49
MRPL15
Mitochondrial ribosomal protein of the large subunit
YKR041W 0.48 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YJL104W 0.47
PAM16
Constituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam18p; forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains J-like domain
YDR010C 0.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL012C 0.47
HTZ1
Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YOR375C 0.46
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YOL039W 0.46
RPP2A
Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YOL154W 0.46
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YNR013C 0.46
PHO91
Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YDR041W 0.46
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YGL147C 0.45
RPL9A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YFL015W-A 0.45 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR069C 0.44
TAT1
Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance
YDR533C 0.44
HSP31
Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YDR094W 0.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YDR040C 0.43
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YER146W 0.42
LSM5
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YGR124W 0.42
ASN2
Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YDR215C 0.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
YDR032C 0.42
PST2
Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCR018C 0.41
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YJR114W 0.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C
YGR052W 0.41
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YPL170W 0.41
DAP1
Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
YLL045C 0.41
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YER182W 0.40
FMP10
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL265W 0.40
DIP5
Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly
YDL173W 0.39 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDL173W is not an essential gene
YER011W 0.38
TIR1
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YER136W 0.38
GDI1
GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YPL014W 0.38 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YPL250W-A 0.37 Identified by fungal homology and RT-PCR
YBR068C 0.37
BAP2
High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains
YMR263W 0.37
SAP30
Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
YCL042W 0.37 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YGR146C-A 0.37 Putative protein of unknown function
YNL024C 0.37 Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene
YKL043W 0.36
PHD1
Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YHR181W 0.36
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YEL033W 0.36
MTC7
Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
YDR091C 0.36
RLI1
Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YPR170W-B 0.35 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YMR108W 0.35
ILV2
Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
YJR113C 0.35
RSM7
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
YHL021C 0.35
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YLR447C 0.35
VMA6
Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane
YBL044W 0.35 Putative protein of unknown function; YBL044W is not an essential protein
YPR017C 0.34
DSS4
Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol
YNL035C 0.34 Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene
YDR344C 0.34 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR154C 0.34
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YPL256C 0.34
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YNL160W 0.34
YGP1
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YER153C 0.34
PET122
Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane
YDR384C 0.33
ATO3
Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
YBR126W-A 0.33 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YJR147W 0.33
HMS2
Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YHR021C 0.33
RPS27B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YDR044W 0.33
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YOL120C 0.32
RPL18A
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation
YJR015W 0.32 Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene
YMR199W 0.32
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YBR183W 0.31
YPC1
Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
YMR272C 0.31
SCS7
Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YBR093C 0.31
PHO5
Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YIL011W 0.31
TIR3
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YPR198W 0.30
SGE1
Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
YML123C 0.30
PHO84
High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YHR092C 0.30
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YOR107W 0.30
RGS2
Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YLR178C 0.29
TFS1
Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway
YLR415C 0.29 Putative protein of unknown function; YLR415C is not an essential gene
YOR226C 0.29
ISU2
Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YKL060C 0.29
FBA1
Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YBR052C 0.29
RFS1
Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YOR072W-B 0.29 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YGR108W 0.29
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YIL096C 0.28 Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit
YCL063W 0.28
VAC17
Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YPR197C 0.28 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL011W 0.27
PLB3
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YBR126C 0.27
TPS1
Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
YDR276C 0.27
PMP3
Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YER026C 0.27
CHO1
Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline
YPL031C 0.27
PHO85
Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle
YGL255W 0.27
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YJL136C 0.27
RPS21B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YLR355C 0.26
ILV5
Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YBR158W 0.26
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YNL178W 0.26
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YCL048W-A 0.26 Putative protein of unknown function
YJR116W 0.26 Putative protein of unknown function
YBR293W 0.26
VBA2
Permease of basic amino acids in the vacuolar membrane
YCL043C 0.26
PDI1
Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds
YGL080W 0.25
FMP37
Putative protein of unknown function; highly conserved across species and orthologous to human gene BRP44L; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL225W 0.24
VRG4
Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YOL058W 0.24
ARG1
Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
YNL231C 0.24
PDR16
Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YDR346C 0.24
SVF1
Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis
YCL040W 0.24
GLK1
Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YEL017W 0.24
GTT3
Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
YBR085W 0.24
AAC3
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration
YML028W 0.24
TSA1
Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype
YBR082C 0.23
UBC4
Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response
YOR103C 0.23
OST2
Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YCL049C 0.23 Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene;
YHL006C 0.23
SHU1
Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p
YPL059W 0.23
GRX5
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p
YIR027C 0.23
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YER074W 0.23
RPS24A
Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YMR143W 0.23
RPS16A
Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins
YGL209W 0.22
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YOL155C 0.22
HPF1
Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines

Network of associatons between targets according to the STRING database.

First level regulatory network of TBS1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0000296 spermine transport(GO:0000296)
0.6 4.4 GO:0009098 leucine biosynthetic process(GO:0009098)
0.6 1.7 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.5 2.0 GO:0009099 valine biosynthetic process(GO:0009099)
0.5 1.5 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.4 2.5 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.3 1.0 GO:0000101 sulfur amino acid transport(GO:0000101)
0.3 1.4 GO:0098609 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.3 1.0 GO:0006567 threonine catabolic process(GO:0006567)
0.3 0.9 GO:0006824 cobalt ion transport(GO:0006824)
0.3 0.8 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.2 0.7 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.2 1.6 GO:0019655 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.2 1.5 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.2 1.2 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.2 1.2 GO:0007155 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.2 0.6 GO:0009094 tyrosine biosynthetic process(GO:0006571) L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.2 0.5 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) isoleucine biosynthetic process(GO:0009097)
0.2 0.5 GO:0008216 spermidine metabolic process(GO:0008216)
0.2 0.6 GO:0035337 long-chain fatty acid transport(GO:0015909) fatty-acyl-CoA metabolic process(GO:0035337)
0.2 0.5 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.2 0.8 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.9 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.3 GO:0044091 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 0.8 GO:0070941 eisosome assembly(GO:0070941)
0.1 0.5 GO:0044070 regulation of anion transport(GO:0044070)
0.1 0.2 GO:0072367 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.1 0.3 GO:0023021 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 1.1 GO:0090662 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1 0.7 GO:0031506 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.1 0.4 GO:0071169 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.1 0.5 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.1 2.6 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 0.8 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.1 0.3 GO:0006850 mitochondrial pyruvate transport(GO:0006850)
0.1 1.1 GO:0007120 axial cellular bud site selection(GO:0007120)
0.1 0.4 GO:0032443 regulation of steroid metabolic process(GO:0019218) regulation of ergosterol biosynthetic process(GO:0032443) regulation of steroid biosynthetic process(GO:0050810)
0.1 0.4 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.1 0.3 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 0.1 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.1 1.0 GO:0007009 plasma membrane organization(GO:0007009)
0.1 0.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 0.2 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.1 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 0.5 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 0.2 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.1 1.9 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.1 0.3 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.1 0.3 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
0.1 0.8 GO:0015833 peptide transport(GO:0015833)
0.1 0.2 GO:0015886 heme transport(GO:0015886)
0.1 0.1 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 0.2 GO:0030048 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 1.0 GO:0009636 response to toxic substance(GO:0009636)
0.1 0.2 GO:0015908 fatty acid transport(GO:0015908)
0.1 0.4 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 0.3 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 0.2 GO:0019413 acetate biosynthetic process(GO:0019413)
0.0 0.5 GO:0006458 'de novo' protein folding(GO:0006458)
0.0 0.2 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.0 0.1 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 0.6 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 1.0 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.0 0.1 GO:0006687 glycosphingolipid metabolic process(GO:0006687) glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.1 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.0 0.2 GO:0043007 maintenance of rDNA(GO:0043007)
0.0 0.2 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.2 GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947)
0.0 0.1 GO:0048313 Golgi inheritance(GO:0048313)
0.0 0.4 GO:0015893 drug transport(GO:0015893)
0.0 0.3 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.4 GO:0006813 potassium ion transport(GO:0006813)
0.0 0.3 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.1 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.0 0.6 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:0046323 glucose import(GO:0046323)
0.0 0.1 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.0 0.1 GO:0003400 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 0.4 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.0 0.4 GO:0006415 translational termination(GO:0006415)
0.0 0.5 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.0 0.1 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.1 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.2 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.0 0.1 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.2 GO:0043487 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.0 0.1 GO:0032978 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.0 0.1 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 3.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.3 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.3 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 0.5 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.0 0.5 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.0 0.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.3 GO:0000011 vacuole inheritance(GO:0000011)
0.0 0.3 GO:0042493 response to drug(GO:0042493)
0.0 0.0 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.1 GO:0010922 positive regulation of phosphatase activity(GO:0010922)
0.0 0.1 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 1.6 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.2 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.1 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.3 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.1 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.0 0.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.1 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.7 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.3 0.8 GO:0030428 cell septum(GO:0030428)
0.3 2.2 GO:0033101 cellular bud membrane(GO:0033101)
0.3 1.1 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.2 0.7 GO:0070545 PeBoW complex(GO:0070545)
0.2 0.7 GO:0000928 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.2 1.0 GO:0030478 actin cap(GO:0030478)
0.2 0.5 GO:0046930 pore complex(GO:0046930)
0.2 0.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.7 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.5 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.1 2.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 0.3 GO:0033179 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 1.4 GO:0016586 RSC complex(GO:0016586)
0.1 0.4 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 2.2 GO:0005811 lipid particle(GO:0005811)
0.1 0.2 GO:0097196 Shu complex(GO:0097196)
0.1 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.4 GO:0005688 U6 snRNP(GO:0005688)
0.1 0.2 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.0 0.6 GO:0000786 nucleosome(GO:0000786)
0.0 3.2 GO:0005576 extracellular region(GO:0005576)
0.0 0.1 GO:0032301 MutSalpha complex(GO:0032301)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 3.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.4 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 0.7 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.3 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 1.1 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.6 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0070209 ASTRA complex(GO:0070209) R2TP complex(GO:0097255)
0.0 0.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.7 GO:0044445 cytosolic part(GO:0044445)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0032432 actin filament bundle(GO:0032432)
0.0 2.7 GO:0000329 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.0 0.7 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.9 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.1 GO:0000346 transcription export complex(GO:0000346)
0.0 2.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.1 GO:0000814 ESCRT II complex(GO:0000814)
0.0 3.7 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.2 GO:0033698 Rpd3L complex(GO:0033698)
0.0 3.3 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 1.3 GO:0005768 endosome(GO:0005768)
0.0 0.1 GO:0032045 eukaryotic translation initiation factor 2B complex(GO:0005851) guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.3 GO:0000502 proteasome complex(GO:0000502)
0.0 0.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.0 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.5 GO:0005840 ribosome(GO:0005840)
0.0 0.1 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.2 GO:0005844 polysome(GO:0005844)
0.0 0.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 2.6 GO:0005886 plasma membrane(GO:0005886)
0.0 0.2 GO:0005685 U1 snRNP(GO:0005685)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.3 1.7 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.3 1.9 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3 1.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.3 1.2 GO:0016841 ammonia-lyase activity(GO:0016841)
0.3 2.5 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.3 0.8 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.3 0.8 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.2 1.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.2 0.7 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.2 0.2 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.2 0.6 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.2 1.0 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.2 0.8 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.2 0.9 GO:0017048 Rho GTPase binding(GO:0017048)
0.2 0.5 GO:0022829 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.2 0.9 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.2 0.5 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.2 1.1 GO:0005216 ion channel activity(GO:0005216)
0.2 0.5 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.1 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 1.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.6 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 0.6 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.5 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.1 2.3 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.7 GO:0010181 FMN binding(GO:0010181)
0.1 0.4 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 0.3 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.1 0.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.4 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 0.5 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 0.3 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.1 1.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.3 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 2.0 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 0.9 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.3 GO:0005384 inorganic phosphate transmembrane transporter activity(GO:0005315) manganese ion transmembrane transporter activity(GO:0005384)
0.1 0.5 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 0.2 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.1 1.0 GO:0051540 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.1 1.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.7 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.9 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.1 1.0 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.9 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.6 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.2 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.1 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 0.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.1 0.3 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.1 0.3 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.2 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.4 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.4 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.0 0.2 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 1.7 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 1.1 GO:0051287 NAD binding(GO:0051287)
0.0 0.1 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.1 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.0 0.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.5 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.4 GO:0004407 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 0.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.1 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.3 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0051880 RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132) G-quadruplex DNA binding(GO:0051880)
0.0 0.1 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.1 GO:0004396 hexokinase activity(GO:0004396)
0.0 0.3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.0 0.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 6.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.0 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.1 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.2 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.0 0.1 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.5 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.0 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.0 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0051087 chaperone binding(GO:0051087)
0.0 0.1 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.1 GO:0043022 ribosome binding(GO:0043022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 PID NOTCH PATHWAY Notch signaling pathway
0.1 0.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 0.2 PID SHP2 PATHWAY SHP2 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 0.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.2 REACTOME INSULIN RECEPTOR SIGNALLING CASCADE Genes involved in Insulin receptor signalling cascade
0.1 0.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 0.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.3 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.0 0.8 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.0 0.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.1 REACTOME PROTEIN FOLDING Genes involved in Protein folding
0.0 0.1 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)