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Results for TBF1

Z-value: 0.67

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Transcription factors associated with TBF1

Gene Symbol Gene ID Gene Info
TBF1
S000006049 Telobox-containing general regulatory factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBF1YPL128C0.691.1e-04Click!

Activity profile of TBF1 motif

Sorted Z-values of TBF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YLR312C 2.19
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YHR212W-A 1.52 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YMR107W 1.51
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YAR053W 1.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL133C-A 1.31 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCR068W 1.26
ATG15
Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YDR490C 1.09
PKH1
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
YFL033C 1.06
RIM15
Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
YGL146C 1.04 Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YKL171W 1.04 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YNL117W 1.03
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YAR060C 1.01 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR212C 0.98 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR120W 0.92 Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YGL219C 0.92
MDM34
Mitochondrial outer membrane protein, required for normal mitochondrial morphology and inheritance; localizes to dots on the mitochondrial surface near mtDNA nucleoids; interacts genetically with MDM31 and MDM32
YMR302C 0.91
YME2
Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
YER169W 0.90
RPH1
JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway
YMR172W 0.88
HOT1
Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
YOL060C 0.87
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YML017W 0.86
PSP2
Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing
YCR073W-A 0.84
SOL2
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p
YLR094C 0.84
GIS3
Protein of unknown function
YKR089C 0.83
TGL4
Triacylglycerol lipase involved in triacylglycerol mobilization and degradation; found in lipid particles; potential Cdc28p substrate
YJR119C 0.82
JHD2
JmjC domain family histone demethylase specific for H3-K4 (lysine at position 4 of the histone H3 protein); removes methyl groups specifically added by Set1p methyltransferase
YPL116W 0.80
HOS3
Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
YFR040W 0.79
SAP155
Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p
YOL051W 0.78
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YKR025W 0.77
RPC37
RNA polymerase III subunit C37
YJR109C 0.75
CPA2
Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor
YMR171C 0.73
EAR1
Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p: YMR171C is not an essential gene
YLL013C 0.71
PUF3
Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
YHR206W 0.71
SKN7
Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation
YFL051C 0.71 Putative protein of unknown function; YFL051C is not an essential gene
YBR072W 0.68
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YOL084W 0.68
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YGL217C 0.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W
YDL170W 0.64
UGA3
Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YBL033C 0.64
RIB1
GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
YPR184W 0.63
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YGL205W 0.63
POX1
Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YAL028W 0.63
FRT2
Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate
YGL216W 0.62
KIP3
Kinesin-related motor protein involved in mitotic spindle positioning
YMR017W 0.61
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YLR189C 0.61
ATG26
UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
YGR230W 0.60
BNS1
Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis
YBR037C 0.59
SCO1
Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins
YOR235W 0.59
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YCR086W 0.59
CSM1
Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance
YDR536W 0.59
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YGR256W 0.57
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YPR030W 0.57
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YKL217W 0.57
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YJR128W 0.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YLR055C 0.56
SPT8
Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
YHR150W 0.55
PEX28
Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
YJL020C 0.55
BBC1
Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
YCL016C 0.55
DCC1
Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
YKL105C 0.55 Putative protein of unknown function
YDL230W 0.55
PTP1
Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria
YEL060C 0.54
PRB1
Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YMR175W 0.53
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YLR402W 0.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR446W 0.53
ECM11
Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
YGR243W 0.53
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL103C 0.52
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YEL009C-A 0.51 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR013C 0.51
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YLL010C 0.50
PSR1
Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
YJR094C 0.50
IME1
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YML007W 0.50
YAP1
Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium
YOR147W 0.50
MDM32
Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
YDR277C 0.50
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YBL038W 0.49
MRPL16
Mitochondrial ribosomal protein of the large subunit
YIL055C 0.49 Putative protein of unknown function
YCR007C 0.47 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YOL100W 0.46
PKH2
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YPL223C 0.46
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YDR542W 0.45
PAU10
Hypothetical protein
YLR403W 0.45
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YER067C-A 0.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
YLR149C 0.43 Putative protein of unknown function; YLR149C is not an essential gene
YKL139W 0.43
CTK1
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing
YGL228W 0.43
SHE10
Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest
YNL172W 0.43
APC1
Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YKL102C 0.43 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YDR342C 0.43
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YHR211W 0.42
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YLR366W 0.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YER014C-A 0.42
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YOR324C 0.42
FRT1
Tail-anchored endoplasmic reticulum membrane protein that is a substrate of the phosphatase calcineurin, interacts with homolog Frt2p, promotes cell growth in conditions of high Na+, alkaline pH, and cell wall stress
YCL014W 0.41
BUD3
Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
YDR102C 0.40 Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YGL089C 0.40
MF(ALPHA)2
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
YDR103W 0.40
STE5
Pheromone-response scaffold protein; binds kinases Ste11p, Ste7p, and Fus3p to form a MAPK cascade complex that interacts with the plasma membrane, via a PH (pleckstrin homology) and PM/NLS domain, and with Ste4p-Ste18p, during signaling
YOL035C 0.40 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER065C 0.40
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YLR174W 0.39
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YNL093W 0.39
YPT53
GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YLR019W 0.39
PSR2
Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
YEL010W 0.39 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR325W 0.38 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1
YPR010C-A 0.38 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YPR151C 0.38
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YLR356W 0.38 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YCR005C 0.38
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YPL026C 0.37
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YOR211C 0.37
MGM1
Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YPL024W 0.37
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YJR115W 0.37 Putative protein of unknown function
YMR118C 0.37 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YOL131W 0.37 Putative protein of unknown function
YML034W 0.36
SRC1
Inner nuclear membrane (INM) protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence
YJR061W 0.36 Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p
YNL339C 0.36
YRF1-6
Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YOR382W 0.35
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YPL230W 0.35
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YGL177W 0.35 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR301W 0.34
CFT1
RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF
YHR193C-A 0.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified ORF MDM31
YAL039C 0.34
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YBL073W 0.34 Hypothetical protein; open reading frame overlaps 5' end of essential AAR2 gene encoding a component of the U5 snRNP required for splicing of U3 precursors
YLR425W 0.33
TUS1
Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
YPL058C 0.33
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YMR313C 0.33
TGL3
Triacylglycerol lipase of the lipid particle, responsible for all the TAG lipase activity of the lipid particle; contains the consensus sequence motif GXSXG, which is found in lipolytic enzymes
YAL062W 0.33
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YFR036W 0.33
CDC26
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YCL001W-B 0.32 Putative protein of unknown function; identified by homology
YDL231C 0.32
BRE4
Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport
YHR194W 0.32
MDM31
Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
YKL023W 0.32 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YOR098C 0.32
NUP1
Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate
YDR059C 0.32
UBC5
Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YPL127C 0.31
HHO1
Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation
YLR431C 0.31
ATG23
Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway; cycles between the pre-autophagosome (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p
YDR358W 0.31
GGA1
Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
YHR151C 0.31
MTC6
Putative protein of unknown function; YHR151C is synthetically sick with cdc13-1
YMR068W 0.31
AVO2
Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YJL163C 0.31 Putative protein of unknown function
YOR140W 0.30
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YBL074C 0.30
AAR2
Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
YGL013C 0.30
PDR1
Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes
YJL019W 0.30
MPS3
Essential integral membrane protein required for spindle pole body duplication and for nuclear fusion, localizes to the spindle pole body half bridge, interacts with DnaJ-like chaperone Jem1p and with centrin homolog Cdc31p
YOR192C 0.30
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YFL024C 0.30
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YMR014W 0.30
BUD22
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YGR286C 0.30
BIO2
Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YJL037W 0.30
IRC18
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YKR100C 0.29
SKG1
Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
YMR016C 0.29
SOK2
Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YMR240C 0.29
CUS1
Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
YOL034W 0.29
SMC5
Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
YHR096C 0.29
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YPL213W 0.29
LEA1
Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; invovled in telomere maintenance; putative homolog of human U2A' snRNP protein
YBR059C 0.29
AKL1
Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization
YLR007W 0.29
NSE1
Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth; has a nonstructural role in the maintenance of chromosomes
YIL119C 0.29
RPI1
Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
YMR174C 0.28
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YKR011C 0.28 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YDR113C 0.28
PDS1
Securin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nuclei
YCR019W 0.28
MAK32
Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YOR139C 0.28 Hypothetical protein
YDR043C 0.28
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YHR075C 0.27
PPE1
Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
YKL163W 0.27
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YLR136C 0.27
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YKL038W 0.27
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YJL038C 0.27
LOH1
Putative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W
YCR021C 0.27
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YDR255C 0.26
RMD5
Cytosolic protein required for sporulation; also required for the ubiquitination of the gluconeogenetic enzyme fructose-1,6-bisphosphatase, which is degraded rapidly after the switch from gluconeogenesis to glycolysis
YML035C 0.26
AMD1
AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools
YDR441C 0.25
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YBL101C 0.25
ECM21
Non-essential protein of unknown function; promoter contains several Gcn4p binding elements
YJR038C 0.25 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER096W 0.24
SHC1
Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
YKL101W 0.24
HSL1
Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YKL097C 0.24 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YDR231C 0.24
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YIL102C-A 0.24 Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species
YHR071W 0.24
PCL5
Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YHR080C 0.24 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR192C-C 0.24 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YER166W 0.24
DNF1
Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
YKR102W 0.24
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YMR306W 0.24
FKS3
Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR164W 0.24 Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YPR169W-A 0.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B
YJL220W 0.23 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2
YPL189W 0.23
GUP2
Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog
YEL049W 0.23
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YNL025C 0.23
SSN8
Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance
YDR362C 0.23
TFC6
One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
YFR020W 0.23 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR296W 0.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL076W 0.22
MKS1
Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling
YKL065W-A 0.22 Putative protein of unknown function
YER016W 0.22
BIM1
Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
YBR208C 0.22
DUR1,2
Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YFL023W 0.22
BUD27
Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by TOR kinase; diploid mutants show a random budding pattern rather than the wild-type bipolar pattern; plays a role in regulating Ty1 transposition
YDR406W 0.22
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YFL064C 0.22 Putative protein of unknown function

Network of associatons between targets according to the STRING database.

First level regulatory network of TBF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.4 1.3 GO:0036257 multivesicular body organization(GO:0036257)
0.4 1.2 GO:0000304 response to singlet oxygen(GO:0000304)
0.3 1.5 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.3 0.3 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.3 1.2 GO:0006848 pyruvate transport(GO:0006848)
0.2 0.5 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.2 2.2 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 1.2 GO:0046464 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.2 1.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.2 1.0 GO:0015793 glycerol transport(GO:0015793)
0.2 1.1 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.2 0.8 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.2 1.3 GO:0071472 cellular response to salt stress(GO:0071472)
0.2 0.8 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.2 0.6 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.2 1.1 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.2 0.6 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.2 0.2 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151)
0.2 0.3 GO:2001023 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.2 0.6 GO:0051230 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.1 0.4 GO:0018209 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.1 0.6 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.1 1.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.1 GO:0034224 cellular response to zinc ion starvation(GO:0034224) regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation(GO:0034225)
0.1 0.6 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1 0.3 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 0.5 GO:0042357 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.1 0.3 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.1 0.3 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.1 0.2 GO:0043419 urea catabolic process(GO:0043419)
0.1 0.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.1 0.7 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.1 1.6 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.1 0.6 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.1 0.3 GO:0015888 thiamine transport(GO:0015888)
0.1 0.3 GO:0009730 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.1 0.3 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.1 0.2 GO:0046113 nucleobase catabolic process(GO:0046113)
0.1 1.0 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 0.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.4 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.1 0.4 GO:0046323 glucose import(GO:0046323)
0.1 0.4 GO:0032105 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.1 0.6 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 1.3 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.1 0.4 GO:0008054 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054) negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 0.3 GO:0043096 purine nucleobase salvage(GO:0043096)
0.1 0.3 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.1 0.5 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.1 0.4 GO:0043007 maintenance of rDNA(GO:0043007)
0.1 0.6 GO:0015891 siderophore transport(GO:0015891)
0.1 0.2 GO:0044209 AMP salvage(GO:0044209)
0.1 0.3 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 0.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.1 0.2 GO:0090527 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.1 0.2 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 0.6 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 0.4 GO:0007068 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021)
0.1 0.8 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.2 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.1 0.6 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 0.2 GO:0043335 protein unfolding(GO:0043335)
0.1 0.3 GO:0000078 obsolete cytokinesis after mitosis checkpoint(GO:0000078)
0.1 0.1 GO:0042710 biofilm formation(GO:0042710)
0.1 0.4 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.1 0.3 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.1 0.2 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.1 0.2 GO:0055070 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.1 0.2 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.1 0.1 GO:0061414 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.1 0.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.2 GO:0006003 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.2 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.1 0.1 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.1 0.2 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1 0.2 GO:0006598 polyamine catabolic process(GO:0006598)
0.1 0.6 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 0.3 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 0.4 GO:0009749 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.1 0.2 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.1 0.1 GO:0051099 positive regulation of binding(GO:0051099)
0.0 0.3 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.0 0.0 GO:0019627 urea metabolic process(GO:0019627)
0.0 1.0 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.0 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.0 0.2 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.0 0.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.2 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.0 0.2 GO:0046058 cAMP metabolic process(GO:0046058)
0.0 0.3 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.2 GO:0032845 negative regulation of telomere maintenance(GO:0032205) negative regulation of homeostatic process(GO:0032845)
0.0 0.2 GO:0048209 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 0.3 GO:0006279 premeiotic DNA replication(GO:0006279)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.5 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.1 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.0 0.0 GO:0006110 regulation of glycolytic process(GO:0006110)
0.0 0.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.1 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.0 0.3 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.0 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.2 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.0 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.0 0.3 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.1 GO:0000092 mitotic anaphase B(GO:0000092)
0.0 0.1 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.0 0.2 GO:0000411 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.0 0.2 GO:0006452 translational frameshifting(GO:0006452)
0.0 0.5 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.0 0.1 GO:0018216 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.0 0.4 GO:0043086 negative regulation of catalytic activity(GO:0043086)
0.0 0.2 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.0 0.3 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.0 0.1 GO:0043970 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178) histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.0 0.2 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.5 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.1 GO:0070542 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.0 0.1 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.2 GO:0009967 positive regulation of signal transduction(GO:0009967) positive regulation of cell communication(GO:0010647) positive regulation of signaling(GO:0023056)
0.0 0.1 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.0 0.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0042407 cristae formation(GO:0042407)
0.0 0.2 GO:0001009 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.0 0.0 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.1 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:0006536 glutamate metabolic process(GO:0006536)
0.0 0.0 GO:0001324 age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324)
0.0 0.1 GO:0031134 sister chromatid biorientation(GO:0031134)
0.0 0.3 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.1 GO:0006529 asparagine metabolic process(GO:0006528) asparagine biosynthetic process(GO:0006529)
0.0 0.1 GO:2000284 positive regulation of cellular amino acid metabolic process(GO:0045764) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.3 GO:0040020 regulation of meiotic nuclear division(GO:0040020) regulation of meiotic cell cycle(GO:0051445)
0.0 0.1 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.1 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.0 0.0 GO:0015976 carbon utilization(GO:0015976)
0.0 0.4 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.1 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.0 0.0 GO:0032147 activation of protein kinase activity(GO:0032147)
0.0 0.3 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.0 0.1 GO:0046503 glycerolipid catabolic process(GO:0046503)
0.0 0.1 GO:0032106 positive regulation of response to external stimulus(GO:0032103) positive regulation of response to extracellular stimulus(GO:0032106) positive regulation of response to nutrient levels(GO:0032109)
0.0 0.1 GO:0007129 synapsis(GO:0007129)
0.0 0.2 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.2 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.6 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.7 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.0 GO:1902932 positive regulation of alcohol biosynthetic process(GO:1902932)
0.0 0.1 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.0 0.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.1 GO:0070058 tRNA gene clustering(GO:0070058)
0.0 0.2 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.0 0.2 GO:0000045 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.0 GO:0055075 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.0 0.1 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.0 0.2 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.0 0.4 GO:0007265 Ras protein signal transduction(GO:0007265)
0.0 0.2 GO:0006109 regulation of carbohydrate metabolic process(GO:0006109)
0.0 0.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.0 GO:0061392 regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061392)
0.0 0.1 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078) beta-glucan biosynthetic process(GO:0051274)
0.0 0.1 GO:0032365 intracellular lipid transport(GO:0032365)
0.0 0.1 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.0 0.1 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.3 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.2 GO:0006301 postreplication repair(GO:0006301)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320) re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.0 0.2 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.1 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.4 GO:0007124 pseudohyphal growth(GO:0007124)
0.0 0.6 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.0 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.0 0.0 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.4 GO:0000725 recombinational repair(GO:0000725)
0.0 0.7 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.1 GO:0016562 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.0 0.0 GO:0072367 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.0 0.0 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.0 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.1 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.0 0.2 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.0 0.0 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0031070 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.0 0.1 GO:0001101 response to acid chemical(GO:0001101)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0032585 multivesicular body membrane(GO:0032585)
0.2 1.5 GO:0032126 eisosome(GO:0032126)
0.2 0.9 GO:0032865 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.2 1.9 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 0.5 GO:0030061 mitochondrial crista(GO:0030061)
0.2 0.6 GO:0033551 monopolin complex(GO:0033551)
0.1 0.4 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.1 0.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.3 GO:0035649 Nrd1 complex(GO:0035649)
0.1 0.7 GO:0005880 nuclear microtubule(GO:0005880)
0.1 0.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.6 GO:0034657 GID complex(GO:0034657)
0.1 0.5 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.3 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.1 0.6 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.3 GO:0001400 mating projection base(GO:0001400)
0.1 0.2 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.1 1.0 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 0.6 GO:0005686 U2 snRNP(GO:0005686)
0.1 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.1 1.2 GO:0016592 mediator complex(GO:0016592)
0.1 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.3 GO:0051233 spindle midzone(GO:0051233)
0.0 0.6 GO:0005619 ascospore wall(GO:0005619)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.6 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)
0.0 0.1 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.8 GO:0000124 SAGA complex(GO:0000124)
0.0 0.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.2 GO:0033309 SBF transcription complex(GO:0033309)
0.0 0.9 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.0 0.3 GO:0034967 Set3 complex(GO:0034967)
0.0 0.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.3 GO:0030677 ribonuclease P complex(GO:0030677)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.6 GO:0044438 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 0.1 GO:0031499 TRAMP complex(GO:0031499)
0.0 0.2 GO:0005940 septin ring(GO:0005940)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.0 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.1 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.0 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.3 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.1 GO:1902555 endoribonuclease complex(GO:1902555)
0.0 0.6 GO:0005770 late endosome(GO:0005770)
0.0 0.0 GO:0032161 cellular bud neck septin structure(GO:0000399) cleavage apparatus septin structure(GO:0032161) split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.0 0.0 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.0 0.1 GO:0000446 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.0 0.1 GO:0033263 CORVET complex(GO:0033263)
0.0 0.0 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)
0.0 0.2 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.0 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.1 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.0 GO:0000417 HIR complex(GO:0000417)
0.0 0.1 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.5 1.8 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.4 1.7 GO:0032452 histone demethylase activity(GO:0032452)
0.3 0.9 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.2 1.2 GO:0015295 solute:proton symporter activity(GO:0015295)
0.2 1.0 GO:0005537 mannose binding(GO:0005537)
0.2 0.9 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 0.6 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 0.8 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.2 0.2 GO:0005057 receptor signaling protein activity(GO:0005057)
0.2 0.5 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.2 0.8 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.1 0.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.1 0.4 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 1.0 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.5 GO:0017022 myosin binding(GO:0017022)
0.1 0.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.4 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.4 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.1 0.3 GO:0005536 glucose binding(GO:0005536)
0.1 0.3 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.1 0.3 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.1 0.5 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.4 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 0.6 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.5 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 0.2 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.1 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.2 GO:0032183 SUMO binding(GO:0032183)
0.1 0.7 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.3 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 0.8 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 0.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 0.2 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.1 0.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.2 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.1 0.2 GO:0016208 AMP binding(GO:0016208)
0.1 0.8 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.5 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.2 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.9 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.1 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.1 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 0.4 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.0 0.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.0 0.3 GO:0015293 symporter activity(GO:0015293)
0.0 0.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.1 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.1 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.0 0.0 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 1.1 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.3 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.0 0.4 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 2.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.1 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.6 GO:0003684 damaged DNA binding(GO:0003684)
0.0 3.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.1 GO:0004396 hexokinase activity(GO:0004396)
0.0 0.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.6 GO:0001067 regulatory region nucleic acid binding(GO:0001067)
0.0 0.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.2 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.2 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.1 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.1 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.5 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.1 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.0 0.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.6 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 1.1 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0004872 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.0 0.7 GO:0000988 transcription factor activity, protein binding(GO:0000988)
0.0 0.3 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.3 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.1 GO:0004549 tRNA-specific ribonuclease activity(GO:0004549)
0.0 0.0 GO:0004672 protein kinase activity(GO:0004672)
0.0 0.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.0 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.0 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.0 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.0 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.5 GO:0019899 enzyme binding(GO:0019899)
0.0 0.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 0.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.4 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.1 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.2 PID ATR PATHWAY ATR signaling pathway
0.0 0.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.1 PID P73PATHWAY p73 transcription factor network
0.0 0.1 PID FOXO PATHWAY FoxO family signaling
0.0 0.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 0.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.1 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.0 0.1 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.1 REACTOME DNA REPAIR Genes involved in DNA Repair