Results for SWI4
Z-value: 1.97
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Transcription factors associated with SWI4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SWI4
|
S000000913 | DNA binding component of the SBF complex (Swi4p-Swi6p) |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YNL301C Show fit | 27.37 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein |
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| YPL256C Show fit | 24.89 |
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) |
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| YKL096W-A Show fit | 22.75 |
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored |
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| YNL289W Show fit | 21.43 |
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth |
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| YJR094W-A Show fit | 18.31 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein |
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| YGL179C Show fit | 18.29 |
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome |
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| YGR108W Show fit | 17.74 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YNL300W Show fit | 17.43 |
Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid |
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| YER070W Show fit | 17.34 |
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits |
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| YDL055C Show fit | 15.13 |
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure |
Network of associatons between targets according to the STRING database.
First level regulatory network of SWI4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 205.1 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 1.8 | 40.5 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 2.0 | 35.8 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 4.6 | 32.1 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 9.5 | 28.6 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673) |
| 2.9 | 26.1 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
| 0.9 | 23.6 | GO:0006885 | regulation of pH(GO:0006885) |
| 0.7 | 23.6 | GO:0016126 | steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126) |
| 1.7 | 19.8 | GO:0007120 | axial cellular bud site selection(GO:0007120) |
| 1.3 | 18.1 | GO:0006037 | cell wall chitin metabolic process(GO:0006037) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 179.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.2 | 74.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.8 | 62.1 | GO:0005576 | extracellular region(GO:0005576) |
| 3.6 | 60.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.4 | 43.6 | GO:0005935 | cellular bud neck(GO:0005935) |
| 3.6 | 42.9 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 25.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.6 | 22.1 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.6 | 18.1 | GO:0005844 | polysome(GO:0005844) |
| 0.1 | 17.2 | GO:0005730 | nucleolus(GO:0005730) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 219.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 3.4 | 88.2 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 1.5 | 47.7 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.6 | 42.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 3.2 | 38.2 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.2 | 29.3 | GO:0003723 | RNA binding(GO:0003723) |
| 0.4 | 17.2 | GO:0004519 | endonuclease activity(GO:0004519) |
| 5.0 | 15.1 | GO:0070568 | guanylyltransferase activity(GO:0070568) |
| 0.4 | 14.9 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 0.1 | 14.1 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.9 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 1.1 | 3.2 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.8 | 2.5 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.2 | 2.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.5 | 1.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.7 | 1.4 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.4 | 1.2 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.4 | 1.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 1.0 | NABA MATRISOME | Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins |
| 0.7 | 0.7 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 38.8 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 3.7 | 29.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.6 | 11.0 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 1.6 | 6.3 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 1.8 | 5.5 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.9 | 5.2 | REACTOME DNA STRAND ELONGATION | Genes involved in DNA strand elongation |
| 1.3 | 4.0 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 1.3 | 3.8 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 1.3 | 3.8 | REACTOME SIGNALLING TO ERKS | Genes involved in Signalling to ERKs |
| 0.4 | 3.5 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |