Results for SUT2
Z-value: 0.52
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Transcription factors associated with SUT2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SUT2
|
S000006213 | Putative transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YGL258W-A Show fit | 2.07 |
Putative protein of unknown function |
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| YLR174W Show fit | 1.96 |
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose |
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| YJR095W Show fit | 1.84 |
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization |
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| YLR377C Show fit | 1.84 |
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism |
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| YER065C Show fit | 1.68 |
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose |
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| YFR053C Show fit | 1.67 |
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p |
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| YNR002C Show fit | 1.50 |
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p |
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| YBR072W Show fit | 1.36 |
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells |
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| YER066W Show fit | 1.33 |
Putative protein of unknown function; YER066W is not an essential gene |
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| YOR049C Show fit | 1.32 |
Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane |
Network of associatons between targets according to the STRING database.
First level regulatory network of SUT2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.8 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
| 0.1 | 2.2 | GO:0015696 | ammonium transport(GO:0015696) |
| 0.5 | 2.0 | GO:0006103 | 2-oxoglutarate metabolic process(GO:0006103) |
| 0.1 | 2.0 | GO:0072593 | reactive oxygen species metabolic process(GO:0072593) |
| 0.6 | 1.8 | GO:0015740 | C4-dicarboxylate transport(GO:0015740) |
| 0.6 | 1.7 | GO:0015755 | fructose transport(GO:0015755) |
| 0.2 | 1.6 | GO:0015908 | fatty acid transport(GO:0015908) |
| 0.2 | 1.6 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.1 | 1.4 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.3 | 1.3 | GO:0006673 | inositolphosphoceramide metabolic process(GO:0006673) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 2.8 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.3 | 2.4 | GO:0042597 | periplasmic space(GO:0042597) |
| 0.0 | 2.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.7 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 1.3 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.1 | 1.3 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 1.1 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.0 | 1.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.3 | 0.9 | GO:0046930 | pore complex(GO:0046930) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.1 | GO:0016289 | CoA hydrolase activity(GO:0016289) |
| 0.7 | 2.0 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 0.4 | 1.9 | GO:0050308 | sugar-phosphatase activity(GO:0050308) |
| 0.3 | 1.9 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 0.1 | 1.9 | GO:0046906 | heme binding(GO:0020037) tetrapyrrole binding(GO:0046906) |
| 0.5 | 1.8 | GO:0015556 | C4-dicarboxylate transmembrane transporter activity(GO:0015556) |
| 0.4 | 1.8 | GO:0004396 | hexokinase activity(GO:0004396) |
| 0.1 | 1.8 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.1 | 1.4 | GO:0008483 | transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769) |
| 0.3 | 1.3 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.1 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 0.1 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.1 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.0 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 0.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 0.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 0.4 | REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.1 | 0.3 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |
| 0.1 | 0.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.2 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.1 | REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | Genes involved in Transmembrane transport of small molecules |