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Results for STP4

Z-value: 2.90

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Transcription factors associated with STP4

Gene Symbol Gene ID Gene Info
STP4
S000002206 Protein containing a Kruppel-type zinc-finger domain

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STP4YDL048C0.831.2e-07Click!

Activity profile of STP4 motif

Sorted Z-values of STP4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YMR107W 37.42
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YOR100C 33.56
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YLR307C-A 32.06 Putative protein of unknown function
YIL057C 31.08 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YCR010C 25.48
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YKR097W 24.42
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YJL045W 23.26 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YNR002C 23.14
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YAL054C 21.11
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YOR382W 20.97
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YAL062W 20.21
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YPL171C 20.07
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YLR327C 20.04
TMA10
Protein of unknown function that associates with ribosomes
YBR296C 19.98
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YMR206W 19.70 Putative protein of unknown function; YMR206W is not an essential gene
YML042W 19.00
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YGR236C 18.95
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL223C 17.61
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YPL054W 16.26
LEE1
Zinc-finger protein of unknown function
YDR059C 16.24
UBC5
Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YKL217W 15.46
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YNL194C 15.21 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YGL146C 15.00 Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YPR026W 14.99
ATH1
Acid trehalase required for utilization of extracellular trehalose
YMR017W 14.98
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YAR053W 13.96 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR243W 13.86
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR120W 13.32 Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YOL052C-A 11.92
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YDR171W 11.90
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YCR005C 11.71
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YGR142W 11.03
BTN2
v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YMR191W 10.97
SPG5
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YCR021C 10.86
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YNL117W 10.70
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YBR056W-A 10.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YKL038W 10.55
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YMR306W 10.24
FKS3
Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR105C 10.02
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YDL210W 9.74
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YJL185C 9.52 Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene
YAR060C 9.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL055C 9.38 Putative protein of unknown function
YOL084W 9.34
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YJR146W 9.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YLR149C 9.24 Putative protein of unknown function; YLR149C is not an essential gene
YDL085W 9.18
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YHR212C 8.91 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL052W 8.87 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YJL089W 8.82
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YNL014W 8.81
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YDR461C-A 8.76 Putative protein of unknown function
YMR013C 8.75
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YAR070C 8.72 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR069C 8.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR102W 8.57
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YMR056C 8.44
AAC1
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YOR348C 8.21
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YPR001W 8.10
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YDL199C 7.98 Putative transporter, member of the sugar porter family
YHR212W-A 7.95 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLR438W 7.91
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YDR343C 7.83
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YER187W 7.83 Putative protein of unknown function; induced in respiratory-deficient cells
YHR217C 7.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YNL305C 7.64 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YGL184C 7.53
STR3
Cystathionine beta-lyase, converts cystathionine into homocysteine
YOR378W 7.45 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YPL134C 7.41
ODC1
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YLR356W 7.36 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YPL026C 7.34
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YPL222W 7.23
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR346C 7.17 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YPL058C 7.17
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YOR343C 7.12 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGR110W 7.10 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YPL024W 7.09
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YOL100W 7.00
PKH2
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YLR377C 6.97
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YGR258C 6.95
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YBL064C 6.85
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YBR051W 6.77 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YMR096W 6.77
SNZ1
Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
YMR040W 6.75
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YNR001C 6.75
CIT1
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YAR050W 6.71
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YDL194W 6.68
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YHL024W 6.62
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YOL118C 6.58 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YJR138W 6.58
IML1
Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YGL072C 6.57 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YMR280C 6.54
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YMR175W 6.53
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YLR437C-A 6.50 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YGR239C 6.49
PEX21
Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p
YBR050C 6.40
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YLR267W 6.32
BOP2
Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation
YBR076C-A 6.24 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR
YDL214C 6.17
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YLR308W 6.16
CDA2
Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YOL081W 6.13
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YNL180C 6.08
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YCR068W 6.08
ATG15
Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YER162C 6.04
RAD4
Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein
YPR036W-A 6.00 Protein of unknown function; transcription is regulated by Pdr1p
YGR201C 5.92 Putative protein of unknown function
YAL039C 5.92
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YLR094C 5.90
GIS3
Protein of unknown function
YDR505C 5.83
PSP1
Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition
YPR192W 5.82
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YDR273W 5.81
DON1
Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
YPL201C 5.78
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YKL093W 5.74
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YNL179C 5.72 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YAL063C 5.67
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YOL085W-A 5.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YGR065C 5.61
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YFL019C 5.58 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YPL018W 5.51
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YGR067C 5.50 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YDR536W 5.36
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YMR014W 5.33
BUD22
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YOR328W 5.31
PDR10
ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p
YAR047C 5.23 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL182W 5.21
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YGL163C 5.18
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YAR068W 5.14 Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YOR387C 5.14 Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction
YLR294C 5.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14
YPL250C 5.06
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YPL033C 5.01 Putative protein of unknown function; may be involved in DNA metabolism; expression is induced by Kar4p
YNL144C 5.00 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YCL025C 4.99
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YNR064C 4.98 Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
YLR312C 4.97
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YMR135C 4.96
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YPL271W 4.92
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YNL195C 4.83 Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL021W 4.81
ECM23
Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
YJR137C 4.81
ECM17
Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
YHR218W 4.80 Helicase-like protein encoded within the telomeric Y' element
YLR296W 4.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER015W 4.72
FAA2
Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids
YEL059W 4.71 Dubious open reading frame unlikely to encode a functional protein
YBL015W 4.71
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YLL039C 4.70
UBI4
Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YKR049C 4.70
FMP46
Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR055W 4.67
PST1
Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
YJL163C 4.64 Putative protein of unknown function
YMR244W 4.61 Putative protein of unknown function
YNL036W 4.59
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YOR192C 4.57
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YEL074W 4.54 Hypothetical protein
YDR256C 4.49
CTA1
Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation
YEL024W 4.41
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YNL283C 4.41
WSC2
Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
YBL043W 4.39
ECM13
Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YEL009C 4.28
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YOR374W 4.27
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YOR139C 4.24 Hypothetical protein
YKL109W 4.22
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YFL050C 4.20
ALR2
Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition
YBR292C 4.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YJR151C 4.19
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YKL133C 4.18 Putative protein of unknown function
YPR015C 4.15 Putative protein of unknown function
YBR224W 4.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
YOR192C-C 4.11 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YIL146C 4.10
ECM37
Non-essential protein of unknown function
YJR119C 4.10
JHD2
JmjC domain family histone demethylase specific for H3-K4 (lysine at position 4 of the histone H3 protein); removes methyl groups specifically added by Set1p methyltransferase
YGL071W 4.09
AFT1
Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability
YMR095C 4.08
SNO1
Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
YDR036C 4.06
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YEL008W 4.04 Hypothetical protein predicted to be involved in metabolism
YLR247C 4.02
IRC20
Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
YNL282W 4.02
POP3
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YLR402W 4.02 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR117C 3.98
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YDR231C 3.97
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YER186C 3.96 Putative protein of unknown function
YBR212W 3.96
NGR1
RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase
YLR299W 3.95
ECM38
Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
YGL180W 3.91
ATG1
Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p
YOR034C 3.89
AKR2
Ankyrin repeat-containing protein similar to Akr1p; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p
YOL119C 3.89
MCH4
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YFL020C 3.83
PAU5
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YLR403W 3.83
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YEL075C 3.83 Putative protein of unknown function
YLR164W 3.81 Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YOR140W 3.81
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YJL116C 3.80
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YPL036W 3.80
PMA2
Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YKL016C 3.80
ATP7
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YFR034C 3.78
PHO4
Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability
YNL332W 3.77
THI12
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YDR034C 3.76
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YPR065W 3.76
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YBR250W 3.75
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YOR186C-A 3.73 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR381C-A 3.72 Protein of unknown function, localized to the mitochondrial outer membrane

Network of associatons between targets according to the STRING database.

First level regulatory network of STP4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 22.1 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
7.3 29.3 GO:0006848 pyruvate transport(GO:0006848)
6.7 6.7 GO:0015755 fructose transport(GO:0015755)
5.7 17.0 GO:0035948 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
5.3 16.0 GO:0005993 trehalose catabolic process(GO:0005993)
5.1 15.3 GO:0019676 ammonia assimilation cycle(GO:0019676)
4.1 24.4 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
3.6 10.9 GO:0032780 negative regulation of ATPase activity(GO:0032780)
3.5 20.9 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
3.5 13.8 GO:0046323 glucose import(GO:0046323)
3.4 27.0 GO:0015891 siderophore transport(GO:0015891)
3.2 9.6 GO:0019541 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
3.1 6.1 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
3.0 23.8 GO:0006097 glyoxylate cycle(GO:0006097)
2.9 14.7 GO:0051099 positive regulation of binding(GO:0051099)
2.9 8.7 GO:0051469 vesicle fusion with vacuole(GO:0051469)
2.8 61.6 GO:0019740 nitrogen utilization(GO:0019740)
2.6 7.7 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
2.6 10.2 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
2.5 10.2 GO:0015886 heme transport(GO:0015886)
2.3 2.3 GO:0061410 positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) cellular response to ethanol(GO:0071361) cellular response to alcohol(GO:0097306)
2.2 8.9 GO:0015847 putrescine transport(GO:0015847)
2.1 6.4 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
2.1 8.4 GO:0006527 arginine catabolic process(GO:0006527)
2.0 6.1 GO:0036257 multivesicular body organization(GO:0036257)
2.0 4.0 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
2.0 8.0 GO:0015804 neutral amino acid transport(GO:0015804)
1.8 7.4 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
1.7 5.2 GO:0015888 thiamine transport(GO:0015888)
1.7 8.6 GO:0032075 positive regulation of nuclease activity(GO:0032075)
1.7 5.2 GO:0006740 NADPH regeneration(GO:0006740)
1.7 6.9 GO:0019346 transsulfuration(GO:0019346)
1.7 6.7 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
1.6 4.8 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
1.6 7.9 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
1.6 4.7 GO:0006538 glutamate catabolic process(GO:0006538)
1.5 9.1 GO:0006537 glutamate biosynthetic process(GO:0006537)
1.5 1.5 GO:0071475 cellular response to salt stress(GO:0071472) cellular hyperosmotic salinity response(GO:0071475)
1.5 5.9 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
1.4 22.7 GO:0006754 ATP biosynthetic process(GO:0006754)
1.4 7.0 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
1.4 4.2 GO:0015693 magnesium ion transport(GO:0015693)
1.4 2.8 GO:0051594 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
1.4 23.0 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
1.3 6.6 GO:0051180 vitamin transport(GO:0051180)
1.3 5.3 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
1.3 27.1 GO:0000209 protein polyubiquitination(GO:0000209)
1.3 6.4 GO:0000019 regulation of mitotic recombination(GO:0000019)
1.3 3.8 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
1.2 7.4 GO:0006279 premeiotic DNA replication(GO:0006279)
1.2 3.6 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
1.1 4.6 GO:0015976 carbon utilization(GO:0015976)
1.1 3.3 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
1.1 3.2 GO:0061412 cellular response to amino acid starvation(GO:0034198) cellular alcohol catabolic process(GO:0044109) positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation(GO:0061412)
1.1 8.5 GO:0018345 protein palmitoylation(GO:0018345)
1.1 2.1 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
1.0 3.1 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
1.0 2.0 GO:0015718 monocarboxylic acid transport(GO:0015718)
1.0 5.9 GO:0009746 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
1.0 2.9 GO:0010039 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
1.0 1.0 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
1.0 2.9 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.9 10.4 GO:0046686 response to cadmium ion(GO:0046686)
0.9 5.5 GO:0051260 protein homooligomerization(GO:0051260)
0.9 5.5 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.9 13.8 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.9 4.5 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.9 2.7 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.9 22.6 GO:0006094 gluconeogenesis(GO:0006094)
0.9 4.5 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.9 3.5 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.8 2.5 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.8 4.2 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.8 3.3 GO:0006598 polyamine catabolic process(GO:0006598)
0.8 0.8 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.8 5.7 GO:0006855 drug transmembrane transport(GO:0006855)
0.8 3.2 GO:0031297 replication fork processing(GO:0031297)
0.8 0.8 GO:0015688 iron chelate transport(GO:0015688)
0.8 11.0 GO:0006885 regulation of pH(GO:0006885)
0.8 10.5 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.7 18.7 GO:0098660 inorganic ion transmembrane transport(GO:0098660)
0.7 2.2 GO:0090399 replicative senescence(GO:0090399)
0.7 4.5 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.7 2.9 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.7 5.9 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.7 2.9 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.7 3.6 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.7 4.2 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.7 1.4 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.7 3.3 GO:0015793 glycerol transport(GO:0015793)
0.7 3.3 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.6 3.0 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.6 5.5 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.6 3.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.6 1.8 GO:0008272 sulfate transport(GO:0008272)
0.6 1.8 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.6 6.4 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.6 0.6 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993)
0.6 1.7 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.6 4.4 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078) beta-glucan biosynthetic process(GO:0051274)
0.6 5.5 GO:0015802 basic amino acid transport(GO:0015802)
0.5 12.0 GO:0007266 Rho protein signal transduction(GO:0007266)
0.5 0.5 GO:0071243 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061395) cellular response to arsenic-containing substance(GO:0071243)
0.5 0.5 GO:0071941 urea catabolic process(GO:0043419) nitrogen cycle metabolic process(GO:0071941)
0.5 12.3 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.5 2.1 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.5 20.3 GO:0071940 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.5 4.8 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.5 2.0 GO:0015893 drug transport(GO:0015893)
0.5 9.7 GO:0006119 oxidative phosphorylation(GO:0006119)
0.5 2.4 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.5 2.8 GO:0006591 ornithine metabolic process(GO:0006591)
0.5 7.4 GO:0007129 synapsis(GO:0007129)
0.5 9.2 GO:0012501 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.5 1.4 GO:0043954 cellular component maintenance(GO:0043954)
0.4 1.3 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.4 0.4 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.4 5.4 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.4 10.7 GO:0043248 proteasome assembly(GO:0043248)
0.4 1.6 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.4 1.6 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.4 1.2 GO:0042843 D-xylose catabolic process(GO:0042843)
0.4 0.8 GO:0009190 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.4 1.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.4 1.1 GO:1903138 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.4 1.8 GO:0005980 glycogen catabolic process(GO:0005980)
0.4 2.2 GO:0015851 nucleobase transport(GO:0015851)
0.4 0.4 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.3 2.1 GO:0019932 calcium-mediated signaling(GO:0019722) second-messenger-mediated signaling(GO:0019932)
0.3 1.6 GO:0000023 maltose metabolic process(GO:0000023)
0.3 5.7 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.3 0.9 GO:1903727 positive regulation of phospholipid biosynthetic process(GO:0071073) positive regulation of phospholipid metabolic process(GO:1903727)
0.3 1.8 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.3 1.5 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.3 0.9 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.3 1.2 GO:0051383 centromere complex assembly(GO:0034508) kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.3 0.9 GO:0019933 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.3 0.9 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.3 3.8 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.3 0.9 GO:0034389 lipid particle organization(GO:0034389)
0.3 0.9 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.3 2.8 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
0.3 0.8 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.3 0.6 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.3 1.4 GO:0031507 heterochromatin assembly(GO:0031507)
0.3 1.4 GO:0005977 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.3 2.4 GO:0045332 phospholipid translocation(GO:0045332)
0.3 0.5 GO:0045596 negative regulation of cell differentiation(GO:0045596) negative regulation of developmental process(GO:0051093)
0.3 3.1 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.3 0.8 GO:0051503 adenine nucleotide transport(GO:0051503)
0.2 1.0 GO:0030835 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.2 0.7 GO:0015677 copper ion import(GO:0015677)
0.2 10.5 GO:0007124 pseudohyphal growth(GO:0007124)
0.2 1.0 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.2 0.5 GO:0061392 regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061392)
0.2 0.5 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.2 1.6 GO:1902532 negative regulation of intracellular signal transduction(GO:1902532)
0.2 1.2 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.2 0.7 GO:1902751 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 2.0 GO:0043487 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.2 0.6 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.2 0.9 GO:0043200 response to amino acid(GO:0043200)
0.2 1.7 GO:0031578 mitotic spindle orientation checkpoint(GO:0031578)
0.2 2.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.2 0.4 GO:1902932 positive regulation of alcohol biosynthetic process(GO:1902932)
0.2 0.6 GO:0001666 response to hypoxia(GO:0001666)
0.2 3.1 GO:0006312 mitotic recombination(GO:0006312)
0.2 5.7 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.2 10.1 GO:0006631 fatty acid metabolic process(GO:0006631)
0.2 0.8 GO:0034486 amino acid export(GO:0032973) amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.2 6.2 GO:0034293 sexual sporulation(GO:0034293) sexual sporulation resulting in formation of a cellular spore(GO:0043935)
0.2 0.6 GO:0051259 protein oligomerization(GO:0051259)
0.2 0.8 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.2 1.0 GO:0055088 lipid homeostasis(GO:0055088)
0.2 0.6 GO:0035494 SNARE complex disassembly(GO:0035494)
0.2 0.4 GO:0006108 malate metabolic process(GO:0006108)
0.2 0.6 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.2 1.7 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.2 2.2 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.2 1.6 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.2 0.4 GO:0051304 chromosome separation(GO:0051304)
0.2 0.9 GO:0048478 replication fork protection(GO:0048478)
0.2 0.2 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.2 0.5 GO:0006816 calcium ion transport(GO:0006816)
0.2 0.7 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.2 0.8 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.2 0.5 GO:0006089 lactate metabolic process(GO:0006089)
0.2 1.1 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.2 1.1 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.2 0.3 GO:0019748 secondary metabolic process(GO:0019748)
0.1 2.5 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.9 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.1 3.9 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 2.0 GO:0022900 electron transport chain(GO:0022900)
0.1 0.4 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 0.3 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.3 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.1 1.0 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.6 GO:0006084 acetyl-CoA metabolic process(GO:0006084)
0.1 0.5 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.4 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 1.4 GO:0048278 vesicle docking(GO:0048278)
0.1 0.2 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.1 0.6 GO:0006465 signal peptide processing(GO:0006465)
0.1 1.2 GO:0015918 sterol transport(GO:0015918)
0.1 1.1 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.8 GO:0001558 regulation of cell growth(GO:0001558)
0.1 0.3 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 0.9 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 0.2 GO:0055067 monovalent inorganic cation homeostasis(GO:0055067)
0.1 1.6 GO:0007020 microtubule nucleation(GO:0007020)
0.1 0.3 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.1 0.6 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.1 1.3 GO:0043633 polyadenylation-dependent RNA catabolic process(GO:0043633)
0.1 1.3 GO:0008298 intracellular mRNA localization(GO:0008298)
0.1 0.1 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.1 3.5 GO:0006839 mitochondrial transport(GO:0006839)
0.1 0.3 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.1 0.8 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.3 GO:0003400 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport(GO:0060628) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.1 0.9 GO:0016571 histone methylation(GO:0016571)
0.1 0.2 GO:0051228 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.1 1.2 GO:0006986 response to unfolded protein(GO:0006986)
0.1 0.3 GO:0030100 regulation of endocytosis(GO:0030100)
0.1 0.7 GO:0042026 protein refolding(GO:0042026)
0.1 0.2 GO:0033875 coenzyme A metabolic process(GO:0015936) nucleoside bisphosphate metabolic process(GO:0033865) ribonucleoside bisphosphate metabolic process(GO:0033875) purine nucleoside bisphosphate metabolic process(GO:0034032)
0.1 0.2 GO:0097033 mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.2 GO:0035690 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.1 1.8 GO:0048646 anatomical structure formation involved in morphogenesis(GO:0048646)
0.0 0.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.2 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.2 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.0 GO:0032845 negative regulation of telomere maintenance(GO:0032205) negative regulation of homeostatic process(GO:0032845)
0.0 0.4 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.6 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 2.2 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161)
0.0 0.1 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.0 0.1 GO:0070550 rDNA condensation(GO:0070550)
0.0 0.3 GO:0000271 polysaccharide biosynthetic process(GO:0000271)
0.0 0.1 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.1 GO:0045861 negative regulation of proteolysis(GO:0045861)
0.0 0.1 GO:0072511 zinc II ion transport(GO:0006829) divalent metal ion transport(GO:0070838) divalent inorganic cation transport(GO:0072511)
0.0 0.0 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.1 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.2 GO:0043486 histone exchange(GO:0043486)
0.0 0.1 GO:0031081 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.0 0.1 GO:0009209 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.0 0.1 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.1 GO:0009113 purine nucleobase biosynthetic process(GO:0009113)
0.0 0.1 GO:0051666 actin cortical patch localization(GO:0051666)
0.0 0.1 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.1 GO:0051181 cofactor transport(GO:0051181)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 15.2 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
3.5 7.0 GO:0032126 eisosome(GO:0032126)
3.2 9.5 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
2.6 7.8 GO:0032585 multivesicular body membrane(GO:0032585)
2.6 10.2 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
2.1 15.0 GO:0034657 GID complex(GO:0034657)
1.7 5.2 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
1.7 6.7 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
1.6 4.9 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
1.6 4.8 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
1.5 4.6 GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
1.4 5.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
1.4 2.8 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
1.4 4.2 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
1.4 16.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.3 8.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
1.3 8.0 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
1.2 2.5 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
1.2 4.6 GO:0000817 COMA complex(GO:0000817)
1.1 7.7 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
1.1 5.3 GO:0044426 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
1.1 4.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.0 11.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
1.0 4.1 GO:0042597 periplasmic space(GO:0042597)
1.0 2.0 GO:0070985 TFIIK complex(GO:0070985)
1.0 53.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.0 8.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.9 2.8 GO:0072687 meiotic spindle(GO:0072687)
0.9 22.4 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.9 6.0 GO:0005619 ascospore wall(GO:0005619) spore wall(GO:0031160)
0.8 35.5 GO:0031225 anchored component of membrane(GO:0031225)
0.8 3.1 GO:0031901 early endosome membrane(GO:0031901)
0.7 3.6 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) mitochondrial inner membrane protein insertion complex(GO:0042721) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.7 4.2 GO:0008180 COP9 signalosome(GO:0008180)
0.7 6.1 GO:0000795 synaptonemal complex(GO:0000795)
0.6 1.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.6 1.3 GO:0001400 mating projection base(GO:0001400)
0.6 1.8 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.6 5.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.5 2.1 GO:0033309 SBF transcription complex(GO:0033309)
0.5 6.4 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.5 15.9 GO:0000322 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.4 74.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.4 2.9 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.4 1.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.4 1.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 1.9 GO:0031262 Ndc80 complex(GO:0031262)
0.4 1.5 GO:0033551 monopolin complex(GO:0033551)
0.4 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 10.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.4 3.5 GO:0000812 Swr1 complex(GO:0000812)
0.3 12.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 1.0 GO:0030870 Mre11 complex(GO:0030870)
0.3 1.6 GO:0070772 PAS complex(GO:0070772)
0.3 1.6 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.3 15.4 GO:0000502 proteasome complex(GO:0000502)
0.2 1.0 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.2 1.4 GO:0031932 TORC2 complex(GO:0031932)
0.2 7.8 GO:0005770 late endosome(GO:0005770)
0.2 0.7 GO:0005784 Sec61 translocon complex(GO:0005784)
0.2 3.1 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.2 3.3 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.2 0.2 GO:0038201 TOR complex(GO:0038201)
0.2 1.0 GO:0000133 polarisome(GO:0000133)
0.2 0.6 GO:0005787 signal peptidase complex(GO:0005787)
0.2 29.3 GO:0005774 vacuolar membrane(GO:0005774)
0.2 0.4 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007) catalytic step 2 spliceosome(GO:0071013)
0.2 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 0.7 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.2 2.2 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.2 2.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.4 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.3 GO:0030907 MBF transcription complex(GO:0030907)
0.1 1.6 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.1 0.6 GO:0044232 ERMES complex(GO:0032865) organelle membrane contact site(GO:0044232) ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.3 GO:0000417 HIR complex(GO:0000417)
0.1 0.9 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 1.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 0.7 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.5 GO:0000144 cellular bud neck septin ring(GO:0000144)
0.1 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.7 GO:0098797 plasma membrane protein complex(GO:0098797)
0.1 1.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.3 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 45.0 GO:0005739 mitochondrion(GO:0005739)
0.1 0.6 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.3 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 2.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.3 GO:0031499 TRAMP complex(GO:0031499)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.3 GO:0097346 INO80-type complex(GO:0097346)
0.0 0.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0000818 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.0 0.4 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.1 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.9 26.6 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
7.4 22.1 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
7.0 21.1 GO:0016208 AMP binding(GO:0016208)
6.1 24.4 GO:0005537 mannose binding(GO:0005537)
6.0 30.1 GO:0015295 solute:proton symporter activity(GO:0015295)
5.3 16.0 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
4.6 13.9 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
4.4 13.1 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
4.2 16.8 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
3.5 13.9 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
3.4 10.2 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
3.2 9.5 GO:0005536 glucose binding(GO:0005536)
3.1 34.5 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
3.1 9.3 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
2.9 8.8 GO:0016289 CoA hydrolase activity(GO:0016289)
2.7 24.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
2.4 4.8 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
1.8 7.4 GO:0032452 histone demethylase activity(GO:0032452)
1.7 6.9 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
1.7 13.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.6 11.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
1.5 16.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.5 5.9 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
1.4 5.7 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
1.4 7.0 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.4 6.9 GO:0051183 vitamin transporter activity(GO:0051183)
1.3 20.5 GO:0016831 carboxy-lyase activity(GO:0016831)
1.2 11.0 GO:0000149 SNARE binding(GO:0000149)
1.2 1.2 GO:1901474 azole transmembrane transporter activity(GO:1901474)
1.2 6.1 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
1.2 3.6 GO:0048038 quinone binding(GO:0048038)
1.1 3.3 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
1.1 6.6 GO:0000400 four-way junction DNA binding(GO:0000400)
1.1 3.2 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
1.0 7.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
1.0 23.5 GO:0016881 acid-amino acid ligase activity(GO:0016881)
1.0 46.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.9 13.9 GO:0015297 antiporter activity(GO:0015297)
0.9 5.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.8 6.7 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.8 5.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.8 3.1 GO:0004396 hexokinase activity(GO:0004396)
0.8 0.8 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.7 4.4 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.7 2.9 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.7 2.9 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.7 2.6 GO:0019789 SUMO transferase activity(GO:0019789)
0.6 3.2 GO:0008198 ferrous iron binding(GO:0008198)
0.6 5.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.6 1.3 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.6 1.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.6 2.5 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.6 1.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.6 1.8 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.6 1.8 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.6 1.8 GO:0008172 S-methyltransferase activity(GO:0008172)
0.6 1.7 GO:0032183 SUMO binding(GO:0032183)
0.6 7.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.6 1.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.6 1.7 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.5 4.8 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.5 1.0 GO:0019903 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.5 2.5 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.5 1.5 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.5 2.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.5 3.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.4 2.6 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.4 1.3 GO:0015103 inorganic anion transmembrane transporter activity(GO:0015103)
0.4 1.7 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.4 0.8 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.4 4.5 GO:0004872 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.4 5.9 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
0.4 1.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.4 8.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.4 2.2 GO:0005102 receptor binding(GO:0005102)
0.4 6.3 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.4 1.8 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.4 1.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.4 11.6 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.3 1.0 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.3 2.7 GO:0030246 carbohydrate binding(GO:0030246)
0.3 3.3 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.3 1.7 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.3 1.0 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.3 1.5 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.3 3.3 GO:0022838 substrate-specific channel activity(GO:0022838)
0.3 1.5 GO:0031072 heat shock protein binding(GO:0031072)
0.3 0.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.3 0.9 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.3 0.6 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091) TFIIH-class transcription factor binding(GO:0001097)
0.3 3.3 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.2 3.2 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.2 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 2.1 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 7.2 GO:0001159 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.2 0.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 2.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.2 1.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 0.7 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.2 1.3 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.2 4.2 GO:0051087 chaperone binding(GO:0051087)
0.2 1.7 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 1.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.2 2.0 GO:0042054 histone methyltransferase activity(GO:0042054)
0.2 1.6 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 1.3 GO:0008142 oxysterol binding(GO:0008142)
0.2 11.3 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.2 1.7 GO:0035064 methylated histone binding(GO:0035064)
0.2 3.0 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.2 0.7 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.2 0.9 GO:0008171 O-methyltransferase activity(GO:0008171)
0.2 3.4 GO:0005342 organic acid transmembrane transporter activity(GO:0005342)
0.2 0.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.2 0.9 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.2 0.5 GO:0070569 uridylyltransferase activity(GO:0070569)
0.2 1.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.5 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.2 0.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 2.2 GO:0016209 antioxidant activity(GO:0016209)
0.2 0.3 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 1.2 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.1 8.7 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 8.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.1 0.4 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 1.3 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 1.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.7 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 0.4 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.1 1.2 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.7 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 0.5 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 0.4 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 1.1 GO:0005507 copper ion binding(GO:0005507)
0.1 0.7 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.2 GO:0015293 symporter activity(GO:0015293)
0.1 0.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 1.8 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.1 1.1 GO:0005516 calmodulin binding(GO:0005516)
0.1 2.6 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 0.2 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 7.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 0.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 0.2 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 0.2 GO:0000150 recombinase activity(GO:0000150)
0.1 0.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.3 GO:0017108 5'-flap endonuclease activity(GO:0017108) flap endonuclease activity(GO:0048256)
0.1 0.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.3 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.2 GO:0043177 amino acid binding(GO:0016597) carboxylic acid binding(GO:0031406) organic acid binding(GO:0043177)
0.1 0.6 GO:0032947 protein complex scaffold(GO:0032947)
0.1 0.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.5 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 5.7 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.4 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0000217 DNA secondary structure binding(GO:0000217)
0.0 1.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.6 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 0.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.4 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 1.1 GO:0008233 peptidase activity(GO:0008233)
0.0 0.1 GO:0034595 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595) phosphatidylinositol phosphate phosphatase activity(GO:0052866)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.6 GO:0008047 enzyme activator activity(GO:0008047)
0.0 0.1 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.1 GO:0051184 cofactor transporter activity(GO:0051184)
0.0 0.1 GO:0004526 ribonuclease P activity(GO:0004526)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
8.1 24.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.2 7.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.9 2.8 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.9 8.0 PID FANCONI PATHWAY Fanconi anemia pathway
0.9 2.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 1.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.4 1.8 PID P73PATHWAY p73 transcription factor network
0.3 0.7 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 368.6 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1 0.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 0.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.3 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 23.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
1.2 4.7 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.8 2.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.5 1.6 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.5 2.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.5 3.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.5 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 0.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 0.7 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 368.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.3 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.1 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.0 0.3 REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION Genes involved in Post-translational protein modification
0.0 0.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis