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Results for STP3

Z-value: 1.44

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Transcription factors associated with STP3

Gene Symbol Gene ID Gene Info
STP3
S000004367 Zinc-finger protein of unknown function

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STP3YLR375W0.854.0e-08Click!

Activity profile of STP3 motif

Sorted Z-values of STP3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YMR107W 24.48
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YDR536W 9.73
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YLR327C 8.60
TMA10
Protein of unknown function that associates with ribosomes
YLR122C 8.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YIL160C 7.53
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YLR402W 7.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR206W 7.41 Putative protein of unknown function; YMR206W is not an essential gene
YLR403W 7.20
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YOR348C 7.16
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YDL169C 7.03
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YLR123C 6.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YBL075C 6.77
SSA3
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YCL025C 6.76
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YLR047C 6.74
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YAL039C 5.94
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YML089C 5.88 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YDR342C 5.65
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YPR010C-A 5.64 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YJR078W 5.62
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YLR142W 5.38
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YLR124W 5.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML042W 5.33
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YCR091W 5.33
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YHR138C 5.23 Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YBL048W 5.21 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YAL061W 5.11
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YMR194C-B 5.00 Putative protein of unknown function
YMR096W 4.97
SNZ1
Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
YPR013C 4.91 Putative zinc finger protein; YPR013C is not an essential gene
YLR438W 4.87
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YEL024W 4.80
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YPR184W 4.63
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YKL163W 4.62
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YLR149C 4.58 Putative protein of unknown function; YLR149C is not an essential gene
YKL028W 4.57
TFA1
TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YFL052W 4.49 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YLR125W 4.48 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YBR145W 4.46
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YIR027C 4.40
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YBR077C 4.26
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YLR437C-A 4.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YOR346W 4.09
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YKL093W 3.94
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YPR001W 3.90
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YEL008W 3.88 Hypothetical protein predicted to be involved in metabolism
YEL028W 3.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR053W 3.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR383C 3.87
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YOR345C 3.85 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YKL217W 3.83
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YJR095W 3.81
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YDL054C 3.81
MCH1
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YDL210W 3.75
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YBR072W 3.67
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YKL103C 3.65
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YCR021C 3.57
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YBL015W 3.56
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YML090W 3.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YEL009C 3.54
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YNR058W 3.52
BIO3
7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
YJR048W 3.51
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YOR152C 3.50 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YKL038W 3.49
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YER065C 3.46
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YJR151C 3.41
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YOR100C 3.38
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YKL171W 3.34 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YHR139C 3.32
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YOR343C 3.27 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YPL087W 3.26
YDC1
Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity
YHR217C 3.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YOR120W 3.21
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YKL102C 3.16 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YHR160C 3.14
PEX18
Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p
YOR192C 3.11
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YJR154W 3.04 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLR366W 3.04 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YMR095C 3.03
SNO1
Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
YOR192C-C 2.98 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YMR195W 2.97
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YOR072W 2.96 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YGL045W 2.95
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YFL024C 2.95
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YBR033W 2.95
EDS1
Putative zinc cluster protein; YBR033W is not an essential gene
YBR284W 2.92 Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YDL138W 2.87
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YOR186W 2.86 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YAR060C 2.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFR022W 2.84
ROG3
Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YOL052C-A 2.84
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YOR065W 2.78
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YML091C 2.78
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YJR106W 2.75
ECM27
Non-essential protein of unknown function
YCL038C 2.73
ATG22
Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
YLL056C 2.73 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YAR023C 2.73 Putative integral membrane protein, member of DUP240 gene family
YGL255W 2.71
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YJR077C 2.71
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YIL162W 2.68
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YFR053C 2.65
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YLR228C 2.61
ECM22
Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YIL045W 2.61
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YFL051C 2.59 Putative protein of unknown function; YFL051C is not an essential gene
YEL009C-A 2.59 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML054C 2.53
CYB2
Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YKL029C 2.53
MAE1
Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
YPL024W 2.52
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YHR054W-A 2.49 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2
YHR055C 2.43
CUP1-2
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YCR073W-A 2.42
SOL2
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p
YPR023C 2.40
EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YLR111W 2.38 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL214C 2.37
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YNR057C 2.37
BIO4
Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels
YOR071C 2.37
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YGR043C 2.36
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YDR114C 2.35 Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
YPR120C 2.34
CLB5
B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
YLR356W 2.33 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YOR072W-A 2.32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YAR050W 2.30
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YNL006W 2.29
LST8
Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
YHR211W 2.29
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YBR179C 2.28
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YPR191W 2.26
QCR2
Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YPL026C 2.25
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YLR365W 2.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
YFL030W 2.25
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YLL055W 2.25
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YPL181W 2.24
CTI6
Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
YGL170C 2.24
SPO74
Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
YHR053C 2.21
CUP1-1
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YGR243W 2.20
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL073W 2.18
HSF1
Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
YBR296C 2.17
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YAL067C 2.17
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YOL035C 2.14 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR053C 2.13
STB2
Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p
YPL182C 2.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
YPR106W 2.09
ISR1
Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C
YHL041W 2.08 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YHR048W 2.07
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YOR386W 2.04
PHR1
DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p
YPR030W 2.03
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YPL111W 2.03
CAR1
Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YKL121W 2.01 Putative protein of unknown function
YNL144C 2.00 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YJL213W 2.00 Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YBR180W 2.00
DTR1
Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
YGR142W 1.98
BTN2
v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YDR343C 1.96
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YHR212C 1.96 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR218W 1.96 Helicase-like protein encoded within the telomeric Y' element
YER188C-A 1.94 Putative protein of unknown function
YMR256C 1.93
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YHR092C 1.92
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YBR144C 1.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
YJL161W 1.91
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR139W 1.90 Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
YDR306C 1.88 F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
YAR047C 1.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL093C 1.88
TOK1
Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YLR425W 1.86
TUS1
Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
YOR066W 1.84
MSA1
Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YDR446W 1.84
ECM11
Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
YOR148C 1.84
SPP2
Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
YOR220W 1.83
RCN2
Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
YMR081C 1.82
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YER150W 1.81
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YBR208C 1.80
DUR1,2
Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YNL269W 1.80
BSC4
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p
YDR115W 1.78 Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins
YEL010W 1.78 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR212W-A 1.75 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGR239C 1.75
PEX21
Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p
YJR153W 1.74
PGU1
Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
YBR076W 1.74
ECM8
Non-essential protein of unknown function
YOL051W 1.72
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YKL023W 1.71 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YOL027C 1.70
MDM38
Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
YAL054C 1.69
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YEL030C-A 1.69 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR542W 1.68
PAU10
Hypothetical protein
YLR092W 1.66
SUL2
High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
YDR216W 1.65
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YCR030C 1.65
SYP1
Protein with a potential role in actin cytoskeletal organization; overexpression suppresses a pfy1 (profilin) null mutation
YLR352W 1.64 Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene
YMR316C-B 1.61 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL072W 1.59
RMD6
Protein required for sporulation
YPL258C 1.58
THI21
Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
YNL125C 1.58
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YER189W 1.58 Putative protein of unknown function
YER158C 1.58 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YLR121C 1.58
YPS3
Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YNL018C 1.54 Putative protein of unknown function
YMR317W 1.52 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YHL036W 1.52
MUP3
Low affinity methionine permease, similar to Mup1p
YDR247W 1.50
VHS1
Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YOR057W 1.50
SGT1
Probable cochaperone, regulates activity of Cyr1p (adenylyl cyclase); involved in assembly of the kinetochore complex, associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex
YDR102C 1.49 Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index

Network of associatons between targets according to the STRING database.

First level regulatory network of STP3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.4 GO:0015804 neutral amino acid transport(GO:0015804)
2.0 5.9 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.8 5.5 GO:0015888 thiamine transport(GO:0015888)
1.8 5.4 GO:0006562 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
1.8 5.3 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
1.7 6.9 GO:0006527 arginine catabolic process(GO:0006527)
1.7 8.6 GO:0015793 glycerol transport(GO:0015793)
1.7 1.7 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
1.5 6.1 GO:0046323 glucose import(GO:0046323)
1.5 6.0 GO:0006848 pyruvate transport(GO:0006848)
1.4 13.8 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.3 3.9 GO:0019629 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
1.3 3.8 GO:0015740 C4-dicarboxylate transport(GO:0015740)
1.2 3.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
1.2 7.0 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
1.2 4.6 GO:0046688 response to copper ion(GO:0046688)
1.2 4.6 GO:0015847 putrescine transport(GO:0015847)
1.1 6.8 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
1.1 5.6 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
1.1 2.2 GO:0032006 regulation of TOR signaling(GO:0032006)
1.1 7.6 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
1.1 3.3 GO:0042843 D-xylose catabolic process(GO:0042843)
1.1 3.3 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
1.1 4.3 GO:0051099 positive regulation of binding(GO:0051099)
1.0 9.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
1.0 7.8 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
1.0 2.9 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
1.0 2.9 GO:0034287 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
1.0 4.8 GO:0005980 glycogen catabolic process(GO:0005980)
0.9 3.8 GO:0072367 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.9 4.6 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.9 2.7 GO:0006545 glycine biosynthetic process(GO:0006545)
0.9 3.6 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.8 2.5 GO:0006108 malate metabolic process(GO:0006108)
0.8 1.7 GO:0008272 sulfate transport(GO:0008272)
0.8 4.8 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.7 3.7 GO:0044746 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.7 1.4 GO:0046185 aldehyde catabolic process(GO:0046185)
0.7 2.7 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.6 4.5 GO:0006083 acetate metabolic process(GO:0006083)
0.6 2.6 GO:0060194 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.6 1.9 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.6 13.6 GO:0098656 anion transmembrane transport(GO:0098656)
0.6 3.5 GO:0006097 glyoxylate cycle(GO:0006097)
0.6 3.5 GO:0006279 premeiotic DNA replication(GO:0006279)
0.6 4.0 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.5 6.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.5 4.8 GO:0070987 error-free translesion synthesis(GO:0070987)
0.5 1.5 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.5 1.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.5 3.9 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.5 0.5 GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.5 4.3 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.5 1.4 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.5 2.8 GO:0051382 centromere complex assembly(GO:0034508) kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.5 4.1 GO:0045332 phospholipid translocation(GO:0045332)
0.5 2.7 GO:0006089 lactate metabolic process(GO:0006089)
0.4 2.6 GO:0070873 regulation of glycogen biosynthetic process(GO:0005979) regulation of glycogen metabolic process(GO:0070873)
0.4 3.4 GO:0015891 siderophore transport(GO:0015891)
0.4 1.6 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.4 2.8 GO:0019660 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.4 1.9 GO:0032071 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.4 1.1 GO:0045764 positive regulation of cellular amino acid metabolic process(GO:0045764) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.4 6.6 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.4 2.2 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.3 4.9 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.3 1.0 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.3 1.7 GO:0030007 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.3 2.4 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.3 2.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 1.9 GO:0006855 drug transmembrane transport(GO:0006855)
0.3 0.9 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.3 2.2 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.3 1.5 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.3 2.7 GO:0006829 zinc II ion transport(GO:0006829)
0.3 1.2 GO:0046352 disaccharide catabolic process(GO:0046352)
0.3 1.7 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.3 0.9 GO:0045596 negative regulation of cell differentiation(GO:0045596) negative regulation of developmental process(GO:0051093)
0.3 0.6 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.3 1.6 GO:0015802 basic amino acid transport(GO:0015802)
0.3 0.5 GO:0006538 glutamate catabolic process(GO:0006538)
0.3 8.0 GO:0022900 electron transport chain(GO:0022900)
0.3 1.0 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 3.4 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 1.9 GO:0046686 response to cadmium ion(GO:0046686)
0.2 1.0 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.2 0.2 GO:0018209 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.2 0.9 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.2 1.2 GO:0046461 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.2 1.8 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.2 0.5 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.2 0.4 GO:0035690 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.2 2.0 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.2 0.8 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.2 1.0 GO:0043954 cellular component maintenance(GO:0043954)
0.2 0.6 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.2 2.0 GO:0006865 amino acid transport(GO:0006865)
0.2 1.2 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.2 0.9 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.2 0.7 GO:0045996 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.2 1.3 GO:0006536 glutamate metabolic process(GO:0006536)
0.2 0.2 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.2 1.1 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.2 2.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.2 0.4 GO:0034755 high-affinity iron ion transmembrane transport(GO:0006827) iron ion transmembrane transport(GO:0034755)
0.2 0.7 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.2 0.9 GO:0008053 mitochondrial fusion(GO:0008053)
0.2 1.0 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.2 1.3 GO:0018345 protein palmitoylation(GO:0018345)
0.2 0.2 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.2 0.5 GO:0034389 lipid particle organization(GO:0034389)
0.2 1.1 GO:0000411 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.2 0.3 GO:0071456 cellular response to hypoxia(GO:0071456)
0.2 0.8 GO:0055088 lipid homeostasis(GO:0055088)
0.1 0.4 GO:0042744 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.1 0.6 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.1 0.8 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 0.3 GO:0051225 spindle assembly(GO:0051225)
0.1 1.2 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.1 5.2 GO:0009060 aerobic respiration(GO:0009060)
0.1 2.2 GO:0001558 regulation of cell growth(GO:0001558)
0.1 2.0 GO:0007129 synapsis(GO:0007129)
0.1 1.6 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.1 0.5 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.7 GO:0006808 regulation of nitrogen utilization(GO:0006808)
0.1 0.3 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 1.6 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.7 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.5 GO:0015893 drug transport(GO:0015893)
0.1 0.3 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.1 0.4 GO:0051274 beta-glucan biosynthetic process(GO:0051274)
0.1 0.7 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.1 0.3 GO:0006598 polyamine catabolic process(GO:0006598)
0.1 0.7 GO:0051322 anaphase(GO:0051322)
0.1 0.4 GO:0015976 carbon utilization(GO:0015976)
0.1 0.2 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.1 0.7 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 0.6 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 0.2 GO:0036257 multivesicular body organization(GO:0036257)
0.1 0.3 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.1 0.4 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.1 3.3 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 0.6 GO:0010529 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.1 0.1 GO:0006311 meiotic gene conversion(GO:0006311)
0.1 0.3 GO:0015856 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.1 0.4 GO:0051260 protein homooligomerization(GO:0051260)
0.1 0.3 GO:0034308 primary alcohol metabolic process(GO:0034308)
0.1 3.0 GO:0071940 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 0.5 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 0.8 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 2.7 GO:0016237 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.1 0.3 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 0.1 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.1 0.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 1.0 GO:0042026 protein refolding(GO:0042026)
0.1 0.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 0.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.1 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.1 0.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 0.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.8 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.1 0.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 0.3 GO:0000018 regulation of DNA recombination(GO:0000018) negative regulation of DNA recombination(GO:0045910)
0.1 1.2 GO:0006986 response to unfolded protein(GO:0006986) response to topologically incorrect protein(GO:0035966)
0.1 0.2 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.1 0.3 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.1 0.3 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.1 0.2 GO:0009062 fatty acid catabolic process(GO:0009062)
0.0 0.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.1 GO:0043937 regulation of sporulation(GO:0043937)
0.0 0.3 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.5 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.0 0.1 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 2.0 GO:0006839 mitochondrial transport(GO:0006839)
0.0 1.0 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 1.4 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.1 GO:0032102 negative regulation of autophagy(GO:0010507) negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.0 0.2 GO:0018202 peptidyl-histidine modification(GO:0018202)
0.0 0.2 GO:0006276 plasmid maintenance(GO:0006276)
0.0 0.2 GO:0032447 protein urmylation(GO:0032447)
0.0 0.6 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.3 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.4 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.3 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.0 0.2 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.4 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.6 GO:0006625 protein targeting to peroxisome(GO:0006625) protein import into peroxisome matrix(GO:0016558) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0 0.1 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.4 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.1 GO:0000078 obsolete cytokinesis after mitosis checkpoint(GO:0000078)
0.0 0.4 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.2 GO:0044088 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.1 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.0 GO:0097035 lipid translocation(GO:0034204) regulation of membrane lipid distribution(GO:0097035)
0.0 0.3 GO:0001101 response to acid chemical(GO:0001101)
0.0 0.1 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.3 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.1 GO:0015851 nucleobase transport(GO:0015851)
0.0 0.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.2 GO:0051181 cofactor transport(GO:0051181)
0.0 0.1 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 0.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0010182 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to carbohydrate stimulus(GO:0071322) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.1 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.0 0.4 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.0 0.2 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 0.2 GO:0015918 sterol transport(GO:0015918)
0.0 0.0 GO:0042762 regulation of sulfur metabolic process(GO:0042762)
0.0 0.2 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 10.6 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.0 1.0 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.9 2.7 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.8 2.5 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.8 4.1 GO:0034448 EGO complex(GO:0034448)
0.7 2.1 GO:0032389 MutLalpha complex(GO:0032389)
0.7 4.1 GO:0031932 TORC2 complex(GO:0031932)
0.6 6.7 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.5 1.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.5 2.9 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.5 2.4 GO:0032221 Rpd3S complex(GO:0032221)
0.5 8.4 GO:0070469 respiratory chain(GO:0070469)
0.5 0.9 GO:0030061 mitochondrial crista(GO:0030061)
0.4 1.2 GO:0030870 Mre11 complex(GO:0030870)
0.4 1.5 GO:0001400 mating projection base(GO:0001400)
0.4 1.8 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 1.0 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.3 4.0 GO:0070822 Sin3-type complex(GO:0070822)
0.3 0.9 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.3 1.0 GO:0016587 Isw1 complex(GO:0016587)
0.3 2.6 GO:0030677 ribonuclease P complex(GO:0030677)
0.3 3.3 GO:0005619 ascospore wall(GO:0005619)
0.2 1.5 GO:0032126 eisosome(GO:0032126)
0.2 0.9 GO:0000817 COMA complex(GO:0000817)
0.2 0.5 GO:0005775 vacuolar lumen(GO:0005775)
0.2 0.4 GO:0030478 actin cap(GO:0030478)
0.2 0.6 GO:0005796 Golgi lumen(GO:0005796)
0.2 1.5 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.2 0.9 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.2 1.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 30.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 2.6 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.2 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 0.7 GO:0000446 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.2 1.8 GO:0005769 early endosome(GO:0005769)
0.2 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 0.5 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.1 3.9 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.1 1.2 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 3.1 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 0.6 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.1 1.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.4 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.1 0.7 GO:0016592 mediator complex(GO:0016592)
0.1 0.5 GO:0031010 CHRAC(GO:0008623) ISWI-type complex(GO:0031010)
0.1 0.6 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 0.4 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.1 0.6 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 0.8 GO:0016272 prefoldin complex(GO:0016272)
0.1 1.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 5.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.2 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 0.3 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.1 0.3 GO:0000938 GARP complex(GO:0000938)
0.1 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 4.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 0.6 GO:0034657 GID complex(GO:0034657)
0.1 0.2 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)
0.1 0.7 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 0.9 GO:0000812 Swr1 complex(GO:0000812)
0.1 1.7 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.1 9.4 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.2 GO:0033551 monopolin complex(GO:0033551)
0.1 0.2 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 0.8 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.3 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007) catalytic step 2 spliceosome(GO:0071013)
0.1 15.3 GO:0005886 plasma membrane(GO:0005886)
0.1 0.7 GO:0016586 RSC complex(GO:0016586)
0.0 0.1 GO:0005618 cell wall(GO:0005618) external encapsulating structure(GO:0030312)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 1.1 GO:0005576 extracellular region(GO:0005576)
0.0 0.3 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.2 GO:0070603 SWI/SNF superfamily-type complex(GO:0070603)
0.0 0.1 GO:0070390 transcription export complex 2(GO:0070390)
0.0 0.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 1.2 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0030869 RENT complex(GO:0030869)
0.0 14.6 GO:0005739 mitochondrion(GO:0005739)
0.0 0.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0005940 septin ring(GO:0005940)
0.0 0.1 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.2 GO:0005682 U5 snRNP(GO:0005682)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 18.1 GO:0015295 solute:proton symporter activity(GO:0015295)
3.5 13.9 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.8 5.3 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
1.6 4.9 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.5 6.1 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
1.4 4.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
1.3 7.8 GO:0090599 alpha-glucosidase activity(GO:0090599)
1.2 5.0 GO:0005537 mannose binding(GO:0005537)
1.2 7.3 GO:0016408 C-acyltransferase activity(GO:0016408)
1.2 3.6 GO:0016289 CoA hydrolase activity(GO:0016289)
1.0 7.9 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.0 4.9 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
1.0 8.8 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
1.0 2.9 GO:0005536 glucose binding(GO:0005536)
1.0 3.8 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.8 1.7 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.8 3.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.8 13.2 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.8 3.8 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.7 2.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.7 4.4 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.7 7.2 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.7 4.3 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.7 2.0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.7 2.0 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.7 2.7 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.7 2.7 GO:0004396 hexokinase activity(GO:0004396)
0.6 1.9 GO:0016208 AMP binding(GO:0016208)
0.6 2.4 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.6 11.4 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.6 3.0 GO:0004075 biotin carboxylase activity(GO:0004075)
0.5 2.2 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091)
0.5 5.9 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.5 2.1 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.5 2.9 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.5 1.5 GO:0016882 cyclo-ligase activity(GO:0016882)
0.5 1.9 GO:0005261 cation channel activity(GO:0005261)
0.5 1.4 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 0.9 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.4 2.6 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.4 1.2 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.4 1.2 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.4 5.0 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.4 2.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.4 4.0 GO:0035064 methylated histone binding(GO:0035064)
0.4 11.3 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.4 2.9 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.3 2.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.3 1.0 GO:0016417 S-acyltransferase activity(GO:0016417)
0.3 2.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 1.0 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.3 2.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 1.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 1.9 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.3 6.3 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.3 1.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 3.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.3 2.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.3 10.7 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.2 1.0 GO:0045118 azole transporter activity(GO:0045118)
0.2 2.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 1.2 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.2 2.3 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.7 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.2 1.2 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.2 1.2 GO:0016783 sulfurtransferase activity(GO:0016783)
0.2 2.1 GO:0000149 SNARE binding(GO:0000149)
0.2 1.4 GO:0030983 mismatched DNA binding(GO:0030983)
0.2 0.7 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.2 1.9 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.2 1.5 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 0.9 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.2 0.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.2 0.8 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.2 1.2 GO:0030246 carbohydrate binding(GO:0030246)
0.2 0.6 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.2 1.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 1.7 GO:0004888 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.2 0.7 GO:0008169 C-methyltransferase activity(GO:0008169)
0.2 0.8 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.2 1.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 0.6 GO:0015037 glutathione-disulfide reductase activity(GO:0004362) peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.2 0.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 11.2 GO:0051082 unfolded protein binding(GO:0051082)
0.1 2.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.0 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.1 0.4 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.1 0.4 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.1 0.5 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.1 0.8 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 0.4 GO:0032183 SUMO binding(GO:0032183)
0.1 2.6 GO:0031491 nucleosome binding(GO:0031491)
0.1 1.4 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 1.1 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.1 0.8 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 4.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 0.8 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.3 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.1 1.6 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.5 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 0.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.5 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 1.0 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.2 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.1 0.3 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.9 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.4 GO:0008198 ferrous iron binding(GO:0008198)
0.1 1.0 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.1 0.7 GO:0008374 O-acyltransferase activity(GO:0008374)
0.1 1.0 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 0.1 GO:0019213 deacetylase activity(GO:0019213)
0.1 0.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.2 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.1 0.2 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.4 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.8 GO:0043022 ribosome binding(GO:0043022)
0.0 0.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.4 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.0 0.3 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.1 GO:0005102 receptor binding(GO:0005102)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.2 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.3 GO:0015036 protein disulfide oxidoreductase activity(GO:0015035) disulfide oxidoreductase activity(GO:0015036)
0.0 0.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.5 GO:0015291 secondary active transmembrane transporter activity(GO:0015291)
0.0 0.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.5 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 1.9 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.2 GO:0051184 cofactor transporter activity(GO:0051184)
0.0 0.3 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.1 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.1 GO:0005216 ion channel activity(GO:0005216)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.3 GO:0036459 obsolete ubiquitin thiolesterase activity(GO:0004221) thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 0.0 GO:0070717 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.4 3.4 PID FANCONI PATHWAY Fanconi anemia pathway
0.3 1.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 0.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 0.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.2 0.3 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 0.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 140.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 0.1 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 0.3 PID FOXO PATHWAY FoxO family signaling
0.0 0.1 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
1.2 3.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.4 5.0 REACTOME DNA REPAIR Genes involved in DNA Repair
0.2 0.8 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.2 0.3 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.1 0.4 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.1 0.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 133.0 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 0.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.1 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.1 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.0 0.1 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation