Results for STP2
Z-value: 0.75
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Transcription factors associated with STP2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
STP2
|
S000001048 | Transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YOR348C Show fit | 6.39 |
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells |
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| YCL025C Show fit | 5.79 |
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) |
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| YKL217W Show fit | 4.68 |
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose |
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| YDR343C Show fit | 4.25 |
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3 |
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| YJL116C Show fit | 4.08 |
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family |
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| YLL053C Show fit | 3.77 |
Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin |
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| YDR277C Show fit | 3.64 |
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation |
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| YHR033W Show fit | 3.47 |
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm |
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| YBR296C Show fit | 3.33 |
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p |
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| YLL052C Show fit | 3.32 |
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains |
Network of associatons between targets according to the STRING database.
First level regulatory network of STP2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 6.7 | GO:0008615 | pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819) |
| 0.3 | 6.1 | GO:0098656 | anion transmembrane transport(GO:0098656) |
| 1.4 | 5.7 | GO:0006848 | pyruvate transport(GO:0006848) |
| 0.1 | 5.7 | GO:0009060 | aerobic respiration(GO:0009060) |
| 1.4 | 5.5 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.4 | 5.2 | GO:0008645 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 0.3 | 4.9 | GO:0005978 | glycogen biosynthetic process(GO:0005978) |
| 1.4 | 4.1 | GO:0015755 | fructose transport(GO:0015755) |
| 0.4 | 4.0 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.4 | 4.0 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.2 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.0 | 12.8 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 5.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 4.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 4.7 | GO:0000329 | fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852) |
| 0.8 | 3.8 | GO:0045281 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.5 | 3.2 | GO:0034657 | GID complex(GO:0034657) |
| 0.7 | 2.8 | GO:0000148 | 1,3-beta-D-glucan synthase complex(GO:0000148) |
| 0.2 | 2.8 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.3 | 2.1 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 9.2 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.5 | 7.1 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 1.5 | 6.1 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.5 | 4.6 | GO:0015205 | nucleobase transmembrane transporter activity(GO:0015205) |
| 1.1 | 4.4 | GO:0004396 | hexokinase activity(GO:0004396) |
| 0.8 | 3.8 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 0.5 | 3.8 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.7 | 3.6 | GO:0005315 | inorganic phosphate transmembrane transporter activity(GO:0005315) |
| 0.3 | 3.4 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.2 | 3.4 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 40.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.9 | 2.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 2.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 2.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.4 | 1.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 0.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 0.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 0.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 0.4 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 0.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 38.7 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.3 | 2.7 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.7 | 2.0 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.5 | 1.5 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 1.2 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.2 | 0.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 0.3 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 0.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.3 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.2 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |