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Results for STP2

Z-value: 0.75

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Transcription factors associated with STP2

Gene Symbol Gene ID Gene Info
STP2
S000001048 Transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STP2YHR006W0.261.9e-01Click!

Activity profile of STP2 motif

Sorted Z-values of STP2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YOR348C 6.39
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YCL025C 5.79
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YKL217W 4.68
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YDR343C 4.25
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YJL116C 4.08
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YLL053C 3.77 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YDR277C 3.64
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YHR033W 3.47 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YBR296C 3.33
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YLL052C 3.32
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YFR053C 3.32
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YDR536W 3.31
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YLR327C 3.19
TMA10
Protein of unknown function that associates with ribosomes
YMR251W 2.85
GTO3
Omega class glutathione transferase; putative cytosolic localization
YJR115W 2.79 Putative protein of unknown function
YOR072W 2.71 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YKR097W 2.68
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YAL039C 2.59
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YCR021C 2.56
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YMR306C-A 2.38 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR071C 2.35
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YER065C 2.29
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YML089C 2.21 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YKL148C 2.20
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YOR072W-A 2.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YEL065W 2.17
SIT1
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YMR081C 2.17
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YIL055C 2.13 Putative protein of unknown function
YER185W 2.12
PUG1
Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions
YBL075C 2.10
SSA3
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YLR267W 2.08
BOP2
Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation
YDR216W 2.07
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YNL125C 2.07
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YOL081W 2.02
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YLR122C 2.01 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YNL305C 2.01 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YOR100C 2.01
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YKL093W 2.00
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YPL024W 1.96
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YJL045W 1.95 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YMR135C 1.94
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YPL223C 1.92
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YKL109W 1.91
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YMR194C-B 1.87 Putative protein of unknown function
YIL160C 1.85
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YGR067C 1.81 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YLR296W 1.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL134C 1.81
ODC1
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YBR132C 1.77
AGP2
High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YEL044W 1.77
IES6
Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YDR096W 1.76
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YCR010C 1.75
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YJR128W 1.72 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YCL042W 1.71 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YDR406W 1.71
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YOR343C 1.71 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDR342C 1.70
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YLR123C 1.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YNR064C 1.69 Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
YPL026C 1.68
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YCL040W 1.61
GLK1
Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YPR184W 1.60
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YCR005C 1.57
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YER184C 1.57 Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source
YER004W 1.55
FMP52
Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YMR181C 1.54 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YDL169C 1.53
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YLR295C 1.53
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YEL011W 1.53
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YCR091W 1.52
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YDL194W 1.48
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YDR542W 1.48
PAU10
Hypothetical protein
YPR027C 1.48 Putative protein of unknown function
YPL119C 1.48
DBP1
Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs
YLR332W 1.47
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YGL192W 1.45
IME4
Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YGR032W 1.43
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YGL193C 1.43 Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YPL058C 1.42
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YFL059W 1.41
SNZ3
Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3
YLR331C 1.40
JIP3
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YLR438W 1.38
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YFL030W 1.37
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YOR383C 1.36
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YPR196W 1.32 Putative maltose activator
YJR078W 1.31
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YDL223C 1.31
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YIL162W 1.29
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YNL333W 1.29
SNZ2
Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p
YFL064C 1.28 Putative protein of unknown function
YEL028W 1.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML090W 1.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YMR306W 1.25
FKS3
Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL242W 1.25
ATG2
Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the pre-autophagosomal structure and mitochondria
YKL085W 1.24
MDH1
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YPR065W 1.23
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YDL215C 1.23
GDH2
NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YBR077C 1.22
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YCL054W 1.22
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YFL024C 1.22
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YOR178C 1.21
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YOL084W 1.21
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YPL135W 1.21
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YLR402W 1.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL011C 1.20 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
YPR013C 1.20 Putative zinc finger protein; YPR013C is not an essential gene
YNL179C 1.17 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YJL199C 1.16
MBB1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YDL010W 1.15
GRX6
Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX6
YIL113W 1.15
SDP1
Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
YMR206W 1.13 Putative protein of unknown function; YMR206W is not an essential gene
YLR437C-A 1.12 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YDL210W 1.12
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YNL180C 1.12
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YBL064C 1.11
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YAR069C 1.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR036W-A 1.11 Protein of unknown function; transcription is regulated by Pdr1p
YLR403W 1.10
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YDR092W 1.10
UBC13
Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
YLR304C 1.10
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YNL014W 1.10
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YNL019C 1.10 Putative protein of unknown function
YIL057C 1.10 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YMR195W 1.10
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YFL063W 1.09 Dubious open reading frame, based on available experimental and comparative sequence data
YKL147C 1.09 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
YAR070C 1.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL092W 1.08
SSU1
Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YNL036W 1.07
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YPR150W 1.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YMR250W 1.07
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YGL255W 1.07
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YAR053W 1.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR256C 1.06
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YKR009C 1.06
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YNR002C 1.05
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YHR211W 1.04
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YKL146W 1.04
AVT3
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YJL093C 1.03
TOK1
Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YIL045W 1.03
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YMR272C 1.03
SCS7
Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YLR125W 1.03 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YER158C 1.02 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YBR047W 1.02
FMP23
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR030W 1.02
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YBR147W 1.02
RTC2
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YMR316C-B 1.01 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR541C 1.01 Putative dihydrokaempferol 4-reductase
YFL060C 1.01
SNO3
Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin
YMR279C 1.00 Putative protein of unknown function; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene
YER014C-A 0.99
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YDL214C 0.99
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YKL163W 0.99
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YPL111W 0.99
CAR1
Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YPL017C 0.98
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YOR346W 0.97
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YLR236C 0.97 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL277W 0.96
MET2
L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway
YOR345C 0.96 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YCL038C 0.96
ATG22
Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
YBR051W 0.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YOR152C 0.94 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YBR105C 0.94
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YNL334C 0.94
SNO2
Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin
YLR094C 0.92
GIS3
Protein of unknown function
YDL012C 0.92 Plasma membrane protein of unknown function; YDL012C is not an essential gene
YOL051W 0.92
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YBR046C 0.92
ZTA1
Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity
YLR124W 0.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR050C 0.91
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YFL062W 0.90
COS4
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YFR026C 0.90 Putative protein of unknown function
YLR235C 0.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3
YJL133C-A 0.89 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR178W 0.87
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YGL184C 0.87
STR3
Cystathionine beta-lyase, converts cystathionine into homocysteine
YPL222W 0.87
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YML091C 0.87
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YLR152C 0.87 Putative protein of unknown function; YLR152C is not an essential gene
YMR096W 0.87
SNZ1
Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
YEL024W 0.86
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YMR040W 0.86
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YMR317W 0.85 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YER035W 0.85
EDC2
RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p
YER096W 0.84
SHC1
Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
YGR065C 0.84
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YDR102C 0.84 Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YLR237W 0.84
THI7
Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
YMR118C 0.83 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YNR034W 0.83
SOL1
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p
YDR298C 0.83
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YGR146C 0.83 Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation
YJL161W 0.82
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL127C-B 0.82 Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
YGR256W 0.80
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YOL085W-A 0.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YLR377C 0.79
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YPL089C 0.79
RLM1
MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YGR239C 0.79
PEX21
Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p
YAR050W 0.79
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p

Network of associatons between targets according to the STRING database.

First level regulatory network of STP2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.7 GO:0006848 pyruvate transport(GO:0006848)
1.4 5.5 GO:0015804 neutral amino acid transport(GO:0015804)
1.4 4.1 GO:0015755 fructose transport(GO:0015755)
1.3 3.9 GO:0015888 thiamine transport(GO:0015888)
1.0 2.0 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.9 2.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.9 2.7 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.8 6.7 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.8 2.4 GO:0006538 glutamate catabolic process(GO:0006538)
0.8 1.6 GO:0046323 glucose import(GO:0046323)
0.8 2.3 GO:0006068 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
0.8 3.8 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.7 2.8 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.7 2.0 GO:0006545 glycine biosynthetic process(GO:0006545)
0.6 3.0 GO:0032974 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.6 2.9 GO:0015793 glycerol transport(GO:0015793)
0.6 2.9 GO:0051099 positive regulation of binding(GO:0051099)
0.6 2.3 GO:0015886 heme transport(GO:0015886)
0.6 3.3 GO:0015758 glucose transport(GO:0015758)
0.5 2.2 GO:0006527 arginine catabolic process(GO:0006527)
0.5 3.9 GO:0015891 siderophore transport(GO:0015891)
0.5 1.8 GO:0015847 putrescine transport(GO:0015847)
0.4 4.0 GO:0006097 glyoxylate cycle(GO:0006097)
0.4 1.7 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.4 1.3 GO:0006108 malate metabolic process(GO:0006108)
0.4 2.1 GO:0005980 glycogen catabolic process(GO:0005980)
0.4 0.8 GO:0006102 isocitrate metabolic process(GO:0006102)
0.4 2.0 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.4 1.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.4 4.0 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.4 5.2 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.4 1.5 GO:0042407 cristae formation(GO:0042407)
0.4 1.1 GO:0035786 protein complex oligomerization(GO:0035786)
0.4 0.4 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.4 1.4 GO:1903339 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.4 3.2 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.3 1.0 GO:0019748 secondary metabolic process(GO:0019748)
0.3 1.0 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.3 0.3 GO:0043335 protein unfolding(GO:0043335)
0.3 1.2 GO:0036498 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.3 0.9 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.3 4.9 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.3 0.9 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.3 0.9 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.3 0.8 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.3 1.9 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.3 2.5 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.3 1.1 GO:0015976 carbon utilization(GO:0015976)
0.3 0.8 GO:0005993 trehalose catabolic process(GO:0005993)
0.3 0.8 GO:0036257 multivesicular body organization(GO:0036257)
0.3 6.1 GO:0098656 anion transmembrane transport(GO:0098656)
0.3 0.8 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.2 0.7 GO:0051180 vitamin transport(GO:0051180)
0.2 0.6 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.2 0.6 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.2 1.8 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.2 1.0 GO:0006083 acetate metabolic process(GO:0006083)
0.2 2.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.2 0.4 GO:0046185 aldehyde catabolic process(GO:0046185)
0.2 3.0 GO:0019740 nitrogen utilization(GO:0019740)
0.2 1.1 GO:0043457 regulation of cellular respiration(GO:0043457)
0.2 0.9 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.2 1.1 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.2 1.6 GO:0046352 disaccharide catabolic process(GO:0046352)
0.2 1.1 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.2 0.4 GO:0015691 cadmium ion transport(GO:0015691)
0.2 1.6 GO:0045332 phospholipid translocation(GO:0045332)
0.2 2.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.2 2.4 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
0.2 0.5 GO:0019543 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.2 1.6 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 1.6 GO:0006119 oxidative phosphorylation(GO:0006119)
0.2 0.8 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.2 0.5 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.2 0.8 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 2.2 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.1 2.6 GO:0006094 gluconeogenesis(GO:0006094)
0.1 0.4 GO:0045596 negative regulation of cell differentiation(GO:0045596) negative regulation of developmental process(GO:0051093)
0.1 1.4 GO:0046686 response to cadmium ion(GO:0046686)
0.1 1.1 GO:0015893 drug transport(GO:0015893)
0.1 1.1 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.4 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 5.7 GO:0009060 aerobic respiration(GO:0009060)
0.1 0.4 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.1 0.4 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 1.1 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.7 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.2 GO:0043200 response to amino acid(GO:0043200)
0.1 0.5 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 0.6 GO:0006021 inositol biosynthetic process(GO:0006021)
0.1 0.8 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.1 1.0 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 3.5 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.1 0.6 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.1 0.5 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.1 0.3 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 0.1 GO:0046688 response to copper ion(GO:0046688)
0.1 0.5 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 2.1 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.2 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.1 0.2 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.1 2.2 GO:0022900 electron transport chain(GO:0022900)
0.1 0.1 GO:0034755 high-affinity iron ion transmembrane transport(GO:0006827) iron ion transmembrane transport(GO:0034755)
0.1 2.2 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 0.5 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.1 0.5 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.7 GO:0072348 sulfur compound transport(GO:0072348)
0.1 0.3 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.1 0.5 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.1 0.2 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.1 0.5 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.1 0.4 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.5 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.3 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.1 0.2 GO:0071456 cellular response to hypoxia(GO:0071456)
0.1 1.1 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.1 0.2 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 0.2 GO:0000411 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.1 0.2 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.1 0.3 GO:0046464 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.1 0.3 GO:0051225 spindle assembly(GO:0051225)
0.1 0.3 GO:0000023 maltose metabolic process(GO:0000023)
0.1 0.6 GO:0007130 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.1 0.3 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.1 1.4 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 0.3 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.1 GO:0032069 regulation of nuclease activity(GO:0032069) regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.1 1.1 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.2 GO:1902751 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 0.2 GO:0036294 response to anoxia(GO:0034059) cellular response to decreased oxygen levels(GO:0036294) cellular response to oxygen levels(GO:0071453) cellular response to anoxia(GO:0071454)
0.1 0.3 GO:0090113 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.1 0.2 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.1 0.2 GO:0071495 cellular response to biotic stimulus(GO:0071216) cellular response to endogenous stimulus(GO:0071495) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.1 0.3 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.1 0.2 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.1 0.3 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.1 0.1 GO:0045923 positive regulation of fatty acid metabolic process(GO:0045923)
0.1 0.3 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 0.6 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.1 0.4 GO:0007129 synapsis(GO:0007129)
0.0 0.2 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 0.1 GO:0015868 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.0 0.2 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:0006311 meiotic gene conversion(GO:0006311)
0.0 0.1 GO:0015809 arginine transport(GO:0015809)
0.0 0.1 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.0 0.5 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.0 0.5 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.2 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 1.0 GO:0010324 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.0 1.1 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.1 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0044209 AMP salvage(GO:0044209)
0.0 0.1 GO:0090527 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.0 0.1 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.0 0.2 GO:0070941 eisosome assembly(GO:0070941)
0.0 0.2 GO:0071322 cellular response to carbohydrate stimulus(GO:0071322)
0.0 0.9 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.0 0.2 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.0 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.3 GO:0040031 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.0 0.1 GO:0015802 basic amino acid transport(GO:0015802)
0.0 0.1 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.0 0.2 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.0 0.1 GO:0033993 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.1 GO:0071168 protein localization to chromatin(GO:0071168)
0.0 0.2 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.2 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.3 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.0 0.0 GO:0070482 response to decreased oxygen levels(GO:0036293) response to oxygen levels(GO:0070482)
0.0 0.3 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0042743 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.0 0.2 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.1 GO:0016241 regulation of macroautophagy(GO:0016241)
0.0 0.0 GO:0015688 iron chelate transport(GO:0015688)
0.0 0.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.1 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.0 2.2 GO:0048468 ascospore formation(GO:0030437) cell development(GO:0048468)
0.0 0.1 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.0 0.1 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.0 0.2 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.0 0.8 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.1 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.6 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.2 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.3 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.2 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546)
0.0 1.1 GO:0006839 mitochondrial transport(GO:0006839)
0.0 0.1 GO:0016562 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.0 0.1 GO:0051181 cofactor transport(GO:0051181)
0.0 0.2 GO:0090054 regulation of chromatin silencing at silent mating-type cassette(GO:0090054)
0.0 0.1 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.0 GO:1903513 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.0 0.2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.1 GO:0031134 sister chromatid biorientation(GO:0031134)
0.0 0.1 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.5 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.1 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.1 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.0 GO:0043687 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.0 0.0 GO:0070623 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of sulfur metabolic process(GO:0051176) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.0 0.1 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.3 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.8 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.7 2.8 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.7 2.0 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.7 2.0 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.6 1.8 GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.5 2.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.5 1.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.5 3.2 GO:0034657 GID complex(GO:0034657)
0.4 1.2 GO:0005796 Golgi lumen(GO:0005796)
0.3 2.0 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.3 2.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 0.8 GO:0032585 multivesicular body membrane(GO:0032585)
0.2 2.8 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 2.0 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.2 1.0 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.2 1.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.2 1.7 GO:0070069 cytochrome complex(GO:0070069)
0.2 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 0.5 GO:0072687 meiotic spindle(GO:0072687)
0.1 0.4 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.1 0.4 GO:0051286 cell tip(GO:0051286)
0.1 1.0 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 0.6 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 1.9 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.6 GO:0034967 Set3 complex(GO:0034967)
0.1 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 4.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.5 GO:0034448 EGO complex(GO:0034448)
0.1 1.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.5 GO:0070772 PAS complex(GO:0070772)
0.1 0.9 GO:0005769 early endosome(GO:0005769)
0.1 0.4 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 1.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.2 GO:0032176 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.1 28.2 GO:0005886 plasma membrane(GO:0005886)
0.1 1.8 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 1.1 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 1.4 GO:0016592 mediator complex(GO:0016592)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.6 GO:0030677 ribonuclease P complex(GO:0030677)
0.1 4.7 GO:0000329 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.0 0.2 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.4 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.1 GO:0035649 Nrd1 complex(GO:0035649)
0.0 5.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.7 GO:0010008 endosome membrane(GO:0010008)
0.0 0.1 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784)
0.0 1.0 GO:0000322 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.0 0.3 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.1 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 1.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.2 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.0 0.3 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 0.1 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0005960 glycine cleavage complex(GO:0005960)
0.0 12.8 GO:0005739 mitochondrion(GO:0005739)
0.0 0.8 GO:0061645 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.0 0.1 GO:0032116 SMC loading complex(GO:0032116)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.5 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 0.1 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.0 GO:0000818 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 9.2 GO:0015295 solute:proton symporter activity(GO:0015295)
1.5 6.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.1 4.4 GO:0004396 hexokinase activity(GO:0004396)
0.9 2.8 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.8 3.8 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.7 3.6 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.7 2.7 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.7 2.0 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.6 2.4 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.6 1.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.5 3.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.5 2.1 GO:0005537 mannose binding(GO:0005537)
0.5 7.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.5 3.0 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.5 1.5 GO:0005536 glucose binding(GO:0005536)
0.5 4.6 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.4 1.3 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.4 0.8 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.4 1.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.4 1.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.3 1.0 GO:0015186 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.3 1.7 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.3 1.3 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.3 1.0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.3 1.8 GO:0000400 four-way junction DNA binding(GO:0000400)
0.3 2.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.3 3.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3 3.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.3 0.8 GO:0051183 vitamin transporter activity(GO:0051183)
0.3 0.5 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.3 0.8 GO:0000150 recombinase activity(GO:0000150)
0.3 0.8 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.3 3.1 GO:0022838 substrate-specific channel activity(GO:0022838)
0.3 0.8 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.2 0.7 GO:0016289 CoA hydrolase activity(GO:0016289)
0.2 0.9 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.2 3.2 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.2 0.9 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.2 1.1 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.2 1.7 GO:0031072 heat shock protein binding(GO:0031072)
0.2 2.3 GO:0004888 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.2 0.8 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 0.6 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.2 0.6 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.2 0.7 GO:0004180 carboxypeptidase activity(GO:0004180)
0.2 3.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 1.9 GO:0010181 FMN binding(GO:0010181)
0.2 1.6 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.2 1.7 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.8 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.2 0.8 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.2 2.1 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.2 0.5 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.2 1.2 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 0.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.2 1.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.2 2.0 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 2.6 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 1.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.4 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.1 0.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.9 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.4 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.1 0.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.4 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.4 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.1 1.1 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.9 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.1 0.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 0.2 GO:0045118 azole transporter activity(GO:0045118)
0.1 0.2 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.1 0.5 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.3 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 1.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.5 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 1.0 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 0.9 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.2 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.7 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.1 0.6 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.3 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.1 0.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.1 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 0.6 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 0.1 GO:0019903 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.1 0.2 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1 0.3 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 0.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.3 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.1 0.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.4 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.2 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.4 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.8 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.6 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.2 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782) sulfurtransferase activity(GO:0016783)
0.0 1.1 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.2 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.5 GO:0001099 RNA polymerase II core binding(GO:0000993) basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.2 GO:0015238 drug transmembrane transporter activity(GO:0015238) drug transporter activity(GO:0090484)
0.0 0.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.9 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.2 GO:0015216 purine nucleotide transmembrane transporter activity(GO:0015216)
0.0 0.9 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.0 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0016872 intramolecular lyase activity(GO:0016872)
0.0 0.4 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.0 0.1 GO:0043492 ATPase activity, coupled to movement of substances(GO:0043492)
0.0 0.1 GO:0051184 cofactor transporter activity(GO:0051184)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0015405 primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405)
0.0 0.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.1 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.3 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.3 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0 0.1 GO:0000149 SNARE binding(GO:0000149)
0.0 0.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.3 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.1 GO:0005102 receptor binding(GO:0005102)
0.0 0.0 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620) oxidoreductase activity, acting on the aldehyde or oxo group of donors(GO:0016903)
0.0 0.5 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.0 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.0 0.2 GO:0016298 lipase activity(GO:0016298)
0.0 0.1 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.0 GO:0008171 O-methyltransferase activity(GO:0008171)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 1.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.4 2.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 2.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 0.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 0.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.2 0.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 0.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 0.7 PID PLK1 PATHWAY PLK1 signaling events
0.1 0.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 0.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 40.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.1 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.5 1.5 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.3 2.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 0.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.2 REACTOME DNA REPAIR Genes involved in DNA Repair
0.1 0.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 38.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination