Results for SRD1

Z-value: 0.45

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Transcription factors associated with SRD1

Gene Symbol Gene ID Gene Info
S000000611 Protein involved in the processing of pre-rRNA to mature rRNA

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of SRD1 motif

Sorted Z-values of SRD1 motif

Promoter Log-likelihood Transcript Gene Gene Info
YGL255W 3.29 High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YJR146W 1.76 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YKL217W 1.67 Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YEL070W 1.56 Deletion suppressor of mpt5 mutation
YFR053C 1.55 Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YFL052W 1.43 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YKR097W 1.39 Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YOR343C 1.17 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YJR147W 1.12 Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YOR348C 1.05 Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YGR191W 1.00 High-affinity histidine permease, also involved in the transport of manganese ions
YJR077C 0.99 Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YJL045W 0.97 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YOL154W 0.89 Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YGR190C 0.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YHL021C 0.87 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YJR078W 0.87 Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YIL057C 0.87 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YLR375W 0.86 Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YPR027C 0.85 Putative protein of unknown function
YEL039C 0.83 Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YBR085C-A 0.81 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YLR374C 0.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
YDR453C 0.79 Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YIR027C 0.79 Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YNL052W 0.78 Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YER150W 0.76 GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YMR316C-B 0.76 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML128C 0.75 Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YDR536W 0.75 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YGL258W-A 0.74 Putative protein of unknown function
YHR139C 0.73 Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YGL055W 0.72 Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YLR203C 0.71 Nuclear encoded protein required for translation of COX1 mRNA; binds to Cox1 protein
YIL037C 0.71 Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p
YFR017C 0.69 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YNR034W-A 0.68 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YDR530C 0.68 Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YIL059C 0.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
YBR145W 0.66 Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YGL162W 0.65 Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression
YMR317W 0.64 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YPL250C 0.60 Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YNR014W 0.60 Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
YER147C 0.59 Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
YPR028W 0.59 Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells
YJL093C 0.57 Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YBR035C 0.57 Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YMR319C 0.56 Low-affinity Fe(II) transporter of the plasma membrane
YKL100C 0.55 Putative protein of unknown function with similarity to a human minor histocompatibility antigen; YKL100C is not an essential gene
YHR140W 0.55 Putative integral membrane protein of unknown function
YLR312C 0.55 Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YHR177W 0.53 Putative protein of unknown function
YGR279C 0.53 Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YEL008W 0.52 Hypothetical protein predicted to be involved in metabolism
YBR132C 0.51 High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YER103W 0.51 Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YPL054W 0.49 Zinc-finger protein of unknown function
YHR092C 0.49 High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YPR198W 0.48 Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
YEL009C 0.48 Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YDL120W 0.47 Frataxin, regulates mitochondrial iron accumulation; interacts with Isu1p which promotes Fe-S cluster assembly; interacts with electron transport chain components and may influence respiration; human homolog involved in Friedrich's ataxia
YOR235W 0.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YML054C 0.46 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YPL224C 0.46 Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
YJR148W 0.45 Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase
YPR197C 0.45 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER065C 0.44 Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YBR209W 0.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene
YDR100W 0.43 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
YNR055C 0.43 Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake
YER010C 0.43 Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction
YMR243C 0.43 Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm
YLR295C 0.43 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YOR317W 0.43 Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase
YBL015W 0.42 Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YIL012W 0.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR100C 0.42 Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YNL074C 0.41 Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YER141W 0.41 Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
YNL125C 0.40 Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YIL058W 0.40 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR030W 0.40 Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YDL079C 0.40 Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YDR249C 0.40 Putative protein of unknown function
YAL054C 0.39 Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YDR533C 0.38 Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YFL051C 0.38 Putative protein of unknown function; YFL051C is not an essential gene
YNL144C 0.38 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YNL036W 0.38 Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YGR248W 0.37 6-phosphogluconolactonase with similarity to Sol3p
YKR042W 0.37 Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death
YOL032W 0.37 Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline
YMR155W 0.36 Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen
YHR086W 0.36 RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA
YOR142W 0.36 Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated
YLR331C 0.36 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YOR149C 0.36 Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
YDR304C 0.36 Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
YPL223C 0.36 Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YOR298C-A 0.35 Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations
YPR061C 0.35 Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
YMR042W 0.35 Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
YER066W 0.35 Putative protein of unknown function; YER066W is not an essential gene
YOL082W 0.35 Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YLR311C 0.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR022W 0.34 Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
YGR043C 0.34 Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YLR332W 0.34 O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YKL008C 0.34 Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YGL053W 0.34 Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
YPR013C 0.34 Putative zinc finger protein; YPR013C is not an essential gene
YJR150C 0.33 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YGR268C 0.33 Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YJL067W 0.33 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR210W 0.33 Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
YML123C 0.33 High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YIL166C 0.33 Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
YPR160W 0.33 Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YDR250C 0.33 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YOR152C 0.32 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YNL066W 0.32 Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YNL160W 0.32 Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YPL262W 0.32 Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YLL051C 0.31 Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
YDR124W 0.31 Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
YML100W 0.31 Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YAR047C 0.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR019C 0.31 Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
YPL222W 0.30 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL052W 0.30 Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
YGR068C 0.30 Putative protein of unknown function; YGR068C is not an essential gene.
YNL037C 0.30 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YLR228C 0.30 Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YDR406W 0.30 Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YJL217W 0.30 Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YPR093C 0.30 Protein involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain
YLR037C 0.30 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YGL114W 0.30 Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YJL068C 0.29 Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
YJR001W 0.29 Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YIL047C 0.29 Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
YMR306W 0.28 Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL162W 0.28 Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YDR277C 0.28 Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YDR342C 0.27 High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YBR072W 0.27 Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YOR316C-A 0.27 Putative protein of unknown function; identified by fungal homology and RT-PCR
YDL142C 0.27 Cardiolipin synthase; produces cardiolipin, which is an important constituent of mitochondrial membranes; required for normal mitochondrial membrane potential and function
YOL052C 0.27 S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
YAR019W-A 0.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL185C 0.26 Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene
YAR027W 0.26 Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
YLR122C 0.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YHR078W 0.26 High osmolarity-regulated gene of unknown function
YDR540C 0.25 Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YGR234W 0.25 Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YDR251W 0.25 Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
YCR021C 0.25 Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YPR017C 0.25 Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol
YCL048W-A 0.25 Putative protein of unknown function
YKL051W 0.25 Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YAR053W 0.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR320W 0.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR077C 0.24 Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YBL047C 0.24 Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins
YHR180W 0.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR257C 0.24 Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
YML120C 0.24 NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YDR009W 0.24 Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity
YAR060C 0.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL192W 0.24 Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YOR010C 0.24 Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
YDR034C 0.23 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YGR022C 0.23 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YMR029C 0.23 Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
YKL044W 0.23 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR131W 0.23 Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site
YDL085W 0.23 Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YOL119C 0.23 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YMR021C 0.23 Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
YGR023W 0.23 Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YJR048W 0.23 Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YJL103C 0.23 Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YDR322W 0.23 Mitochondrial ribosomal protein of the large subunit
YIL060W 0.23 Putative protein of unknown function; mutant accumulates less glycogen than does wild type; YIL060W is not an essential gene
YMR135C 0.22 Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YLR023C 0.22 Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YIR020W-A 0.22 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YOR176W 0.22 Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
YKR066C 0.22 Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YDR173C 0.22 Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
YOL030W 0.22 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YOR273C 0.22 Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YDL181W 0.21 Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YHR109W 0.21 Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
YER179W 0.21 Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein
YPL092W 0.21 Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YLR123C 0.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YLR296W 0.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Network of associatons between targets according to the STRING database.

First level regulatory network of SRD1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0015755 fructose transport(GO:0015755)
0.5 4.3 GO:0006829 zinc II ion transport(GO:0006829)
0.4 1.7 GO:0006848 pyruvate transport(GO:0006848)
0.3 1.1 GO:0015804 neutral amino acid transport(GO:0015804)
0.2 1.0 GO:0032371 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.2 2.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 0.7 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.2 1.3 GO:0045117 azole transport(GO:0045117)
0.2 1.0 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.2 0.6 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.2 0.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 0.6 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.2 0.3 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 0.4 GO:0050685 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024) positive regulation of mRNA processing(GO:0050685)
0.1 0.8 GO:0042407 cristae formation(GO:0042407)
0.1 0.4 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.1 0.5 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.1 0.7 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 0.8 GO:0006007 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.1 0.6 GO:0006074 (1->3)-beta-D-glucan metabolic process(GO:0006074)
0.1 0.8 GO:0006083 acetate metabolic process(GO:0006083)
0.1 0.4 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.1 0.1 GO:0046087 cytidine metabolic process(GO:0046087)
0.1 0.4 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.1 0.3 GO:0051238 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.1 0.6 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.2 GO:0046323 glucose import(GO:0046323)
0.1 0.4 GO:0015976 carbon utilization(GO:0015976)
0.1 0.5 GO:0046184 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.1 0.2 GO:0043335 protein unfolding(GO:0043335)
0.1 0.3 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 0.6 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.4 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.1 0.2 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.1 0.5 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.2 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.1 0.1 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 0.7 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.4 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1 0.4 GO:0015793 glycerol transport(GO:0015793)
0.1 0.5 GO:0009098 leucine biosynthetic process(GO:0009098)
0.1 0.3 GO:0015848 spermidine transport(GO:0015848)
0.1 0.2 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) UDP-glucose transport(GO:0015786)
0.1 0.2 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 0.3 GO:0051503 adenine nucleotide transport(GO:0051503)
0.1 1.9 GO:0098656 anion transmembrane transport(GO:0098656)
0.1 2.0 GO:0006094 gluconeogenesis(GO:0006094)
0.1 0.2 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.1 0.9 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.1 0.5 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 0.8 GO:0006783 porphyrin-containing compound biosynthetic process(GO:0006779) heme biosynthetic process(GO:0006783) tetrapyrrole biosynthetic process(GO:0033014)
0.1 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.2 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 0.4 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.1 0.2 GO:0000431 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.1 0.4 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.1 0.2 GO:0007157 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.1 0.9 GO:0006099 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.1 0.1 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.1 0.3 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.1 0.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.3 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.1 0.4 GO:0006276 plasmid maintenance(GO:0006276)
0.1 0.2 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.0 0.3 GO:0010821 regulation of mitochondrion organization(GO:0010821)
0.0 0.1 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.0 0.0 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.0 0.1 GO:1900461 positive regulation of cell growth(GO:0030307) positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter(GO:1900461) positive regulation of pseudohyphal growth(GO:2000222)
0.0 0.0 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.0 0.4 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.2 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.2 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.0 0.6 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.1 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.0 0.2 GO:0051322 anaphase(GO:0051322)
0.0 0.1 GO:0006598 polyamine catabolic process(GO:0006598)
0.0 0.3 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 0.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.2 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.0 0.1 GO:0046688 response to copper ion(GO:0046688)
0.0 0.2 GO:0044247 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.1 GO:0036213 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.0 0.4 GO:0034204 lipid translocation(GO:0034204) regulation of membrane lipid distribution(GO:0097035)
0.0 0.3 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.0 1.0 GO:0042493 response to drug(GO:0042493)
0.0 0.4 GO:0006754 ATP biosynthetic process(GO:0006754)
0.0 0.3 GO:0015891 siderophore transport(GO:0015891)
0.0 0.1 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.0 0.1 GO:0042843 D-xylose catabolic process(GO:0042843)
0.0 0.1 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.0 0.2 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.1 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.3 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.1 GO:0000272 polysaccharide catabolic process(GO:0000272) aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0 0.8 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.1 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.0 0.2 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.0 0.1 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.3 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.0 GO:0051099 positive regulation of binding(GO:0051099)
0.0 0.1 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.0 0.6 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.1 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.0 0.3 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.0 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.2 GO:0070272 proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.1 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.0 0.1 GO:0015940 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.0 0.1 GO:0006113 fermentation(GO:0006113)
0.0 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.1 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.0 0.1 GO:0007155 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.0 0.1 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.0 0.1 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.0 0.0 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.1 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.0 0.1 GO:0018195 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.0 0.3 GO:0015850 organic hydroxy compound transport(GO:0015850)
0.0 0.0 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.1 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.0 GO:0015691 cadmium ion transport(GO:0015691)
0.0 0.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.0 GO:0034090 maintenance of meiotic sister chromatid cohesion(GO:0034090)
0.0 0.1 GO:1903339 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.0 0.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.1 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.0 0.4 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.2 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.0 0.3 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.2 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.2 GO:0007120 axial cellular bud site selection(GO:0007120)
0.0 0.1 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.1 GO:0009310 amine catabolic process(GO:0009310) cellular biogenic amine catabolic process(GO:0042402)
0.0 0.0 GO:0015886 heme transport(GO:0015886)
0.0 0.0 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 0.0 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 1.0 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.2 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.1 GO:0051273 beta-glucan metabolic process(GO:0051273)
0.0 0.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.1 GO:0035269 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0 0.0 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.0 0.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.1 GO:0019400 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.0 0.1 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0009636 response to toxic substance(GO:0009636)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 0.6 GO:0032116 SMC loading complex(GO:0032116)
0.1 1.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.1 0.6 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.9 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.4 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.1 1.8 GO:0070469 respiratory chain(GO:0070469)
0.1 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 1.1 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.1 0.1 GO:0031160 spore wall(GO:0031160)
0.0 0.3 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.0 0.2 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 4.1 GO:0009277 fungal-type cell wall(GO:0009277)
0.0 0.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.2 GO:0030869 RENT complex(GO:0030869)
0.0 0.3 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 0.1 GO:0000837 Doa10p ubiquitin ligase complex(GO:0000837)
0.0 0.1 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.0 0.2 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.0 0.2 GO:0044233 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.2 GO:0034657 GID complex(GO:0034657)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.5 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.3 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 3.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.2 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 0.1 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.0 0.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 1.6 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 0.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.0 GO:0033255 SAS acetyltransferase complex(GO:0033255)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.0 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.0 0.2 GO:0005576 extracellular region(GO:0005576)
0.0 0.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)
0.0 0.1 GO:0034967 Set3 complex(GO:0034967)
0.0 0.4 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 4.9 GO:0005739 mitochondrion(GO:0005739)
0.0 0.1 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:0015295 solute:proton symporter activity(GO:0015295)
0.5 3.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 1.7 GO:0004396 hexokinase activity(GO:0004396)
0.3 1.0 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.3 1.4 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 0.7 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.2 0.9 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.2 0.9 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.2 1.7 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 0.5 GO:0016289 CoA hydrolase activity(GO:0016289)
0.2 0.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 0.5 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.6 GO:0005261 cation channel activity(GO:0005261)
0.1 0.4 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.1 0.8 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.1 0.5 GO:0016898 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.1 0.4 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.7 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 0.8 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 1.0 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.4 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 0.7 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1 0.3 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.1 0.3 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.1 0.3 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.1 0.4 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.1 0.6 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 1.0 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.1 0.6 GO:0010181 FMN binding(GO:0010181)
0.1 0.5 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 0.5 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 0.3 GO:0005537 mannose binding(GO:0005537)
0.1 0.2 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.2 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.1 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.4 GO:0050661 NADP binding(GO:0050661)
0.1 0.2 GO:0048038 quinone binding(GO:0048038)
0.1 0.2 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.1 0.7 GO:0015293 symporter activity(GO:0015293)
0.1 0.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.3 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.1 0.2 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 0.5 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 1.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 1.1 GO:0015926 glucosidase activity(GO:0015926)
0.1 0.4 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 0.2 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.1 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.2 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.6 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.2 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.3 GO:0005216 ion channel activity(GO:0005216)
0.0 0.6 GO:0015297 antiporter activity(GO:0015297)
0.0 0.4 GO:0005507 copper ion binding(GO:0005507)
0.0 0.2 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.3 GO:0051287 NAD binding(GO:0051287)
0.0 0.4 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.0 2.2 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 0.6 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
0.0 0.4 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.5 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.8 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.0 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 1.0 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.5 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.2 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 0.1 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.0 0.5 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.2 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.3 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.1 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.1 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.0 0.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.0 GO:0022838 substrate-specific channel activity(GO:0022838)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.1 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.0 0.1 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.1 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.1 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.0 0.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.0 0.0 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.0 0.7 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.0 0.0 GO:0097027 cyclin binding(GO:0030332) ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.0 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 1.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.3 0.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.0 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 1.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.1 REACTOME TRIF MEDIATED TLR3 SIGNALING Genes involved in TRIF mediated TLR3 signaling
0.0 0.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.3 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.0 0.1 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions