Results for SRD1
Z-value: 0.45
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Transcription factors associated with SRD1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
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SRD1
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S000000611 | Protein involved in the processing of pre-rRNA to mature rRNA |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YGL255W Show fit | 3.29 |
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor |
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| YJR146W Show fit | 1.76 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2 |
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| YKL217W Show fit | 1.67 |
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose |
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| YEL070W Show fit | 1.56 |
Deletion suppressor of mpt5 mutation |
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| YFR053C Show fit | 1.55 |
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p |
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| YFL052W Show fit | 1.43 |
Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity |
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| YKR097W Show fit | 1.39 |
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
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| YOR343C Show fit | 1.17 |
Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data |
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| YJR147W Show fit | 1.12 |
Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant |
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| YOR348C Show fit | 1.05 |
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells |
Network of associatons between targets according to the STRING database.
First level regulatory network of SRD1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.3 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.2 | 2.1 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 2.0 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 0.1 | 1.9 | GO:0098656 | anion transmembrane transport(GO:0098656) |
| 0.4 | 1.7 | GO:0006848 | pyruvate transport(GO:0006848) |
| 0.5 | 1.5 | GO:0015755 | fructose transport(GO:0015755) |
| 0.2 | 1.3 | GO:0045117 | azole transport(GO:0045117) |
| 0.3 | 1.1 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.2 | 1.0 | GO:0032371 | positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911) |
| 0.2 | 1.0 | GO:0034354 | 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.5 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 4.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 4.1 | GO:0009277 | fungal-type cell wall(GO:0009277) |
| 0.0 | 3.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 1.8 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 1.6 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.0 | 1.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 1.2 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.1 | 1.1 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
| 0.1 | 1.0 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.5 | 2.4 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.0 | 2.2 | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616) |
| 0.4 | 1.7 | GO:0004396 | hexokinase activity(GO:0004396) |
| 0.2 | 1.7 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.3 | 1.4 | GO:0005315 | inorganic phosphate transmembrane transporter activity(GO:0005315) |
| 0.1 | 1.1 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.1 | 1.1 | GO:0015926 | glucosidase activity(GO:0015926) |
| 0.3 | 1.0 | GO:1901474 | azole transmembrane transporter activity(GO:1901474) |
| 0.1 | 1.0 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 1.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 0.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.0 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.4 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.3 | 1.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 0.3 | REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | Genes involved in Metabolism of lipids and lipoproteins |
| 0.1 | 0.2 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.1 | REACTOME TRIF MEDIATED TLR3 SIGNALING | Genes involved in TRIF mediated TLR3 signaling |
| 0.0 | 0.1 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.0 | 0.1 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 0.1 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.0 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |