Results for SPT15
Z-value: 1.76
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Transcription factors associated with SPT15
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SPT15
|
S000000950 | TATA-binding protein |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YBR117C Show fit | 23.08 |
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids |
||
| YJL089W Show fit | 19.98 |
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus |
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| YMR271C Show fit | 18.34 |
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5 |
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| YJR048W Show fit | 14.88 |
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration |
||
| YNR034W-A Show fit | 14.81 |
Putative protein of unknown function; expression is regulated by Msn2p/Msn4p |
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| YMR107W Show fit | 14.37 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YPL171C Show fit | 14.15 |
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism |
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| YNL014W Show fit | 10.56 |
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells |
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| YFL030W Show fit | 10.36 |
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases |
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| YLR307C-A Show fit | 10.32 |
Putative protein of unknown function |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPT15
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 37.1 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 2.0 | 35.4 | GO:0006772 | thiamine metabolic process(GO:0006772) |
| 1.9 | 28.1 | GO:0006098 | pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682) |
| 3.3 | 26.5 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 1.4 | 24.4 | GO:0005978 | glycogen biosynthetic process(GO:0005978) |
| 7.5 | 22.6 | GO:0061414 | regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414) |
| 2.4 | 21.7 | GO:0006537 | glutamate biosynthetic process(GO:0006537) |
| 1.6 | 18.7 | GO:0046352 | disaccharide catabolic process(GO:0046352) |
| 5.9 | 17.6 | GO:0009437 | amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437) |
| 4.4 | 17.6 | GO:0046323 | glucose import(GO:0046323) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 40.5 | GO:0005886 | plasma membrane(GO:0005886) |
| 1.8 | 39.4 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.6 | 38.5 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 37.6 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.3 | 37.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 34.5 | GO:0000323 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
| 0.4 | 18.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 3.3 | 16.3 | GO:0045283 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.2 | 13.9 | GO:0005774 | vacuolar membrane(GO:0005774) |
| 1.9 | 11.1 | GO:0045239 | tricarboxylic acid cycle enzyme complex(GO:0045239) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 28.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 1.4 | 22.2 | GO:0046906 | heme binding(GO:0020037) tetrapyrrole binding(GO:0046906) |
| 1.9 | 21.1 | GO:0015293 | symporter activity(GO:0015293) |
| 3.5 | 20.9 | GO:0016744 | transferase activity, transferring aldehyde or ketonic groups(GO:0016744) |
| 4.0 | 19.8 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 5.9 | 17.6 | GO:0004092 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 1.2 | 16.4 | GO:0016645 | oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645) |
| 3.3 | 16.3 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 3.9 | 15.7 | GO:0004396 | hexokinase activity(GO:0004396) |
| 0.8 | 15.3 | GO:0008483 | transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 226.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 4.3 | 12.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.9 | 5.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.9 | 4.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.6 | 3.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 1.4 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.3 | 1.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 1.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.8 | 0.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 0.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 226.0 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 4.6 | 13.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.4 | 12.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 2.0 | 6.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.4 | 3.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 2.1 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.6 | 1.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.5 | 1.1 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.4 | 1.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 0.7 | REACTOME HEMOSTASIS | Genes involved in Hemostasis |