Results for SPT15

Z-value: 1.76

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Transcription factors associated with SPT15

Gene Symbol Gene ID Gene Info
S000000950 TATA-binding protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of SPT15 motif

Sorted Z-values of SPT15 motif

Promoter Log-likelihood Transcript Gene Gene Info
YBR117C 23.08 Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YJL089W 19.98 C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YMR271C 18.34 Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YJR048W 14.88 Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YNR034W-A 14.81 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YMR107W 14.37 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YPL171C 14.15 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YNL014W 10.56 Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YFL030W 10.36 Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YLR307C-A 10.32 Putative protein of unknown function
YCL001W-B 9.78 Putative protein of unknown function; identified by homology
YFR017C 9.67 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YKR097W 9.22 Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YEL039C 9.21 Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YMR206W 8.97 Putative protein of unknown function; YMR206W is not an essential gene
YLR174W 8.84 Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YAR035W 8.66 Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YAL062W 8.52 NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YCR005C 8.52 Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YMR175W 8.35 Protein of unknown function whose expression is induced by osmotic stress
YCL040W 8.31 Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YBL043W 7.93 Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YLR356W 7.76 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YPR027C 7.64 Putative protein of unknown function
YLR142W 7.62 Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YPR030W 7.53 Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YER015W 7.48 Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids
YLR004C 7.45 Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YCL042W 7.44 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YGR243W 7.33 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR377C 7.21 Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YDL210W 7.02 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YIL099W 6.96 Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YGR032W 6.78 Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YNL036W 6.77 Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YER158C 6.76 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YKL065W-A 6.66 Putative protein of unknown function
YFR053C 6.63 Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YML087C 6.58 Putative protein of unknown function; highly conserved across species and orthologous to human CYB5R4; null mutant shows increased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YNR002C 6.27 Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YDR536W 6.25 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YBL015W 6.24 Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YIL045W 6.21 Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YJR146W 6.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YAL054C 6.19 Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YKL141W 6.13 Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YFR022W 6.10 Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YPL222C-A 6.10 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR406W 6.05 Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YHL046W-A 5.93 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR002W 5.88 Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YFL058W 5.83 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YLR327C 5.81 Protein of unknown function that associates with ribosomes
YBL064C 5.81 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YFL019C 5.77 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YJR095W 5.75 Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YEL011W 5.74 Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YKR034W 5.71 Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YPL165C 5.71 Protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
YKL163W 5.68 O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YDR343C 5.64 High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YCL025C 5.63 Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YKL177W 5.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YPR010C-A 5.59 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YOR152C 5.58 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YHR096C 5.48 Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YML042W 5.46 Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YDR277C 5.41 Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YDL138W 5.38 Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YJR078W 5.37 Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YNR058W 5.35 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
YHL047C 5.32 Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YBR116C 5.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YHR217C 5.23 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YHR092C 5.18 High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YDR119W-A 5.16 Putative protein of unknown function
YHR053C 5.15 Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YHR139C 5.12 Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YAR050W 5.04 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YDR070C 5.04 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR147W 5.02 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YHR001W-A 5.02 Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YPL027W 5.02 Protein of unknown function involved in the assembly of the prospore membrane during sporulation
YKR102W 4.87 Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YPL156C 4.85 Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YKL217W 4.83 Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YNL200C 4.82 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR256W 4.82 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YOR343C 4.80 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YPR184W 4.76 Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YBR296C 4.73 Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YOR382W 4.70 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YNR050C 4.70 Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway
YPL006W 4.67 Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
YPL240C 4.67 Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YGL121C 4.65 Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Grp1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p
YMR244W 4.65 Putative protein of unknown function
YIL101C 4.57 Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YLR122C 4.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YAL060W 4.56 NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
YGR066C 4.55 Putative protein of unknown function
YDR036C 4.55 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YNL144C 4.53 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YDL223C 4.52 Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YKR046C 4.51 Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
YGR142W 4.50 v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YLL013C 4.48 Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
YBR201C-A 4.47 Putative protein of unknown function
YDR540C 4.43 Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YHR033W 4.43 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YIL162W 4.43 Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YDR234W 4.42 Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
YPL250C 4.42 Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YJL144W 4.42 Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS
YKL178C 4.42 Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YOL035C 4.41 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR011C 4.40 Putative ATP-dependent permease of the ABC transporter family of proteins
YGR065C 4.38 High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YOL118C 4.36 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YER065C 4.29 Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YBR105C 4.27 Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YAR047C 4.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML120C 4.21 NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YPR191W 4.16 Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YER150W 4.15 GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YLR258W 4.15 Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YNL093W 4.13 GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YER038W-A 4.11 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria
YIL059C 4.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
YMR056C 4.08 Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YGL255W 4.07 High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YGR144W 4.07 Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YJL152W 4.03 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL262W 3.96 Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YPL229W 3.96 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene
YFL011W 3.94 Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YIR034C 3.94 Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway
YBL033C 3.94 GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
YNL037C 3.93 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YPR028W 3.92 Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells
YML083C 3.92 Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
YMR194C-B 3.91 Putative protein of unknown function
YGR067C 3.90 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YLR350W 3.89 Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YDL026W 3.89 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YIL136W 3.88 Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YLR296W 3.83 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR374C 3.82 Putative protein of unknown function
YKL148C 3.81 Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YML131W 3.80 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YNR057C 3.79 Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels
YCL067C 3.75 Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression
YKL031W 3.74 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YCR091W 3.74 Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YNL194C 3.74 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YKL034W 3.74 Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes
YCR010C 3.73 Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YDR258C 3.73 Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YPL134C 3.71 Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YLR123C 3.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YLR295C 3.68 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YGR146C 3.68 Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDL085W 3.68 Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YGL062W 3.66 Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YLR237W 3.66 Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
YFL052W 3.64 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YMR306W 3.64 Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR104C 3.64 Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
YPR015C 3.64 Putative protein of unknown function
YBR183W 3.62 Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
YPL247C 3.61 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; YPL247C is not an essential gene
YOL119C 3.59 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YPR192W 3.58 Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YNL322C 3.57 Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
YCR021C 3.57 Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YLR136C 3.56 mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YPL186C 3.56 Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YNL104C 3.55 Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YBR101C 3.55 Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum
YGR197C 3.55 Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance
YHR126C 3.54 Putative protein of unknown function; transcription dependent upon Azf1p
YHR071W 3.53 Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YBR076C-A 3.53 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR
YDR178W 3.52 Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YMR118C 3.51 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YJL199C 3.51 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YGR182C 3.49 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
YDL204W 3.49 Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YOR393W 3.47 Protein of unknown function, has similarity to enolases
YDL027C 3.46 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene
YER024W 3.46 Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
YHR218W 3.46 Helicase-like protein encoded within the telomeric Y' element
YFL020C 3.46 Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YIL100C-A 3.45 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR081C 3.45 Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YMR141C 3.44 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL067W 3.44 Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
YGL227W 3.44 Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); shifts the balance of nitrogen metabolism toward the production of glutamate; localized to the nucleus and the cytoplasm
YMR251W 3.44 Omega class glutathione transferase; putative cytosolic localization
YDL244W 3.43 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13

Network of associatons between targets according to the STRING database.

First level regulatory network of SPT15

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 22.6 GO:0061414 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
5.9 17.6 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
4.4 17.6 GO:0046323 glucose import(GO:0046323)
3.9 11.8 GO:0006545 glycine biosynthetic process(GO:0006545)
3.7 37.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
3.3 26.5 GO:0006097 glyoxylate cycle(GO:0006097)
3.3 16.3 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
2.9 11.8 GO:0006848 pyruvate transport(GO:0006848)
2.9 17.3 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
2.6 10.3 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
2.4 12.2 GO:0005980 glycogen catabolic process(GO:0005980)
2.4 21.7 GO:0006537 glutamate biosynthetic process(GO:0006537)
2.3 6.8 GO:0072488 ammonium transmembrane transport(GO:0072488)
2.2 13.5 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
2.2 6.6 GO:0051594 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
2.1 16.7 GO:0015891 siderophore transport(GO:0015891)
2.0 6.1 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
2.0 8.2 GO:0046688 response to copper ion(GO:0046688)
2.0 8.1 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
2.0 35.4 GO:0006772 thiamine metabolic process(GO:0006772)
2.0 5.9 GO:0019543 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
1.9 5.8 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
1.9 5.7 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
1.9 28.1 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
1.9 11.2 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.8 5.5 GO:0015888 thiamine transport(GO:0015888)
1.8 7.2 GO:0015976 carbon utilization(GO:0015976)
1.8 16.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
1.8 12.3 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
1.7 5.2 GO:0043335 protein unfolding(GO:0043335)
1.7 8.6 GO:0015793 glycerol transport(GO:0015793)
1.7 6.7 GO:0015847 putrescine transport(GO:0015847)
1.7 16.6 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
1.6 8.1 GO:0032974 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
1.6 8.0 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
1.6 4.7 GO:0006538 glutamate catabolic process(GO:0006538)
1.6 18.7 GO:0046352 disaccharide catabolic process(GO:0046352)
1.6 4.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
1.5 3.1 GO:0006740 NADPH regeneration(GO:0006740)
1.5 6.1 GO:0015886 heme transport(GO:0015886)
1.5 7.4 GO:0042732 D-xylose metabolic process(GO:0042732)
1.4 4.3 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
1.4 24.4 GO:0005978 glycogen biosynthetic process(GO:0005978)
1.4 1.4 GO:0000304 response to singlet oxygen(GO:0000304)
1.4 6.9 GO:0006083 acetate metabolic process(GO:0006083)
1.4 2.7 GO:0072353 cellular age-dependent response to reactive oxygen species(GO:0072353)
1.4 5.5 GO:0051180 vitamin transport(GO:0051180)
1.3 4.0 GO:0051469 vesicle fusion with vacuole(GO:0051469)
1.3 3.9 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
1.3 3.8 GO:0045117 azole transport(GO:0045117)
1.3 11.4 GO:0006829 zinc II ion transport(GO:0006829)
1.2 1.2 GO:0009313 oligosaccharide catabolic process(GO:0009313)
1.2 4.9 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
1.2 3.5 GO:0006527 arginine catabolic process(GO:0006527)
1.2 5.8 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
1.1 3.4 GO:0006624 vacuolar protein processing(GO:0006624)
1.1 16.8 GO:0019740 nitrogen utilization(GO:0019740)
1.1 4.4 GO:0019320 glucose catabolic process(GO:0006007) hexose catabolic process(GO:0019320) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
1.1 4.3 GO:0016242 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
1.1 1.1 GO:0006552 leucine catabolic process(GO:0006552)
1.0 6.3 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
1.0 3.1 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
1.0 4.0 GO:0006598 polyamine catabolic process(GO:0006598)
1.0 8.9 GO:0046686 response to cadmium ion(GO:0046686)
1.0 2.9 GO:0006572 tyrosine catabolic process(GO:0006572)
0.9 1.9 GO:0008272 sulfate transport(GO:0008272)
0.9 15.1 GO:0006754 ATP biosynthetic process(GO:0006754)
0.9 2.8 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.9 8.8 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.9 2.6 GO:0009438 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.8 2.5 GO:0019388 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.8 2.5 GO:0006089 lactate metabolic process(GO:0006089)
0.8 3.3 GO:0043954 cellular component maintenance(GO:0043954)
0.8 4.1 GO:0009208 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.8 4.9 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.8 7.0 GO:0000755 cytogamy(GO:0000755)
0.8 6.8 GO:0071709 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.7 0.7 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.7 3.7 GO:0051099 positive regulation of binding(GO:0051099)
0.7 12.6 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.7 2.9 GO:2000911 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.7 2.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.7 2.1 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.7 3.5 GO:0006012 galactose metabolic process(GO:0006012)
0.7 4.2 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.7 6.3 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.7 2.0 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.7 2.6 GO:0052652 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.6 1.3 GO:0001324 age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324)
0.6 2.6 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.6 3.2 GO:0051260 protein homooligomerization(GO:0051260)
0.6 3.8 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.6 1.7 GO:0015680 intracellular copper ion transport(GO:0015680)
0.6 3.4 GO:0006591 ornithine metabolic process(GO:0006591)
0.6 1.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.6 1.1 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.5 1.1 GO:0010507 negative regulation of autophagy(GO:0010507)
0.5 2.2 GO:0000023 maltose metabolic process(GO:0000023)
0.5 4.1 GO:0045332 phospholipid translocation(GO:0045332)
0.5 1.0 GO:0061395 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061395) cellular response to arsenic-containing substance(GO:0071243)
0.5 2.1 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993)
0.5 3.1 GO:0070941 eisosome assembly(GO:0070941)
0.5 0.5 GO:0061410 positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) cellular response to ethanol(GO:0071361) cellular response to alcohol(GO:0097306)
0.5 1.4 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.5 2.8 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.5 3.8 GO:0018345 protein palmitoylation(GO:0018345)
0.5 3.8 GO:0015893 drug transport(GO:0015893)
0.5 2.3 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.5 2.8 GO:0006465 signal peptide processing(GO:0006465)
0.5 6.9 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.4 1.3 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.4 7.4 GO:0008219 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.4 0.4 GO:0051259 protein oligomerization(GO:0051259)
0.4 3.0 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.4 1.3 GO:0051093 negative regulation of cell differentiation(GO:0045596) negative regulation of developmental process(GO:0051093)
0.4 2.1 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.4 1.2 GO:0006000 fructose metabolic process(GO:0006000)
0.4 9.1 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.4 1.6 GO:0044070 regulation of anion transport(GO:0044070)
0.4 14.3 GO:0009060 aerobic respiration(GO:0009060)
0.4 4.8 GO:0042026 protein refolding(GO:0042026)
0.4 1.6 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.4 2.7 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.4 3.0 GO:0010526 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.4 1.9 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.4 4.8 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.4 13.6 GO:0070726 cell wall assembly(GO:0070726)
0.4 0.7 GO:0000042 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.4 1.1 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.3 10.6 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.3 1.0 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.3 1.5 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.3 1.2 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.3 3.3 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.3 2.6 GO:0015802 basic amino acid transport(GO:0015802)
0.3 0.3 GO:0046185 aldehyde catabolic process(GO:0046185)
0.3 1.5 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.3 0.9 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.3 2.0 GO:0006816 calcium ion transport(GO:0006816)
0.3 3.5 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.3 2.6 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.3 2.0 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.3 1.4 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.3 1.6 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.3 5.1 GO:0006895 Golgi to endosome transport(GO:0006895)
0.3 0.8 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.3 2.1 GO:0051181 cofactor transport(GO:0051181)
0.2 1.0 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.2 2.5 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.2 1.9 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.2 1.2 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.2 0.7 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.2 2.6 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.2 1.4 GO:0006279 premeiotic DNA replication(GO:0006279)
0.2 0.7 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.2 0.2 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.2 4.6 GO:0098660 inorganic ion transmembrane transport(GO:0098660)
0.2 0.2 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) DNA double-strand break processing(GO:0000729)
0.2 0.7 GO:0090399 replicative senescence(GO:0090399)
0.2 0.7 GO:0043484 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024) positive regulation of mRNA processing(GO:0050685)
0.2 0.9 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.2 2.7 GO:0006885 regulation of pH(GO:0006885)
0.2 0.2 GO:0006824 cobalt ion transport(GO:0006824)
0.2 1.1 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.2 1.7 GO:0006826 iron ion transport(GO:0006826)
0.2 0.6 GO:0042407 cristae formation(GO:0042407)
0.2 0.9 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.2 0.9 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.2 0.6 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.2 0.2 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.2 3.8 GO:0016579 protein deubiquitination(GO:0016579)
0.2 0.8 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.2 0.6 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.2 0.6 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.2 1.6 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.2 0.2 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.2 1.4 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.2 1.4 GO:0000080 mitotic G1 phase(GO:0000080) G1 phase(GO:0051318)
0.2 0.2 GO:0007032 endosome organization(GO:0007032)
0.2 0.6 GO:0032079 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.2 0.6 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.2 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.2 1.9 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.2 2.0 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.2 0.6 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.2 0.7 GO:0070988 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.2 0.9 GO:0060628 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport(GO:0060628) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.2 0.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.2 0.5 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.2 0.2 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.2 0.5 GO:0043200 response to amino acid(GO:0043200)
0.2 0.8 GO:0006544 glycine metabolic process(GO:0006544)
0.2 0.7 GO:0097271 protein localization to bud neck(GO:0097271)
0.2 0.5 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 1.3 GO:0007323 peptide pheromone maturation(GO:0007323)
0.2 0.5 GO:0000730 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.2 1.4 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.2 0.5 GO:0055088 lipid homeostasis(GO:0055088)
0.2 0.8 GO:0045996 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.2 0.2 GO:0006074 (1->3)-beta-D-glucan metabolic process(GO:0006074)
0.1 3.9 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 1.3 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 1.4 GO:0030242 pexophagy(GO:0030242)
0.1 0.3 GO:0006311 meiotic gene conversion(GO:0006311)
0.1 1.0 GO:0006638 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.1 0.4 GO:0051383 centromere complex assembly(GO:0034508) kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.1 0.6 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.1 0.3 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.1 0.8 GO:0016574 histone ubiquitination(GO:0016574)
0.1 0.5 GO:0051274 beta-glucan biosynthetic process(GO:0051274)
0.1 0.4 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) regulation of transcription during mitosis(GO:0045896) regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021)
0.1 0.4 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.7 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 1.3 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.2 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.1 0.1 GO:0042148 strand invasion(GO:0042148)
0.1 0.1 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.1 1.2 GO:0034620 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.1 0.5 GO:0007050 cell cycle arrest(GO:0007050)
0.1 0.5 GO:0000733 DNA strand renaturation(GO:0000733)
0.1 0.1 GO:0071941 nitrogen cycle metabolic process(GO:0071941)
0.1 0.2 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.1 0.3 GO:0034308 primary alcohol metabolic process(GO:0034308)
0.1 1.5 GO:0007129 synapsis(GO:0007129)
0.1 1.6 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.8 GO:0035269 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.1 0.4 GO:0009098 leucine biosynthetic process(GO:0009098)
0.1 0.7 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.1 0.3 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.1 0.3 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 0.6 GO:0001101 response to acid chemical(GO:0001101)
0.1 0.3 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.1 0.1 GO:2000217 regulation of invasive growth in response to glucose limitation(GO:2000217)
0.1 0.2 GO:0090110 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.5 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.5 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.1 0.3 GO:0016239 positive regulation of autophagy(GO:0010508) positive regulation of macroautophagy(GO:0016239)
0.1 0.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 0.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.2 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.2 GO:0065005 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.1 0.1 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 0.3 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.1 0.2 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 0.7 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0017004 cytochrome complex assembly(GO:0017004)
0.0 0.6 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.2 GO:0006048 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0019748 secondary metabolic process(GO:0019748)
0.0 0.1 GO:0015851 nucleobase transport(GO:0015851)
0.0 0.2 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.4 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.4 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.3 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.0 GO:0010528 regulation of transposition(GO:0010528)
0.0 0.1 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) UDP-glucose transport(GO:0015786)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:0071495 cellular response to endogenous stimulus(GO:0071495)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.0 GO:0042727 flavin-containing compound metabolic process(GO:0042726) flavin-containing compound biosynthetic process(GO:0042727)
0.0 0.0 GO:0031555 transcriptional attenuation(GO:0031555) transcription antitermination(GO:0031564)
0.0 0.1 GO:0030042 actin filament depolymerization(GO:0030042)
0.0 0.0 GO:0032365 intracellular lipid transport(GO:0032365)
0.0 0.1 GO:0009306 protein secretion(GO:0009306)
0.0 0.0 GO:0051707 immune effector process(GO:0002252) immune system process(GO:0002376) defense response(GO:0006952) response to virus(GO:0009615) response to external biotic stimulus(GO:0043207) defense response to virus(GO:0051607) response to other organism(GO:0051707) defense response to other organism(GO:0098542)
0.0 0.1 GO:0045033 peroxisome inheritance(GO:0045033)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 3.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
3.3 16.3 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
2.3 9.1 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
1.9 5.7 GO:0031166 integral component of vacuolar membrane(GO:0031166)
1.9 11.1 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
1.8 39.4 GO:0070469 respiratory chain(GO:0070469)
1.6 4.8 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
1.4 10.0 GO:0034657 GID complex(GO:0034657)
1.3 3.9 GO:0032585 multivesicular body membrane(GO:0032585)
1.2 9.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.0 10.1 GO:0005775 vacuolar lumen(GO:0005775)
0.9 1.9 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.9 2.7 GO:0001400 mating projection base(GO:0001400)
0.8 2.3 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.7 2.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.7 4.0 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.7 1.3 GO:0033263 CORVET complex(GO:0033263)
0.6 3.7 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.6 0.6 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.6 2.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.6 38.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.6 10.2 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.6 2.8 GO:0031931 TORC1 complex(GO:0031931)
0.5 2.1 GO:0008623 CHRAC(GO:0008623)
0.5 1.0 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.5 3.7 GO:0042597 periplasmic space(GO:0042597)
0.5 1.4 GO:0034099 luminal surveillance complex(GO:0034099)
0.4 0.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.4 1.3 GO:0070211 Snt2C complex(GO:0070211)
0.4 2.4 GO:0032126 eisosome(GO:0032126)
0.4 18.6 GO:0031225 anchored component of membrane(GO:0031225)
0.4 7.4 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.4 4.6 GO:0031160 spore wall(GO:0031160)
0.3 1.7 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.3 5.7 GO:0044455 mitochondrial membrane part(GO:0044455)
0.3 1.3 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.3 0.6 GO:0032389 MutLalpha complex(GO:0032389)
0.3 2.3 GO:0002178 palmitoyltransferase complex(GO:0002178) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.3 0.9 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.3 5.0 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.3 6.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.3 37.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 1.6 GO:0008180 COP9 signalosome(GO:0008180)
0.3 4.5 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.3 4.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.2 3.0 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.2 0.7 GO:0032176 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.2 7.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 2.2 GO:0000795 synaptonemal complex(GO:0000795)
0.2 0.9 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2 0.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 34.5 GO:0000323 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.2 8.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.2 1.5 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.2 0.9 GO:0000815 ESCRT III complex(GO:0000815)
0.2 1.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 1.0 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.2 0.8 GO:0033101 cellular bud membrane(GO:0033101)
0.2 2.8 GO:0033698 Rpd3L complex(GO:0033698)
0.2 13.9 GO:0005774 vacuolar membrane(GO:0005774)
0.2 1.1 GO:0005770 late endosome(GO:0005770)
0.2 0.5 GO:0035649 Nrd1 complex(GO:0035649)
0.2 2.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.2 0.7 GO:0030128 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.2 0.5 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.2 0.5 GO:0005787 signal peptidase complex(GO:0005787)
0.1 40.5 GO:0005886 plasma membrane(GO:0005886)
0.1 0.4 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.1 1.1 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.1 0.4 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 0.3 GO:0033255 SAS acetyltransferase complex(GO:0033255)
0.1 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.1 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.3 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.3 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 0.7 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.2 GO:0070274 RES complex(GO:0070274)
0.1 0.2 GO:0005675 holo TFIIH complex(GO:0005675)
0.1 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.1 37.6 GO:0005739 mitochondrion(GO:0005739)
0.1 0.4 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 1.9 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.2 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0000417 HIR complex(GO:0000417)
0.0 0.3 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.1 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.0 0.1 GO:0030869 RENT complex(GO:0030869)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.0 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.0 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 17.6 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
4.1 12.3 GO:0016289 CoA hydrolase activity(GO:0016289)
4.0 19.8 GO:0015295 solute:proton symporter activity(GO:0015295)
3.9 15.7 GO:0004396 hexokinase activity(GO:0004396)
3.8 11.3 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
3.6 10.8 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
3.5 20.9 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
3.5 10.4 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
3.3 16.3 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
3.2 9.7 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
3.2 12.9 GO:0005537 mannose binding(GO:0005537)
3.1 9.3 GO:0016208 AMP binding(GO:0016208)
3.1 12.3 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
2.6 10.4 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
2.5 7.5 GO:1901474 azole transmembrane transporter activity(GO:1901474)
2.4 4.7 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
2.3 6.9 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
2.3 6.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
2.3 6.9 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
2.2 4.4 GO:0004930 G-protein coupled receptor activity(GO:0004930)
2.2 6.6 GO:0005536 glucose binding(GO:0005536)
2.0 6.1 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
2.0 7.9 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
1.9 21.1 GO:0015293 symporter activity(GO:0015293)
1.9 5.6 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
1.9 11.2 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
1.8 7.1 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
1.7 8.3 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.6 4.8 GO:0090599 alpha-glucosidase activity(GO:0090599)
1.5 12.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.5 6.1 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
1.5 10.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.4 2.9 GO:0045118 azole transporter activity(GO:0045118)
1.4 2.9 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
1.4 11.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.4 22.2 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
1.3 8.8 GO:0004364 glutathione transferase activity(GO:0004364)
1.2 3.7 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
1.2 6.1 GO:0019238 cyclohydrolase activity(GO:0019238)
1.2 16.4 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
1.1 7.9 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
1.1 12.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.1 5.6 GO:0008198 ferrous iron binding(GO:0008198)
1.1 2.2 GO:0016790 thiolester hydrolase activity(GO:0016790)
1.1 4.4 GO:0022821 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
1.1 13.1 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
1.1 14.1 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
1.1 4.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
1.0 3.0 GO:0016882 cyclo-ligase activity(GO:0016882)
0.9 1.9 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.9 2.8 GO:0016417 S-acyltransferase activity(GO:0016417)
0.9 3.6 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.8 8.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.8 4.1 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.8 15.3 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.8 3.2 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.8 1.6 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.8 2.3 GO:0004458 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.7 5.0 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.7 2.8 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.7 2.7 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.7 3.9 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.6 1.9 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.6 10.1 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.6 1.2 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.6 0.6 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.6 28.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.6 1.7 GO:0032183 SUMO binding(GO:0032183)
0.6 1.7 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.5 1.6 GO:0022829 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.5 10.3 GO:0016831 carboxy-lyase activity(GO:0016831)
0.5 6.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.5 1.6 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.5 4.7 GO:0016722 oxidoreductase activity, oxidizing metal ions(GO:0016722)
0.5 4.7 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.5 1.5 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.5 6.1 GO:0005199 structural constituent of cell wall(GO:0005199)
0.5 3.4 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.5 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.5 6.7 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.5 1.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.5 1.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.5 1.4 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.4 1.8 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.4 3.5 GO:0000149 SNARE binding(GO:0000149)
0.4 3.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 1.7 GO:0016531 copper chaperone activity(GO:0016531)
0.4 2.1 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.4 3.4 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.4 2.1 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.4 1.2 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.4 2.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.4 1.2 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.4 3.8 GO:0022838 substrate-specific channel activity(GO:0022838)
0.4 1.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.4 2.1 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.4 1.4 GO:0008169 C-methyltransferase activity(GO:0008169)
0.3 8.7 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.3 0.3 GO:0019902 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.3 2.0 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.3 1.0 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.3 2.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.3 0.3 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.3 0.6 GO:0048256 5'-flap endonuclease activity(GO:0017108) flap endonuclease activity(GO:0048256)
0.3 1.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.3 3.2 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.3 1.2 GO:0004180 carboxypeptidase activity(GO:0004180)
0.3 1.4 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.3 1.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.3 3.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.3 8.1 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.3 1.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.3 0.8 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.3 0.3 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.3 1.3 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.2 0.5 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.2 2.1 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 2.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 1.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 0.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 0.9 GO:0030246 carbohydrate binding(GO:0030246)
0.2 2.1 GO:0016209 antioxidant activity(GO:0016209)
0.2 1.1 GO:0031072 heat shock protein binding(GO:0031072)
0.2 1.5 GO:0051184 cofactor transporter activity(GO:0051184)
0.2 1.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 0.2 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.2 15.0 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.2 0.6 GO:0030332 cyclin binding(GO:0030332)
0.2 3.4 GO:0051087 chaperone binding(GO:0051087)
0.2 0.2 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.2 1.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 0.4 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.2 1.8 GO:0035064 methylated histone binding(GO:0035064)
0.2 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 2.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.7 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.1 0.4 GO:0008236 serine-type peptidase activity(GO:0008236)
0.1 0.5 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.1 1.1 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.0 GO:0034979 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.1 0.5 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 1.3 GO:0032947 protein complex scaffold(GO:0032947)
0.1 9.2 GO:0019787 ubiquitin-like protein transferase activity(GO:0019787)
0.1 4.3 GO:0042626 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 0.3 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 0.1 GO:0004075 biotin carboxylase activity(GO:0004075)
0.1 0.7 GO:0010181 FMN binding(GO:0010181)
0.1 0.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.6 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.5 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 0.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.3 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 0.3 GO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly(GO:0001128)
0.1 0.3 GO:0046527 glucosyltransferase activity(GO:0046527)
0.1 0.1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.1 0.2 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.1 0.5 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 0.3 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 0.4 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 0.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.2 GO:0015216 purine nucleotide transmembrane transporter activity(GO:0015216)
0.1 0.6 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 0.4 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.9 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.3 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.5 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.1 GO:0016530 metallochaperone activity(GO:0016530)
0.1 0.7 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 0.1 GO:0001129 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129)
0.1 1.3 GO:0005509 calcium ion binding(GO:0005509)
0.1 0.9 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 0.5 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.2 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.1 0.8 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.1 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091)
0.1 0.1 GO:0019842 vitamin binding(GO:0019842)
0.0 0.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.2 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.8 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.7 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.4 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 0.1 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.5 GO:0015266 protein channel activity(GO:0015266)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.3 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.3 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.3 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.6 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.0 GO:0015081 monovalent cation:proton antiporter activity(GO:0005451) sodium ion transmembrane transporter activity(GO:0015081) solute:cation antiporter activity(GO:0015298) solute:proton antiporter activity(GO:0015299) sodium:proton antiporter activity(GO:0015385) cation:cation antiporter activity(GO:0015491)
0.0 0.1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.4 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.0 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.0 0.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 12.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.9 5.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.9 4.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.8 0.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.6 3.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.4 1.4 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.3 1.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 1.0 PID CMYB PATHWAY C-MYB transcription factor network
0.2 0.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 0.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.2 0.6 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 226.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 0.1 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 0.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 0.2 PID FOXO PATHWAY FoxO family signaling
0.0 0.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
2.0 6.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
1.4 12.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.6 1.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.5 1.1 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.4 0.4 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.4 3.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.4 1.1 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.3 0.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 2.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 0.4 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.2 0.2 REACTOME SIGNALING BY NOTCH Genes involved in Signaling by NOTCH
0.2 0.7 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.1 226.0 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.4 REACTOME MEIOSIS Genes involved in Meiosis
0.1 0.1 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.1 0.4 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.4 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.1 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C