Results for SOK2
Z-value: 0.48
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Transcription factors associated with SOK2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SOK2
|
S000004618 | Nuclear protein that negatively regulates pseudohyphal differentiation |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YOR315W Show fit | 3.96 |
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate |
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| YNL178W Show fit | 3.86 |
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins |
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| YLR413W Show fit | 3.44 |
Putative protein of unknown function; YLR413W is not an essential gene |
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| YGR108W Show fit | 3.38 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YKL218C Show fit | 2.46 |
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate |
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| YKR092C Show fit | 2.46 |
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 |
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| YHR094C Show fit | 2.37 |
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting |
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| YFR055W Show fit | 2.33 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YHL028W Show fit | 2.28 |
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3 |
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| YIR021W Show fit | 2.19 |
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOK2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.5 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.4 | 6.8 | GO:0006407 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 0.8 | 5.3 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 0.0 | 3.8 | GO:0006913 | nucleocytoplasmic transport(GO:0006913) |
| 0.1 | 3.1 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 0.1 | 3.1 | GO:0007124 | pseudohyphal growth(GO:0007124) |
| 0.2 | 2.9 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 2.9 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.0 | 2.8 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.5 | 2.5 | GO:0042710 | biofilm formation(GO:0042710) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 15.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 11.4 | GO:0005730 | nucleolus(GO:0005730) |
| 0.3 | 4.2 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.2 | 3.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.2 | 2.6 | GO:0005940 | septin ring(GO:0005940) |
| 0.1 | 2.3 | GO:0031228 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.0 | 2.2 | GO:0000922 | spindle pole(GO:0000922) |
| 0.6 | 1.9 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.1 | 1.6 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 6.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.6 | 3.7 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 0.1 | 3.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.7 | 2.9 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.0 | 2.6 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.4 | 2.2 | GO:0005354 | galactose transmembrane transporter activity(GO:0005354) |
| 0.5 | 2.1 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.3 | 2.1 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.1 | 2.0 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.4 | 1.5 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 0.8 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 0.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 0.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 0.3 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 0.3 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.3 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 0.1 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.1 | 0.1 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.0 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.3 | 4.1 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.5 | 1.8 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.8 | 1.5 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.3 | 1.3 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 1.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.4 | 0.7 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.2 | 0.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 0.7 | REACTOME GPCR DOWNSTREAM SIGNALING | Genes involved in GPCR downstream signaling |
| 0.2 | 0.7 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |