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Results for SOK2

Z-value: 0.48

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Transcription factors associated with SOK2

Gene Symbol Gene ID Gene Info
SOK2
S000004618 Nuclear protein that negatively regulates pseudohyphal differentiation

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOK2YMR016C0.019.5e-01Click!

Activity profile of SOK2 motif

Sorted Z-values of SOK2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YOR315W 3.96
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YNL178W 3.86
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YLR413W 3.44 Putative protein of unknown function; YLR413W is not an essential gene
YGR108W 3.38
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YKL218C 2.46
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YKR092C 2.46
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YHR094C 2.37
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YFR055W 2.33
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YHL028W 2.28
WSC4
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YIR021W 2.19
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YKL063C 2.14 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YLR154W-A 2.09 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YJR094W-A 2.08
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YFR056C 1.93 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YBR066C 1.92
NRG2
Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YLR154W-B 1.92 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YPR119W 1.90
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YLR154C 1.85
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YOR101W 1.85
RAS1
GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YDL023C 1.78 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YPL245W 1.74 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YCR031C 1.73
RPS14A
Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YCR018C 1.66
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YER001W 1.63
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YDL022W 1.55
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YHR181W 1.53
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YNR001W-A 1.51 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YGL147C 1.48
RPL9A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YLR154W-C 1.47
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YOR313C 1.47
SPS4
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YCL024W 1.43
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YOR314W 1.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL118W 1.35
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YAL003W 1.33
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YGR214W 1.32
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YDR133C 1.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YML074C 1.30
FPR3
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YGL076C 1.30
RPL7A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YER045C 1.27
ACA1
Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources
YGR052W 1.27
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YEL001C 1.26
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YGL031C 1.23
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YBL029W 1.23 Non-essential protein of unknown function
YDR044W 1.23
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YIL133C 1.23
RPL16A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YKL164C 1.23
PIR1
O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YCL023C 1.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YGR050C 1.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR145C 1.19
RPS4A
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YOL086C 1.19
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YER046W 1.18
SPO73
Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
YDL022C-A 1.16 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YOR293W 1.16
RPS10A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10
YKL096W-A 1.16
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YBR032W 1.13 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YER109C 1.13
FLO8
Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
YER074W 1.10
RPS24A
Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YKL182W 1.10
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YGR051C 1.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YOR096W 1.06
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YLR312W-A 1.05
MRPL15
Mitochondrial ribosomal protein of the large subunit
YMR205C 1.05
PFK2
Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YLR333C 1.02
RPS25B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YGL030W 1.01
RPL30
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YHR180W-A 1.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YDL055C 0.95
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YER011W 0.94
TIR1
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YMR016C 0.94
SOK2
Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YNL234W 0.93 Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p
YJL105W 0.89
SET4
Protein of unknown function, contains a SET domain
YMR006C 0.88
PLB2
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
YPR014C 0.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YDL211C 0.84 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YNL069C 0.84
RPL16B
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YOR309C 0.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
YBR238C 0.84 Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
YIL009W 0.84
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YOR222W 0.83
ODC2
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
YAR020C 0.83
PAU7
Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
YMR123W 0.82
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YGL158W 0.82
RCK1
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YLR349W 0.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YBR158W 0.80
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YBR210W 0.80
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YLR449W 0.79
FPR4
Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YDR074W 0.78
TPS2
Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YDR508C 0.77
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YAL025C 0.77
MAK16
Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
YEL053W-A 0.77 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YJR074W 0.77
MOG1
Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
YMR281W 0.76
GPI12
ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
YLR348C 0.76
DIC1
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YNL235C 0.76 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
YDR509W 0.76 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL148W 0.75
RPA34
RNA polymerase I subunit A34.5
YDL047W 0.74
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YAL033W 0.74
POP5
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YGR123C 0.74
PPT1
Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YKR093W 0.73
PTR2
Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YPL177C 0.72
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YMR263W 0.72
SAP30
Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
YOR107W 0.71
RGS2
Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YOL031C 0.71
SIL1
Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
YPR157W 0.71 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YOR026W 0.71
BUB3
Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
YHL029C 0.70
OCA5
Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YBL087C 0.70
RPL23A
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins
YOR342C 0.70 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YDR341C 0.69 Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR199W 0.69
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YER137C 0.68 Putative protein of unknown function
YJL193W 0.68 Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
YKR079C 0.68
TRZ1
tRNase Z, involved in RNA processing, has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif, homolog of the human candidate prostate cancer susceptibility gene ELAC2
YOL015W 0.67
IRC10
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
YMR009W 0.65
ADI1
Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YHR013C 0.65
ARD1
Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YGR155W 0.65
CYS4
Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YCR004C 0.65
YCP4
Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL209C 0.65
STE6
Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YGL039W 0.65 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YPL108W 0.64 Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YMR202W 0.64
ERG2
C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
YGR293C 0.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W
YNL301C 0.64
RPL18B
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YBR249C 0.64
ARO4
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YJL190C 0.63
RPS22A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YMR011W 0.63
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YML119W 0.63 Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YCL018W 0.62
LEU2
Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YGR078C 0.61
PAC10
Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
YGL135W 0.61
RPL1B
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YMR083W 0.60
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YJR123W 0.60
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YDR088C 0.59
SLU7
RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YGR040W 0.59
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YHR183W 0.58
GND1
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
YER055C 0.58
HIS1
ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YDL082W 0.58
RPL13A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein
YOR028C 0.58
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YIL009C-A 0.57
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YJR102C 0.57
VPS25
Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
YGR287C 0.57 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to alpha-D-glucosidase (maltase); authentic, non-tagged protein detected in purified mitochondria in high-throughput studies
YOR025W 0.57
HST3
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YDL007W 0.57
RPT2
One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
YKL062W 0.57
MSN4
Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YKR059W 0.56
TIF1
Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
YOR029W 0.56 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YEL068C 0.55 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL110C 0.55
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YNL118C 0.54
DCP2
Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family
YDL083C 0.54
RPS16B
Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins
YJL033W 0.54
HCA4
Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
YGL001C 0.54
ERG26
C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YHR182C-A 0.54 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL153W 0.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YDR261C 0.54
EXG2
Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YDR210W 0.54 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YGR294W 0.53
PAU12
Hypothetical protein
YOR063W 0.53
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YHL015W 0.52
RPS20
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YHR021C 0.51
RPS27B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YIL169C 0.51 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YJR076C 0.51
CDC11
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YGL209W 0.50
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YPL246C 0.50
RBD2
Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
YPL265W 0.49
DIP5
Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly
YER086W 0.48
ILV1
Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
YGR229C 0.48
SMI1
Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
YGR124W 0.48
ASN2
Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YHL003C 0.48
LAG1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YPL141C 0.48 Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YDL241W 0.47 Putative protein of unknown function; YDL241W is not an essential gene
YNL289W 0.47
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YOL085C 0.46 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YER088C-A 0.46 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR411W 0.46
CTR3
High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YER034W 0.46 Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage
YFR054C 0.46 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL097W 0.46
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YLR137W 0.46 Putative protein of unknown function
YOL016C 0.46
CMK2
Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II
YKL078W 0.46
DHR2
Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
YMR290W-A 0.45 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YKR013W 0.45
PRY2
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YBR138C 0.44 Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
YDR454C 0.44
GUK1
Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
YMR290C 0.44
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YGR106C 0.44
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YLR011W 0.44
LOT6
FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature
YER070W 0.44
RNR1
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YKR075C 0.44 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YDL019C 0.44
OSH2
Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YKL166C 0.44
TPK3
cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p
YDR292C 0.44
SRP101
Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p
YDR324C 0.44
UTP4
Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YOR143C 0.44
THI80
Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
YLR339C 0.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
YOL161C 0.43
PAU20
Hypothetical protein
YBR087W 0.43
RFC5
Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YDR534C 0.43
FIT1
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall

Network of associatons between targets according to the STRING database.

First level regulatory network of SOK2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.8 5.3 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.7 2.2 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.5 2.0 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
0.5 2.5 GO:0042710 biofilm formation(GO:0042710)
0.4 1.7 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.4 6.8 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.4 1.5 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.3 1.0 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.3 1.4 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.3 0.7 GO:0007188 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187) adenylate cyclase-modulating G-protein coupled receptor signaling pathway(GO:0007188)
0.3 0.3 GO:0071331 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.3 0.3 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.3 1.8 GO:0006491 N-glycan processing(GO:0006491)
0.3 0.9 GO:0043484 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
0.3 1.2 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.3 2.5 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.3 2.2 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.3 1.9 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.2 2.2 GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947)
0.2 0.7 GO:0035955 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.2 0.9 GO:0000296 spermine transport(GO:0000296)
0.2 0.7 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.2 1.4 GO:0045014 negative regulation of transcription from RNA polymerase II promoter by glucose(GO:0000433) negative regulation of transcription by glucose(GO:0045014)
0.2 0.8 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 2.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 0.8 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.2 0.6 GO:1900062 regulation of cell aging(GO:0090342) regulation of replicative cell aging(GO:1900062)
0.2 0.6 GO:0042992 negative regulation of transcription factor import into nucleus(GO:0042992)
0.2 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.2 0.6 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.2 0.6 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.2 0.2 GO:0042990 regulation of transcription factor import into nucleus(GO:0042990)
0.2 0.9 GO:0070813 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.2 1.2 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.2 0.9 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.2 21.5 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 1.1 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.2 0.5 GO:0006567 threonine catabolic process(GO:0006567)
0.2 1.6 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.2 0.2 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785)
0.1 0.4 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 1.0 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 0.4 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.1 1.1 GO:0033313 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.1 0.8 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.1 0.3 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.1 0.7 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.1 0.4 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.9 GO:0043102 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.1 0.4 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.1 1.0 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.7 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.1 0.1 GO:0000955 amino acid catabolic process via Ehrlich pathway(GO:0000955)
0.1 0.6 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.8 GO:0009098 leucine biosynthetic process(GO:0009098)
0.1 0.6 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.1 1.3 GO:0015758 glucose transport(GO:0015758)
0.1 1.0 GO:0031070 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.1 0.5 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.6 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.1 0.2 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571) G1 DNA damage checkpoint(GO:0044783) mitotic G1/S transition checkpoint(GO:0044819)
0.1 0.7 GO:0043457 regulation of cellular respiration(GO:0043457)
0.1 0.2 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.1 0.3 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.1 3.1 GO:0045047 protein targeting to ER(GO:0045047)
0.1 0.4 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.1 1.2 GO:0007120 axial cellular bud site selection(GO:0007120)
0.1 1.2 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.3 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.3 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 0.5 GO:0035392 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392)
0.1 0.5 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.1 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.4 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.1 0.1 GO:0010695 regulation of spindle pole body separation(GO:0010695)
0.1 0.3 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.1 0.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.3 GO:0000304 response to singlet oxygen(GO:0000304)
0.1 0.3 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.1 0.3 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.1 0.6 GO:0015833 peptide transport(GO:0015833)
0.1 0.3 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.4 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.1 0.4 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.1 0.8 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.1 0.3 GO:0030308 negative regulation of cell growth(GO:0030308) negative regulation of pseudohyphal growth(GO:2000221)
0.1 0.7 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 0.2 GO:0044209 AMP salvage(GO:0044209)
0.1 0.8 GO:0006272 leading strand elongation(GO:0006272)
0.1 0.2 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.1 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.3 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.4 GO:0046037 GMP metabolic process(GO:0046037)
0.1 0.1 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015)
0.1 0.2 GO:0009847 spore germination(GO:0009847)
0.1 0.4 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.1 0.1 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.1 1.1 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.3 GO:0007535 donor selection(GO:0007535)
0.1 0.6 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.1 1.7 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 0.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.1 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.1 3.1 GO:0007124 pseudohyphal growth(GO:0007124)
0.1 0.9 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.1 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.1 0.6 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 0.6 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.1 0.5 GO:0009306 protein secretion(GO:0009306)
0.1 0.1 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.1 0.5 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.1 0.2 GO:0007232 osmosensory signaling pathway via Sho1 osmosensor(GO:0007232)
0.1 0.4 GO:0006855 drug transmembrane transport(GO:0006855)
0.1 1.2 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.1 0.4 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.1 0.6 GO:0000084 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.1 0.1 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.1 0.2 GO:0006021 inositol biosynthetic process(GO:0006021)
0.1 0.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 0.8 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.1 1.0 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.1 0.1 GO:0006721 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.1 0.1 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.5 GO:0042559 folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound biosynthetic process(GO:0042559)
0.1 0.5 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 0.3 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) maintenance of protein localization in organelle(GO:0072595)
0.1 1.6 GO:0016129 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.1 0.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 0.2 GO:0045862 positive regulation of proteolysis(GO:0045862)
0.1 0.6 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 0.2 GO:0009099 valine biosynthetic process(GO:0009099)
0.1 0.4 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.0 0.7 GO:0017148 negative regulation of translation(GO:0017148) negative regulation of cellular amide metabolic process(GO:0034249)
0.0 2.9 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.0 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.0 0.3 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.6 GO:0010383 cell wall polysaccharide metabolic process(GO:0010383)
0.0 0.1 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.0 0.5 GO:0044774 mitotic DNA integrity checkpoint(GO:0044774)
0.0 0.1 GO:0015680 intracellular copper ion transport(GO:0015680)
0.0 1.1 GO:0006885 regulation of pH(GO:0006885)
0.0 0.2 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.4 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.8 GO:0030473 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.0 0.1 GO:0051051 negative regulation of transport(GO:0051051)
0.0 0.2 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.8 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.3 GO:0009263 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.9 GO:0051445 regulation of meiotic nuclear division(GO:0040020) regulation of meiotic cell cycle(GO:0051445)
0.0 0.2 GO:0044070 regulation of anion transport(GO:0044070)
0.0 0.3 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.2 GO:0015867 ATP transport(GO:0015867)
0.0 1.1 GO:0006414 translational elongation(GO:0006414)
0.0 0.0 GO:1902931 negative regulation of alcohol biosynthetic process(GO:1902931)
0.0 0.1 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 0.4 GO:0051028 mRNA transport(GO:0051028)
0.0 0.1 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 0.3 GO:0046470 phosphatidylcholine biosynthetic process(GO:0006656) ethanolamine-containing compound metabolic process(GO:0042439) phosphatidylcholine metabolic process(GO:0046470)
0.0 0.1 GO:0046087 cytidine metabolic process(GO:0046087)
0.0 3.8 GO:0006913 nucleocytoplasmic transport(GO:0006913)
0.0 0.2 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.1 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.0 0.2 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.2 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.0 0.2 GO:0008202 steroid metabolic process(GO:0008202) sterol metabolic process(GO:0016125)
0.0 0.2 GO:0000921 septin ring assembly(GO:0000921)
0.0 2.8 GO:0006364 rRNA processing(GO:0006364)
0.0 0.4 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.0 0.2 GO:0000741 karyogamy(GO:0000741)
0.0 0.2 GO:1903338 regulation of cell wall organization or biogenesis(GO:1903338)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0007329 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.0 0.1 GO:0006068 ethanol catabolic process(GO:0006068) acetate biosynthetic process(GO:0019413) primary alcohol catabolic process(GO:0034310)
0.0 0.1 GO:0048211 Golgi vesicle docking(GO:0048211)
0.0 0.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.0 0.5 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.1 GO:0090180 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of sulfur metabolic process(GO:0051176) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.0 0.2 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.1 GO:0046219 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.0 0.0 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.0 0.1 GO:0046083 adenine metabolic process(GO:0046083)
0.0 0.1 GO:0015809 arginine transport(GO:0015809)
0.0 0.2 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.1 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.0 0.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:0051046 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.0 0.2 GO:0006783 porphyrin-containing compound biosynthetic process(GO:0006779) heme biosynthetic process(GO:0006783) tetrapyrrole biosynthetic process(GO:0033014)
0.0 0.1 GO:0034517 ribophagy(GO:0034517)
0.0 0.1 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.3 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.0 GO:0033875 coenzyme A metabolic process(GO:0015936) nucleoside bisphosphate metabolic process(GO:0033865) ribonucleoside bisphosphate metabolic process(GO:0033875) purine nucleoside bisphosphate metabolic process(GO:0034032)
0.0 0.1 GO:0015883 FAD transport(GO:0015883)
0.0 0.1 GO:0044038 cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.0 0.5 GO:0006413 translational initiation(GO:0006413)
0.0 0.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.2 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.2 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.4 GO:0006400 tRNA modification(GO:0006400)
0.0 0.1 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.5 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.0 GO:0031292 gene conversion at mating-type locus, DNA double-strand break processing(GO:0031292)
0.0 0.1 GO:0044091 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.0 0.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.1 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.6 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.5 GO:0009135 purine nucleoside diphosphate metabolic process(GO:0009135) purine ribonucleoside diphosphate metabolic process(GO:0009179) ribonucleoside diphosphate metabolic process(GO:0009185) ADP metabolic process(GO:0046031)
0.0 0.1 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.1 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.0 0.0 GO:1901983 regulation of histone acetylation(GO:0035065) positive regulation of histone acetylation(GO:0035066) regulation of protein acetylation(GO:1901983) positive regulation of protein acetylation(GO:1901985) regulation of peptidyl-lysine acetylation(GO:2000756) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.3 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.0 0.2 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.0 0.0 GO:0051984 positive regulation of sister chromatid cohesion(GO:0045876) positive regulation of chromosome segregation(GO:0051984)
0.0 0.1 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.0 GO:0031047 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.0 0.0 GO:0016926 protein desumoylation(GO:0016926)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.5 1.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 4.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.3 0.3 GO:0030686 90S preribosome(GO:0030686)
0.3 15.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 1.0 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.2 1.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 0.7 GO:0031415 NatA complex(GO:0031415)
0.2 3.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 0.6 GO:0000814 ESCRT II complex(GO:0000814)
0.2 0.6 GO:0030428 cell septum(GO:0030428)
0.2 15.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 0.7 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.2 2.6 GO:0005940 septin ring(GO:0005940)
0.1 0.7 GO:0031389 DNA replication factor C complex(GO:0005663) Rad17 RFC-like complex(GO:0031389) Elg1 RFC-like complex(GO:0031391)
0.1 0.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.5 GO:0000818 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.1 0.4 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.1 0.4 GO:0005845 mRNA cap binding complex(GO:0005845)
0.1 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 1.0 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.1 1.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.5 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.1 0.8 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 2.3 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 0.1 GO:0005880 nuclear microtubule(GO:0005880)
0.1 0.6 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.3 GO:0046930 pore complex(GO:0046930)
0.1 0.6 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.5 GO:0034455 t-UTP complex(GO:0034455)
0.1 0.3 GO:0000938 GARP complex(GO:0000938)
0.1 0.4 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 0.6 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.4 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.5 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.9 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.2 GO:0008275 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.1 0.7 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.2 GO:0097344 Rix1 complex(GO:0097344)
0.1 0.4 GO:0042555 MCM complex(GO:0042555)
0.1 0.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 11.4 GO:0005730 nucleolus(GO:0005730)
0.1 0.4 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 0.2 GO:0031518 CBF3 complex(GO:0031518)
0.1 0.2 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.1 0.4 GO:0016459 myosin complex(GO:0016459)
0.0 0.6 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.3 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 0.2 GO:0044453 nuclear membrane part(GO:0044453)
0.0 0.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 1.2 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.3 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.1 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.0 0.2 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.6 GO:0044445 cytosolic part(GO:0044445)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.6 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.3 GO:0005791 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.1 GO:0034518 RNA cap binding complex(GO:0034518)
0.0 2.2 GO:0000922 spindle pole(GO:0000922)
0.0 0.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.2 GO:0034044 exomer complex(GO:0034044)
0.0 0.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.4 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.1 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.0 1.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0000346 transcription export complex(GO:0000346)
0.0 0.1 GO:0071819 DUBm complex(GO:0071819)
0.0 0.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.3 GO:0030133 transport vesicle(GO:0030133)
0.0 0.1 GO:0043529 GET complex(GO:0043529)
0.0 0.1 GO:0032301 MutSalpha complex(GO:0032301)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 1.2 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.3 GO:0035770 ribonucleoprotein granule(GO:0035770) cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.2 GO:0042597 periplasmic space(GO:0042597)
0.0 0.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:0036452 ESCRT complex(GO:0036452)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.4 GO:0070847 core mediator complex(GO:0070847)
0.0 0.2 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.1 GO:0070985 TFIIK complex(GO:0070985)
0.0 0.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0000133 polarisome(GO:0000133)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.1 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.2 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.1 GO:0000142 cellular bud neck contractile ring(GO:0000142)
0.0 0.0 GO:0070823 HDA1 complex(GO:0070823)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0016841 ammonia-lyase activity(GO:0016841)
0.6 3.7 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.5 2.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.5 1.5 GO:0072341 modified amino acid binding(GO:0072341)
0.5 1.9 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.4 2.2 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.3 1.0 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.3 2.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.3 1.3 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.3 1.6 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.3 0.9 GO:0070568 guanylyltransferase activity(GO:0070568)
0.3 1.8 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3 0.8 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.3 0.8 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.3 6.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 1.0 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.2 0.9 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.2 1.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 0.6 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.2 1.0 GO:0008443 phosphofructokinase activity(GO:0008443)
0.2 1.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 0.8 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 0.6 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.2 0.2 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.2 0.6 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.2 1.1 GO:0016790 C-acyltransferase activity(GO:0016408) thiolester hydrolase activity(GO:0016790)
0.2 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 1.6 GO:0005516 calmodulin binding(GO:0005516)
0.2 0.5 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.2 0.5 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.1 0.4 GO:0042973 beta-glucosidase activity(GO:0008422) glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.1 0.9 GO:0015248 sterol transporter activity(GO:0015248)
0.1 1.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 28.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 1.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.6 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.1 0.7 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.4 GO:0019003 GDP binding(GO:0019003)
0.1 0.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.8 GO:0016778 diphosphotransferase activity(GO:0016778)
0.1 0.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.9 GO:1901681 sulfur compound binding(GO:1901681)
0.1 1.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.5 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.1 0.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.7 GO:0019201 nucleotide kinase activity(GO:0019201)
0.1 0.5 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.1 0.3 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.1 0.4 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.3 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.1 0.3 GO:0009922 fatty acid elongase activity(GO:0009922)
0.1 0.3 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1 0.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.3 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 0.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 1.8 GO:0019213 deacetylase activity(GO:0019213)
0.1 0.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.4 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.3 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 0.4 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 1.7 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 0.3 GO:0022829 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.1 0.3 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 0.7 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 0.3 GO:0004771 sterol esterase activity(GO:0004771)
0.1 1.4 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 2.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.3 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.4 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.1 0.3 GO:0019206 nucleoside kinase activity(GO:0019206)
0.1 0.2 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.1 0.6 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.1 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.2 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 0.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.2 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 1.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 3.6 GO:0003924 GTPase activity(GO:0003924)
0.1 0.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.6 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 0.8 GO:0000049 tRNA binding(GO:0000049)
0.1 0.4 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.1 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.5 GO:0003724 RNA helicase activity(GO:0003724)
0.1 0.4 GO:0031386 protein tag(GO:0031386)
0.1 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.3 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129)
0.1 0.6 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 0.5 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.7 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.2 GO:0005034 osmosensor activity(GO:0005034)
0.0 0.1 GO:0016872 intramolecular lyase activity(GO:0016872)
0.0 0.1 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.0 2.6 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.5 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 1.6 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.7 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.3 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.0 0.4 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.0 1.4 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.5 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.2 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.1 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.1 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.3 GO:0010181 FMN binding(GO:0010181)
0.0 0.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 1.0 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 1.4 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 0.1 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.3 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.0 0.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.3 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 0.1 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 0.1 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.0 0.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.3 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.3 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.1 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.6 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 0.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.2 GO:0019843 rRNA binding(GO:0019843)
0.0 0.5 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.0 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.1 GO:0000295 adenine nucleotide transmembrane transporter activity(GO:0000295)
0.0 0.3 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.2 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.1 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.0 0.1 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.1 GO:0051015 actin filament binding(GO:0051015)
0.0 0.0 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.0 0.3 GO:0016835 carbon-oxygen lyase activity(GO:0016835)
0.0 0.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.0 0.1 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.2 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.4 1.5 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 0.8 PID P73PATHWAY p73 transcription factor network
0.2 0.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.3 PID SHP2 PATHWAY SHP2 signaling
0.1 0.1 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.1 0.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 0.8 PID ATR PATHWAY ATR signaling pathway
0.1 0.1 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.1 PID E2F PATHWAY E2F transcription factor network
0.0 0.3 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 0.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.0 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.1 NABA MATRISOME Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 1.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.6 5.0 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.5 1.8 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.4 0.7 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.3 1.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.3 4.1 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.2 0.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 0.7 REACTOME GPCR DOWNSTREAM SIGNALING Genes involved in GPCR downstream signaling
0.2 0.7 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.2 0.3 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.1 0.6 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 0.3 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.1 0.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 1.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 0.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.1 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 0.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.1 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.0 0.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.0 REACTOME CELL CYCLE MITOTIC Genes involved in Cell Cycle, Mitotic
0.0 0.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins