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Results for SNT2

Z-value: 0.73

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Transcription factors associated with SNT2

Gene Symbol Gene ID Gene Info
SNT2
S000003099 DNA binding protein with similarity to the S. pombe Snt2 protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SNT2YGL131C0.924.8e-11Click!

Activity profile of SNT2 motif

Sorted Z-values of SNT2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YMR107W 9.05
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YJR095W 5.93
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YLR327C 4.74
TMA10
Protein of unknown function that associates with ribosomes
YIL160C 4.25
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YBL075C 3.63
SSA3
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YJR078W 3.44
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YAL039C 3.20
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YOR343C 3.05 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YAR050W 2.84
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YHR138C 2.60 Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YOR348C 2.47
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YMR096W 2.39
SNZ1
Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
YDR536W 2.37
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YLR149C 2.35 Putative protein of unknown function; YLR149C is not an essential gene
YBR145W 2.35
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YAR047C 2.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR091W 2.13
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YPR184W 2.11
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YGL121C 2.09
GPG1
Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Grp1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p
YPR027C 2.06 Putative protein of unknown function
YIL055C 2.06 Putative protein of unknown function
YPR010C-A 2.06 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YLR205C 1.99
HMX1
ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1
YDL169C 1.98
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YDL214C 1.83
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YPR120C 1.78
CLB5
B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
YMR141C 1.73 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR438W 1.66
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YBR144C 1.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
YHR211W 1.60
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YMR090W 1.60 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YJR128W 1.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YCL038C 1.55
ATG22
Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
YPL017C 1.51
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YNL133C 1.48
FYV6
Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining
YNL274C 1.47
GOR1
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR542W 1.47
PAU10
Hypothetical protein
YGL073W 1.47
HSF1
Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
YMR095C 1.43
SNO1
Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
YJL037W 1.43
IRC18
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YOL025W 1.41
LAG2
Protein involved in determination of longevity; LAG2 gene is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cells
YDL138W 1.39
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YGR043C 1.39
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YJR077C 1.38
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YLR437C-A 1.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YER084W 1.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL020C 1.33
SPT23
ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
YBR117C 1.33
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YFL007W 1.28
BLM10
Proteosome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
YDR277C 1.27
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YHR160C 1.27
PEX18
Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p
YMR118C 1.27 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YPL164C 1.24
MLH3
Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability
YEL009C 1.24
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YDL114W 1.24 Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene
YML120C 1.22
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YEL008W 1.20 Hypothetical protein predicted to be involved in metabolism
YOR011W-A 1.20 Putative protein of unknown function
YEL028W 1.18 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR019W-A 1.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR316C-B 1.15 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL093W 1.15
SPC105
Protein required for accurate chromosome segregation, localizes to the nuclear side of the spindle pole body; forms a complex with Ydr532cp
YGL074C 1.15 Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
YLR111W 1.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR307W 1.13
CDA1
Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YBR180W 1.13
DTR1
Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
YER121W 1.13 Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YMR017W 1.12
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YBR179C 1.12
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YHR008C 1.12
SOD2
Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
YFR053C 1.11
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YBR208C 1.10
DUR1,2
Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YOR152C 1.10 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YOR148C 1.08
SPP2
Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
YJR151C 1.06
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YPL258C 1.03
THI21
Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
YAR019C 1.03
CDC15
Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
YMR317W 1.02 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YOR186W 1.02 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YBR071W 1.02 Putative protein of unknown function; (GFP)-fusion and epitope-tagged proteins localize to the cytoplasm; mRNA expression may be regulated by the cell cycle and/or cell wall stress
YFL055W 1.02
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YLR142W 1.01
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YML054C 1.01
CYB2
Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YLR377C 1.00
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YJR106W 0.98
ECM27
Non-essential protein of unknown function
YDR343C 0.96
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YER187W 0.96 Putative protein of unknown function; induced in respiratory-deficient cells
YOR065W 0.95
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YDR446W 0.92
ECM11
Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
YGL170C 0.91
SPO74
Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
YDR070C 0.90
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL067C 0.89
RTG1
Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus
YIL107C 0.89
PFK26
6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A
YAR035W 0.89
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YEL009C-A 0.89 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNR002C 0.89
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YGL033W 0.87
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YOL100W 0.87
PKH2
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YHR082C 0.87
KSP1
Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation
YLR228C 0.84
ECM22
Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YEL007W 0.84 Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YLR176C 0.83
RFX1
Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
YJL038C 0.83
LOH1
Putative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W
YBR077C 0.83
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YDR216W 0.82
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YOL060C 0.82
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YNL240C 0.81
NAR1
Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf
YBR212W 0.81
NGR1
RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase
YER167W 0.81
BCK2
Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YLR402W 0.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL139C 0.79
SCM3
Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p
YOR386W 0.78
PHR1
DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p
YLR403W 0.78
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YLL056C 0.78 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YMR279C 0.77 Putative protein of unknown function; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene
YJL093C 0.77
TOK1
Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YHR002W 0.76
LEU5
Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized
YBR139W 0.76 Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
YOR235W 0.74
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YDR218C 0.72
SPR28
Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
YHR125W 0.72 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR256W 0.70
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YDL130W-A 0.70
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YLR035C 0.70
MLH2
Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p
YCL069W 0.67
VBA3
Permease of basic amino acids in the vacuolar membrane
YGR053C 0.67 Putative protein of unknown function
YHR210C 0.67 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YNL223W 0.66
ATG4
Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation; mediates attachment of autophagosomes to microtubules through interactions with Tub1p and Tub2p
YKL023W 0.65 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YOL026C 0.65
MIM1
Mitochondrial outer membrane protein, required for assembly of the translocase of the outer membrane (TOM) complex and thereby for mitochondrial protein import; N terminus is exposed to the cytosol: transmembrane segment is highly conserved
YGR110W 0.65 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YJR115W 0.63 Putative protein of unknown function
YEL010W 0.60 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKR021W 0.60
ALY1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YPR023C 0.59
EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YCL025C 0.59
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YAL034C 0.59
FUN19
Non-essential protein of unknown function
YGL094C 0.58
PAN2
Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
YGL096W 0.58
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YOR062C 0.58 Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YDR247W 0.58
VHS1
Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YBL100C 0.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YOR072W 0.57 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YJR085C 0.57 Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL099W 0.57
ATP1
Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YDR287W 0.56
INM2
Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
YPR054W 0.56
SMK1
Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
YEL059W 0.56 Dubious open reading frame unlikely to encode a functional protein
YBR039W 0.55
ATP3
Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YJL116C 0.55
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YIR014W 0.55 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene
YKL217W 0.55
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YDR090C 0.54 Putative protein of unknown function
YGL197W 0.54
MDS3
Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions
YMR053C 0.54
STB2
Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p
YPL214C 0.53
THI6
Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
YLR122C 0.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YHR075C 0.52
PPE1
Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
YDR541C 0.52 Putative dihydrokaempferol 4-reductase
YAR053W 0.50 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR041W 0.50
BUD9
Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
YDL054C 0.50
MCH1
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YMR170C 0.49
ALD2
Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YIL057C 0.48 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YAL001C 0.48
TFC3
Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
YDR014W-A 0.48
HED1
Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase
YDR282C 0.48 Putative protein of unknown function
YLL055W 0.48
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YKL028W 0.47
TFA1
TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YKR040C 0.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
YBR209W 0.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene
YKR049C 0.47
FMP46
Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL025C 0.47
SSN8
Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance
YKL171W 0.46 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YER098W 0.46
UBP9
Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YLR346C 0.46 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YLR123C 0.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YLR425W 0.46
TUS1
Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
YOR382W 0.46
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YFR007W 0.46
YFH7
Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YPR169W-A 0.45 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B
YKR105C 0.45
VBA5
Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny
YGL236C 0.45
MTO1
Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
YMR041C 0.45
ARA2
NAD-dependent arabinose dehydrogenase, involved in biosynthesis of erythroascorbic acid; similar to plant L-galactose dehydrogenase
YOR071C 0.45
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YGL163C 0.45
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YDR445C 0.45 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL092W 0.44
SRS2
DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
YCR073W-A 0.44
SOL2
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p
YGR048W 0.44
UFD1
Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol
YPL006W 0.44
NCR1
Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
YNR019W 0.43
ARE2
Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen
YCL040W 0.42
GLK1
Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YLR070C 0.42
XYL2
Xylitol dehydrogenase, converts xylitol to D-xylulose in the endogenous xylose utilization pathway
YLR454W 0.42
FMP27
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR124W 0.42
CTR1
High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels
YPR123C 0.42 Hypothetical protein
YBR083W 0.42
TEC1
Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member
YDR085C 0.42
AFR1
Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; required for Spa2p to recruit Mpk1p to shmoo tip during mating; interacts with Cdc12p
YER097W 0.41 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Network of associatons between targets according to the STRING database.

First level regulatory network of SNT2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:0015740 C4-dicarboxylate transport(GO:0015740)
1.1 3.2 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.7 4.4 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.7 1.5 GO:0032006 regulation of TOR signaling(GO:0032006)
0.7 3.4 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.6 2.6 GO:0015804 neutral amino acid transport(GO:0015804)
0.6 2.2 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.5 2.1 GO:0006527 arginine catabolic process(GO:0006527)
0.5 1.9 GO:0046323 glucose import(GO:0046323)
0.5 1.4 GO:0009593 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.5 2.3 GO:0015793 glycerol transport(GO:0015793)
0.4 1.3 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559) positive regulation of fatty acid biosynthetic process(GO:0045723)
0.4 2.0 GO:0005980 glycogen catabolic process(GO:0005980)
0.4 3.3 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.4 1.2 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.4 3.6 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.4 1.2 GO:0006000 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.4 1.6 GO:0042357 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.4 5.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.4 1.1 GO:0043419 urea metabolic process(GO:0019627) urea catabolic process(GO:0043419)
0.4 1.1 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.4 1.1 GO:0006089 lactate metabolic process(GO:0006089)
0.4 2.2 GO:0006279 premeiotic DNA replication(GO:0006279)
0.4 1.8 GO:0046185 aldehyde catabolic process(GO:0046185)
0.3 1.0 GO:0006562 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.3 2.3 GO:0006007 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.3 1.5 GO:0034486 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.3 0.9 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.3 1.2 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.3 1.2 GO:0001315 age-dependent response to reactive oxygen species(GO:0001315)
0.3 3.7 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.3 0.8 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.2 0.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 1.4 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.2 1.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.2 0.9 GO:0071396 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.2 1.5 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.2 1.9 GO:0045332 phospholipid translocation(GO:0045332)
0.2 0.8 GO:0006848 pyruvate transport(GO:0006848)
0.2 1.0 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.2 0.6 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.2 0.8 GO:0051503 adenine nucleotide transport(GO:0051503)
0.2 0.6 GO:0046838 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.2 0.9 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.2 0.9 GO:0032105 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.2 1.2 GO:0051322 anaphase(GO:0051322)
0.2 0.7 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.2 0.6 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.2 0.5 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.1 0.4 GO:0015888 thiamine transport(GO:0015888)
0.1 0.9 GO:0051098 regulation of binding(GO:0051098)
0.1 0.7 GO:0015758 glucose transport(GO:0015758)
0.1 0.7 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 1.5 GO:0045931 positive regulation of mitotic cell cycle(GO:0045931)
0.1 0.5 GO:0006598 polyamine catabolic process(GO:0006598)
0.1 1.2 GO:0015802 basic amino acid transport(GO:0015802)
0.1 0.4 GO:1903339 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.1 0.4 GO:0006559 L-phenylalanine catabolic process(GO:0006559) tyrosine catabolic process(GO:0006572) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.1 0.5 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.8 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.1 0.9 GO:0000411 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.1 1.2 GO:0006817 phosphate ion transport(GO:0006817)
0.1 0.4 GO:0032079 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1 0.7 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.4 GO:0019568 arabinose metabolic process(GO:0019566) arabinose catabolic process(GO:0019568)
0.1 0.6 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.3 GO:0071281 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.1 0.9 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 0.8 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.1 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.8 GO:0043487 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.1 1.3 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.1 0.5 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.4 GO:0051180 vitamin transport(GO:0051180)
0.1 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.3 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.2 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 1.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.2 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.1 0.1 GO:0015691 cadmium ion transport(GO:0015691)
0.1 0.3 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.1 0.2 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099)
0.1 0.7 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.1 0.8 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.1 0.4 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.1 1.1 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.1 0.3 GO:0031134 sister chromatid biorientation(GO:0031134)
0.1 0.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 0.4 GO:0015677 copper ion import(GO:0015677)
0.1 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.8 GO:0007129 synapsis(GO:0007129)
0.0 0.9 GO:0019740 nitrogen utilization(GO:0019740)
0.0 0.4 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 1.1 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.2 GO:0015883 FAD transport(GO:0015883)
0.0 0.2 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.6 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 2.0 GO:0001403 invasive growth in response to glucose limitation(GO:0001403)
0.0 0.3 GO:0015891 siderophore transport(GO:0015891)
0.0 0.4 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
0.0 1.8 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.2 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.0 0.3 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.2 GO:0006452 translational frameshifting(GO:0006452)
0.0 0.2 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.3 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.2 GO:0051569 positive regulation of histone methylation(GO:0031062) regulation of histone H3-K4 methylation(GO:0051569)
0.0 1.0 GO:1903050 regulation of proteasomal protein catabolic process(GO:0061136) regulation of proteolysis involved in cellular protein catabolic process(GO:1903050) regulation of cellular protein catabolic process(GO:1903362)
0.0 0.1 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.1 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.3 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.0 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.0 0.9 GO:0071940 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.0 0.1 GO:0016559 mitochondrial fission(GO:0000266) peroxisome fission(GO:0016559)
0.0 0.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.0 0.2 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.0 0.4 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.1 GO:0001041 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.0 0.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.0 GO:0009746 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.0 0.1 GO:0015858 nucleoside transport(GO:0015858)
0.0 0.1 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.0 0.1 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.1 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.0 0.3 GO:0016237 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.0 0.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.2 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.0 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.0 0.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.3 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.0 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.0 GO:0000076 DNA replication checkpoint(GO:0000076) replication fork protection(GO:0048478)
0.0 0.4 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.3 GO:0022900 electron transport chain(GO:0022900)
0.0 0.1 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.0 0.2 GO:0003333 amino acid transmembrane transport(GO:0003333)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.4 4.6 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 1.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 0.7 GO:0032389 MutLalpha complex(GO:0032389)
0.2 0.7 GO:0072687 meiotic spindle(GO:0072687)
0.2 1.1 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.2 1.1 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 0.8 GO:0034448 EGO complex(GO:0034448)
0.2 1.2 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.4 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.1 0.5 GO:0001400 mating projection base(GO:0001400)
0.1 2.2 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.6 GO:0032221 Rpd3S complex(GO:0032221)
0.1 2.7 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 0.6 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.9 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 0.3 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 1.8 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.1 0.6 GO:0032126 eisosome(GO:0032126)
0.1 1.6 GO:0070469 respiratory chain(GO:0070469)
0.1 11.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 0.3 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.1 3.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.4 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.1 0.3 GO:0016587 Isw1 complex(GO:0016587)
0.1 0.7 GO:0005769 early endosome(GO:0005769)
0.1 0.2 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 0.3 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 0.6 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 1.3 GO:0044439 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.9 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.5 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.3 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0005771 multivesicular body(GO:0005771)
0.0 0.1 GO:0042597 periplasmic space(GO:0042597)
0.0 0.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.8 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 0.9 GO:0005874 microtubule(GO:0005874)
0.0 0.2 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.5 GO:0005576 extracellular region(GO:0005576)
0.0 0.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 7.7 GO:0005739 mitochondrion(GO:0005739)
0.0 0.1 GO:0031499 TRAMP complex(GO:0031499)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 5.8 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
1.1 4.4 GO:0005537 mannose binding(GO:0005537)
0.7 4.2 GO:0016408 C-acyltransferase activity(GO:0016408)
0.7 2.7 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.6 2.9 GO:0015295 solute:proton symporter activity(GO:0015295)
0.5 1.4 GO:0005536 glucose binding(GO:0005536)
0.4 2.7 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.4 1.3 GO:0016504 peptidase activator activity(GO:0016504)
0.4 2.5 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.4 1.2 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 1.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.4 3.1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.4 2.3 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.4 1.5 GO:0004396 hexokinase activity(GO:0004396)
0.4 1.1 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.3 0.9 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.3 1.4 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.3 0.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 1.1 GO:0004457 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.2 0.7 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.2 0.6 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.2 0.8 GO:0005261 cation channel activity(GO:0005261)
0.2 0.8 GO:0051185 coenzyme transporter activity(GO:0051185)
0.2 6.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.2 2.0 GO:0030983 mismatched DNA binding(GO:0030983)
0.2 2.1 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.2 0.5 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.1 0.4 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.1 0.8 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.4 GO:0004100 chitin synthase activity(GO:0004100)
0.1 1.3 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.1 1.3 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 1.5 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 0.4 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 0.6 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.4 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.1 0.8 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 1.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.5 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705)
0.1 0.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 0.3 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825) trehalose-phosphatase activity(GO:0004805)
0.1 0.3 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1 0.8 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.6 GO:0051184 cofactor transporter activity(GO:0051184)
0.1 0.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.9 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 2.8 GO:0004871 signal transducer activity(GO:0004871)
0.1 1.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 0.4 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.1 0.1 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.1 0.3 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.1 0.3 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 0.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 0.2 GO:0001025 transcription factor activity, core RNA polymerase III binding(GO:0000995) RNA polymerase III transcription factor binding(GO:0001025) TFIIIB-type transcription factor activity(GO:0001026) TFIIIC-class transcription factor binding(GO:0001156)
0.1 0.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.8 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.1 2.6 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.5 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 0.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 0.4 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.7 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 3.0 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.4 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 3.5 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.9 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.0 0.8 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.7 GO:0008017 microtubule binding(GO:0008017)
0.0 0.2 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 0.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.1 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.4 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.5 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0 0.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.3 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.0 1.0 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 0.1 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0001003 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III transcription factor binding(GO:0001007) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III regulatory region DNA binding(GO:0001016) RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034) transcription factor activity, RNA polymerase III transcription factor recruiting(GO:0001153) 5S rDNA binding(GO:0080084)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0004364 glutathione transferase activity(GO:0004364) glutathione peroxidase activity(GO:0004602)
0.0 0.5 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.5 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.0 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.1 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.2 GO:0008374 O-acyltransferase activity(GO:0008374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 PID FOXO PATHWAY FoxO family signaling
0.2 0.8 PID P73PATHWAY p73 transcription factor network
0.1 0.3 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 0.1 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 0.1 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 0.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 25.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.3 REACTOME MEIOSIS Genes involved in Meiosis
0.1 1.0 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.3 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 0.2 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 21.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.2 REACTOME TRANSCRIPTION Genes involved in Transcription
0.0 0.0 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane