Navigation
Downloads

Results for SIP4

Z-value: 2.84

Motif logo

logo of

Transcription factors associated with SIP4

Gene Symbol Gene ID Gene Info
SIP4
S000003625 Transcriptional activator that regulates gluconeogenic genes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIP4YJL089W0.981.8e-17Click!

Activity profile of SIP4 motif

Sorted Z-values of SIP4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YLR307C-A 82.73 Putative protein of unknown function
YJR095W 62.11
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YKR097W 51.78
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YNL117W 48.99
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YER065C 41.77
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YPL223C 26.06
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YKL217W 25.54
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YHR096C 25.50
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YOR100C 23.34
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YDR536W 22.26
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YCR005C 21.09
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YAR035W 20.30
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YML042W 17.98
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YPL054W 15.29
LEE1
Zinc-finger protein of unknown function
YER024W 14.37
YAT2
Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
YAL054C 13.22
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YJL045W 12.81 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YBL015W 12.12
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YLR308W 11.95
CDA2
Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YLR377C 11.94
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YBR296C 11.63
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YGR067C 11.58 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YBR147W 11.40
RTC2
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YPL222W 10.88
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL089W 10.09
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YBR051W 9.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YBR050C 9.00
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YFL030W 8.93
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YER066W 8.91 Putative protein of unknown function; YER066W is not an essential gene
YAR053W 8.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR186C-A 8.84 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YKL163W 8.82
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YDR542W 8.66
PAU10
Hypothetical protein
YFL024C 8.31
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YBR230C 7.70
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YHR211W 7.34
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YLR004C 7.33
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YNL194C 7.25 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YPL021W 7.20
ECM23
Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
YLR296W 7.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR146W 6.98 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YOR338W 6.56 Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen
YER088C 6.53
DOT6
Protein of unknown function, involved in telomeric gene silencing and filamentation
YPR026W 6.49
ATH1
Acid trehalase required for utilization of extracellular trehalose
YMR017W 6.44
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YNR064C 6.33 Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
YAR060C 6.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR033W 5.99 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YMR191W 5.96
SPG5
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YOL126C 5.95
MDH2
Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
YMR135C 5.85
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YMR175W 5.78
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YOR343C 5.69 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YLR295C 5.58
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YIL146C 5.56
ECM37
Non-essential protein of unknown function
YIR039C 5.51
YPS6
Putative GPI-anchored aspartic protease
YGL096W 5.44
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YEL059W 5.37 Dubious open reading frame unlikely to encode a functional protein
YGR043C 5.30
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YGR065C 5.30
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YPR009W 5.29
SUT2
Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
YML131W 5.29 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YMR081C 5.19
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YIL066C 4.91
RNR3
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YEL024W 4.88
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YLR111W 4.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL134C 4.69
ODC1
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YFL055W 4.66
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YPR153W 4.60 Putative protein of unknown function
YPL036W 4.53
PMA2
Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YPR036W-A 4.48 Protein of unknown function; transcription is regulated by Pdr1p
YIL045W 4.48
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YPL061W 4.43
ALD6
Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YDR541C 4.40 Putative dihydrokaempferol 4-reductase
YMR103C 4.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL104C 4.36
VPS73
Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family
YGR289C 4.26
MAL11
Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; broad substrate specificity that includes maltotriose
YJR152W 4.21
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YFR033C 4.20
QCR6
Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
YGL208W 4.15
SIP2
One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane
YDR034C 4.14
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YER158C 4.04 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YHR095W 4.04 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL163C 4.03 Putative protein of unknown function
YHR086W 3.98
NAM8
RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA
YPR078C 3.94 Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YKR011C 3.87 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YDR342C 3.87
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YPL206C 3.80
PGC1
Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs
YBR200W-A 3.78 Putative protein of unknown function; identified by fungal homology and RT-PCR
YOR348C 3.71
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YDL244W 3.71
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YJR008W 3.64 Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source.
YGR290W 3.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)
YLR235C 3.51 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3
YBR212W 3.51
NGR1
RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase
YIL086C 3.47 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR230W-A 3.44 Putative protein of unknown function
YLR173W 3.44 Putative protein of unknown function
YDR223W 3.40
CRF1
Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus
YNL055C 3.38
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YLL019C 3.37
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YPL150W 3.32 Putative protein kinase of unknown cellular role
YML129C 3.31
COX14
Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
YKL044W 3.31 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR236C 3.31 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL115C 3.30 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
YML058W 3.22
SML1
Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
YDR042C 3.19 Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
YLR346C 3.18 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YGL177W 3.18 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR210C 3.18 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YDR275W 3.17
BSC2
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YJR061W 3.16 Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p
YDR171W 3.09
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YDR205W 3.04
MSC2
Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
YLR297W 3.01 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YGL192W 2.97
IME4
Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YGL193C 2.95 Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YPR120C 2.89
CLB5
B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
YJL100W 2.89
LSB6
Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YJR155W 2.87
AAD10
Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
YBR292C 2.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YBR045C 2.85
GIP1
Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
YBR056W-A 2.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YDR216W 2.83
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YIL055C 2.82 Putative protein of unknown function
YNL104C 2.81
LEU4
Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YCR007C 2.71 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YNL332W 2.70
THI12
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YDL246C 2.69
SOR2
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YMR206W 2.65 Putative protein of unknown function; YMR206W is not an essential gene
YKL093W 2.63
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YLR237W 2.62
THI7
Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
YIL087C 2.62
LRC2
Putative protein of unknown function; protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YPR145C-A 2.59 Putative protein of unknown function
YDR258C 2.59
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YDR256C 2.59
CTA1
Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation
YLL029W 2.58
FRA1
Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
YHR139C 2.54
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YFL023W 2.53
BUD27
Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by TOR kinase; diploid mutants show a random budding pattern rather than the wild-type bipolar pattern; plays a role in regulating Ty1 transposition
YGR087C 2.52
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YPL183W-A 2.46
RTC6
Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome; null mutation suppresses cdc13-1 temperature sensitivity
YER053C 2.46
PIC2
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
YGR292W 2.45
MAL12
Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus
YBR201C-A 2.44 Putative protein of unknown function
YDL243C 2.37
AAD4
Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YJR160C 2.34
MPH3
Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication
YJR147W 2.33
HMS2
Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YIL160C 2.33
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YGL139W 2.32
FLC3
Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER
YPR127W 2.31 Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YHR071W 2.31
PCL5
Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YPL151C 2.28
PRP46
Splicing factor that is found in the Cef1p subcomplex of the spliceosome
YMR174C 2.27
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YPR027C 2.26 Putative protein of unknown function
YDR186C 2.25 Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YNL103W 2.25
MET4
Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
YHR009C 2.25 Putative protein of unknown function; not an essential gene
YAL005C 2.22
SSA1
ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
YHR048W 2.22
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YDL204W 2.22
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YNL015W 2.21
PBI2
Cytosolic inhibitor of vacuolar proteinase B, required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion
YIL143C 2.17
SSL2
Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3
YKL043W 2.16
PHD1
Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YBR054W 2.12
YRO2
Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YKL109W 2.12
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YKL221W 2.08
MCH2
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YER167W 2.07
BCK2
Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YGR184C 2.06
UBR1
Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome
YDR379W 2.03
RGA2
GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
YGL140C 2.03 Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
YLR140W 2.03 Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I
YNL243W 2.02
SLA2
Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo
YFL041W 2.02
FET5
Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
YPL024W 2.01
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YNL005C 2.01
MRP7
Mitochondrial ribosomal protein of the large subunit
YLR122C 1.98 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YHR180W 1.98 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL156W 1.97
HXT11
Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance
YNR002C 1.96
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YDL245C 1.94
HXT15
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YOL157C 1.93 Putative protein of unknown function
YER101C 1.91
AST2
Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
YPL058C 1.89
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YPL026C 1.89
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YNL250W 1.88
RAD50
Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
YNL308C 1.88
KRI1
Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p
YGL255W 1.88
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YPL262W 1.84
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YMR172W 1.84
HOT1
Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
YMR272C 1.83
SCS7
Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YFL011W 1.82
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YDR406W 1.81
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YKR042W 1.81
UTH1
Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death
YIL136W 1.78
OM45
Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YOR316C 1.77
COT1
Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium
YKL159C 1.77
RCN1
Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region
YBR241C 1.76 Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
YEL070W 1.76
DSF1
Deletion suppressor of mpt5 mutation

Network of associatons between targets according to the STRING database.

First level regulatory network of SIP4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
20.7 62.1 GO:0015740 C4-dicarboxylate transport(GO:0015740)
17.6 52.7 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
12.2 109.5 GO:0006097 glyoxylate cycle(GO:0006097)
6.4 25.5 GO:0006848 pyruvate transport(GO:0006848)
5.0 10.1 GO:0061414 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
4.5 22.5 GO:0015793 glycerol transport(GO:0015793)
3.9 27.4 GO:0006083 acetate metabolic process(GO:0006083)
3.0 8.9 GO:0006545 glycine biosynthetic process(GO:0006545)
2.8 2.8 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
2.6 75.3 GO:0006094 gluconeogenesis(GO:0006094)
2.3 11.4 GO:0034487 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
2.2 11.0 GO:0006026 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
2.2 6.5 GO:0005993 trehalose catabolic process(GO:0005993)
1.5 10.8 GO:0016239 positive regulation of macroautophagy(GO:0016239)
1.5 4.5 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
1.4 4.3 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
1.4 8.3 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.4 5.5 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
1.3 4.0 GO:0050685 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024) positive regulation of mRNA processing(GO:0050685)
1.3 5.3 GO:0072367 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
1.3 9.0 GO:0000023 maltose metabolic process(GO:0000023)
1.2 9.2 GO:0051180 vitamin transport(GO:0051180)
1.1 4.5 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
1.1 3.4 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
1.1 10.8 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.1 11.7 GO:0006817 phosphate ion transport(GO:0006817)
1.1 4.3 GO:0016241 regulation of macroautophagy(GO:0016241) negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.9 5.6 GO:0042407 cristae formation(GO:0042407)
0.9 3.7 GO:0015804 neutral amino acid transport(GO:0015804)
0.9 2.6 GO:0043335 protein unfolding(GO:0043335)
0.8 3.4 GO:0044070 regulation of anion transport(GO:0044070)
0.8 9.2 GO:0015758 glucose transport(GO:0015758)
0.8 4.1 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.8 3.1 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.8 3.0 GO:0032071 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.7 6.7 GO:0006829 zinc II ion transport(GO:0006829)
0.7 2.9 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.7 1.3 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.6 0.6 GO:0051099 positive regulation of binding(GO:0051099)
0.6 0.6 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.6 2.5 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.6 4.9 GO:0070873 regulation of glycogen biosynthetic process(GO:0005979) regulation of glycogen metabolic process(GO:0070873)
0.6 4.2 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.6 1.8 GO:0005980 glycogen catabolic process(GO:0005980)
0.5 2.2 GO:0001109 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111) transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.5 0.5 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.5 1.6 GO:0090630 activation of GTPase activity(GO:0090630)
0.5 3.2 GO:0071472 cellular response to salt stress(GO:0071472)
0.5 2.6 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.5 3.1 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.5 2.1 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.5 1.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.5 2.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.5 6.0 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.5 1.4 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.5 6.9 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.5 2.7 GO:0019388 galactose catabolic process(GO:0019388)
0.4 2.2 GO:0043954 cellular component maintenance(GO:0043954)
0.4 1.7 GO:0006012 galactose metabolic process(GO:0006012)
0.4 5.4 GO:0006754 ATP biosynthetic process(GO:0006754)
0.4 0.4 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.4 2.5 GO:0019722 calcium-mediated signaling(GO:0019722)
0.4 1.2 GO:0031292 gene conversion at mating-type locus, DNA double-strand break processing(GO:0031292)
0.4 3.9 GO:0015893 drug transport(GO:0015893)
0.4 5.0 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.4 6.4 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.4 1.5 GO:0072417 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.4 0.4 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.4 1.8 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.4 2.9 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.4 1.1 GO:0072530 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.4 1.4 GO:0006103 2-oxoglutarate metabolic process(GO:0006103) aspartate family amino acid catabolic process(GO:0009068)
0.4 3.5 GO:0043487 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.4 4.6 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.3 0.7 GO:0034755 high-affinity iron ion transmembrane transport(GO:0006827) iron ion transmembrane transport(GO:0034755)
0.3 4.2 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.3 3.5 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.3 2.7 GO:0046686 response to cadmium ion(GO:0046686)
0.3 1.0 GO:0006527 arginine catabolic process(GO:0006527)
0.3 3.0 GO:0046777 protein autophosphorylation(GO:0046777)
0.3 0.7 GO:0000729 meiotic DNA double-strand break processing(GO:0000706) DNA double-strand break processing(GO:0000729)
0.3 1.6 GO:0000173 inactivation of MAPK activity involved in osmosensory signaling pathway(GO:0000173)
0.3 1.0 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.3 1.3 GO:0046688 response to copper ion(GO:0046688)
0.3 1.2 GO:0019748 secondary metabolic process(GO:0019748)
0.3 1.8 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.3 0.9 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.3 0.3 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.3 3.2 GO:0006826 iron ion transport(GO:0006826)
0.3 0.6 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.3 1.2 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.3 0.8 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.3 2.2 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.3 4.3 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.3 0.8 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.3 2.4 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.3 0.8 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.2 0.2 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.2 0.9 GO:0046503 glycerolipid catabolic process(GO:0046503)
0.2 0.9 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.2 11.0 GO:0009060 aerobic respiration(GO:0009060)
0.2 1.5 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.2 0.6 GO:0018195 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.2 0.8 GO:0060194 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.2 1.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 1.2 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.2 2.2 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.2 0.6 GO:0044273 sulfur compound catabolic process(GO:0044273)
0.2 1.2 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.2 6.4 GO:0000902 cell morphogenesis(GO:0000902)
0.2 1.5 GO:0007130 synaptonemal complex assembly(GO:0007130) meiotic sister chromatid cohesion(GO:0051177)
0.2 0.7 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.2 1.6 GO:0042766 nucleosome mobilization(GO:0042766)
0.2 0.5 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.2 1.0 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.2 1.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.2 0.9 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.2 0.7 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.2 0.5 GO:0019627 putrescine transport(GO:0015847) urea metabolic process(GO:0019627) urea catabolic process(GO:0043419)
0.2 0.8 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.2 0.5 GO:1902533 positive regulation of intracellular signal transduction(GO:1902533)
0.2 0.8 GO:0006828 manganese ion transport(GO:0006828)
0.2 4.3 GO:0043248 proteasome assembly(GO:0043248)
0.2 0.8 GO:0009208 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.1 0.9 GO:0051322 anaphase(GO:0051322)
0.1 0.4 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.1 0.7 GO:0001881 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.1 2.3 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.1 0.4 GO:2001247 positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
0.1 1.5 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.1 1.2 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 1.2 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.1 1.5 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.1 1.1 GO:0001558 regulation of cell growth(GO:0001558)
0.1 1.1 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 5.6 GO:0007124 pseudohyphal growth(GO:0007124)
0.1 1.1 GO:0031167 rRNA methylation(GO:0031167)
0.1 1.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 4.4 GO:0015849 organic acid transport(GO:0015849)
0.1 0.7 GO:0046337 phosphatidylethanolamine metabolic process(GO:0046337)
0.1 0.6 GO:0090435 protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
0.1 1.0 GO:0006119 oxidative phosphorylation(GO:0006119)
0.1 0.5 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.6 GO:0001041 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.1 0.6 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.1 1.4 GO:0023057 negative regulation of signal transduction(GO:0009968) negative regulation of cell communication(GO:0010648) negative regulation of signaling(GO:0023057)
0.1 0.2 GO:0090527 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.1 0.9 GO:0007129 synapsis(GO:0007129)
0.1 0.4 GO:0015883 FAD transport(GO:0015883)
0.1 0.5 GO:0006465 signal peptide processing(GO:0006465)
0.1 2.8 GO:0070590 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 0.3 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 0.8 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.1 1.5 GO:0031503 protein complex localization(GO:0031503)
0.1 0.5 GO:0030100 regulation of endocytosis(GO:0030100)
0.1 0.3 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.1 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.1 0.5 GO:0000266 mitochondrial fission(GO:0000266)
0.1 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.1 2.2 GO:0006631 fatty acid metabolic process(GO:0006631)
0.1 0.7 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.1 0.8 GO:0042493 response to drug(GO:0042493)
0.1 0.7 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.1 0.6 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.3 GO:0006452 translational frameshifting(GO:0006452)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 4.5 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.1 GO:0009847 spore germination(GO:0009847)
0.0 0.3 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.2 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.0 0.2 GO:0019933 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.0 1.3 GO:0044843 G1/S transition of mitotic cell cycle(GO:0000082) cell cycle G1/S phase transition(GO:0044843)
0.0 0.5 GO:0000001 mitochondrion inheritance(GO:0000001) mitochondrion distribution(GO:0048311)
0.0 0.1 GO:0045117 azole transport(GO:0045117)
0.0 0.3 GO:0006056 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0009607 response to biotic stimulus(GO:0009607)
0.0 1.6 GO:0072666 protein targeting to vacuole(GO:0006623) establishment of protein localization to vacuole(GO:0072666)
0.0 0.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.1 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.9 GO:0061025 membrane fusion(GO:0061025)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0009268 response to pH(GO:0009268)
0.0 0.8 GO:0006839 mitochondrial transport(GO:0006839)
0.0 0.4 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.5 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 0.2 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0051274 (1->6)-beta-D-glucan biosynthetic process(GO:0006078) beta-glucan biosynthetic process(GO:0051274)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 52.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
3.8 11.4 GO:0031166 integral component of vacuolar membrane(GO:0031166)
2.4 12.0 GO:0044426 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
1.6 12.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.4 8.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
1.1 3.4 GO:0046930 pore complex(GO:0046930)
1.1 3.2 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
1.0 9.1 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.0 6.8 GO:0034657 GID complex(GO:0034657)
0.8 4.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.8 148.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.7 9.9 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.6 1.9 GO:0030870 Mre11 complex(GO:0030870)
0.6 1.8 GO:0032177 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.6 1.2 GO:0032126 eisosome(GO:0032126)
0.5 3.3 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.5 2.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.5 7.5 GO:0033698 Rpd3L complex(GO:0033698)
0.5 3.0 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.5 3.2 GO:0000439 nucleotide-excision repair factor 3 complex(GO:0000112) core TFIIH complex(GO:0000439)
0.4 1.7 GO:0070469 respiratory chain(GO:0070469)
0.4 23.9 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 1.2 GO:0098562 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.4 1.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 3.0 GO:0042597 periplasmic space(GO:0042597)
0.3 1.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 6.8 GO:0031201 SNARE complex(GO:0031201)
0.3 1.4 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.3 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 2.4 GO:0000974 Prp19 complex(GO:0000974)
0.2 4.1 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.2 2.6 GO:0000243 commitment complex(GO:0000243)
0.2 2.5 GO:0005619 ascospore wall(GO:0005619)
0.2 1.3 GO:0033101 cellular bud membrane(GO:0033101)
0.2 2.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.2 1.1 GO:0031932 TORC2 complex(GO:0031932)
0.2 0.7 GO:0033309 SBF transcription complex(GO:0033309)
0.2 59.4 GO:0005886 plasma membrane(GO:0005886)
0.2 1.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.9 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.8 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.9 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 5.2 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.4 GO:0005784 Sec61 translocon complex(GO:0005784)
0.1 1.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.6 GO:0000796 transcription factor TFIIIC complex(GO:0000127) condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.1 0.3 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.1 2.2 GO:0005811 lipid particle(GO:0005811)
0.1 0.9 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.5 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.2 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 2.9 GO:0031965 nuclear membrane(GO:0031965)
0.1 1.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.4 GO:0005769 early endosome(GO:0005769)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.3 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 1.5 GO:0005643 nuclear pore(GO:0005643)
0.0 0.9 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.1 GO:0034990 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.0 0.2 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.6 GO:0061645 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.8 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 0.4 GO:0031984 organelle subcompartment(GO:0031984)
0.0 0.0 GO:0097196 Shu complex(GO:0097196)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
17.6 52.7 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
15.5 62.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
10.4 52.1 GO:0015295 solute:proton symporter activity(GO:0015295)
7.0 21.1 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
6.0 41.8 GO:0016833 oxo-acid-lyase activity(GO:0016833)
5.8 46.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
5.0 15.0 GO:0016208 AMP binding(GO:0016208)
4.0 12.1 GO:0016289 CoA hydrolase activity(GO:0016289)
3.0 9.1 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
2.8 53.1 GO:0016831 carboxy-lyase activity(GO:0016831)
2.4 11.9 GO:0050308 sugar-phosphatase activity(GO:0050308)
2.2 8.8 GO:0005537 mannose binding(GO:0005537)
2.2 6.5 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
1.5 12.4 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
1.5 4.5 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
1.5 17.4 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
1.4 8.5 GO:0051183 vitamin transporter activity(GO:0051183)
1.3 3.8 GO:0004629 phospholipase C activity(GO:0004629)
1.2 3.6 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
1.2 2.3 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.2 4.7 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
1.1 9.1 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.1 3.4 GO:0008308 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
1.0 14.3 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
1.0 4.9 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
1.0 17.6 GO:0015297 antiporter activity(GO:0015297)
0.9 1.8 GO:0019903 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.9 1.7 GO:0045118 azole transporter activity(GO:0045118)
0.8 6.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.8 4.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.8 3.3 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.8 2.4 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.7 3.7 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.7 13.8 GO:0019213 deacetylase activity(GO:0019213)
0.7 2.8 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.7 2.0 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.7 7.8 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.6 1.9 GO:0032183 SUMO binding(GO:0032183)
0.6 1.9 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.6 6.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.5 1.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.5 5.5 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.5 0.5 GO:0015489 putrescine transmembrane transporter activity(GO:0015489) spermidine transmembrane transporter activity(GO:0015606)
0.5 1.5 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.5 8.5 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.5 5.6 GO:0005199 structural constituent of cell wall(GO:0005199)
0.4 2.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 21.1 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.4 2.3 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.4 0.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 1.1 GO:0070336 flap-structured DNA binding(GO:0070336)
0.4 2.9 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.4 1.4 GO:0016417 S-acyltransferase activity(GO:0016417)
0.3 1.4 GO:0016725 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 2.0 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.3 1.7 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.3 1.9 GO:0000400 four-way junction DNA binding(GO:0000400)
0.3 8.3 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.3 0.9 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.3 2.1 GO:0005216 ion channel activity(GO:0005216)
0.3 1.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.3 1.4 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.3 6.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.3 1.8 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.2 7.2 GO:0005342 organic acid transmembrane transporter activity(GO:0005342)
0.2 0.9 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.2 1.1 GO:0008171 O-methyltransferase activity(GO:0008171)
0.2 0.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 0.6 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.2 1.7 GO:0004177 aminopeptidase activity(GO:0004177)
0.2 0.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 1.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 0.9 GO:0016530 metallochaperone activity(GO:0016530)
0.2 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 2.9 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.2 38.9 GO:0008270 zinc ion binding(GO:0008270)
0.2 0.8 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.2 0.8 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 1.1 GO:0005507 copper ion binding(GO:0005507)
0.1 0.9 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 0.4 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.1 0.7 GO:0017108 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) 5'-flap endonuclease activity(GO:0017108) flap endonuclease activity(GO:0048256)
0.1 0.2 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.1 GO:0016722 oxidoreductase activity, oxidizing metal ions(GO:0016722)
0.1 0.7 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.1 0.7 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 1.0 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 1.5 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 0.4 GO:0005034 osmosensor activity(GO:0005034)
0.1 0.6 GO:0001153 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034) transcription factor activity, RNA polymerase III transcription factor recruiting(GO:0001153) 5S rDNA binding(GO:0080084)
0.1 1.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 0.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.3 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 0.4 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.1 0.5 GO:0016408 C-acyltransferase activity(GO:0016408)
0.1 2.4 GO:0003678 DNA helicase activity(GO:0003678)
0.1 0.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.8 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 0.9 GO:0045182 translation regulator activity(GO:0045182)
0.1 1.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.3 GO:0015293 symporter activity(GO:0015293)
0.1 1.2 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 1.5 GO:0019900 kinase binding(GO:0019900)
0.1 0.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.0 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 1.3 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.1 0.8 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 0.9 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.2 GO:0015038 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 0.1 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 1.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.3 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.4 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 3.1 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.7 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.1 GO:0017171 serine hydrolase activity(GO:0017171)
0.0 0.3 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 0.7 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.2 GO:0000149 SNARE binding(GO:0000149)
0.0 0.2 GO:0003968 RNA polymerase II activity(GO:0001055) RNA-directed RNA polymerase activity(GO:0003968)
0.0 0.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 1.6 GO:0032403 protein complex binding(GO:0032403)
0.0 0.1 GO:0000384 first spliceosomal transesterification activity(GO:0000384) second spliceosomal transesterification activity(GO:0000386)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
17.3 51.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.7 4.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.7 2.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.6 1.9 PID ATM PATHWAY ATM pathway
0.3 0.6 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.3 2.0 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 0.4 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.2 0.3 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 199.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.1 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 69.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.3 3.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.7 1.4 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.7 2.0 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.5 2.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.3 1.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.2 0.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 0.3 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.1 2.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 0.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 197.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane