Results for SIP4
Z-value: 2.84
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Transcription factors associated with SIP4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SIP4
|
S000003625 | Transcriptional activator that regulates gluconeogenic genes |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YLR307C-A Show fit | 82.73 |
Putative protein of unknown function |
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| YJR095W Show fit | 62.11 |
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization |
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| YKR097W Show fit | 51.78 |
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
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| YNL117W Show fit | 48.99 |
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium |
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| YER065C Show fit | 41.77 |
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose |
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| YPL223C Show fit | 26.06 |
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway |
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| YKL217W Show fit | 25.54 |
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose |
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| YHR096C Show fit | 25.50 |
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs |
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| YOR100C Show fit | 23.34 |
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation |
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| YDR536W Show fit | 22.26 |
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIP4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.2 | 109.5 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 2.6 | 75.3 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 20.7 | 62.1 | GO:0015740 | C4-dicarboxylate transport(GO:0015740) |
| 17.6 | 52.7 | GO:0009437 | amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437) |
| 3.9 | 27.4 | GO:0006083 | acetate metabolic process(GO:0006083) |
| 6.4 | 25.5 | GO:0006848 | pyruvate transport(GO:0006848) |
| 4.5 | 22.5 | GO:0015793 | glycerol transport(GO:0015793) |
| 1.1 | 11.7 | GO:0006817 | phosphate ion transport(GO:0006817) |
| 2.3 | 11.4 | GO:0034487 | amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746) |
| 2.2 | 11.0 | GO:0006026 | aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 148.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 59.4 | GO:0005886 | plasma membrane(GO:0005886) |
| 4.4 | 52.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.4 | 23.9 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 1.6 | 12.7 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 2.4 | 12.0 | GO:0044426 | cell wall part(GO:0044426) external encapsulating structure part(GO:0044462) |
| 3.8 | 11.4 | GO:0031166 | integral component of vacuolar membrane(GO:0031166) |
| 0.7 | 9.9 | GO:0031307 | intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307) |
| 1.0 | 9.1 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 1.4 | 8.3 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.5 | 62.1 | GO:0015556 | C4-dicarboxylate transmembrane transporter activity(GO:0015556) |
| 2.8 | 53.1 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 17.6 | 52.7 | GO:0004092 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 10.4 | 52.1 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 5.8 | 46.6 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 6.0 | 41.8 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 0.2 | 38.9 | GO:0008270 | zinc ion binding(GO:0008270) |
| 7.0 | 21.1 | GO:0004108 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 0.4 | 21.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 1.0 | 17.6 | GO:0015297 | antiporter activity(GO:0015297) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 199.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 17.3 | 51.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.7 | 4.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.7 | 2.0 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.3 | 2.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.6 | 1.9 | PID ATM PATHWAY | ATM pathway |
| 0.3 | 0.6 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.2 | 0.4 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.2 | 0.3 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 0.1 | PID P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 197.4 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 7.7 | 69.7 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 1.3 | 3.8 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.5 | 2.1 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 2.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.7 | 2.0 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.7 | 1.4 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.3 | 1.1 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 0.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 0.6 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |