Results for SIG1
Z-value: 1.65
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Transcription factors associated with SIG1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
MOT2
|
S000000870 | Ubiquitin-protein ligase subunit of the CCR4-NOT complex |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YKR097W Show fit | 22.77 |
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
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| YBR117C Show fit | 17.34 |
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids |
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| YMR107W Show fit | 14.90 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YKL065W-A Show fit | 11.65 |
Putative protein of unknown function |
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| YJL089W Show fit | 11.59 |
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus |
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| YJR048W Show fit | 11.35 |
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration |
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| YCL040W Show fit | 11.13 |
Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources |
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| YFR017C Show fit | 11.04 |
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene |
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| YER158C Show fit | 10.94 |
Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p |
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| YCL042W Show fit | 10.81 |
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIG1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 38.1 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 1.1 | 28.9 | GO:0046364 | monosaccharide biosynthetic process(GO:0046364) |
| 1.3 | 22.9 | GO:0005978 | glycogen biosynthetic process(GO:0005978) |
| 1.5 | 22.1 | GO:0019682 | pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682) |
| 0.5 | 17.0 | GO:0006200 | obsolete ATP catabolic process(GO:0006200) |
| 0.9 | 15.4 | GO:0008645 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 3.8 | 15.3 | GO:0046323 | glucose import(GO:0046323) |
| 1.3 | 15.2 | GO:0006772 | thiamine metabolic process(GO:0006772) |
| 4.6 | 13.8 | GO:0061413 | regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414) |
| 2.7 | 13.7 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 46.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 36.0 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.2 | 28.2 | GO:0000329 | fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852) |
| 2.0 | 26.0 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.5 | 25.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 2.5 | 22.6 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 20.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.4 | 15.4 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.3 | 15.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 2.7 | 13.7 | GO:0005749 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 23.2 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 2.6 | 21.1 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.4 | 19.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 2.8 | 17.1 | GO:0016744 | transferase activity, transferring aldehyde or ketonic groups(GO:0016744) |
| 0.4 | 16.8 | GO:0016820 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.2 | 16.4 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 1.3 | 14.8 | GO:0015293 | symporter activity(GO:0015293) |
| 2.9 | 14.4 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 3.5 | 13.9 | GO:0004396 | hexokinase activity(GO:0004396) |
| 0.8 | 13.2 | GO:0020037 | heme binding(GO:0020037) tetrapyrrole binding(GO:0046906) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 213.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 8.2 | 24.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 3.5 | 10.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 1.3 | 6.3 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.6 | 3.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.9 | 1.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.4 | 1.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 1.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.3 | 0.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 0.4 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 209.7 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 2.9 | 25.7 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 3.6 | 10.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 3.1 | 9.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 3.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 3.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.9 | 2.6 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 2.0 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 1.5 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.3 | 1.1 | REACTOME HEMOSTASIS | Genes involved in Hemostasis |