Results for SIG1

Z-value: 1.65

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Transcription factors associated with SIG1

Gene Symbol Gene ID Gene Info
S000000870 Ubiquitin-protein ligase subunit of the CCR4-NOT complex

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of SIG1 motif

Sorted Z-values of SIG1 motif

Promoter Log-likelihood Transcript Gene Gene Info
YKR097W 22.77 Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YBR117C 17.34 Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YMR107W 14.90 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YKL065W-A 11.65 Putative protein of unknown function
YJL089W 11.59 C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YJR048W 11.35 Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YCL040W 11.13 Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YFR017C 11.04 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YER158C 10.94 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YCL042W 10.81 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YBL043W 10.55 Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YBR116C 10.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YKL163W 10.08 O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YJL133C-A 10.01 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR095W 9.57 Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YMR175W 8.88 Protein of unknown function whose expression is induced by osmotic stress
YGL121C 8.72 Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Grp1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p
YCL001W-B 8.51 Putative protein of unknown function; identified by homology
YNR034W-A 7.84 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YJR146W 7.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YNL194C 7.69 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YHR001W-A 7.59 Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YBL049W 7.58 Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YIL099W 7.38 Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YMR271C 7.38 Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YGR032W 7.34 Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YMR206W 7.08 Putative protein of unknown function; YMR206W is not an essential gene
YNL036W 7.01 Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YFR022W 6.98 Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YPR010C-A 6.94 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YAL054C 6.90 Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YJL166W 6.82 Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YML087C 6.82 Putative protein of unknown function; highly conserved across species and orthologous to human CYB5R4; null mutant shows increased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YDL210W 6.79 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YMR013C 6.57 Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YMR056C 6.55 Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YNL014W 6.42 Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YAL062W 6.41 NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YDR406W 6.34 Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YFL030W 6.31 Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YNL203C 6.26 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YPL165C 6.15 Protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
YIL057C 6.11 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YIL045W 5.99 Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YPL247C 5.89 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; YPL247C is not an essential gene
YBL074C 5.88 Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
YHR033W 5.86 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YPL222C-A 5.85 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YBL073W 5.83 Hypothetical protein; open reading frame overlaps 5' end of essential AAR2 gene encoding a component of the U5 snRNP required for splicing of U3 precursors
YDR540C 5.81 Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YLR174W 5.80 Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YAR035W 5.72 Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YGR243W 5.71 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL118C 5.69 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YKR034W 5.69 Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YPR191W 5.62 Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YDR231C 5.56 Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YOR348C 5.56 Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YPL171C 5.52 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YBL030C 5.46 Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene
YBR201C-A 5.41 Putative protein of unknown function
YLR122C 5.38 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YDR234W 5.38 Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
YFL011W 5.36 Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YKL177W 5.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YGL184C 5.25 Cystathionine beta-lyase, converts cystathionine into homocysteine
YDR453C 5.20 Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YOR343C 5.19 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YNL200C 5.15 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR343C 5.10 High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YLR377C 5.07 Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YBL015W 5.02 Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YER150W 5.01 GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YIL101C 4.95 Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YPR015C 4.89 Putative protein of unknown function
YOL119C 4.88 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YLR142W 4.81 Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YHR096C 4.81 Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YJL116C 4.78 Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YGR256W 4.78 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YLR350W 4.74 Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YDR232W 4.68 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YDR070C 4.63 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR066C 4.58 Putative protein of unknown function
YLR258W 4.58 Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YNL104C 4.53 Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YOL081W 4.51 GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YLR004C 4.43 Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YLR123C 4.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YHR092C 4.37 High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YBR101C 4.37 Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum
YLR152C 4.37 Putative protein of unknown function; YLR152C is not an essential gene
YDR178W 4.35 Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YJL199C 4.33 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YGL156W 4.28 Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
YFL058W 4.24 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YGR067C 4.24 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YOL035C 4.21 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER096W 4.19 Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
YLL053C 4.19 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YEL039C 4.18 Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YNL144C 4.11 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YNL037C 4.11 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YPL258C 4.08 Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
YDL138W 4.06 Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YKL067W 4.04 Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
YOR152C 4.01 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YKL217W 3.97 Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YHL035C 3.95 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ATP-binding cassette (ABC) family; potential Cdc28p substrate; detected in purified mitochondria in high-throughput studies
YKL178C 3.94 Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YEL011W 3.94 Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YKL141W 3.93 Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YPL058C 3.93 Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YER038W-A 3.92 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria
YEL065W 3.88 Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YBR147W 3.84 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YML042W 3.81 Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YLL013C 3.75 Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
YIL023C 3.75 Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
YGR182C 3.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
YKL028W 3.66 TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YLL052C 3.66 Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YNL190W 3.61 Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YML083C 3.59 Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
YGL192W 3.55 Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YCR005C 3.55 Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YLR307C-A 3.54 Putative protein of unknown function
YHR008C 3.52 Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
YKL031W 3.52 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YFL036W 3.52 Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
YOR100C 3.49 Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YIL100C-A 3.48 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER088C 3.47 Protein of unknown function, involved in telomeric gene silencing and filamentation
YHR071W 3.46 Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YCL041C 3.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
YIL134C-A 3.46 Putative protein of unknown function, identified by fungal homology and RT-PCR
YPL156C 3.46 Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YJR078W 3.42 Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YMR174C 3.41 Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YGL193C 3.40 Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YMR250W 3.39 Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YHL046W-A 3.39 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL064C 3.39 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YBR296C 3.38 Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YGR019W 3.38 Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization
YNL006W 3.35 Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
YNR002C 3.35 Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YGL255W 3.34 High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YJR147W 3.34 Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YMR104C 3.31 Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
YMR081C 3.30 Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YHR104W 3.29 Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway
YBR035C 3.29 Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YFL052W 3.25 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YPR127W 3.25 Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YOR347C 3.23 Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux
YBR222C 3.22 Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
YFR015C 3.21 Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
YDR342C 3.20 High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YMR194C-B 3.18 Putative protein of unknown function
YFL059W 3.17 Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3
YEL028W 3.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR010C 3.15 Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YHL047C 3.13 Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YLR356W 3.12 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YGL062W 3.12 Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YCR021C 3.11 Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YKL026C 3.11 Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YPL250C 3.10 Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YOR066W 3.09 Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YNL117W 3.07 Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YDL085W 3.06 Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YLR296W 3.05 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHL024W 3.04 Putative RNA-binding protein required for the expression of early and middle sporulation genes
YJL156W-A 3.02 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL142W 3.01 Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YHR180W 3.01 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR169C 3.01 Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p
YDR476C 3.00 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YDR277C 3.00 Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YBL066C 2.98 Putative transcription factor, has homolog in Kluyveromyces lactis
YIL100W 2.98 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YIL136W 2.97 Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YNR050C 2.96 Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway
YKL148C 2.96 Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YER163C 2.95 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YKL034W 2.93 Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes
YNL160W 2.93 Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YDR258C 2.91 Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YNL055C 2.90 Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YPR150W 2.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YOR192C 2.88 Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YGR149W 2.88 Putative protein of unknown function; predicted to be an integal membrane protein
YFL019C 2.88 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YER121W 2.87 Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YOL037C 2.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W
YNR036C 2.87 Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins
YLR402W 2.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR030W 2.86 Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YDR263C 2.85 Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination

Network of associatons between targets according to the STRING database.

First level regulatory network of SIG1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.8 GO:0061413 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
3.8 15.3 GO:0046323 glucose import(GO:0046323)
3.8 38.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
3.7 11.1 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
3.1 3.1 GO:0032780 negative regulation of ATPase activity(GO:0032780)
3.0 12.0 GO:0015886 heme transport(GO:0015886)
2.7 13.7 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
2.5 7.6 GO:0006545 glycine biosynthetic process(GO:0006545)
2.5 10.0 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
2.4 11.8 GO:0006102 isocitrate metabolic process(GO:0006102)
2.2 8.8 GO:0006848 pyruvate transport(GO:0006848)
2.1 6.3 GO:0015740 C4-dicarboxylate transport(GO:0015740)
2.0 10.1 GO:0005980 glycogen catabolic process(GO:0005980)
2.0 6.0 GO:0051606 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
2.0 5.9 GO:0006538 glutamate catabolic process(GO:0006538)
1.9 5.7 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
1.9 5.7 GO:0015888 thiamine transport(GO:0015888)
1.9 11.1 GO:0046487 glyoxylate metabolic process(GO:0046487)
1.8 3.6 GO:0006013 mannose metabolic process(GO:0006013)
1.8 7.1 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
1.8 7.0 GO:0015976 carbon utilization(GO:0015976)
1.7 5.2 GO:0043335 protein unfolding(GO:0043335)
1.7 3.4 GO:0072353 cellular age-dependent response to reactive oxygen species(GO:0072353)
1.7 5.0 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
1.7 5.0 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.6 6.5 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
1.6 6.5 GO:0019388 galactose catabolic process(GO:0019388)
1.6 4.8 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
1.6 11.2 GO:0006083 acetate metabolic process(GO:0006083)
1.6 6.4 GO:0015847 putrescine transport(GO:0015847)
1.5 10.8 GO:0042819 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
1.5 4.6 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
1.5 22.1 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
1.4 4.3 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
1.4 4.2 GO:0045117 azole transport(GO:0045117)
1.3 22.9 GO:0005978 glycogen biosynthetic process(GO:0005978)
1.3 4.0 GO:0006527 arginine catabolic process(GO:0006527)
1.3 4.0 GO:0072488 ammonium transmembrane transport(GO:0072488)
1.3 10.3 GO:0015891 siderophore transport(GO:0015891)
1.3 15.2 GO:0006772 thiamine metabolic process(GO:0006772)
1.2 11.1 GO:0006829 zinc II ion transport(GO:0006829)
1.2 12.2 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
1.2 3.7 GO:0005993 trehalose catabolic process(GO:0005993)
1.2 6.1 GO:0034487 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
1.2 1.2 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
1.2 10.7 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
1.2 5.9 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
1.2 3.5 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
1.2 10.5 GO:0022904 respiratory electron transport chain(GO:0022904) ATP synthesis coupled electron transport(GO:0042773) mitochondrial ATP synthesis coupled electron transport(GO:0042775)
1.2 4.6 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
1.1 1.1 GO:0006119 oxidative phosphorylation(GO:0006119)
1.1 10.2 GO:0009313 oligosaccharide catabolic process(GO:0009313)
1.1 3.4 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
1.1 28.9 GO:0046364 monosaccharide biosynthetic process(GO:0046364)
1.1 3.3 GO:0006108 malate metabolic process(GO:0006108)
1.0 5.0 GO:0009208 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
1.0 3.0 GO:0070583 spore membrane bending pathway(GO:0070583)
1.0 5.9 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
1.0 3.9 GO:0046688 response to copper ion(GO:0046688)
0.9 6.6 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.9 0.9 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.9 3.7 GO:0051099 positive regulation of binding(GO:0051099)
0.9 0.9 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.9 3.5 GO:0015804 neutral amino acid transport(GO:0015804)
0.9 11.4 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.9 3.5 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.9 2.6 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.9 0.9 GO:0034225 cellular response to zinc ion starvation(GO:0034224) regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation(GO:0034225)
0.9 3.4 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.9 3.4 GO:0006598 polyamine catabolic process(GO:0006598)
0.9 15.4 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.8 4.2 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.8 1.7 GO:0008272 sulfate transport(GO:0008272)
0.8 2.4 GO:0006000 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.8 0.8 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.8 3.9 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.8 3.8 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.7 3.0 GO:0042743 hydrogen peroxide metabolic process(GO:0042743)
0.7 2.2 GO:0009438 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.7 0.7 GO:0010507 negative regulation of autophagy(GO:0010507)
0.7 8.0 GO:0019740 nitrogen utilization(GO:0019740)
0.7 1.4 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.7 4.2 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856) 'de novo' UMP biosynthetic process(GO:0044205)
0.7 2.1 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.7 4.1 GO:0042407 cristae formation(GO:0042407)
0.7 0.7 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.7 6.0 GO:0000755 cytogamy(GO:0000755)
0.6 3.9 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.6 5.7 GO:0046686 response to cadmium ion(GO:0046686)
0.6 1.9 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.6 2.4 GO:2000909 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.6 2.4 GO:0051180 vitamin transport(GO:0051180)
0.6 2.4 GO:0006012 galactose metabolic process(GO:0006012)
0.6 2.4 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.6 3.6 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.6 2.4 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.6 6.9 GO:0019395 fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
0.6 1.7 GO:0006089 lactate metabolic process(GO:0006089)
0.6 2.2 GO:0019346 transsulfuration(GO:0019346)
0.6 7.2 GO:0006754 ATP biosynthetic process(GO:0006754)
0.6 3.3 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.6 1.7 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.6 5.0 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.5 1.1 GO:0008216 spermidine metabolic process(GO:0008216)
0.5 3.2 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.5 1.1 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.5 17.0 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.5 3.1 GO:0044091 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.5 2.0 GO:0000023 maltose metabolic process(GO:0000023)
0.5 6.5 GO:0001101 response to acid chemical(GO:0001101)
0.5 2.0 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.5 1.5 GO:0018216 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.5 2.0 GO:0051865 protein autoubiquitination(GO:0051865)
0.5 1.0 GO:0001324 age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324)
0.5 2.0 GO:0015793 glycerol transport(GO:0015793)
0.5 3.9 GO:0018345 protein palmitoylation(GO:0018345)
0.5 1.4 GO:0090630 activation of GTPase activity(GO:0090630)
0.5 1.4 GO:0019629 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.5 1.0 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.5 2.8 GO:0034508 centromere complex assembly(GO:0034508) kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.5 1.9 GO:0001881 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.5 10.6 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.5 1.4 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.4 1.3 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.4 1.3 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.4 1.3 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.4 5.4 GO:0042026 protein refolding(GO:0042026)
0.4 2.5 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.4 2.9 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.4 2.0 GO:0070941 eisosome assembly(GO:0070941)
0.4 2.4 GO:0006279 premeiotic DNA replication(GO:0006279)
0.4 1.2 GO:0006572 tyrosine catabolic process(GO:0006572)
0.4 1.2 GO:0046058 cAMP metabolic process(GO:0046058)
0.4 1.9 GO:0044070 regulation of anion transport(GO:0044070)
0.4 2.6 GO:0006816 calcium ion transport(GO:0006816)
0.4 3.0 GO:0046471 phosphatidylglycerol metabolic process(GO:0046471)
0.4 2.2 GO:0006526 arginine biosynthetic process(GO:0006526)
0.4 0.7 GO:0043171 peptide catabolic process(GO:0043171)
0.4 0.7 GO:0045471 response to ethanol(GO:0045471)
0.4 13.2 GO:0009060 aerobic respiration(GO:0009060)
0.4 1.1 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.4 1.8 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.4 1.1 GO:0032365 intracellular lipid transport(GO:0032365)
0.3 1.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 1.0 GO:0042732 D-xylose metabolic process(GO:0042732)
0.3 1.0 GO:0009062 fatty acid catabolic process(GO:0009062)
0.3 1.7 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.3 1.0 GO:0015856 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.3 1.0 GO:0050685 positive regulation of mRNA processing(GO:0050685)
0.3 1.9 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.3 0.6 GO:0000304 response to singlet oxygen(GO:0000304)
0.3 1.9 GO:0015802 basic amino acid transport(GO:0015802)
0.3 2.2 GO:0009098 leucine biosynthetic process(GO:0009098)
0.3 1.3 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993)
0.3 1.2 GO:0072348 sulfur compound transport(GO:0072348)
0.3 0.9 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.3 0.6 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.3 0.6 GO:0015693 magnesium ion transport(GO:0015693)
0.3 3.0 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.3 1.4 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.3 0.3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.3 0.8 GO:1902751 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.3 1.1 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.3 9.7 GO:0070726 cell wall assembly(GO:0070726)
0.3 1.6 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.3 2.8 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.2 1.2 GO:0019722 calcium-mediated signaling(GO:0019722)
0.2 0.2 GO:0009411 response to UV(GO:0009411)
0.2 0.5 GO:0006826 iron ion transport(GO:0006826)
0.2 0.5 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.2 0.7 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.2 1.1 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.2 1.1 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.2 1.3 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.2 1.9 GO:0070987 error-free translesion synthesis(GO:0070987)
0.2 1.0 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.2 0.6 GO:0031297 replication fork processing(GO:0031297)
0.2 0.2 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.2 0.8 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.2 0.6 GO:0018206 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
0.2 3.6 GO:0098656 anion transmembrane transport(GO:0098656)
0.2 0.4 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.2 0.4 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.2 0.4 GO:0034755 high-affinity iron ion transmembrane transport(GO:0006827) iron ion transmembrane transport(GO:0034755)
0.2 0.5 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.2 0.2 GO:0043270 positive regulation of ion transport(GO:0043270)
0.2 2.6 GO:0007129 synapsis(GO:0007129)
0.2 1.0 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.2 0.5 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.2 4.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.2 0.3 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.2 0.9 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) positive regulation of cell cycle G1/S phase transition(GO:1902808)
0.2 6.3 GO:0048468 ascospore formation(GO:0030437) cell development(GO:0048468)
0.2 0.2 GO:0071168 protein localization to chromatin(GO:0071168)
0.2 0.3 GO:0006624 vacuolar protein processing(GO:0006624)
0.2 0.7 GO:0043462 regulation of ATPase activity(GO:0043462)
0.2 0.8 GO:0051259 protein oligomerization(GO:0051259)
0.2 0.8 GO:0046461 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.2 0.2 GO:0009314 response to radiation(GO:0009314)
0.2 1.8 GO:0016925 protein sumoylation(GO:0016925)
0.2 0.6 GO:0060195 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.2 0.6 GO:0006465 signal peptide processing(GO:0006465)
0.2 1.0 GO:0015677 copper ion import(GO:0015677)
0.2 1.3 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
0.2 1.1 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.2 0.5 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.7 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.1 0.4 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.1 0.3 GO:0035376 sterol import(GO:0035376)
0.1 1.0 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 1.1 GO:0045332 phospholipid translocation(GO:0045332)
0.1 1.4 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 2.5 GO:0008361 regulation of cell size(GO:0008361)
0.1 0.1 GO:0051403 stress-activated protein kinase signaling cascade(GO:0031098) regulation of stress-activated MAPK cascade(GO:0032872) stress-activated MAPK cascade(GO:0051403) regulation of stress-activated protein kinase signaling cascade(GO:0070302)
0.1 0.3 GO:0042148 strand invasion(GO:0042148)
0.1 0.7 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.1 0.5 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 0.3 GO:0043966 histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.1 0.1 GO:0006824 cobalt ion transport(GO:0006824)
0.1 0.3 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1 0.6 GO:0045116 protein neddylation(GO:0045116)
0.1 2.5 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.4 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 0.4 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.1 0.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 0.5 GO:0001304 progressive alteration of chromatin involved in replicative cell aging(GO:0001304)
0.1 2.2 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.1 0.3 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.1 0.5 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.1 1.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.9 GO:0007323 peptide pheromone maturation(GO:0007323)
0.1 1.2 GO:0034308 primary alcohol metabolic process(GO:0034308)
0.1 0.5 GO:0016241 regulation of macroautophagy(GO:0016241)
0.1 0.4 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.1 0.6 GO:0035268 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.1 0.2 GO:0019748 secondary metabolic process(GO:0019748)
0.1 0.8 GO:0015893 drug transport(GO:0015893)
0.1 0.3 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.1 0.6 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.1 GO:0006074 (1->3)-beta-D-glucan metabolic process(GO:0006074)
0.1 2.7 GO:0001403 invasive growth in response to glucose limitation(GO:0001403)
0.1 1.0 GO:0001558 regulation of cell growth(GO:0001558)
0.1 0.8 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.3 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.1 0.2 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.1 0.4 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.1 0.2 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.1 0.5 GO:0006865 amino acid transport(GO:0006865)
0.1 0.1 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.3 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.1 2.7 GO:0007031 peroxisome organization(GO:0007031)
0.1 0.4 GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086)
0.1 1.0 GO:0016579 protein deubiquitination(GO:0016579)
0.1 1.8 GO:0006839 mitochondrial transport(GO:0006839)
0.1 0.3 GO:0009092 homoserine metabolic process(GO:0009092)
0.1 0.9 GO:0031503 protein complex localization(GO:0031503)
0.0 0.0 GO:0015688 iron chelate transport(GO:0015688)
0.0 0.1 GO:0097271 protein localization to bud neck(GO:0097271)
0.0 0.2 GO:0072529 pyrimidine-containing compound catabolic process(GO:0072529)
0.0 0.1 GO:0000348 mRNA branch site recognition(GO:0000348)
0.0 0.1 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.3 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.4 GO:0006778 porphyrin-containing compound metabolic process(GO:0006778) tetrapyrrole metabolic process(GO:0033013) heme metabolic process(GO:0042168)
0.0 0.1 GO:0030835 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.0 0.1 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.0 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 0.1 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.0 0.1 GO:0010674 regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010672) negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.0 0.1 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.0 0.2 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.0 0.0 GO:2001025 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.0 0.3 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.1 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.0 0.1 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.0 0.4 GO:0006665 sphingolipid metabolic process(GO:0006665)
0.0 0.1 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.1 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.0 0.5 GO:0036503 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0 0.1 GO:0000080 mitotic G1 phase(GO:0000080) G1 phase(GO:0051318)
0.0 0.0 GO:0000173 inactivation of MAPK activity involved in osmosensory signaling pathway(GO:0000173)
0.0 0.1 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.0 GO:0018344 protein geranylgeranylation(GO:0018344)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 13.7 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
2.5 22.6 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
2.3 9.1 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
2.0 26.0 GO:0070469 respiratory chain(GO:0070469)
1.6 9.4 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
1.5 1.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.4 4.2 GO:0031166 integral component of vacuolar membrane(GO:0031166)
1.3 3.9 GO:0046930 pore complex(GO:0046930)
1.2 2.5 GO:0001400 mating projection base(GO:0001400)
1.1 4.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
1.0 3.1 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
1.0 6.9 GO:0034657 GID complex(GO:0034657)
0.9 4.7 GO:0031931 TORC1 complex(GO:0031931)
0.9 2.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.8 9.5 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.7 2.1 GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.7 0.7 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.7 5.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.7 2.0 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.6 5.0 GO:0005619 ascospore wall(GO:0005619) spore wall(GO:0031160)
0.6 1.8 GO:0032177 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.6 5.3 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.5 1.6 GO:0034099 luminal surveillance complex(GO:0034099)
0.5 2.7 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.5 3.1 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.5 8.7 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.5 1.4 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.5 25.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 3.4 GO:0031211 palmitoyltransferase complex(GO:0002178) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.4 8.2 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.4 2.8 GO:0034967 Set3 complex(GO:0034967)
0.4 46.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.4 15.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.4 1.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.4 6.8 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304)
0.3 9.8 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.3 0.7 GO:0005775 vacuolar lumen(GO:0005775)
0.3 1.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.3 15.2 GO:0031225 anchored component of membrane(GO:0031225)
0.3 1.0 GO:0009277 cell wall(GO:0005618) fungal-type cell wall(GO:0009277) external encapsulating structure(GO:0030312)
0.3 2.0 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.3 0.7 GO:0032389 MutLalpha complex(GO:0032389)
0.3 8.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.3 1.3 GO:0030869 RENT complex(GO:0030869)
0.3 1.9 GO:0032432 actin filament bundle(GO:0032432)
0.3 0.9 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.3 1.8 GO:0033263 CORVET complex(GO:0033263)
0.3 1.1 GO:0032221 Rpd3S complex(GO:0032221)
0.3 4.0 GO:0005682 U5 snRNP(GO:0005682)
0.3 3.7 GO:0044455 mitochondrial membrane part(GO:0044455)
0.3 1.6 GO:0033101 cellular bud membrane(GO:0033101)
0.2 28.2 GO:0000329 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.2 1.7 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153) ER ubiquitin ligase complex(GO:0000835)
0.2 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.2 2.1 GO:0000795 synaptonemal complex(GO:0000795)
0.2 0.7 GO:0035649 Nrd1 complex(GO:0035649)
0.2 0.7 GO:0070211 Snt2C complex(GO:0070211)
0.2 8.4 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.2 7.5 GO:0005576 extracellular region(GO:0005576)
0.2 1.3 GO:0008180 COP9 signalosome(GO:0008180)
0.2 1.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 1.4 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.2 0.7 GO:0033309 SBF transcription complex(GO:0033309)
0.2 13.5 GO:0044437 vacuolar membrane(GO:0005774) vacuolar part(GO:0044437)
0.2 0.5 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 1.0 GO:0032126 eisosome(GO:0032126)
0.2 1.8 GO:0098797 plasma membrane protein complex(GO:0098797)
0.2 1.6 GO:0033698 Rpd3L complex(GO:0033698)
0.2 0.5 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 6.0 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.1 0.8 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 36.0 GO:0005886 plasma membrane(GO:0005886)
0.1 1.0 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 2.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 0.5 GO:0008623 CHRAC(GO:0008623)
0.1 1.4 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.3 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 0.2 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 4.8 GO:0005740 mitochondrial envelope(GO:0005740)
0.1 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.4 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.2 GO:0000417 HIR complex(GO:0000417)
0.1 0.6 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.3 GO:0019867 outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.1 0.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.1 GO:0070274 RES complex(GO:0070274)
0.0 20.9 GO:0005739 mitochondrion(GO:0005739)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.0 0.0 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.0 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 12.0 GO:0016208 AMP binding(GO:0016208)
3.7 11.1 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
3.5 13.9 GO:0004396 hexokinase activity(GO:0004396)
3.4 10.1 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
3.0 12.0 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
2.9 14.4 GO:0015295 solute:proton symporter activity(GO:0015295)
2.8 17.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
2.8 8.3 GO:0048038 quinone binding(GO:0048038)
2.6 21.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
2.6 7.9 GO:0016289 CoA hydrolase activity(GO:0016289)
2.5 7.5 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
2.4 11.8 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
2.3 9.3 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
2.0 6.0 GO:0005536 glucose binding(GO:0005536)
2.0 3.9 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.9 5.7 GO:1901474 azole transmembrane transporter activity(GO:1901474)
1.8 5.4 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.7 6.8 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
1.6 6.5 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
1.6 4.9 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.6 4.8 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
1.6 4.8 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
1.5 4.6 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.4 4.3 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
1.4 7.2 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.4 11.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.4 11.0 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.3 14.8 GO:0015293 symporter activity(GO:0015293)
1.3 3.9 GO:0022829 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
1.2 3.7 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
1.2 4.8 GO:0005537 mannose binding(GO:0005537)
1.2 11.7 GO:0010181 FMN binding(GO:0010181)
1.2 23.2 GO:0016831 carboxy-lyase activity(GO:0016831)
1.1 5.5 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
1.1 4.3 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
1.1 3.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
1.0 4.1 GO:0015386 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
1.0 7.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
1.0 4.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.0 2.9 GO:0016854 racemase and epimerase activity(GO:0016854)
0.9 3.8 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.9 5.6 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.9 9.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.9 2.7 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.9 11.5 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.9 6.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.9 0.9 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.9 10.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.8 5.9 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.8 1.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.8 11.7 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.8 13.2 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.8 5.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.8 3.1 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.8 10.8 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.8 8.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.8 7.5 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.7 3.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.7 2.2 GO:0004457 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.7 5.0 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.7 8.4 GO:0005199 structural constituent of cell wall(GO:0005199)
0.7 1.4 GO:0045118 azole transporter activity(GO:0045118)
0.7 2.0 GO:0032183 SUMO binding(GO:0032183)
0.7 2.0 GO:0004629 phospholipase C activity(GO:0004629)
0.6 2.6 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.6 3.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.6 1.9 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.6 11.7 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.6 1.8 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.6 4.7 GO:0034979 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.6 0.6 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.6 1.8 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.6 3.5 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.6 1.7 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.6 2.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.6 2.8 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.5 4.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.5 1.6 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.5 1.6 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.5 1.1 GO:0019902 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.5 2.0 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.5 1.5 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.5 1.4 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.5 2.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.5 0.5 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.5 2.3 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.4 1.8 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.4 11.0 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.4 4.7 GO:0005507 copper ion binding(GO:0005507)
0.4 3.3 GO:0016209 antioxidant activity(GO:0016209)
0.4 1.2 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.4 3.6 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.4 2.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.4 19.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.4 1.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.4 1.1 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.4 0.4 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.4 1.5 GO:0008169 C-methyltransferase activity(GO:0008169)
0.4 16.8 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.4 3.3 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.4 1.1 GO:0008198 ferrous iron binding(GO:0008198)
0.3 2.4 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.3 1.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.3 1.0 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.3 1.0 GO:0030332 cyclin binding(GO:0030332)
0.3 1.3 GO:0004180 carboxypeptidase activity(GO:0004180)
0.3 1.2 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.3 1.2 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.3 2.8 GO:0099600 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.3 1.2 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.3 2.0 GO:0031072 heat shock protein binding(GO:0031072)
0.3 0.9 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.3 1.4 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.3 0.5 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.3 2.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.3 1.3 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.2 4.2 GO:0051087 chaperone binding(GO:0051087)
0.2 1.5 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 2.4 GO:0022838 substrate-specific channel activity(GO:0022838)
0.2 1.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 0.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 0.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 2.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 1.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 0.2 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.2 1.4 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.2 2.9 GO:0032947 protein complex scaffold(GO:0032947)
0.2 0.2 GO:0016530 metallochaperone activity(GO:0016530)
0.2 16.4 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.2 0.5 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.2 0.5 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.2 12.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 0.5 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.2 0.5 GO:0000150 recombinase activity(GO:0000150)
0.2 1.9 GO:0035064 methylated histone binding(GO:0035064)
0.2 0.2 GO:0016841 ammonia-lyase activity(GO:0016841)
0.2 0.5 GO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly(GO:0001128)
0.2 0.6 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 0.9 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 1.7 GO:0008236 serine-type peptidase activity(GO:0008236)
0.1 0.7 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.1 0.7 GO:0004075 biotin carboxylase activity(GO:0004075)
0.1 0.1 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.1 0.4 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 0.4 GO:0015216 purine nucleotide transmembrane transporter activity(GO:0015216)
0.1 0.6 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 0.4 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 2.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.1 GO:0008374 O-acyltransferase activity(GO:0008374)
0.1 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.2 GO:0043495 protein anchor(GO:0043495)
0.1 0.3 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 1.7 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.1 1.9 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.2 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 1.2 GO:0051015 actin filament binding(GO:0051015)
0.1 0.1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.1 0.2 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.1 0.8 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.1 0.5 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 1.3 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.2 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 0.5 GO:0000149 SNARE binding(GO:0000149)
0.1 0.3 GO:0017022 myosin binding(GO:0017022)
0.1 0.1 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 0.2 GO:0046527 glucosyltransferase activity(GO:0046527)
0.1 0.1 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.1 0.2 GO:0097617 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.1 0.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.3 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.1 0.3 GO:1901618 alcohol transmembrane transporter activity(GO:0015665) organic hydroxy compound transmembrane transporter activity(GO:1901618)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.5 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.3 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.1 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.1 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.0 0.1 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.1 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.2 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
8.2 24.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
3.5 10.5 PID IL4 2PATHWAY IL4-mediated signaling events
1.9 1.9 PID AR PATHWAY Coregulation of Androgen receptor activity
1.3 6.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.6 3.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.4 1.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 0.8 PID CMYB PATHWAY C-MYB transcription factor network
0.2 0.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.2 0.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 0.4 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 1.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 213.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 0.2 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 0.0 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.1 PID FOXO PATHWAY FoxO family signaling
0.0 0.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
3.1 9.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
2.9 25.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.9 2.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.5 0.5 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.5 0.9 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.4 0.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.3 0.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3 3.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.3 1.1 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.2 0.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.2 0.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 3.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 2.0 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 0.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.2 0.4 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.2 1.5 REACTOME DNA REPAIR Genes involved in DNA Repair
0.1 209.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.2 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.1 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 0.7 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.4 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane