Results for RTG3
Z-value: 0.68
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Transcription factors associated with RTG3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
RTG3
|
S000000199 | Transcription factor for retrograde (RTG) and TOR pathways |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YPL250C Show fit | 10.85 |
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate |
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| YJL133C-A Show fit | 7.87 |
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
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| YHL036W Show fit | 5.78 |
Low affinity methionine permease, similar to Mup1p |
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| YAL054C Show fit | 4.88 |
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions |
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| YCL040W Show fit | 4.65 |
Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources |
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| YCL042W Show fit | 4.44 |
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm |
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| YJR095W Show fit | 4.17 |
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization |
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| YKL016C Show fit | 4.13 |
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis |
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| YAL062W Show fit | 3.94 |
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources |
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| YML120C Show fit | 3.75 |
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID |
Network of associatons between targets according to the STRING database.
First level regulatory network of RTG3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 14.0 | GO:0000422 | mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726) |
| 0.8 | 8.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.5 | 7.1 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 1.6 | 6.5 | GO:0046323 | glucose import(GO:0046323) |
| 1.3 | 5.1 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.8 | 4.9 | GO:0006085 | acetyl-CoA biosynthetic process(GO:0006085) |
| 0.8 | 4.7 | GO:0000128 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
| 1.4 | 4.2 | GO:0015740 | C4-dicarboxylate transport(GO:0015740) |
| 0.4 | 3.9 | GO:0016241 | regulation of macroautophagy(GO:0016241) |
| 0.3 | 3.9 | GO:0034087 | establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 9.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 1.0 | 8.7 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.1 | 6.3 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 1.4 | 4.1 | GO:0045265 | mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265) |
| 0.9 | 3.5 | GO:0097042 | extrinsic component of fungal-type vacuolar membrane(GO:0097042) |
| 0.3 | 3.5 | GO:0070469 | respiratory chain(GO:0070469) |
| 1.1 | 3.3 | GO:0031422 | RecQ helicase-Topo III complex(GO:0031422) |
| 0.1 | 3.2 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.1 | 2.9 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 7.4 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.9 | 7.1 | GO:0016679 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.6 | 7.1 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 1.5 | 6.0 | GO:0004396 | hexokinase activity(GO:0004396) |
| 1.8 | 5.3 | GO:0050136 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 1.6 | 4.9 | GO:0016208 | AMP binding(GO:0016208) |
| 0.4 | 4.4 | GO:0015293 | symporter activity(GO:0015293) |
| 0.2 | 4.3 | GO:0004402 | histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733) |
| 1.0 | 4.2 | GO:0015556 | C4-dicarboxylate transmembrane transporter activity(GO:0015556) |
| 1.3 | 4.0 | GO:0036440 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 28.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.4 | 3.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.5 | 1.6 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.2 | 0.7 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.3 | 0.6 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 0.5 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.1 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.2 | 2.2 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.5 | 2.0 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.2 | 1.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.3 | 0.8 | REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | Genes involved in MyD88:Mal cascade initiated on plasma membrane |
| 0.1 | 0.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 0.3 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.0 | 0.3 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 0.2 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.1 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |