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Results for RSC3

Z-value: 1.64

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Transcription factors associated with RSC3

Gene Symbol Gene ID Gene Info
RSC3
S000002711 Component of the RSC chromatin remodeling complex

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RSC3YDR303C0.115.8e-01Click!

Activity profile of RSC3 motif

Sorted Z-values of RSC3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YGR108W 14.05
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YCR018C 12.99
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YOL086C 11.93
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YJL190C 10.64
RPS22A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YJR094W-A 10.14
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YPL250W-A 9.41 Identified by fungal homology and RT-PCR
YDL023C 9.37 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YKL096W-A 9.17
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YDR133C 8.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YGL148W 8.38
ARO2
Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YER177W 8.25
BMH1
14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YDL055C 8.13
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YMR199W 8.01
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YDL022W 7.89
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YDL047W 7.78
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YDL022C-A 7.75 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YNL030W 7.29
HHF2
One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YER131W 7.18
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YNL301C 7.10
RPL18B
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YLR110C 7.02
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YKR094C 6.67
RPL40B
Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YHR216W 6.41
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YPL112C 6.41
PEX25
Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YOL039W 6.37
RPP2A
Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YDR344C 6.27 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR315W 6.17
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YDR509W 6.09 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL152C 6.01
GPM1
Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YDR508C 5.96
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YBL063W 5.79
KIP1
Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YOR096W 5.79
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YNL300W 5.77 Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YHR070C-A 5.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W
YMR102C 5.67 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YLR406C 5.64
RPL31B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YOL085C 5.62 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YPL177C 5.62
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YOL155C 5.50
HPF1
Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YDR044W 5.45
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YOL040C 5.40
RPS15
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YGR180C 5.35
RNR4
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YMR246W 5.29
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YLR154C 5.25
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YFR055W 5.17
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YGR138C 5.12
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YNR054C 5.01
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YNL182C 4.87
IPI3
Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YER146W 4.84
LSM5
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YPL079W 4.76
RPL21B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein
YGL201C 4.69
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YNR016C 4.66
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YFR056C 4.60 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YML088W 4.56
UFO1
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YDR345C 4.55
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YGR181W 4.44
TIM13
Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YKL218C 4.41
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YGL147C 4.41
RPL9A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YOL107W 4.40 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
YLR154W-B 4.37 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YOR108W 4.35
LEU9
Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YGR052W 4.24
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YHR174W 4.19
ENO2
Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose
YDL048C 4.19
STP4
Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YKL063C 4.17 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YNR009W 4.16
NRM1
Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
YLR154W-A 4.13 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YCR102W-A 4.05 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL179C 4.03
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YJR114W 3.94 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C
YDR064W 3.86
RPS13
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins
YDR497C 3.86
ITR1
Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
YNL031C 3.85
HHT2
One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YIL118W 3.81
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YNL079C 3.81
TPM1
Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
YNL078W 3.73
NIS1
Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
YOR008C-A 3.71 Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YBR126W-A 3.71 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YGR060W 3.69
ERG25
C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YBR189W 3.63
RPS9B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins
YDR447C 3.62
RPS17B
Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YJR113C 3.62
RSM7
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
YDR465C 3.62
RMT2
Arginine methyltransferase; ribosomal protein L12 is a substrate
YDR033W 3.59
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YPL249C-A 3.53
RPL36B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YAL038W 3.51
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YIL056W 3.49
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YPL014W 3.49 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YNR001W-A 3.44 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YKR074W 3.42
AIM29
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YGR106C 3.41
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YKL110C 3.40
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YGR121W-A 3.35 Putative protein of unknown function
YPL037C 3.35
EGD1
Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YML063W 3.35
RPS1B
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YLR314C 3.33
CDC3
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YGR139W 3.26 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR140W 3.23
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YOL127W 3.21
RPL25
Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YCL024W 3.16
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YDR309C 3.12
GIC2
Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
YPL197C 3.11 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
YGR118W 3.11
RPS23A
Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
YER019C-A 3.08
SBH2
Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
YGR050C 3.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL209C 3.06
STE6
Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YMR194C-A 3.04 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR107W 3.03 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL085W 3.00
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YIL053W 3.00
RHR2
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YLR257W 2.98 Putative protein of unknown function
YBR106W 2.96
PHO88
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YBR283C 2.93
SSH1
Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential
YOR376W-A 2.92 Putative protein of unknown function; identified by fungal homology and RT-PCR
YIL114C 2.90
POR2
Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability
YJR009C 2.88
TDH2
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YLR109W 2.86
AHP1
Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YGR151C 2.82 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C
YJR043C 2.78
POL32
Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
YOR277C 2.77 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
YBL032W 2.77
HEK2
RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
YKL119C 2.73
VPH2
Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
YDR450W 2.69
RPS18A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YPL198W 2.67
RPL7B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YCR104W 2.67
PAU3
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YDL211C 2.66 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YCL023C 2.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YKL096W 2.65
CWP1
Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization
YHR020W 2.65 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene
YGR037C 2.65
ACB1
Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes
YER130C 2.64 Hypothetical protein
YLR437C 2.64 Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm
YOR317W 2.61
FAA1
Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase
YJR123W 2.60
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YBR126C 2.58
TPS1
Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
YLR420W 2.58
URA4
Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YMR112C 2.58
MED11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
YJR118C 2.57
ILM1
Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth
YCR102C 2.52 Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene
YNL327W 2.51
EGT2
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YGR086C 2.50
PIL1
Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YLL064C 2.50
PAU18
Hypothetical protein
YKL073W 2.50
LHS1
Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway
YDR072C 2.50
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YPR052C 2.45
NHP6A
High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters
YGR234W 2.45
YHB1
Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YDR047W 2.44
HEM12
Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YOR342C 2.43 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YKL030W 2.42 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
YOR312C 2.42
RPL20B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
YCR019W 2.35
MAK32
Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YDL226C 2.34
GCS1
ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
YEL027W 2.30
CUP5
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YAR071W 2.30
PHO11
One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YER088C-A 2.29 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR025C 2.29
HIS2
Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YMR113W 2.27
FOL3
Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
YIL169C 2.25 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YOR314W 2.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL090C 2.23
RPS6A
Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YJR105W 2.23
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YJL048C 2.22
UBX6
UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline
YOR375C 2.22
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YNL178W 2.20
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YNL338W 2.20 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
YBR009C 2.19
HHF1
One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YHR144C 2.18
DCD1
Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YDR451C 2.18
YHP1
One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval
YOL012C 2.17
HTZ1
Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YCL058C 2.16
FYV5
Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in ion homeostasis
YGR051C 2.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YOL080C 2.13
REX4
Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
YKL118W 2.09 Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2
YPL066W 2.07 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
YKR041W 2.07 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOL079W 2.07 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDR240C 2.04
SNU56
Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YFL034C-A 2.03
RPL22B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein
YKL051W 2.00
SFK1
Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YNL089C 2.00 Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins
YGL050W 1.97
TYW3
tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YEL020C-B 1.96 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YLR351C 1.95
NIT3
Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YPR102C 1.94
RPL11A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YLR108C 1.94 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YMR119W 1.90
ASI1
Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YLR002C 1.89
NOC3
Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation
YLR400W 1.89 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR242W 1.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YHR019C 1.86
DED81
Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
YOR349W 1.86
CIN1
Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
YOR050C 1.85 Hypothetical protein
YMR049C 1.84
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YJR143C 1.84
PMT4
Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals
YKL074C 1.81
MUD2
Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
YOL011W 1.81
PLB3
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YER003C 1.81
PMI40
Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YLR154W-C 1.80
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YPR053C 1.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C
YMR177W 1.79
MMT1
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YDR091C 1.79
RLI1
Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase

Network of associatons between targets according to the STRING database.

First level regulatory network of RSC3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.9 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
3.3 9.9 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
3.1 12.4 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
2.1 8.4 GO:0009423 chorismate biosynthetic process(GO:0009423)
2.0 19.9 GO:0006116 NADH oxidation(GO:0006116)
1.9 5.8 GO:2000877 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
1.9 5.8 GO:0006183 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
1.9 5.8 GO:0030541 plasmid partitioning(GO:0030541)
1.8 5.4 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
1.8 7.0 GO:0098609 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
1.7 5.2 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
1.7 11.8 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
1.5 5.9 GO:0000296 spermine transport(GO:0000296)
1.4 9.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
1.3 24.0 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
1.3 2.6 GO:0015909 long-chain fatty acid transport(GO:0015909)
1.3 6.4 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
1.3 8.9 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
1.3 8.8 GO:0034729 histone H3-K79 methylation(GO:0034729)
1.2 3.6 GO:0018216 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
1.1 3.3 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
1.0 5.2 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
1.0 3.8 GO:0090337 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
1.0 4.8 GO:0044070 regulation of anion transport(GO:0044070)
0.9 3.7 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.9 2.8 GO:0019419 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.9 3.6 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.9 2.6 GO:0009221 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) 2'-deoxyribonucleotide biosynthetic process(GO:0009265) 2'-deoxyribonucleotide metabolic process(GO:0009394) deoxyribose phosphate biosynthetic process(GO:0046385)
0.8 4.2 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.8 1.6 GO:0061422 positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422)
0.8 2.4 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.8 3.9 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.8 2.3 GO:0046901 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.8 1.5 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.7 10.5 GO:0006450 regulation of translational fidelity(GO:0006450)
0.7 4.5 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.7 2.2 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.7 10.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.7 5.9 GO:0016559 peroxisome fission(GO:0016559)
0.7 6.4 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.7 89.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.7 6.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.7 2.7 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.7 7.9 GO:0000921 septin ring assembly(GO:0000921)
0.7 2.6 GO:0019357 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.6 1.9 GO:0044209 AMP salvage(GO:0044209)
0.6 2.5 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.6 2.5 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.6 1.8 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.6 1.8 GO:0000348 mRNA branch site recognition(GO:0000348)
0.6 4.1 GO:0009098 leucine biosynthetic process(GO:0009098)
0.5 1.6 GO:0043171 peptide catabolic process(GO:0043171)
0.5 15.2 GO:0046939 nucleotide phosphorylation(GO:0046939)
0.5 3.0 GO:0048255 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.5 1.5 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.5 4.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.5 1.9 GO:0030497 fatty acid elongation(GO:0030497)
0.5 2.4 GO:0070941 eisosome assembly(GO:0070941)
0.5 1.4 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.5 0.5 GO:0070189 kynurenine metabolic process(GO:0070189)
0.5 11.3 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.4 7.2 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.4 1.8 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.4 4.6 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.4 2.4 GO:0006491 N-glycan processing(GO:0006491)
0.4 1.2 GO:1900434 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.4 2.3 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.4 1.9 GO:0046219 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.4 1.9 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.4 1.8 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.4 3.5 GO:0006817 phosphate ion transport(GO:0006817)
0.4 1.1 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.3 7.8 GO:0006885 regulation of pH(GO:0006885)
0.3 1.3 GO:0009099 valine biosynthetic process(GO:0009099)
0.3 1.0 GO:0051320 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.3 0.6 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.3 3.6 GO:0007120 axial cellular bud site selection(GO:0007120)
0.3 1.5 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.3 1.7 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.3 5.4 GO:0006614 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.3 1.7 GO:0001009 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.3 0.8 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.3 2.2 GO:0033014 porphyrin-containing compound biosynthetic process(GO:0006779) heme biosynthetic process(GO:0006783) tetrapyrrole biosynthetic process(GO:0033014)
0.3 1.3 GO:0006972 hyperosmotic response(GO:0006972)
0.3 0.8 GO:1901985 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.3 1.1 GO:0015680 intracellular copper ion transport(GO:0015680)
0.3 0.8 GO:0015691 cadmium ion transport(GO:0015691)
0.3 0.8 GO:0006624 vacuolar protein processing(GO:0006624)
0.3 2.6 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.3 0.8 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.3 0.3 GO:0071478 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.3 1.0 GO:1902931 negative regulation of alcohol biosynthetic process(GO:1902931)
0.2 0.7 GO:0046495 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.2 0.7 GO:0023021 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.2 2.6 GO:0015833 peptide transport(GO:0015833)
0.2 0.9 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.2 1.3 GO:0032508 DNA duplex unwinding(GO:0032508)
0.2 0.6 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.2 0.8 GO:0001927 exocyst assembly(GO:0001927)
0.2 0.8 GO:0018196 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.2 1.0 GO:0035268 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.2 0.8 GO:1900461 positive regulation of cell growth(GO:0030307) positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter(GO:1900461) positive regulation of pseudohyphal growth(GO:2000222)
0.2 1.5 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.2 2.6 GO:0030488 tRNA methylation(GO:0030488)
0.2 3.7 GO:0006334 nucleosome assembly(GO:0006334)
0.2 1.1 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.2 0.4 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.2 2.5 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.2 1.2 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.2 1.1 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.2 0.5 GO:0030308 negative regulation of cell growth(GO:0030308) negative regulation of pseudohyphal growth(GO:2000221)
0.2 0.3 GO:1901352 regulation of phosphatidylglycerol biosynthetic process(GO:1901351) negative regulation of phosphatidylglycerol biosynthetic process(GO:1901352)
0.2 1.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 0.7 GO:0042990 regulation of transcription factor import into nucleus(GO:0042990)
0.2 0.5 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.2 1.5 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.2 1.3 GO:0015891 siderophore transport(GO:0015891)
0.2 2.1 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.2 29.1 GO:0006364 rRNA processing(GO:0006364)
0.2 1.1 GO:0007323 peptide pheromone maturation(GO:0007323)
0.2 3.0 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.2 0.8 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.2 3.0 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.2 1.4 GO:0032120 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.2 0.5 GO:2000220 regulation of pseudohyphal growth(GO:2000220)
0.2 2.1 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.1 0.6 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.9 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.1 3.5 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 0.9 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 1.5 GO:0007009 plasma membrane organization(GO:0007009)
0.1 0.5 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 3.0 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 1.8 GO:0009636 response to toxic substance(GO:0009636)
0.1 0.3 GO:0009847 spore germination(GO:0009847)
0.1 0.5 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 1.3 GO:0016075 rRNA catabolic process(GO:0016075)
0.1 0.5 GO:0015883 FAD transport(GO:0015883)
0.1 0.2 GO:0034030 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.1 0.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 1.1 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 2.8 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.3 GO:0007050 cell cycle arrest(GO:0007050)
0.1 3.1 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 1.8 GO:0046785 microtubule nucleation(GO:0007020) microtubule polymerization(GO:0046785)
0.1 1.8 GO:0006999 nuclear pore organization(GO:0006999)
0.1 0.1 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.1 1.0 GO:0006272 leading strand elongation(GO:0006272)
0.1 0.4 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.1 1.7 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.1 0.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 0.3 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.1 0.7 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.1 0.3 GO:1903313 negative regulation of translational initiation(GO:0045947) positive regulation of mRNA metabolic process(GO:1903313)
0.1 1.2 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.1 3.0 GO:0007124 pseudohyphal growth(GO:0007124)
0.1 1.4 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 1.9 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 0.2 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.1 0.5 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.1 0.4 GO:0009306 protein secretion(GO:0009306)
0.1 0.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 1.4 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.1 0.5 GO:0018345 protein palmitoylation(GO:0018345)
0.1 1.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 5.7 GO:0032543 mitochondrial translation(GO:0032543)
0.1 0.2 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.1 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.1 0.4 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.4 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.1 0.7 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 0.2 GO:0032988 spliceosomal complex disassembly(GO:0000390) ribonucleoprotein complex disassembly(GO:0032988)
0.0 0.6 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.1 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.0 1.0 GO:0006400 tRNA modification(GO:0006400)
0.0 0.2 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.2 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.1 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.0 0.1 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402) positive regulation of translational initiation(GO:0045948)
0.0 0.4 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.3 GO:0051495 positive regulation of cytoskeleton organization(GO:0051495)
0.0 0.1 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.0 GO:1903530 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.0 0.4 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.2 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.4 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.0 GO:0010978 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.0 0.2 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.1 GO:0015677 copper ion import(GO:0015677)
0.0 0.1 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.1 GO:0006665 sphingolipid metabolic process(GO:0006665)
0.0 0.1 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.0 0.2 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
2.3 6.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
2.0 6.0 GO:0071261 Ssh1 translocon complex(GO:0071261)
1.7 5.0 GO:0030428 cell septum(GO:0030428)
1.6 4.9 GO:0097344 Rix1 complex(GO:0097344)
1.5 4.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
1.4 16.3 GO:0000788 nuclear nucleosome(GO:0000788)
1.3 5.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.1 3.3 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
1.1 2.2 GO:0000786 nucleosome(GO:0000786)
1.1 65.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.0 4.2 GO:0030907 MBF transcription complex(GO:0030907)
1.0 2.9 GO:0046930 pore complex(GO:0046930)
1.0 5.8 GO:0005871 kinesin complex(GO:0005871)
0.9 2.8 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.9 5.5 GO:0042555 MCM complex(GO:0042555)
0.8 3.3 GO:0032160 septin filament array(GO:0032160)
0.8 2.5 GO:0032301 MutSalpha complex(GO:0032301)
0.8 68.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.7 3.7 GO:0030478 actin cap(GO:0030478)
0.7 2.9 GO:0031518 CBF3 complex(GO:0031518)
0.7 2.7 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.6 5.1 GO:0005688 U6 snRNP(GO:0005688)
0.6 1.8 GO:0070545 PeBoW complex(GO:0070545)
0.6 10.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.6 2.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.6 4.0 GO:0032432 actin filament bundle(GO:0032432)
0.5 1.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.5 5.3 GO:0032161 cellular bud neck septin structure(GO:0000399) cleavage apparatus septin structure(GO:0032161)
0.5 2.0 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.5 6.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.4 2.4 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.4 1.9 GO:0030689 Noc complex(GO:0030689)
0.4 1.5 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.4 1.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.4 2.2 GO:0032126 eisosome(GO:0032126)
0.4 2.5 GO:0072686 mitotic spindle(GO:0072686)
0.4 1.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.4 3.9 GO:0000243 commitment complex(GO:0000243)
0.3 1.4 GO:0000938 GARP complex(GO:0000938)
0.3 1.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.3 4.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 0.9 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.3 1.7 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.3 0.8 GO:0000814 ESCRT II complex(GO:0000814)
0.3 9.5 GO:0005811 lipid particle(GO:0005811)
0.2 0.5 GO:0044453 nuclear membrane part(GO:0044453)
0.2 16.9 GO:0005576 extracellular region(GO:0005576)
0.2 1.2 GO:0031262 Ndc80 complex(GO:0031262)
0.2 2.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 1.0 GO:0032545 CURI complex(GO:0032545)
0.2 1.7 GO:0030008 TRAPP complex(GO:0030008)
0.2 0.8 GO:0005797 Golgi medial cisterna(GO:0005797)
0.2 0.6 GO:0070985 TFIIK complex(GO:0070985)
0.2 1.0 GO:0031389 DNA replication factor C complex(GO:0005663) Rad17 RFC-like complex(GO:0031389) Elg1 RFC-like complex(GO:0031391)
0.2 0.8 GO:0005940 septin ring(GO:0005940)
0.2 1.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 1.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 0.7 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.2 1.3 GO:0034455 t-UTP complex(GO:0034455)
0.2 5.7 GO:0015935 small ribosomal subunit(GO:0015935)
0.2 0.9 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)
0.2 1.2 GO:0000346 transcription export complex(GO:0000346)
0.2 2.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 2.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.4 GO:0000229 cytoplasmic chromosome(GO:0000229) mitochondrial chromosome(GO:0000262)
0.1 6.2 GO:0030686 90S preribosome(GO:0030686)
0.1 0.9 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 1.8 GO:0034399 nuclear periphery(GO:0034399)
0.1 0.4 GO:0000930 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.1 1.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.9 GO:0000145 exocyst(GO:0000145)
0.1 0.8 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.3 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 1.0 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.4 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.1 1.3 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 1.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.7 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 3.4 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 12.9 GO:0005933 cellular bud(GO:0005933)
0.1 0.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.3 GO:0032116 SMC loading complex(GO:0032116)
0.1 0.3 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.1 0.9 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 0.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.2 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.1 2.7 GO:0031965 nuclear membrane(GO:0031965)
0.1 0.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.4 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.3 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 8.7 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.4 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)
0.0 0.2 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase complex(GO:0033176)
0.0 2.4 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.7 GO:0070847 core mediator complex(GO:0070847)
0.0 4.4 GO:0005794 Golgi apparatus(GO:0005794)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.6 GO:0005844 polysome(GO:0005844)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.5 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.0 GO:0070823 HDA1 complex(GO:0070823)
0.0 1.8 GO:0005730 nucleolus(GO:0005730)
0.0 0.6 GO:0005840 ribosome(GO:0005840)
0.0 0.3 GO:0000502 proteasome complex(GO:0000502)
0.0 0.1 GO:0016586 RSC complex(GO:0016586)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.9 GO:0051219 phosphoprotein binding(GO:0051219)
2.8 8.4 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
2.7 8.1 GO:0070568 guanylyltransferase activity(GO:0070568)
2.4 9.4 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
2.1 6.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
2.0 12.0 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
1.9 5.8 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
1.7 6.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.5 5.9 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
1.4 5.5 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
1.3 5.4 GO:0016725 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.3 5.3 GO:0009378 four-way junction helicase activity(GO:0009378)
1.3 4.0 GO:0072341 modified amino acid binding(GO:0072341)
1.3 3.9 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
1.2 3.6 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
1.1 4.4 GO:0016841 ammonia-lyase activity(GO:0016841)
1.0 3.1 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
1.0 2.9 GO:0015288 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
1.0 3.9 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
1.0 2.9 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.9 11.1 GO:0005199 structural constituent of cell wall(GO:0005199)
0.9 9.1 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.9 9.1 GO:0031386 protein tag(GO:0031386)
0.8 4.0 GO:0017048 Rho GTPase binding(GO:0017048)
0.8 2.3 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.7 5.8 GO:0003777 microtubule motor activity(GO:0003777)
0.7 2.8 GO:0008310 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.7 2.7 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.7 2.0 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.6 129.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 1.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.6 2.4 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.6 18.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.6 14.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.6 2.2 GO:0019206 nucleoside kinase activity(GO:0019206)
0.6 2.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.5 1.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.5 4.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.5 4.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.5 1.5 GO:0009922 fatty acid elongase activity(GO:0009922)
0.5 3.0 GO:0003993 acid phosphatase activity(GO:0003993)
0.5 1.9 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.5 1.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.5 1.8 GO:0004622 lysophospholipase activity(GO:0004622)
0.4 2.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.4 1.3 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.4 1.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.4 1.2 GO:0008251 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.4 2.4 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.4 8.1 GO:0015926 glucosidase activity(GO:0015926)
0.4 2.6 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.4 1.1 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.4 2.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 2.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4 2.6 GO:0019237 centromeric DNA binding(GO:0019237)
0.4 2.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.3 2.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.3 10.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.3 1.7 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.3 2.3 GO:0005216 ion channel activity(GO:0005216)
0.3 6.4 GO:0042803 protein homodimerization activity(GO:0042803)
0.3 3.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.3 3.8 GO:0051015 actin filament binding(GO:0051015)
0.3 0.9 GO:0000339 RNA cap binding(GO:0000339)
0.3 2.2 GO:0019239 deaminase activity(GO:0019239)
0.3 1.6 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.3 0.9 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.3 6.0 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.3 1.8 GO:0005516 calmodulin binding(GO:0005516)
0.3 1.5 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.3 4.0 GO:0001671 ATPase activator activity(GO:0001671)
0.3 1.7 GO:0001004 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.3 2.2 GO:1901681 sulfur compound binding(GO:1901681)
0.3 2.3 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.2 1.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.2 0.7 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.2 0.9 GO:0001168 transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.2 0.6 GO:0016624 pyruvate dehydrogenase activity(GO:0004738) oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.2 3.0 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.2 1.0 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.2 0.6 GO:0019901 protein kinase binding(GO:0019901)
0.2 0.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 0.6 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.2 1.5 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 1.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 1.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.2 2.1 GO:0008320 protein transmembrane transporter activity(GO:0008320) macromolecule transmembrane transporter activity(GO:0022884)
0.2 1.0 GO:0016408 C-acyltransferase activity(GO:0016408)
0.2 5.0 GO:0015631 tubulin binding(GO:0015631)
0.2 2.6 GO:0051087 chaperone binding(GO:0051087)
0.2 0.3 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163)
0.2 0.5 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.2 1.0 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 2.7 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 2.5 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.2 0.5 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.2 0.8 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 0.7 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 1.3 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 5.7 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.7 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129)
0.1 0.9 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.5 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.1 2.8 GO:0003779 actin binding(GO:0003779)
0.1 0.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.6 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 3.1 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 1.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 7.4 GO:0003924 GTPase activity(GO:0003924)
0.1 1.5 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.5 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.1 0.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 2.7 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.4 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.1 0.4 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 1.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.0 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.3 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.1 0.9 GO:0019207 kinase regulator activity(GO:0019207)
0.1 1.0 GO:0050661 NADP binding(GO:0050661)
0.1 0.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 1.8 GO:0030674 protein binding, bridging(GO:0030674)
0.1 0.5 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.1 0.6 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.2 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.8 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.4 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.0 0.2 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.2 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.2 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.6 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.1 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.1 GO:0000049 tRNA binding(GO:0000049)
0.0 0.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.0 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.4 2.1 PID PLK1 PATHWAY PLK1 signaling events
0.3 0.6 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.2 0.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 1.6 PID ATR PATHWAY ATR signaling pathway
0.1 0.3 PID E2F PATHWAY E2F transcription factor network
0.1 0.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 7.9 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
1.8 14.1 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
1.1 4.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.8 5.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.8 6.0 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.3 2.6 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 1.0 REACTOME GLOBAL GENOMIC NER GG NER Genes involved in Global Genomic NER (GG-NER)
0.2 1.3 REACTOME PROTEIN FOLDING Genes involved in Protein folding
0.2 2.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 2.8 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.2 0.8 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 0.7 REACTOME GPCR DOWNSTREAM SIGNALING Genes involved in GPCR downstream signaling
0.1 0.8 REACTOME MITOTIC M M G1 PHASES Genes involved in Mitotic M-M/G1 phases
0.1 0.3 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.0 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism