Results for RPN4
Z-value: 0.90
Motif logo
Transcription factors associated with RPN4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
RPN4
|
S000002178 | Transcription factor that stimulates expression of proteasome genes |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YJR005C-A Show fit | 2.00 |
Putative protein of unknown function, originally identified as a syntenic homolog of an Ashbya gossypii gene |
||
| YJL115W Show fit | 1.85 |
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition |
||
| YBL085W Show fit | 1.71 |
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain |
||
| YJR094C Show fit | 1.51 |
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p |
||
| YGL035C Show fit | 1.44 |
Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase |
||
| YJL116C Show fit | 1.43 |
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family |
||
| YKL218C Show fit | 1.32 |
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate |
||
| YDR510W Show fit | 1.06 |
Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics |
||
| YOL123W Show fit | 1.02 |
Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences |
||
| YOR052C Show fit | 1.02 |
Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid |
Network of associatons between targets according to the STRING database.
First level regulatory network of RPN4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.2 | 2.9 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.4 | 1.9 | GO:2000758 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-dependent nucleosome organization(GO:0034723) positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758) |
| 0.2 | 1.8 | GO:0007109 | obsolete cytokinesis, completion of separation(GO:0007109) |
| 0.1 | 1.6 | GO:0040020 | regulation of meiotic nuclear division(GO:0040020) |
| 0.4 | 1.5 | GO:0036170 | filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436) |
| 0.4 | 1.4 | GO:0000715 | nucleotide-excision repair, DNA damage recognition(GO:0000715) |
| 0.2 | 1.4 | GO:0009102 | biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102) |
| 0.2 | 1.4 | GO:0042219 | cellular modified amino acid catabolic process(GO:0042219) |
| 0.1 | 1.4 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.3 | 1.8 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.2 | 1.8 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.1 | 1.6 | GO:0005940 | septin ring(GO:0005940) |
| 0.0 | 1.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.3 | 1.4 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 1.4 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 1.4 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 1.3 | GO:0043332 | mating projection tip(GO:0043332) |
| 0.0 | 1.3 | GO:0000428 | DNA-directed RNA polymerase complex(GO:0000428) RNA polymerase complex(GO:0030880) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 2.9 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 2.5 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.1 | 2.4 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 2.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 2.1 | GO:0005543 | phospholipid binding(GO:0005543) |
| 0.0 | 2.0 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.1 | 1.8 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 1.5 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.3 | 1.3 | GO:0016854 | racemase and epimerase activity(GO:0016854) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 0.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 0.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 0.5 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 0.2 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.0 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.2 | 1.3 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.2 | 1.0 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.1 | 0.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.2 | 0.5 | REACTOME SIGNALLING TO ERKS | Genes involved in Signalling to ERKs |
| 0.1 | 0.4 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 0.4 | REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION | Genes involved in E2F mediated regulation of DNA replication |
| 0.2 | 0.3 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 0.3 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 0.2 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |