Navigation
Downloads

Results for RPN4

Z-value: 0.90

Motif logo

logo of

Transcription factors associated with RPN4

Gene Symbol Gene ID Gene Info
RPN4
S000002178 Transcription factor that stimulates expression of proteasome genes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RPN4YDL020C0.203.2e-01Click!

Activity profile of RPN4 motif

Sorted Z-values of RPN4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YJR005C-A 2.00 Putative protein of unknown function, originally identified as a syntenic homolog of an Ashbya gossypii gene
YJL115W 1.85
ASF1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YBL085W 1.71
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YJR094C 1.51
IME1
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YGL035C 1.44
MIG1
Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YJL116C 1.43
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YKL218C 1.32
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YDR510W 1.06
SMT3
Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
YOL123W 1.02
HRP1
Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YOR052C 1.02 Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid
YLL045C 0.91
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YDL037C 0.91
BSC1
Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YGR286C 0.91
BIO2
Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YNL251C 0.91
NRD1
RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs
YBR114W 0.88
RAD16
Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
YAL003W 0.86
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YJL107C 0.85 Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YGL103W 0.84
RPL28
Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance
YMR100W 0.82
MUB1
Protein of unknown function, deletion causes multi-budding phenotype; has similarity to Aspergillus nidulans samB gene
YER177W 0.80
BMH1
14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YMR102C 0.79 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YDR224C 0.79
HTB1
One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YFL023W 0.75
BUD27
Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by TOR kinase; diploid mutants show a random budding pattern rather than the wild-type bipolar pattern; plays a role in regulating Ty1 transposition
YBR112C 0.73
CYC8
General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
YJR094W-A 0.73
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YGR255C 0.70
COQ6
Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
YBR184W 0.69 Putative protein of unknown function; YBR184W is not an essential gene
YFR056C 0.66 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YGR060W 0.66
ERG25
C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YKL216W 0.66
URA1
Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YBR208C 0.62
DUR1,2
Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YLR260W 0.61
LCB5
Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
YLR448W 0.60
RPL6B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
YIL031W 0.59
ULP2
Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
YHR021C 0.58
RPS27B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YGR048W 0.57
UFD1
Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol
YML007W 0.56
YAP1
Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium
YDR414C 0.56
ERD1
Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
YGR140W 0.54
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YJL090C 0.53
DPB11
Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis, also required for S/M checkpoint control
YOL038W 0.53
PRE6
Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
YNL323W 0.53
LEM3
Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
YFR055W 0.52
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YIL142C-A 0.51 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL211C 0.50 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YKL190W 0.50
CNB1
Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1
YFL022C 0.49
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YNR051C 0.49
BRE5
Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
YML032C 0.49
RAD52
Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
YBR106W 0.48
PHO88
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YDL070W 0.47
BDF2
Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p
YMR101C 0.47
SRT1
Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
YLL027W 0.47
ISA1
Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources
YHL024W 0.47
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YAL005C 0.47
SSA1
ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
YML088W 0.46
UFO1
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YAL053W 0.46
FLC2
Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YPL110C 0.46
GDE1
Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
YOR355W 0.46
GDS1
Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER012W 0.46
PRE1
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YKL118W 0.45 Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2
YPL177C 0.44
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YJR006W 0.44
POL31
DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair
YKL054C 0.44
DEF1
RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis
YOR226C 0.43
ISU2
Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YGR138C 0.43
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YCL058C 0.43
FYV5
Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in ion homeostasis
YIL142W 0.43
CCT2
Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YKL110C 0.42
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YHR006W 0.42
STP2
Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes
YDL246C 0.42
SOR2
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YEL037C 0.41
RAD23
Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins
YOL086W-A 0.41 Putative protein of unknown function; identified by homology
YAL035W 0.41
FUN12
GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2
YIL072W 0.40
HOP1
Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation
YGR051C 0.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YDR043C 0.39
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YCR061W 0.39 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation
YJL106W 0.39
IME2
Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YGR052W 0.39
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YEL033W 0.39
MTC7
Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
YHR183W 0.39
GND1
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
YHL031C 0.39
GOS1
v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
YKR092C 0.38
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YER064C 0.38 Non-essential nuclear protein; null mutation has global effects on transcription
YGL122C 0.38
NAB2
Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
YBR171W 0.38
SEC66
Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YOR362C 0.37
PRE10
Alpha 7 subunit of the 20S proteasome
YBR174C 0.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective
YBR009C 0.37
HHF1
One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YNL027W 0.37
CRZ1
Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation
YBR113W 0.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
YLR287C-A 0.36
RPS30A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein
YOR062C 0.36 Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YDL007W 0.36
RPT2
One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
YDR073W 0.36
SNF11
Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YCR081C-A 0.35 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with SRB8/YCR081W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YML125C 0.35
PGA3
Essential protein required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; GFP-fusion protein localizes to the endoplasmic reticulum; null mutants have a cell separation defect
YDL193W 0.35
NUS1
Prenyltransferase, required for cell viability; involved in protein trafficking
YGR047C 0.35
TFC4
One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
YKR011C 0.35 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YJL036W 0.35
SNX4
Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX domain; forms complexes with Snx41p and with Atg20p
YPR008W 0.35
HAA1
Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins; involved in adaptation to weak acid stress
YER095W 0.35
RAD51
Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
YML111W 0.35
BUL2
Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1
YJL200C 0.35
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YOR157C 0.34
PUP1
Endopeptidase with trypsin-like activity that cleaves after basic residues; beta 2 subunit of 20S proteasome, synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
YBL086C 0.34 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YLL043W 0.34
FPS1
Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
YGL201C 0.34
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YGL172W 0.34
NUP49
Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes
YOR389W 0.34 Putative protein of unknown function; expression regulated by copper levels
YHR182C-A 0.34 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR003C 0.33
YPI1
Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen
YGL033W 0.33
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YML092C 0.33
PRE8
Alpha 2 subunit of the 20S proteasome
YDR431W 0.33 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR374W-A 0.32 Putative protein of unknown function
YJL007C 0.32 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR159W 0.32
SOR1
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol
YDL028C 0.32
MPS1
Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p
YOL087C 0.32 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid
YDL145C 0.31
COP1
Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
YKL117W 0.31
SBA1
Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity
YBL058W 0.31
SHP1
UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
YPR102C 0.31
RPL11A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YOR050C 0.31 Hypothetical protein
YMR067C 0.31
UBX4
UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
YLR096W 0.30
KIN2
Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p
YML065W 0.30
ORC1
Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity
YLR154W-A 0.30 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YMR246W 0.29
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YPR041W 0.29
TIF5
Translation initiation factor eIF-5; N-terminal domain functions as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP; C-terminal domain is the core of ribosomal preinitiation complex formation
YOR051C 0.29 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YML130C 0.28
ERO1
Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum
YLR154W-B 0.28 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YFL036W 0.28
RPO41
Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
YOL034W 0.28
SMC5
Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
YKL015W 0.28
PUT3
Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain
YER075C 0.27
PTP3
Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
YOR146W 0.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
YDR363W-A 0.27
SEM1
Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1
YBL041W 0.27
PRE7
Beta 6 subunit of the 20S proteasome
YCR082W 0.27
AHC2
Protein of unknown function, putative transcriptional regulator; proposed to be a Ada Histone acetyltransferase complex component; GFP tagged protein is localized to the cytoplasm and nucleus
YDR285W 0.27
ZIP1
Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate
YER129W 0.27
SAK1
Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YBR300C 0.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
YNL155W 0.27 Putative protein of unknown function, contains DHHC domain, also predicted to have thiol-disulfide oxidoreductase active site
YBR010W 0.27
HHT1
One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YHR021W-A 0.27
ECM12
Non-essential protein of unknown function
YEL056W 0.27
HAT2
Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YNL172W 0.26
APC1
Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YMR281W 0.26
GPI12
ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
YCL024W 0.26
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YEL032W 0.26
MCM3
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YIL126W 0.26
STH1
ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
YGL011C 0.26
SCL1
Alpha 1 subunit of the 20S core complex of the 26S proteasome involved in the degradation of ubiquitinated substrates; essential for growth; detected in the mitochondria
YHR027C 0.26
RPN1
Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions
YNL313C 0.26 Putative protein of unknown function; identified as interacting with Kar2p, Grs1p, and Tub3p in high-throughput TAP-tagging experiments; YNL313C is an essential gene
YJL014W 0.26
CCT3
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YNL304W 0.26
YPT11
Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells
YPR185W 0.26
ATG13
Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling
YPL058C 0.26
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YOR145C 0.26
PNO1
Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain
YJL105W 0.26
SET4
Protein of unknown function, contains a SET domain
YJL008C 0.25
CCT8
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YOR359W 0.25
VTS1
Post-transcriptional gene regulator, RNA-binding protein containing a SAM domain; shows genetic interactions with Vti1p, which is a v-SNARE involved in cis-Golgi membrane traffic
YBR202W 0.25
MCM7
Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YER054C 0.25
GIP2
Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p
YJL015C 0.25 Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W
YFR051C 0.25
RET2
Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YPR065W 0.25
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YEL034C-A 0.24 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A
YLR154W-C 0.24
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YOL086C 0.24
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YOL159C-A 0.24 Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YFL015W-A 0.24 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR097W 0.24
ASK10
Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes
YDR270W 0.24
CCC2
Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases
YPL108W 0.24 Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YHR203C 0.23
RPS4B
Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
YGL148W 0.23
ARO2
Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YPL205C 0.23 Hypothetical protein; deletion of locus affects telomere length
YBR060C 0.23
ORC2
Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
YPL204W 0.23
HRR25
Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
YBR049C 0.23
REB1
RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription
YOR315W 0.23
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YIR007W 0.23 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
YHR154W 0.23
RTT107
Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition
YDR279W 0.23
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YGR146C-A 0.23 Putative protein of unknown function
YML031C-A 0.23 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF NDC1/YML031W; questionable ORF from MIPS
YIL164C 0.22
NIT1
Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
YPR125W 0.22
YLH47
Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome
YNR054C 0.22
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YDL143W 0.22
CCT4
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YMR108W 0.22
ILV2
Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
YMR244C-A 0.22 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene
YFR037C 0.22
RSC8
Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
YPL128C 0.22
TBF1
Telobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by blocking silent chromatin propagation

Network of associatons between targets according to the STRING database.

First level regulatory network of RPN4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0035950 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.4 1.5 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.4 1.9 GO:2000758 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-dependent nucleosome organization(GO:0034723) positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.4 1.4 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.3 0.9 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.2 0.9 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.2 0.9 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.2 1.4 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.2 0.6 GO:0043419 urea catabolic process(GO:0043419)
0.2 2.9 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 0.6 GO:0000304 response to singlet oxygen(GO:0000304)
0.2 0.7 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.2 0.5 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.2 0.5 GO:0061422 positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422)
0.2 0.5 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.2 0.7 GO:0048313 Golgi inheritance(GO:0048313)
0.2 0.5 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.2 0.5 GO:0034517 ribophagy(GO:0034517)
0.2 1.8 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.2 1.4 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.4 GO:0071469 response to alkaline pH(GO:0010446) cellular response to alkaline pH(GO:0071469)
0.1 0.5 GO:0000296 spermine transport(GO:0000296)
0.1 0.5 GO:0015883 FAD transport(GO:0015883)
0.1 1.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.1 GO:2000756 regulation of histone acetylation(GO:0035065) regulation of protein acetylation(GO:1901983) regulation of peptidyl-lysine acetylation(GO:2000756)
0.1 0.4 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.5 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.6 GO:0015793 glycerol transport(GO:0015793)
0.1 0.3 GO:0010922 positive regulation of phosphatase activity(GO:0010922)
0.1 0.8 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 0.5 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.1 0.6 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 0.6 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.4 GO:0051225 spindle assembly(GO:0051225)
0.1 0.5 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.3 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.1 0.1 GO:0019627 urea metabolic process(GO:0019627)
0.1 0.3 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133) regulation of cellular amine catabolic process(GO:0033241)
0.1 0.4 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.1 0.4 GO:1903829 retrograde protein transport, ER to cytosol(GO:0030970) positive regulation of protein localization to nucleus(GO:1900182) endoplasmic reticulum to cytosol transport(GO:1903513) positive regulation of cellular protein localization(GO:1903829)
0.1 0.6 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.3 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.1 1.0 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.2 GO:0034059 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 1.3 GO:0006334 nucleosome assembly(GO:0006334)
0.1 0.5 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.1 0.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 0.6 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 0.3 GO:0031134 sister chromatid biorientation(GO:0031134)
0.1 0.4 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.1 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.1 0.3 GO:0042256 mature ribosome assembly(GO:0042256)
0.1 1.2 GO:0006513 protein monoubiquitination(GO:0006513)
0.1 0.3 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.1 1.4 GO:0006378 mRNA polyadenylation(GO:0006378)
0.1 0.1 GO:0015908 fatty acid transport(GO:0015908)
0.1 0.2 GO:0072363 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
0.1 0.5 GO:2000278 regulation of telomere maintenance via telomerase(GO:0032210) regulation of telomere maintenance via telomere lengthening(GO:1904356) regulation of DNA biosynthetic process(GO:2000278)
0.1 0.5 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.1 0.2 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.1 0.3 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.1 1.0 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.7 GO:0042181 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.1 0.3 GO:0032079 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1 0.7 GO:0006817 phosphate ion transport(GO:0006817)
0.1 0.2 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.1 0.4 GO:0001009 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.1 0.5 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.2 GO:0032443 regulation of steroid metabolic process(GO:0019218) regulation of ergosterol biosynthetic process(GO:0032443) regulation of steroid biosynthetic process(GO:0050810)
0.1 0.2 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 0.2 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.1 0.3 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 0.4 GO:0019655 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.1 1.6 GO:0040020 regulation of meiotic nuclear division(GO:0040020)
0.0 0.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.1 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
0.0 0.1 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.4 GO:0045860 positive regulation of protein kinase activity(GO:0045860)
0.0 0.3 GO:0071039 nuclear polyadenylation-dependent CUT catabolic process(GO:0071039)
0.0 0.3 GO:0009099 valine biosynthetic process(GO:0009099)
0.0 0.1 GO:0042148 strand invasion(GO:0042148)
0.0 0.1 GO:1900151 regulation of mRNA 3'-end processing(GO:0031440) regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151)
0.0 0.1 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111) regulation of microtubule depolymerization(GO:0031114)
0.0 0.1 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.0 0.0 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 0.1 GO:0070482 response to decreased oxygen levels(GO:0036293) response to oxygen levels(GO:0070482)
0.0 0.4 GO:2000144 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 1.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.7 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.9 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:0000090 mitotic anaphase(GO:0000090)
0.0 0.2 GO:0043007 maintenance of rDNA(GO:0043007)
0.0 0.1 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.4 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.2 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.0 0.2 GO:0016559 peroxisome fission(GO:0016559)
0.0 0.1 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.0 0.2 GO:0010529 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.0 0.3 GO:0007129 synapsis(GO:0007129)
0.0 0.1 GO:0001111 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.0 0.1 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.4 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.5 GO:0043248 proteasome assembly(GO:0043248)
0.0 3.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.1 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 0.1 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0000735 removal of nonhomologous ends(GO:0000735)
0.0 0.8 GO:0051304 chromosome separation(GO:0051304)
0.0 0.3 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 0.1 GO:0030308 negative regulation of cell growth(GO:0030308) negative regulation of pseudohyphal growth(GO:2000221)
0.0 0.1 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.0 0.0 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 0.2 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.0 0.0 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021)
0.0 0.1 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.2 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.1 GO:0006750 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.0 0.1 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.2 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.3 GO:0032005 pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0000750) signal transduction involved in conjugation with cellular fusion(GO:0032005)
0.0 0.1 GO:0006021 inositol biosynthetic process(GO:0006021)
0.0 0.3 GO:0000754 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion(GO:0000754) adaptation of signaling pathway(GO:0023058)
0.0 0.1 GO:0000921 septin ring assembly(GO:0000921)
0.0 0.1 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.0 1.3 GO:0006457 protein folding(GO:0006457)
0.0 0.0 GO:1902749 regulation of G2/M transition of mitotic cell cycle(GO:0010389) regulation of cell cycle G2/M phase transition(GO:1902749)
0.0 0.0 GO:0015791 polyol transport(GO:0015791)
0.0 0.1 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.0 0.3 GO:0001101 response to acid chemical(GO:0001101)
0.0 0.1 GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process(GO:0071035)
0.0 0.1 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.1 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.0 0.0 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.2 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.0 0.1 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.0 0.1 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.1 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.1 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.0 0.0 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.2 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.2 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.3 GO:0005977 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.4 GO:0001302 replicative cell aging(GO:0001302)
0.0 0.1 GO:0046219 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.0 0.1 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.0 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.0 0.0 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.0 0.1 GO:0051051 negative regulation of transport(GO:0051051)
0.0 0.1 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)
0.0 0.0 GO:0042938 dipeptide transport(GO:0042938)
0.0 0.3 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.4 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.0 GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.0 0.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0034063 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) stress granule assembly(GO:0034063)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.3 0.9 GO:0035649 Nrd1 complex(GO:0035649)
0.3 1.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.3 1.8 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 0.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 1.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 0.5 GO:0005955 calcineurin complex(GO:0005955)
0.2 1.1 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.2 0.9 GO:0042555 MCM complex(GO:0042555)
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.4 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.1 0.5 GO:0031518 CBF3 complex(GO:0031518)
0.1 0.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.7 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 1.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.6 GO:0005940 septin ring(GO:0005940)
0.1 0.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.3 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.4 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 0.7 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.4 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.1 1.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.8 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 1.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.4 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.2 GO:0033551 monopolin complex(GO:0033551)
0.1 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.2 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.2 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.1 4.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.3 GO:0043614 multi-eIF complex(GO:0043614)
0.0 0.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.5 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.2 GO:0070772 PAS complex(GO:0070772)
0.0 0.1 GO:0030874 nucleolar chromatin(GO:0030874)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.1 GO:0043529 GET complex(GO:0043529)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.5 GO:0016586 RSC complex(GO:0016586)
0.0 0.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.2 GO:0008278 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.0 0.4 GO:0005769 early endosome(GO:0005769)
0.0 0.4 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)
0.0 0.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0005884 actin filament(GO:0005884)
0.0 0.2 GO:0036452 ESCRT complex(GO:0036452)
0.0 1.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.1 GO:0032126 eisosome(GO:0032126)
0.0 0.1 GO:0032301 MutSalpha complex(GO:0032301)
0.0 0.2 GO:0031261 DNA replication preinitiation complex(GO:0031261)
0.0 0.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.9 GO:0005811 lipid particle(GO:0005811)
0.0 0.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.2 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0097344 Rix1 complex(GO:0097344)
0.0 0.1 GO:0031499 TRAMP complex(GO:0031499)
0.0 0.1 GO:0031391 DNA replication factor C complex(GO:0005663) Rad17 RFC-like complex(GO:0031389) Elg1 RFC-like complex(GO:0031391)
0.0 0.1 GO:0032545 CURI complex(GO:0032545)
0.0 0.1 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.4 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 0.1 GO:0005880 nuclear microtubule(GO:0005880)
0.0 0.1 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112) core TFIIH complex(GO:0000439)
0.0 0.2 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.7 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 0.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 1.3 GO:0043332 mating projection tip(GO:0043332)
0.0 1.3 GO:0000428 DNA-directed RNA polymerase complex(GO:0000428) RNA polymerase complex(GO:0030880)
0.0 0.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 0.0 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)
0.0 0.1 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 0.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.1 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.0 GO:0070390 transcription export complex 2(GO:0070390)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0016854 racemase and epimerase activity(GO:0016854)
0.3 0.9 GO:0051219 phosphoprotein binding(GO:0051219)
0.3 0.8 GO:0000150 recombinase activity(GO:0000150)
0.2 1.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 2.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 0.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 0.9 GO:0016783 sulfurtransferase activity(GO:0016783)
0.2 0.7 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.2 0.5 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.2 0.5 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.2 0.6 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 2.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.8 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.4 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.1 0.5 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.1 0.5 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.1 0.4 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.4 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.1 1.1 GO:0031386 protein tag(GO:0031386)
0.1 0.3 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 0.4 GO:0008310 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 0.3 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 0.1 GO:0000403 Y-form DNA binding(GO:0000403)
0.1 0.9 GO:0019904 protein domain specific binding(GO:0019904)
0.1 0.6 GO:0008143 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.1 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.5 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 0.3 GO:0032183 SUMO binding(GO:0032183)
0.1 0.3 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.2 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 0.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.2 GO:0072341 modified amino acid binding(GO:0072341)
0.1 1.8 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.3 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.1 0.7 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 2.4 GO:0042393 histone binding(GO:0042393)
0.1 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.2 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.8 GO:0004659 prenyltransferase activity(GO:0004659)
0.1 0.4 GO:0001004 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.1 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.6 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.3 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)
0.0 0.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.2 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.0 1.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.4 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.8 GO:0051536 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.0 0.4 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 2.5 GO:0003682 chromatin binding(GO:0003682)
0.0 0.1 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.1 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.2 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.6 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 2.0 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0008198 ferrous iron binding(GO:0008198)
0.0 2.1 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.9 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.0 0.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 1.0 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.2 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.0 0.3 GO:0019208 phosphatase regulator activity(GO:0019208)
0.0 5.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.6 GO:0032182 ubiquitin-like protein binding(GO:0032182) ubiquitin binding(GO:0043130)
0.0 0.2 GO:0051087 chaperone binding(GO:0051087)
0.0 0.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.1 GO:0016872 intramolecular lyase activity(GO:0016872)
0.0 0.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.4 GO:0005507 copper ion binding(GO:0005507)
0.0 0.1 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.0 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.1 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.3 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.1 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.3 GO:0043022 ribosome binding(GO:0043022)
0.0 1.2 GO:0000988 transcription factor activity, protein binding(GO:0000988)
0.0 0.2 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.2 GO:0042802 identical protein binding(GO:0042802)
0.0 0.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.0 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.0 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.2 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.1 GO:0005199 structural constituent of cell wall(GO:0005199)
0.0 0.0 GO:0031683 receptor binding(GO:0005102) G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 0.0 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.0 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0099600 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 0.5 PID SHP2 PATHWAY SHP2 signaling
0.1 0.6 PID E2F PATHWAY E2F transcription factor network
0.1 0.8 PID ATR PATHWAY ATR signaling pathway
0.1 0.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 1.3 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.2 0.5 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.2 0.3 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 0.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 0.2 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 0.4 REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION Genes involved in E2F mediated regulation of DNA replication
0.0 1.4 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.1 REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION Genes involved in Cleavage of Growing Transcript in the Termination Region
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.1 REACTOME TRANSCRIPTION COUPLED NER TC NER Genes involved in Transcription-coupled NER (TC-NER)
0.0 0.1 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.0 0.0 REACTOME SIGNALING BY NOTCH Genes involved in Signaling by NOTCH
0.0 0.1 REACTOME RNA POL II TRANSCRIPTION Genes involved in RNA Polymerase II Transcription
0.0 0.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors