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Results for RLM1

Z-value: 1.13

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Transcription factors associated with RLM1

Gene Symbol Gene ID Gene Info
RLM1
S000006010 MADS-box transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RLM1YPL089C0.572.3e-03Click!

Activity profile of RLM1 motif

Sorted Z-values of RLM1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YHR212C 6.14 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR013C 6.08
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YHR212W-A 5.96 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YAR053W 5.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR097W 5.72
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YAL062W 5.48
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YIL125W 5.01
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YPL171C 4.87
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YAR060C 4.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR120W 4.48
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YMR107W 4.40
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YDR342C 4.32
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YNL093W 4.22
YPT53
GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YEL012W 4.21
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YFR053C 4.19
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YOR381W 4.09
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YNR073C 4.03 Putative mannitol dehydrogenase
YKR102W 3.88
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YDR343C 3.80
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YEL008W 3.67 Hypothetical protein predicted to be involved in metabolism
YAR023C 3.60 Putative integral membrane protein, member of DUP240 gene family
YCL001W-B 3.57 Putative protein of unknown function; identified by homology
YEL009C 3.43
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YFL051C 3.42 Putative protein of unknown function; YFL051C is not an essential gene
YHR217C 3.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YKL217W 3.18
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YIL162W 3.11
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YAR050W 3.03
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YPR010C-A 3.01 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YAL054C 3.01
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YOR152C 2.99 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YAR047C 2.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL163W 2.91
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YPL165C 2.89
SET6
Protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
YGL187C 2.86
COX4
Subunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; N-terminal 25 residues of precursor are cleaved during mitochondrial import; phosphorylated
YDR538W 2.82
PAD1
Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiX
YML089C 2.81 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YMR090W 2.80 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YGR070W 2.78
ROM1
GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YEL009C-A 2.77 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER065C 2.71
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YDR059C 2.63
UBC5
Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YGR069W 2.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL210W 2.56
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YBR200W-A 2.48 Putative protein of unknown function; identified by fungal homology and RT-PCR
YDL169C 2.48
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YER014C-A 2.48
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YLR366W 2.38 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YGR087C 2.38
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YER158C 2.37 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YER103W 2.35
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YJL045W 2.33 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YFL063W 2.30 Dubious open reading frame, based on available experimental and comparative sequence data
YGR032W 2.28
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YMR081C 2.24
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YNR034W-A 2.23 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YHR071W 2.21
PCL5
Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YDR540C 2.21
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YBR076W 2.19
ECM8
Non-essential protein of unknown function
YCR025C 2.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YLR047C 2.14
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YDR119W-A 2.13 Putative protein of unknown function
YER033C 2.13
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YPR150W 2.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YDR043C 2.10
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YJL130C 2.06
URA2
Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YPL119C-A 2.05 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YMR014W 2.03
BUD22
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YEL010W 2.02 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR211C 2.02
MGM1
Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YGR144W 1.98
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YOR100C 1.94
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YBR077C 1.93
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YGR045C 1.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR023W 1.90
MTL1
Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YEL070W 1.90
DSF1
Deletion suppressor of mpt5 mutation
YAL063C 1.89
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YIL155C 1.87
GUT2
Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YCR091W 1.86
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YBR182C 1.85
SMP1
Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors
YGL146C 1.81 Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YHR138C 1.79 Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YHR218W 1.74 Helicase-like protein encoded within the telomeric Y' element
YLL053C 1.74 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YJR150C 1.71
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YLR004C 1.70
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YML090W 1.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YDR536W 1.65
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YGR022C 1.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YHR211W 1.64
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YPR027C 1.63 Putative protein of unknown function
YFL011W 1.61
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YCR040W 1.60
MATALPHA1
Transcriptional co-activator involved in regulation of mating-type-specific gene expression; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette
YOL082W 1.59
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YJL116C 1.59
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YEL007W 1.58 Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YMR104C 1.58
YPK2
Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
YGL081W 1.55 Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
YKL004W 1.55
AUR1
Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
YLL052C 1.54
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YDL194W 1.53
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YNL333W 1.52
SNZ2
Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p
YMR206W 1.52 Putative protein of unknown function; YMR206W is not an essential gene
YPR015C 1.49 Putative protein of unknown function
YOL154W 1.45
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YBR212W 1.44
NGR1
RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase
YGR088W 1.42
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YFL064C 1.42 Putative protein of unknown function
YOR235W 1.41
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YNL334C 1.41
SNO2
Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin
YPR202W 1.41 Putative protein of unknown function with similarity to telomere-encoded helicases; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
YLR365W 1.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
YAR027W 1.38
UIP3
Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
YHR009C 1.37 Putative protein of unknown function; not an essential gene
YJL161W 1.36
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YML091C 1.36
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YLR377C 1.35
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YOL060C 1.32
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YAL039C 1.30
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YCR007C 1.30 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YPL216W 1.29 Putative protein of unknown function; YPL216W is not an essential gene
YKL044W 1.28 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR196W 1.28 Putative maltose activator
YPR078C 1.27 Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YPL089C 1.27
RLM1
MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YDR461C-A 1.26 Putative protein of unknown function
YOR011W-A 1.26 Putative protein of unknown function
YDR014W-A 1.25
HED1
Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase
YER150W 1.24
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YLL030C 1.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL005C 1.20
BYE1
Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
YCL038C 1.20
ATG22
Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
YEL049W 1.20
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YFL062W 1.19
COS4
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YHR092C 1.18
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YDR313C 1.18
PIB1
RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YMR137C 1.17
PSO2
Required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation
YER024W 1.16
YAT2
Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
YDL244W 1.15
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YGR065C 1.15
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YCL065W 1.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps HMLALPHA1
YDR542W 1.13
PAU10
Hypothetical protein
YNL202W 1.12
SPS19
Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
YCL054W 1.12
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YDL180W 1.12 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YFL012W 1.12 Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin
YGR041W 1.11
BUD9
Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
YBR292C 1.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YNL144C 1.10 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YNL326C 1.10
PFA3
Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions
YIL059C 1.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
YPL088W 1.09 Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YCR039C 1.06
MATALPHA2
Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette
YDR223W 1.05
CRF1
Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus
YGR066C 1.05 Putative protein of unknown function
YHR002W 1.02
LEU5
Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized
YER163C 1.02 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YEL030C-A 1.02 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YBR296C 1.00
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YGR039W 1.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YLR189C 0.98
ATG26
UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
YOR289W 0.96 Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YER167W 0.96
BCK2
Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YHR048W 0.96
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YEL072W 0.95
RMD6
Protein required for sporulation
YLR023C 0.95
IZH3
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YOR348C 0.94
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YLL029W 0.94
FRA1
Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
YIL134C-A 0.94 Putative protein of unknown function, identified by fungal homology and RT-PCR
YDR387C 0.94 Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
YLR327C 0.93
TMA10
Protein of unknown function that associates with ribosomes
YKL109W 0.93
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YJL037W 0.92
IRC18
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YOR156C 0.92
NFI1
SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length
YGL255W 0.92
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YNL005C 0.91
MRP7
Mitochondrial ribosomal protein of the large subunit
YER187W 0.91 Putative protein of unknown function; induced in respiratory-deficient cells
YLR356W 0.91 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YER101C 0.90
AST2
Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
YOR339C 0.90
UBC11
Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2
YBR045C 0.90
GIP1
Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
YHR096C 0.90
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YJR120W 0.90 Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YLR331C 0.89
JIP3
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YOL159C 0.89 Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA
YER066W 0.89 Putative protein of unknown function; YER066W is not an essential gene
YDR528W 0.88
HLR1
Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YGL219C 0.88
MDM34
Mitochondrial outer membrane protein, required for normal mitochondrial morphology and inheritance; localizes to dots on the mitochondrial surface near mtDNA nucleoids; interacts genetically with MDM31 and MDM32
YNL142W 0.88
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YHR210C 0.88 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YOL118C 0.88 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YOL075C 0.87 Putative ABC transporter
YHL041W 0.87 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YCL066W 0.87
HMLALPHA1
Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression
YOR292C 0.87 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
YCR073W-A 0.86
SOL2
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p
YGR121C 0.86
MEP1
Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YER004W 0.86
FMP52
Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YLR332W 0.85
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YHL024W 0.85
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes

Network of associatons between targets according to the STRING database.

First level regulatory network of RLM1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0015755 fructose transport(GO:0015755)
1.7 10.4 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.6 4.9 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.5 4.6 GO:0042843 D-xylose catabolic process(GO:0042843)
1.5 5.9 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
1.1 4.2 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.9 3.8 GO:0006848 pyruvate transport(GO:0006848)
0.9 2.8 GO:0090630 activation of GTPase activity(GO:0090630)
0.8 2.5 GO:0045895 positive regulation of mating-type specific transcription, DNA-templated(GO:0045895)
0.8 2.3 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.8 3.1 GO:0019748 secondary metabolic process(GO:0019748)
0.6 0.6 GO:0071361 positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) cellular response to ethanol(GO:0071361) cellular response to alcohol(GO:0097306)
0.6 2.4 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.6 1.7 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.6 1.7 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.6 2.3 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.6 3.9 GO:0015891 siderophore transport(GO:0015891)
0.6 1.7 GO:0045894 regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001196) negative regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001198) negative regulation of mating-type specific transcription, DNA-templated(GO:0045894)
0.5 2.6 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.5 4.5 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.5 1.9 GO:0015847 putrescine transport(GO:0015847)
0.5 1.4 GO:0042744 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.5 2.8 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.5 4.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 1.4 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.5 8.1 GO:0006772 thiamine metabolic process(GO:0006772)
0.4 3.6 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.4 2.2 GO:0016242 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.4 2.2 GO:0008053 mitochondrial fusion(GO:0008053)
0.4 2.1 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.4 1.6 GO:0015793 glycerol transport(GO:0015793)
0.4 1.2 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.4 1.1 GO:0015976 carbon utilization(GO:0015976)
0.4 7.6 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.4 0.7 GO:0043419 urea catabolic process(GO:0043419)
0.3 1.4 GO:0046352 disaccharide catabolic process(GO:0046352)
0.3 3.0 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.3 7.5 GO:0006094 gluconeogenesis(GO:0006094)
0.3 1.3 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.3 1.6 GO:0070941 eisosome assembly(GO:0070941)
0.3 0.9 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.3 0.9 GO:0015691 cadmium ion transport(GO:0015691)
0.3 1.8 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.3 0.6 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.3 1.7 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.2 1.2 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.2 0.5 GO:0000304 response to singlet oxygen(GO:0000304)
0.2 0.5 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.2 1.5 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.2 1.5 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.2 1.2 GO:0034487 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.2 1.0 GO:0006171 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.2 1.0 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.2 0.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 5.5 GO:0006915 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.2 0.7 GO:0071467 cellular response to pH(GO:0071467)
0.2 0.9 GO:0046185 aldehyde catabolic process(GO:0046185)
0.2 0.9 GO:0032373 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.2 4.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.2 0.9 GO:0051503 adenine nucleotide transport(GO:0051503)
0.2 0.4 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.2 1.3 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.2 2.0 GO:0045332 phospholipid translocation(GO:0045332)
0.2 1.0 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.2 0.2 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993)
0.2 0.6 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.2 1.7 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.2 1.3 GO:0036297 interstrand cross-link repair(GO:0036297)
0.2 0.4 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.2 3.8 GO:0000209 protein polyubiquitination(GO:0000209)
0.2 0.7 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.2 1.4 GO:0018345 protein palmitoylation(GO:0018345)
0.2 0.7 GO:0070054 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.2 0.5 GO:0015886 heme transport(GO:0015886)
0.2 0.7 GO:0051346 negative regulation of hydrolase activity(GO:0051346)
0.2 1.0 GO:0006279 premeiotic DNA replication(GO:0006279)
0.2 1.2 GO:0006012 galactose metabolic process(GO:0006012)
0.2 0.7 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.2 0.7 GO:0000023 maltose metabolic process(GO:0000023)
0.2 0.6 GO:0031297 replication fork processing(GO:0031297)
0.2 2.5 GO:0006754 ATP biosynthetic process(GO:0006754)
0.2 1.3 GO:0051180 vitamin transport(GO:0051180)
0.2 0.6 GO:0015804 neutral amino acid transport(GO:0015804)
0.2 0.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 1.2 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.1 0.9 GO:0010508 positive regulation of autophagy(GO:0010508)
0.1 0.9 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 0.9 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.7 GO:0005991 trehalose metabolic process(GO:0005991)
0.1 1.1 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.4 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.1 0.4 GO:0045117 azole transport(GO:0045117)
0.1 1.2 GO:0043487 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.1 0.7 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 0.7 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 0.7 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 0.1 GO:0034086 maintenance of sister chromatid cohesion(GO:0034086) regulation of maintenance of sister chromatid cohesion(GO:0034091)
0.1 0.4 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.1 1.5 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.5 GO:0046464 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.1 0.5 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.1 1.7 GO:0001101 response to acid chemical(GO:0001101)
0.1 0.7 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 0.8 GO:0030242 pexophagy(GO:0030242)
0.1 0.4 GO:0046021 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021)
0.1 0.2 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.1 1.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 0.6 GO:0006829 zinc II ion transport(GO:0006829)
0.1 1.7 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.1 2.5 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.5 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.1 0.3 GO:0071850 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.1 3.4 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.1 GO:0035494 SNARE complex disassembly(GO:0035494)
0.1 0.5 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.6 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 1.1 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.1 0.3 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 0.3 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.1 0.2 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 0.6 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.2 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.1 0.1 GO:0019627 urea metabolic process(GO:0019627)
0.1 0.5 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 0.3 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 0.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 1.9 GO:0010324 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.1 0.5 GO:0044247 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 0.4 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.1 1.0 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.1 0.8 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 0.6 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.2 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.1 0.9 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.1 0.5 GO:0015802 basic amino acid transport(GO:0015802)
0.1 0.3 GO:0015856 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.1 0.5 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.1 0.3 GO:0006641 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.1 0.8 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 1.3 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.1 0.3 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.5 GO:0043461 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.1 0.6 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.1 0.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.1 0.2 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.1 GO:0070726 cell wall assembly(GO:0070726)
0.1 0.3 GO:0072337 modified amino acid transport(GO:0072337)
0.1 0.4 GO:0031397 negative regulation of protein ubiquitination(GO:0031397) negative regulation of protein modification by small protein conjugation or removal(GO:1903321)
0.1 0.2 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.4 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 0.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.1 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.1 0.8 GO:0015914 phospholipid transport(GO:0015914)
0.1 0.3 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.1 0.3 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.2 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 1.4 GO:0032258 CVT pathway(GO:0032258)
0.1 0.3 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 0.2 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.1 0.4 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.1 0.8 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 0.2 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.1 0.3 GO:0034982 protein processing involved in protein targeting to mitochondrion(GO:0006627) mitochondrial protein processing(GO:0034982)
0.1 0.4 GO:0010529 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.1 0.3 GO:0046033 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.1 0.5 GO:0031578 mitotic spindle orientation checkpoint(GO:0031578)
0.1 0.6 GO:0019740 nitrogen utilization(GO:0019740)
0.1 0.2 GO:0042762 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of sulfur metabolic process(GO:0042762)
0.1 0.1 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.1 0.4 GO:0055074 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)
0.1 2.3 GO:0009060 aerobic respiration(GO:0009060)
0.1 0.2 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.1 0.2 GO:0045596 negative regulation of cell differentiation(GO:0045596) negative regulation of developmental process(GO:0051093)
0.1 0.1 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.1 0.3 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.1 0.2 GO:0034755 high-affinity iron ion transmembrane transport(GO:0006827) iron ion transmembrane transport(GO:0034755)
0.1 0.5 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.0 GO:0000416 positive regulation of histone H3-K36 methylation(GO:0000416) histone H3-K36 trimethylation(GO:0097198) regulation of histone H3-K36 trimethylation(GO:2001253) positive regulation of histone H3-K36 trimethylation(GO:2001255)
0.0 0.0 GO:0009730 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.0 0.4 GO:0000755 cytogamy(GO:0000755)
0.0 0.8 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 0.2 GO:0042537 benzene-containing compound metabolic process(GO:0042537)
0.0 0.3 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.5 GO:0042026 protein refolding(GO:0042026)
0.0 0.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.2 GO:0051382 centromere complex assembly(GO:0034508) kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.0 0.1 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.0 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.0 0.2 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.2 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.7 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.3 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.2 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.3 GO:0010038 response to metal ion(GO:0010038)
0.0 0.3 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.1 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.0 0.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.1 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.0 0.0 GO:0031111 negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0 0.1 GO:2000002 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.0 0.1 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.0 0.1 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.2 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.6 GO:0007031 peroxisome organization(GO:0007031)
0.0 0.1 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.0 0.3 GO:0040001 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.0 0.2 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.0 0.1 GO:0071168 protein localization to chromatin(GO:0071168)
0.0 0.6 GO:0071173 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0 0.1 GO:0072417 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.0 0.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.3 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.0 0.6 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.0 0.2 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.1 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.0 0.0 GO:0050685 positive regulation of mRNA processing(GO:0050685)
0.0 0.0 GO:0015851 nucleobase transport(GO:0015851)
0.0 0.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.2 GO:0006826 iron ion transport(GO:0006826)
0.0 0.1 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.0 0.1 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.0 0.0 GO:0044275 cellular carbohydrate catabolic process(GO:0044275)
0.0 0.0 GO:0030308 negative regulation of cell growth(GO:0030308) negative regulation of pseudohyphal growth(GO:2000221)
0.0 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.0 GO:0043270 positive regulation of ion transport(GO:0043270)
0.0 0.1 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.0 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.0 0.5 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.0 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.0 0.1 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
0.0 0.5 GO:0000282 cellular bud site selection(GO:0000282) mitotic cytokinesis, site selection(GO:1902408)
0.0 0.0 GO:0042407 cristae formation(GO:0042407)
0.0 0.0 GO:0031494 regulation of cell fate commitment(GO:0010453) positive regulation of cell fate commitment(GO:0010455) regulation of mating type switching(GO:0031494) positive regulation of mating type switching(GO:0031496) positive regulation of cell differentiation(GO:0045597) positive regulation of developmental process(GO:0051094)
0.0 0.1 GO:0009306 protein secretion(GO:0009306)
0.0 1.1 GO:0030435 sporulation resulting in formation of a cellular spore(GO:0030435)
0.0 0.1 GO:0010647 positive regulation of cell communication(GO:0010647)
0.0 0.1 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.1 GO:0090522 vesicle tethering involved in exocytosis(GO:0090522)
0.0 0.1 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.0 GO:0046475 glycerophospholipid catabolic process(GO:0046475)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.8 2.5 GO:0030061 mitochondrial crista(GO:0030061)
0.6 2.4 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.6 1.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.4 1.3 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.4 1.2 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.3 3.1 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.3 1.7 GO:0034448 EGO complex(GO:0034448)
0.3 1.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.3 1.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 0.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 0.8 GO:0033309 SBF transcription complex(GO:0033309)
0.2 0.9 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.2 0.9 GO:0032865 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.2 5.4 GO:0005770 late endosome(GO:0005770)
0.1 0.4 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.1 0.3 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.1 0.4 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.7 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.4 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.6 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.1 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.7 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 1.3 GO:0030677 ribonuclease P complex(GO:0030677)
0.1 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.4 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 0.7 GO:0008180 COP9 signalosome(GO:0008180)
0.1 2.0 GO:0070469 respiratory chain(GO:0070469)
0.1 0.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.5 GO:0016587 Isw1 complex(GO:0016587)
0.1 0.7 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.4 GO:0033551 monopolin complex(GO:0033551)
0.1 0.6 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 2.4 GO:0031226 integral component of plasma membrane(GO:0005887) intrinsic component of plasma membrane(GO:0031226)
0.1 0.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.4 GO:0031105 septin complex(GO:0031105)
0.1 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.6 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112) core TFIIH complex(GO:0000439)
0.1 4.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.2 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306)
0.1 0.3 GO:0008623 CHRAC(GO:0008623)
0.1 0.3 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.1 0.5 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.2 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 0.9 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 0.6 GO:0005775 vacuolar lumen(GO:0005775)
0.1 0.7 GO:0000795 synaptonemal complex(GO:0000795)
0.1 1.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942) phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 0.2 GO:0046930 pore complex(GO:0046930)
0.1 3.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.8 GO:0005643 nuclear pore(GO:0005643)
0.1 1.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.3 GO:0001400 mating projection base(GO:0001400)
0.1 2.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.9 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 0.3 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.3 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 1.0 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.1 GO:0070211 Snt2C complex(GO:0070211)
0.0 0.4 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.8 GO:0005795 Golgi stack(GO:0005795)
0.0 0.1 GO:0070274 RES complex(GO:0070274)
0.0 0.3 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.1 GO:0070823 HDA1 complex(GO:0070823)
0.0 5.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.3 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.9 GO:0031201 SNARE complex(GO:0031201)
0.0 0.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.3 GO:0034657 GID complex(GO:0034657)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 1.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 3.3 GO:0098852 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.4 GO:0033698 Rpd3L complex(GO:0033698)
0.0 18.7 GO:0031224 intrinsic component of membrane(GO:0031224)
0.0 0.1 GO:0000818 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.0 0.2 GO:0005619 ascospore wall(GO:0005619) spore wall(GO:0031160)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940) condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.1 GO:0030139 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.1 GO:0044455 mitochondrial membrane part(GO:0044455)
0.0 0.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)
0.0 0.1 GO:0032126 eisosome(GO:0032126)
0.0 0.3 GO:0070847 core mediator complex(GO:0070847)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 10.4 GO:0005537 mannose binding(GO:0005537)
1.5 7.7 GO:0015295 solute:proton symporter activity(GO:0015295)
1.3 5.4 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
1.3 5.2 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
1.2 4.7 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
1.2 4.6 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.1 3.4 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
1.0 4.2 GO:0004396 hexokinase activity(GO:0004396)
1.0 3.0 GO:0016880 AMP binding(GO:0016208) acid-ammonia (or amide) ligase activity(GO:0016880)
0.8 2.4 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.8 6.9 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.7 2.1 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.7 2.0 GO:0005536 glucose binding(GO:0005536)
0.6 2.5 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.6 1.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.6 2.3 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.5 2.2 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.5 3.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.5 3.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 0.4 GO:0005057 receptor signaling protein activity(GO:0005057)
0.4 4.4 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.4 7.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.4 1.2 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.4 1.8 GO:0008198 ferrous iron binding(GO:0008198)
0.4 1.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.4 1.4 GO:0022821 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.3 3.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 4.1 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.3 1.7 GO:0019903 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.3 1.0 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.3 7.9 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.3 1.6 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.3 2.6 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.3 1.3 GO:0032452 histone demethylase activity(GO:0032452)
0.3 1.5 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.3 0.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.3 3.2 GO:0015293 symporter activity(GO:0015293)
0.3 1.1 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.3 2.7 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.3 0.8 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.3 0.8 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 1.5 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.2 1.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 0.9 GO:0019789 SUMO transferase activity(GO:0019789)
0.2 2.0 GO:0035064 methylated histone binding(GO:0035064)
0.2 1.0 GO:0016783 sulfurtransferase activity(GO:0016783)
0.2 0.6 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 1.1 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.2 0.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 0.7 GO:0016531 copper chaperone activity(GO:0016531)
0.2 0.5 GO:0017108 5'-flap endonuclease activity(GO:0017108) flap endonuclease activity(GO:0048256)
0.2 0.9 GO:0004075 biotin carboxylase activity(GO:0004075)
0.2 0.5 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.2 0.6 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.2 0.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.1 0.7 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.6 GO:0060089 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.1 0.4 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 1.1 GO:0034979 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.1 2.9 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.4 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.1 1.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.5 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 1.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 1.0 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.3 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.1 0.6 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.1 1.2 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.2 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 0.3 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.1 0.6 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 1.2 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.1 0.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.5 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.1 0.6 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.1 0.7 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 0.3 GO:0032183 SUMO binding(GO:0032183)
0.1 0.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 2.5 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 0.1 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.1 0.8 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 3.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.3 GO:0016417 S-acyltransferase activity(GO:0016417)
0.1 0.5 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.1 0.3 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.1 1.0 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 1.2 GO:0005507 copper ion binding(GO:0005507)
0.1 1.2 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.1 1.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 0.2 GO:0015288 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.1 1.6 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.1 0.7 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.1 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.3 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.1 0.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.2 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 0.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.6 GO:0043495 protein anchor(GO:0043495)
0.1 0.2 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 1.2 GO:0005506 iron ion binding(GO:0005506)
0.1 0.3 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.3 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 0.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.2 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.2 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.0 0.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.2 GO:0017022 myosin binding(GO:0017022)
0.0 0.5 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.2 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.3 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.2 GO:0031406 amino acid binding(GO:0016597) carboxylic acid binding(GO:0031406) organic acid binding(GO:0043177)
0.0 0.4 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.5 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.2 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.0 0.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0045118 azole transporter activity(GO:0045118)
0.0 0.5 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.2 GO:0000104 succinate dehydrogenase activity(GO:0000104) succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.0 0.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.2 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.5 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.0 0.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.5 GO:0034061 DNA polymerase activity(GO:0034061)
0.0 0.5 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 3.8 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)
0.0 0.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.3 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.0 0.0 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.0 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.3 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.1 GO:0052866 phosphatidylinositol phosphate phosphatase activity(GO:0052866)
0.0 0.0 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.1 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.2 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.0 0.0 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters(GO:0016894)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.5 2.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 1.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 0.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 0.4 PID ATM PATHWAY ATM pathway
0.1 0.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 124.3 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 0.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.1 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 0.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.1 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.0 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.7 2.0 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.3 0.8 REACTOME DNA REPAIR Genes involved in DNA Repair
0.2 0.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 0.5 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.2 0.6 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.1 0.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 0.6 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 0.2 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.1 0.2 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.1 124.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.2 REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
0.1 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 0.2 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 0.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.1 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 0.1 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 0.1 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein